Halogénures organiques

<p>Applications 1-Chloroethyl isopropyl carbonate (cas# 98298-66-9) is a useful research chemical.<br></p>

<p>Applications 1-Bromocyclopentyl 2-Chlorophenyl Ketone is a reactant in the dehydrohalogenation of axial 6-bromoketamine III and is also an intermediate in the synthesis of S-(-)-Norketamine (N692060).<br>References Parcell, R., et al.: J. Org. Chem., 45, 5055 (1981);<br></p>

<p>Applications 1-Amino-2,4-dibromo-anthraquinone is a useful compound to study the uPAR·uPA protein-protein interaction (PPI) involved in signaling and proteolytic events that lead to tumor invasion and metastasis. It is also used to evaluate potential renal toxicants based on a relationship between chemical-induced kidney weight gain and kidney histopathology in rats. 1-Amino-2,4-dibromo-anthraquinone is a reagent utilized in copper-catalyzed Ullmann condensation to synthesize anthraquinone derivatives as novel dyes.<br>References Malik, E. M., et al.: Dyes Pigm. 131, 33 (2016); Craig, E. A., et al.: J. Appl. Toxicol. 35, 729 (2015); Mani, T., et al.: Bioorg. Med. Chem 21, 2145 (2013)<br></p>

<p>Applications Decafluorobiphenyl is used for step−growth polymers synthesis (1).<br>References (1) Deck, P. A. and Maiorana, C. R. Macromolecules 34, 9 (2001)<br></p>

<p>Applications 2-Amino-6-fluorobenzothiazole is a useful research chemical. An intermediate for the synthesis of benzothiazoles and aminobenzothiazoles with antimicrobial activity.<br>References Defrenza, I., et al.: J. Heterocycl. Chem., 52, 1705 (2015); Catalano, A., et al.: Eur. J. Med. Chem., 64, 357 (2013)<br></p>

<p>Applications 2,4-DINITROBENZYL BROMIDE (cas# 3013-38-5) is a useful research chemical.<br></p>

<p>Stability Hygroscopic<br>Applications Quaternary ammonium salts useful as paint strippers, foaming stabilizers, and bactericidal lotions.<br>References Bhattacharya, S., et al.: Biochemistry, 37, 7764 (1998), Raspaud, E., et al.: Biophys. J., 74, 381 (1998), Asgatay, S., et al.: Int. J. Pharm., 285, 121 (2004), Goracci, L., et al.: ChemBioChem., 6, 197 (2005),<br></p>

<p>Stability Light Sensitive<br>Applications 3-Chlorocyclohexene (cas# 2441-97-6) is a useful research chemical.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications 2,5-Dichlorophenol is an intermediates in the manufacture of more complex chemical compounds such as fungicides.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Wang, F., et al.: Bull. Enviro. Contamin. Toxicol., 89, 316 (2012); Zhong, W., et al.: J. Hazard. Mat., 217, 286 (2012);<br></p>

<p>Applications p-Trifluoromethylphenyl is used in the synthesis of P2Y1 antagonists and antithrombotic agents. Also, used in the synthesis of potent myeloid cell leukemia inhibitors.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Chao, H. et al.: J. Med. Chem., 56, 1704, 2013; Friberg, A. et al.: J. Med. Chem., 56, 15 (2013);<br></p>

<p>Applications 2,2,2-Trichloroacetamide was an aliphatic halogenated DBP precursor identified in drinking water treatment; a pollutant.<br>References Zhang, Y., et al.: J. Environ. Sci. (Beijing, China), 58, 322 (2017)<br></p>

<p>Applications Methyltriphenylphosphonium Bromide is a lipophilic molecule with a cation allowing for it to be used to deliver molecules to specific cell components. Also considered an antineoplastic agent.<br>References Selassie, C.D. et al.: J. Med. Chem., 33, 1914 (1990); Venkatachalam, M.A et al.: Kidney Int., 49, 449 (1996);<br></p>

<p>Applications 3-Pyridylacetic Acid is a metabolite of Nicotine (N412420). 3-Pyridylacetic Acid is an antilipemic.<br>References Baer, T.A., et al.: J. Med. Chem., 16, 85 (1973); Kyerematen, G. A., et al.: Drug Metab. Dispos., 16, 125 (1988);<br></p>

