Nicotine et dérivés de nicotine

<p>Applications 1,4-Dihydro-1-methyl-4-oxo-3-pyridinecarboxamide-d3 is the isotope labelled analog of 1,4-Dihydro-1-methyl-4-oxo-3-pyridinecarboxamide (D453415); a compound that has been shown to be one of the potential novel biomarkers of peroxisome proliferation in the rat.<br>References Ringeissen, S., Biomarkers, 8, 240 (2003); Shibata, K., et al.: Biosci. Biotech. and Biochem., 77, 2105 (2013)<br></p>

<p>Applications N-Ethylnicotinamide is a derivative of Nicotinamide (N407750), which is a water-soluble vitamin and is part of the vitamin B group.<br>References Sharma, M., et al.: J. Chem. Pharm. Res., 2, 416 (2010), Al-Nadaf, A., et al.: Bioorg. Medi. Chem., 18, 3088 (2010),<br></p>

<p>Applications A metabolite of Nicotine. S-Enantiomer of Cotinine.<br>References Sugasawa, S., et al.: Pharma. Bull., et al.: 2, 39 (1954), Thompson, J.A., et al.: J. Chromatog., 231, 53 (1982); Seeman, J.I., et al.: J. Org. Chem., 51, 1548 (1986)<br></p>

<p>Stability Hygroscopic<br>Applications A major metabolite of Nicotine in humans. Carcinogen.<br>References Benowitz, N., et al.: Clin. Pharmacol. Ther., 56, 483 (1994), Nakajima, M., et al.: Drug Metab. Dispos., 24, 1212 (1996), Messina, E., et al.: J. Pharmacol. Exp. Ther., 282, 1608 (1997), Oscarson, M., et al.: Hum. Mutat., 20, 275 (2002),<br></p>

<p>Stability Hygroscopic<br>Applications trans-3'-Hydroxy Cotinine-d3 (Racemic Mixtures) (cas# 159956-78-2) is a compound useful in organic synthesis.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Desai, D., et al.: Chem. Res. Toxicol., 3, 47 (1990)<br></p>

<p>Stability Hygroscopic<br>Applications Labelled (R,S)-Anatabine is a metabolite of Nicotine (N412420).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Quan, P.M., et al.: J. Org. Chem., 30, 2769 (1965), Maciuk, A., et al.: J. Pharm. Biomed. Anal., 48, 238 (2008),<br></p>

<p>Applications rac N’-Nitrosonornicotine-d4 is present in cigarettes and patches in reduced amounts in order to facilitate the cessation of smoking. Induces down-regulation of nonmuscle myosin II affecting cell motility and wound healing.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Hatsukami, D. et al.: Canc. Epid. Bio. Prev., 22, 1015 (2013); Prins, J. et al.: J. Prot. Res., 12, 1282 (2013);<br></p>

<p>Applications Sorbicillin analog. A bioactive secondary metabolites from terrestrial Streptomyces species TN262.<br>References Ma, L. et al. : J. Anitibiot. 64, 645 (2011); Elleuch, L. et al.: Appl. Biochem. Biotech. 162, 579 (2010)<br></p>

<p>Stability Hygroscopic, Light Sensitive<br>Applications (R,S)-Anatabine is a metabolite of Nicotine (N412420).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Quan, P.M., et al.: J. Org. Chem., 30, 2769 (1965), Maciuk, A., et al.: J. Pharm. Biomed. Anal., 48, 238 (2008),<br></p>

<p>Stability Very Hygroscopic<br>Applications Nicotine N-β-D-Glucuronide is a Nicotine (N412420) metabolite in rat brain. Nicotine N-β-D-Glucuronide is used as a Nicotine biomarker in rat brain.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Alexandrov, K., et al.: Toxicol. Lett., 198, 63 (2010), Huang, L., et al.: J. Neurochem., 109, 826 (2009), Quik, M., et al.: Biochem. Pharmacol., 78, 677 (2009), Weems, J., et al.: Chem. Res. Toxicol., 23, 696 (2010),<br></p>

<p>Applications A labelled major metabolite of nicotine in humans. Carcinogen.<br>References Sugasawa, S., et al.: Pharma. Bull., et al.: 2, 39 (1954), Thompson, J.A., et al.: J. Chromatog., 231, 53 (1982); Seeman, J.I., et al.: J. Org. Chem., 51, 1548 (1986)<br></p>

<p>Applications 2-Chloro-rac-Nicotine is a metabolite of rac-Nicotine (N412420); an active stimulant having both addictive and carcinogenic properties.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Lowry, T., et al.: J. Chem. Soc., 319 (1931);<br></p>

<p>Applications A major metabolite of Nicotine in humans. Carcinogen.<br>References Sugasawa, S., et al.: Pharma. Bull., et al.: 2, 39 (1954), Thompson, J.A., et al.: J. Chromatog., 231, 53 (1982); Seeman, J.I., et al.: J. Org. Chem., 51, 1548 (1986)<br></p>

<p>Stability Light Sensitive<br>Applications (±)-Nicotine-d7 (N-methyl-d3; pyridine-d4) is the labelled version of Nicotine (N412420(M)) is an alkaloid isolated from plants. Nicotine is an active stimulant, having both addictive and carcinogenic properties. Nicotine can be absorbed through the alimentary canal, respiratory tract and intact skin. Nicotine is used in the treatment of smoking withdrawal syndrome. Nicotine has been used as an anthelmintic.<br>References Ferretti, G., et al.: J. Med. Chem., 45, 4724 (2002), Guillen, M., et al.: J. Agric. Food Chem., 53, 1093 (2005), Ramunno, A., et al.: Bioorg. Med. Chem. Lett., 15, 3237 (2005), Alburges, M., et al.: Eur. J. Pharmacol., 573, 124 (2007),<br></p>