<p>Stability Hygroscopic<br>Applications 3-[[[2-[(Diaminomethylene)amino]-4-thiazolyl]methyl]thio]propanimidamide hydrochloride (cas# 76833-47-1) is a useful research chemical.<br></p>

<p>Applications Bromochloroacetic acid is a halogenated disinfection byproduct commonly found in drinking water, fruit juice, and cheese. Bromochloroacetic acid has been shown to cause mesothelioma, fibroadenomas, and adenomas in rats<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Hang, C., et al.: Sci Total Environ. 543, 425 (2016); Cardador, M. J. and Gallego, M.: Food Chem. 173, 685 (2015); Natl Toxicol Program Tech Rep Ser. 549, 1 (2009)<br></p>

<p>Impurity Azelastine EP Impurity E /Azelastine USP RC E<br>Applications Stilbene-related benzalphthalide derivative with with potential anti-HIV and leishmanicidal activity. It has anxiolytic effects and maybe useful in the development of a non-benzodiazepinic and non-nitrogenated antianxiety agents.An impurity arising in the synthesis of azelastine (A808250).<br>References Zamilpa, A. et al.: Bioorg. Med. Chem. Lett., 15, 3483 (2005); Bedoya, L.M. et al.: Bioorg. Med. Chem. Lett., 16, 4075 (2006); del Olmo, E. et al.: Bioorg. Med. Chem. Lett., 11, 2123 (2001);<br></p>

<p>Applications Ethyl 4-Bromobutanoate is a building block which has been used as a reactant for the preparation of firefly luciferase inhibitor-conjugated peptide derivatives.<br>References Poutiainen, P.K., et. al.: Bioconjugate Chem., 25, 4 (2014)<br></p>

<p>Applications 2-Bromoethanol is an widely used intermediate in organic synthesis.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Tian, Z., et al.: Int. J. Quant. Chem., 111, 631 (2011); Thayer, F.K., et al.: Org. Syntheses., 6, (1926);<br></p>

<p>Applications 3-Chloro-4-fluorobenzotrifluoride acts as a reagent in the synthesis of β-substituted 3-(4-aryloxyaryl)propanoic acid as GPR40 agonists.<br>References Walsh, S. P., et al.: Bioorg. Med. Chem. Lett., 21, 3390 (2011)<br></p>

<p>Stability Hygroscopic<br>Applications Omeprazole Sulfide Hydrochloride is a metabolite of Omeprazole (O635000), which binds covalently to proton pump. It inhibits gastric secretion. Used as an anttiulcerative.<br>References Muller, P., et al.: Arzneimittel-Forsch., 33, 1685 (1983); Wallmark, B., et al.: Biochim. Biophys. Acta., 778, 549 (1984); Morii, M., et al.: J. Biol. chem., 268, 21553 (1993); Ritter, M., et al.: Br. J. Pharmacol., 124, 627 (1998)<br></p>

<p>Applications N,N-Dimethyl-3-phenylpentan-3-amine Hydrochloride is a useful research chemical.<br></p>

<p>Applications Perfluorodecyl iodide is used to prepare 3,5-bis(perfluorodecyl)phenylboronic acid, "green" catalyst for the direct amide condensation reaction. It is also used to synthesize 3-(perfluorodecyl)prop-1-ene.<br>References Ishihara, K, et al.: Synlett., 9, 1371 (2001); Ryu, I., et al.: Tetrahedron Lett., 42, 947 (2001)<br></p>

<p>Applications Trigonelline (chloride) is an alkaloid found in plants and coffee. Trigonelline is a product of niacin metabolism that is excreted in urine.<br></p>

<p>Applications 4-[(2-chloroacetyl)amino]benzoic acid (cas# 4596-39-8) is a useful research chemical.<br></p>

<p>Applications Reagent used in the addition of dichlorobenzene.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Marchand, P., et al.: Bioorg. Med. Chem., 17, 6715 (2009); Singh, J., et al.: J. Med. Chem., 53, 18 (2010);<br></p>

<p>Applications 2-Chloro-1,3,2-dioxaphospholane-2-oxide is used in the synthesis of α-naphthylphosphorylcholine as a method to detect phospholipase C activity.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Durban, M. et al.: Eur. J. Lipid. Sci. Tech., 105, 633 (2003);<br></p>

<p>Applications 4-​Hydrazinobenzoic acid hydrochloride (cas# 24589-77-3) is a useful research chemical.<br></p>

<p>Applications Diamino-5-phenylthiazole Hydrobromide is an phenylthiazole derivative used in the preparation of antiallergic and antiinflammatory agents.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Ban, M. et al.: Bioorg. Med. Chem., 6, 1069 (1998);<br></p>

<p>Applications 4-Bromophenol is used as a reagent in Stille reactions.<br>References Littke, A.F. et al.: J. Am. Chem. Soc., 124, 6343 (2002);<br></p>

<p>Stability Moisture Sensitive<br>Applications 2-Chloro-5-(1-chloro-1,3-dihydro-3-oxo-1-isobenzofuranyl)-benzenesulfonyl Chloride is a useful synthetic intermediate.<br></p>

<p>Applications O-2-Propynylhydroxylamine hydrochloride (cas# 21663-79-6) is a useful research chemical.<br></p>

<p>Applications 7-(2-Chloroethyl)theophylline (cas# 5878-61-5) is a useful research chemical.<br></p>

<p>Applications 1-[(2-Chlorophenyl)(methylimino)methyl]cyclopentanol has potential use as a component of household cleaning solution products. IT is also an intermediate in the production of the cyclohexanone analogue.Ketamine (K165300) related compound.<br></p>

<p>Applications 2,3,4-Trichlorotoluene is a general chemical reagent. Used in the preparation of sulfonamide based hypoglycemics. Generally used in reduction and oxidation reactions in the preparation of dyes.<br>References Goudarzi, N. et al.: Mol. Phys., 107, 1739 (2009);<br></p>

<p>Applications 1-Cyclopropyl-2-(2-fluorophenyl)-2-hydroxy-ethanone is a useful synthetic intermediate in the synthesis of Prasugrel (P701150, HCl); an antiplatelet agent.<br>References Wiviott, S.D., et al.: Circulation, 116, 2923 (2007); Xu, X., et al. Faming Zhuanli Shenqing. CN 102718642 A 20121010. Oct 10, 2012; Wang, G., et al. Faming Zhuanli Shenqing. CN 101402556 A 20090408. Apr 8, 2009<br></p>

<p>Stability Light Sensitive, Volatile<br>Applications Trichloroacetonitrile is a by-product of the chlorine disinfection of water and is commonly used as a fumigant. It is also used as a direct alkylating agent and reacts with primary and secondary aliphatic amines to produce N-substituted trichloroacetamidines.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Christ, S.: J. Toxicol. Env. Health A, 47, 233 (1996); Davies, M. &amp; Jenkin, D.: J. Chem. Soc., No vol. given, 2374 (1954); Grivas, J. &amp; Taurins, A.: J. Chem., 36, 771 (1958)<br></p>

<p>Stability Hygroscopic<br>Applications Dihydrogen Hexachloroplatinate Hexahydrate is a reactant used in the synthesis of platinum, carbon dot hybrid nanoparticles.<br>References Shin, H. et al.: ACS. Catal., 6, 3914 (2016);<br></p>

<p>Applications 2-chloro-N-[(furan-2-yl)methyl]-7H-purin-6-amine (cas# 101862-47-9) is a useful research chemical.<br></p>

<p>Applications 4-Chlorobenzal Chloride is an impurity that is formed in the synthesis of Benoxaprofen (B165300); a non-steroidal anti-inflammatory ophthalmic agent.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Cockerill, A.F., et al.: J. Chromatogr., 129, 339 (1976); Mathur, K., et al.: Bioorg. Med. Chem., 11, 1915 (2003); Zhao, M., et al.: Bioorg. Med. Chem., 15, 2815 (2007); Roy, K., et al.: Eur. J. Med. Chem., 44, 2913 (2009)<br></p>

<p>Applications 5,6-dibromonicotinic acid (cas# 29241-64-3) is a useful research chemical.<br></p>

<p>Applications N-Alkyl(C12-16)-N-benzyl-N,N-dimethylammonium chloride, tech. (cas# 68424-85-1) is a useful research chemical.<br></p>

<p>Applications 5H-Octafluoropentanal (cas# 2648-47-7) is a useful research chemical.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications Used for preparation of substituted indazole amides as glucokinase activators.<br>References Perles, J., et al.: J. Mater. Chem., 14, 2683 (2004),<br></p>

<p>Applications 4-Chloro-2,5-dimethoxyaniline was an analyte identified in a screening study of electronic nicotine delivery systems (ENDS), which are regulated tobacco products.<br>References Hung, P. H., et al.: J. Applied Toxic., 40, 1566 (2020)<br></p>

<p>Applications 4-[2,2-dichloro-1-(4-hydroxyphenyl)ethenyl]phenol (cas# 14868-03-2) is a useful research chemical.<br></p>

<p>Applications 5-Chloronicotinic Acid is used as reagent/reactant luminescence and hydrothermal preparation of cobalt/cadmium/lead chloronicotinate phenanthroline MOF.<br>References Gao, Z.Q., et al.: J. Solid State Chem., 241, 121-130 (2016)<br></p>

<p>Applications Ethylamine Hydrochloride a chemical used in various chemical organic syntheses and biological studies.<br>References Miller, M.M. et al.: Bioorg. Med. Chem. Lett., 22, 6503 (2012); Yasui, K. et al.: Prot. Sci., 19, 486 (2010);<br></p>

<p>Applications 2-(2-Chloro-4-iodophenylamino)-3,4-difluorobenzoic Acid (cas# 303175-44-2) is a compound useful in organic synthesis.<br></p>

<p>Applications 4-Aminomethyl Benzamidine Dihydrochloride is a small molecule CXCR4 antagonist.<br>References Zhan, Weiqiang, et al.: J. of Med. Chem., 50(23), 5655-5664 (2007)<br></p>

<p>Applications 4-Aminocatechol Hydrochloride is an acidic salt form of 4-Aminocatechol (A603280). 4-Aminocatechol is a phenol derivative with inhibitory activity against matrix metalloproteinase (MMP).<br>References Rubino, M.T. et al.: Arch. Pharm., 344, 557 (2011);<br></p>

<p>Applications Epichlorohydrin is used as a solvent for natural and synthetic resins, gums, cellulose esters and ethers, paints, varnishes, nail enamels and lacquers, cement for Celluloid. Also, it is used as stabilizer.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Smyth, H.F., et al.: J. Ind. Hyg. Toxicol., 30, 63 (1948),<br></p>

<p>Applications Anticonvulsant against audiogenic convulsion.<br>References Kim, K., et al.: J. Med. Chem., 51, 5330 (2008), Ruel, R., et al.: Bioorg. Med. Chem. Lett., 18, 2985 (2008),<br></p>

<p>Applications cis-1-(3-Chloroallyl)-3,5,7-triaza-1-azoniaadamantantane Chloride is a quaternary ammonium salt used as a preservative in many cosmetics and industrial substances.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Marouchoc, S.: Cosm. Sci. Technol. Series, 1, 143 (1984); Cheng, J., et al.: J. Toxicol. Cutan. Ocul. Toxicol., 14, 287 (1995);<br></p>

<p>Applications 2-Amino-3-(2-chlorobenzoyl)thiophene is a useful compound for the synthetic process of Brotizolam (B689280(M)), which is a hypnotic and a sedative.<br>References Du, D. P., et al.: Zhongguo Yaowu Huaxue Zazhi, 25, 280 (2015); Sato, T., et al.: J. Med. Chem., 51, 7705 (2008); Nishino, T., et al.: J. Pharmacol. Sci., 107, 349 (2008); Yamashiro, T., et al.: J. Clin. Pharm, Ther., 33, 273 (2008); Ma, C., et al.: J. Pharm. Biomed. Anal., 47, 677 (2008)<br></p>

<p>Stability Moisture Sensitive<br>Applications 3,5-Dinitrobenzoyl Chloride was used as a derivatization agent for high performance liquid chromatographic analysis of several compounds including polyamines and acteylated derivatives, taurine and hypotaurine and biogenic amines in fermented foods. It was also used in the synthesis of several organic compounds including that of a novel starch derivative which has adsorption property for creatinine and may therefore be useful in treatment of renal failure.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Kirschbaum, J., et al.: J. Chromatogr A., 881, 517 (2000); Wongyai, S., et al.: Biomed. Chromatogr., 2, 254 (1988); Masuoka, N., et al.: J. Chromatogr B., 660, 31 (1994); Jiu-gao, Y., et al.: Acta Pharm. Sin., 38, 191 (2003);<br></p>

<p>Applications (R,R)-Ethambutol Dihydrochloride shows antitumor properties when complexed with platinum. Also an isomer of Ethambutol (E889800), an antibacterial (tuberculostatic).<br>References Coluccia, M. et al.: Anticanc. Res., 11, 281 (1991); Wilkinson, et al.: J. Med. Chem., 5, 835 (1962), Kulig, et al.: Diss. Pharm. Pharmacol., 23, 463 (1971), Lee, C.S., et al.: Anal. Profiles Drug Subs., 7, 231 (1978)<br></p>

<p>Applications Methyl 6-aminohexanoate is used as a reagent to synthesize straight chain hydroxamates, compounds that act as inhibitors of Human Histone Deacetylase (HDAC) that have the potential to treat cancer. Methyl 6-aminohexanoate is also sometimes used as a spacer unit for peptide synthesis.<br>References Matthews, S., et al.: J. Chem. Soc. Chem. Commun., 17, 1809 (1995); Remiszewski, S., et al.: J. Med. Chem., 45, 753 (2002)<br></p>

<p>Stability Hygroscopic<br>Applications Cyclopropylmethyl Bromide is a reagent used in the synthesis of human dihydroorotate dehydrogensase inhibitors which are based on azole scaffolds. In addition it is used in the preparation of ([11C]CMDC) for PET imaging of mGlur2 which has been a proposed target in the treatment of schizophrenia.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Sainas, S. et al.: Eur. J. Med. Chem., 129, 287 (2017); Ma, Y. et al.: Bioorg. Med. Chem., 25, 1014 (2017);<br></p>

<p>Applications Heptafluorobutyranilide (cas# 336-61-8) is a compound useful in organic synthesis.<br></p>

<p>Applications 2-Bromo-4,5-dimethoxybenzoic Acid (cas# 6286-46-0) is a compound useful in organic synthesis.<br></p>

<p>Applications 2-Amino-6-(chloromethyl)-4(3H)-pteridinone is a reagent/intermediate used in the preparation of Folic Acid (F680300) and its derivatives.<br>References Qi, Y., et al.: Faming Zhuanli Shenqing. CN 103755706 A 20140430. Apr 30, 2014;<br></p>

<p>Applications 2-Cyclopentyl-4-chlorophenol, Technical Grade (cas# 13347-42-7) is a compound useful in organic synthesis.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications 2-Amino-4-chlorobenzenethiol is used as reagent in the synthesis of several organic compounds including that of MHY908 which is an inhibitor of melanogenesis and can potentially be used in the prevention and treatment of pigmentation disorders. Also used in the synthesis of γ-lactam analogs of prostaglandin E2 which may act as EP4 agonists.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Park, M., et al.: Arch. Pharm. Res., 38, 505 (2015); Kambe, T., et al.: Bioorgan. Med. Chem., 20, 3502 (2012);<br></p>

<p>Applications 2-Iodoacetamide is an alkylating agent commonly used in the alkylation of proteins.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Woods, A.G.,et. al.: Biochem. Bioph. Res. Co., 419, 305 (2012); Samgina, T.Y., et. al.: J. Am. Soc. Mass Spec., 22, 2246 (2011)<br></p>

<p>Applications 2-Bromo-3,3,3-trifluoropropene is a useful research chemical for organic synthesis and other chemical processes.<br>References Zhao, Q., et al.: Tetrahedron, 74, 6033 (2018); Zhang, M., et al.: Nat. Commun., 9, 1 (2018); Hou, X., et al.: Org. Process Res. Dev., 20, 989 (2016)<br></p>

<p>Applications Shows some anti-viral activity due to the adamantane structure. In addition it shows anti-microbial activity and cytotoxic application.<br>References Aigami, K. et al.: J. Med. Chem., 18, 713 (1975); Aigami, K. et al.: J. Pharm. Res., 4, 1407 (2011);<br></p>

<p>Applications 4-Chlorobenzenethiol is a reagent used in the synthesis of small-molecule inhibitors of the protein geranylgeranyltransferase Type I (GGTase-I), acting as anti-tumor agents. Also is used in the synthesis of β-sulfanyl carbonyl compounds via Michael addition.<br>References Ranu, B. et al.: Tetrahedron, 60, 4183 (2004); J. Med. Chem., 43, 2310 (2000);<br></p>

<p>Applications Dihexadecyl(dimethyl)azanium bromide is an ionic olefin derivative used in the preparation of metal-containing ionic liquids for use in particle synthesis and materials with magnetic or thermochromic properties.<br>References Zabel, A.; et al.: Int. J. Mol. Sci., 17, 596/1 (2016).<br></p>

<p>Stability Very Hygroscopic<br>Applications Magnesium Chloride is used in magnesium replacement therapy for those deficient in magnesium. Effective anaesthetic for cephalopods.<br>References Iezhitsa, I. et al.: Nutr. Neurosci., 14, 10 (2011); Culloty, S. et al.: Aquaculture., 107, 249 (1992);<br></p>

<p>Applications 5-Amino-2-chlorobenzotrifluoride is a compound useful in organic synthesis. It also performs a radioprotective activity against ionizing radiations.<br>References Blickenstaff, R. T., et al.: J. Pharm. Sci., 83, 219 (1994); Kumari, P., et al.: Org. Biomol. Chem., 16, 2049 (2018)<br></p>

<p>Applications 2,4'-Dichlorobenzophenone is used in the synthesis of triarylcarbinol analogs of fenarimol as potent inhibitors of Trypanosoma cruzi. It can also be used to prepare fatty acid amide hydrolase inhibitors.<br>References Keenan, M., et al.: J. Med. Chem., 55, 4189 (2012); Roughley, S., et al.: Bioorg. Med. Chem. Lett., 22, 901 (2012)<br></p>

<p>Applications 1-Chlorotetradecane is a useful synthetic intermediate. It is an intermediate used to prepare Dimethyldimyristyl ammonium chloride (D472560), a surfactant.<br>References Cipiciani, A., et al.: Austr. J. Chem., 44, 1505 (1991);<br></p>

<p>Stability Moisture Sensitive<br>Applications 2-Chloro-1-propanesulfonyl Chloride is a reagent used as a building block in medicinal chemistry in the synthesis of heterocyclic compounds.<br>References Virgil, P. et al.: J Org. Chem., 66, 2104 (2001);<br></p>

<p>Applications 2-Chloro-N-phenylacetamide is used as a reagent in the synthesis of indolylmethylene benzo[h]thiazolo[2,3-b]quinazolinones which exhibit anticancer and antimicrobial activities in vitro.<br>References Gali, R., et al.: Bioorg. Med. Chem. Lett., 24, 4239 (2014)<br></p>

<p>Applications 4-chlorobenzamide (cas# 619-56-7) is a useful research chemical.<br></p>

<p>Stability Moisture Sensitive<br>Applications Thiophosphoryl chloride is a starting material for O-ethyl dichlorothiophosphate synthesis.<br> E0<br></p>

<p>Applications 2-Chlorothiophene (cas# 96-43-5) is a useful research chemical.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications 4-Fluorobenzenesulfonyl Chloride is found to be an excellent activating agent for the covalent attachment of biological substances to a variety of solid supports e.g. Sepharose beads. 4-Fluorobenzenesulfonyl Chloride is also used as a reagent for the studies of proteins by fluorine NMR.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Chang, Y.A., et al.: Bioconjugate Chem., 3, 200 (1992); Liao, T.H., et al.: Anal. Biochem., 148, 365 (1985)<br></p>

<p>Applications 1,1-Dibromoethane is a useful reagent for setereoselective synthesis of (+)-phorboxazole A via Petasis-Ferrier rearrangement. It is also used for preparation of olefinic enol ether.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Smith, A., et al.: J. Am. Chem. Soc., 123, 10942 (2001); Fujimura, O, et al.: J. Org. Chem., 59, 4029 (1994);<br></p>

<p>Applications Di-β,β'-Chloroethylphosphoric Acid, is a dialkyl hydrogen phosphates, that can undergo the electrophilic trifluor- omethylation to produce trifluoromethyl phosphates in order to increase the lipophilicity of functional groups.<br>References Santschi, N., et al.: J. Fluorine Chem., 135, 83 (2012);<br></p>

<p>Applications Ethyl 2-Chloracetoacetate is used in the preparation of oxazoles and thiazoles as agonists for peroxisome proliferator-activated receptor δ. It is also used to synthesize dimethylimidazothiadiazolecarbohydrazides with anticancer activities.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Sznaidman, M., et al.: Bioorg. Med. chem. Lett., 13, 1517 (2003); Terzioglu, N., et al.: Eur. J. Med. Chem., 38, 781 (2003)<br></p>

<p>Applications 3,5-Dichlorotoluene is a common chemical reactant used in the synthesis of various pharmaceuticals and biological agents. Used in the preparation of pyrazole amide derivatives as RORγ inhibitors as well as cross coupling reactions.<br>References WO Patent 2015129926 (Sep 3, 2015); Sun, X. et al.: Angew. Chem., Int. Ed., 52, 4440 (2013);<br></p>

<p>Applications Bromocyclopropane (cas# 4333-56-6) is a compound useful in organic synthesis.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Stability Volatile<br>Applications 5-Fluoro-1-pentyne use as a reactant/reagent for preparation of glutamic acid-based peptidomimetic prostate-specific membrane antigen binding agents for imaging use.<br>References Wang, E., et al.: PCT Int. Appl., WO 2013028664 A1 20130228 (2013)<br></p>

<p>Stability Light Sensitive<br>Applications Dibromoacetonitrile is a carcinogenic nitrogenous disinfection byproduct. Dibromoacetonitrile in drinking water was linked to oral cavity cancer in rats and forestomach cancer in mice. In addition, Dibromoacetonitrile may cause oxidative damage in rat brain.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Guo, Z., et al.: Chem. Eng. J. 306, 1180 (2016); Krasner, S. W., et al.: Environ. Sci. Technol. 50, 9583 (2016); Natl Toxicol Program Tech Rep Ser. 544, 1 (2010); Klattisaksiri, P., et al.: Water Res 98, 160 (2016); Sayed, R. H., et al.: Environ Toxicol Pharmacol. 34, 849 (2012)<br></p>

<p>Applications N-(4-Chlorobenzyl)-1-(5-nitrothiophen-2-yl)methanamine is an analogue of GSK 4112 (G797700) which is a synthetic ligand for REV-ERBα, a member of the nuclear receptor superfamily that functions as a receptor for the porphoryin heme. GSK 4112 mimics the action of heme acting as agonist and suppresses the expression of REV-ERBα target genes involved in gluconeogenesis.<br>References Kojetin, D. et al.: ACS Chem. Biol., 6, 131 (2011); Grant, D. et al.: ACS Chem. Biol., 5, 925 (2010)<br></p>

<p>Applications 2-Iodoheptafluoropropane is a useful synthetic intermediate. It is a reagent used to prepare a-trifluoromethyl carbonyl compounds and novel amino acids.<br>References Pham, P., et al.: Angewandte Chemie, 50, 6119 (2011); McNabb, S., et al.: Org. Lett., 6, 1911 (2004)<br></p>

<p>Applications Octyl Bromide, is a versatile halogenated building block in chemical synthesis. It has also industrial applications. It is used in the preparation of fluorous polymers, which serve as a surface modifier and an emulsifier.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Golling, F. E., et al.: Poly. Prep.(Amer. Chem. Soci. Div. Poly. Chem), 52, 735 (2011);<br></p>

<p>Stability Moisture Sensitive<br>Applications Pentafluorobenzoyl Chloride is a useful analytical reagent in the derivatization amphetamines as well as other primary amines.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Koster, E. et al.: Analyst, 127, 598 (2002);<br></p>

<p>Applications 2-Amino-4-(trifluoromethyl)benzenethiol Hydrochloride can be used as reactant/reagent in preparation of fused benzo-diazepinones/oxazocinone/thiazapines/diazapines/diazocins/thiazine/indoles via CuI-L-proline catalyzed SN2 reaction.<br>References Srinivasulu, V., et al.: Tetrahedron, 73, 2139 (2017)<br></p>

<p>Applications Chlorendic Anhydride is a chlorinated hydrocarbon used in the synthesis of unsaturated polyester resins. It is also an environmental pollutant. Chlorinated Reactive flame retardant Intermediate<br>References Bongiovanni, R., et al.: J. Appl. Polym. Sci., 75, 651 (2000); Brown, T., Wania, F.: Environ. Sci. Technol., 42, 5202 (2008); Howard, P., Muir, D.: Environ. Sci. Technol., 44, 2277 (2010);<br></p>

<p>Applications 7-Bromoheptanol is a useful synthetic intermediate. It can be used to prepare N-substituted [(carboxymethyl)phenoxy]ethyl benzoxazinones as PPARγ agonists and antidiabetic (type 2) agents. It can also be used to prepare thiochroman and chroman derivatives as pure antiestrogens.<br>References Rybczynski, P., et al.: J. Med. Chem., 47, 196 (2004); Kanbe, Y., et al.: Bioorg. Med. Chem., 14, 4803 (2006)<br></p>