Halogénures organiques

Applications 4-Chloro-2,6-difluorophenylboronic acid

Applications 4-(2-Amino-3,3-dimethyl-1-oxobutyl)benzonitrile hydrochloride is used as a reagent to synthesize phenyloxobutanylpyridinylpiperazinecarboxamide derivatives, compounds that have TRPA1 receptor antagonistic properties.
References Svensson, M. & Weigelt, D. Preparation of Phenyloxobutanylpyridinylpiperazinecarboxamide Derivatives for Use as TRPA1 Receptor Antagonist. PCT Int. Appl. 2012050512. Apr 19, 2012.

Applications N-(4-amino-2-chlorophenyl)-5-chloro-2-hydroxybenzamide (cas# 10558-45-9) is a useful research chemical.

Applications 4-[(2-chloroacetyl)amino]benzoic acid (cas# 4596-39-8) is a useful research chemical.

Applications 1-Bromo-3-(trifluoromethyl)benzene is used in the synthesis of calcium channel inhibitors for inflammatory and neuropathic pain.
References Beebe, X. et al.: Bioorg. Med. Chem. Lett., 23, 4857 (2013);

Applications 2,5-Dichloro-2,5-dimethylhexane is a useful reagent for the preparation of substituted bis-2-indenyl metallocene compounds as catalysts for olefin polymerization.
References Hendriksen, C., et al.: PCT Int. Appl. (2020), WO 2020043815 A1

Applications A useful synthetic intermediate.

Applications 4,4,4-Trifluorobutyryl Chloride can be used in the preparation of hydrazide compounds with pyriproxyfen useful for pest control.
References Ikari, K.: Can. Pat. Appl., CA 2747600 A1 20120203 (2012)

Applications 5-(Aminomethyl)furan-2-carboxylic Acid Hydrochloride is a useful reagent in the preparation of novel heteroaromatic substrates of GABA aminotransferase.
References Hawker, D. D., et al.: Bioorg. Med. Chem., 20, 5763 (2012)

Applications Ethyl (Z)-3-(Dimethylcarbamoylamino)-4,4,4-trifluoro-but-2-enoate is an intermediate in the synthesis of Tiafenacil (T436300), which is a uracil herbicide used as a pesticide for the prevention and control of plants.
References Peng, X., et al. Faming Zhuanli Shenqing, 68pp Patent 2018 CODEN:CNXXEV

Applications 2-Norbornanesulfonyl Chloride, can be used as a building block in chemical synthesis. It is also a Sulfonyl halide that can react readily with nucleophiles like alcohols and amines.
References Drabowicz, J., et al.: Sci. Synth., 39, 19, (2008);

Stability Moisture Sensitive
Applications 2,4,6-Trifluorobenzene-1,3,5-tricarbonitrile (cas# 3638-97-9) is a useful research chemical.

Applications (2S)-pentan-2-amine hydrochloride (cas# 216237-52-4) is a useful research chemical.

Applications (1-Fluorovinyl)methyldiphenylsilane acts as a reagent for the preparation of fluoro C-glycosyl asparagine from C-formyl glucoside by fluorovinylation and Claisen rearrangement for the construction of α-amino acid moiety.
References Usuki, Y., et al.: ITE Lett. Batter., New Technol. Med., 7, 63 (2006)

Applications 2,6-DIBROMO-3-PICOLINE (cas# 887571-15-5) is a useful research chemical.

Applications Dibromoisocyanuric acid is a bromine compound with a superior bactericidal activity.
References Gottardi, W., et al.: J. Appl. Microbiol., 116, 1427 (2014)

Stability Moisture Sensitive
Applications 4-Chlorobutanal Dimethyl Acetal 90% is a compound useful in organic synthesis and other chemical processes. It is used as an intermediate in the synthesis of aripiprazole, buspirone, and NAN-190 via reductive alkylation of piperazine derivatives with aldehydes
References Kowalski, P., et al.: Archiv der Pharmazie, 345, 81 (2012)

Applications 2-Fluoro-5-(trifluoromethyl)benzoic acid

Applications 4-Deiodo-amidotrizoic Acid can be obtained from 3,5-Dinitrobenzenemethanol. It can also be used in biological study for quality environmental risk assessment of photolytic transformation products of iodinated X-ray contrast agent diatrizoic acid.
References Rastogi, T., et al.: Sci. Total Environ., 482-483, 378-388 (2014);

Applications 1-Iododecane (cas# 2050-77-3) is a compound useful in organic synthesis.

Applications Tetrabutylammonium Dibromochloride (cas# 64531-21-1) is a useful research chemical.

Applications (S)-4-Chlorostyrene oxide is used in the biosynthetic preparation though epoxidation of styrene and substituted styrenes by whole cells of Mycobacterium.
References Rigby, S. R., et al.: Bioorg. Med. Chem. 2, 553 (1994);

Applications 1-Iodooctane is used as a reagent to react with polyethylenimine to form ultrasensitive MRI probes that are amphiphilic in nature. These probes are then used to label chondrocyte cells for further study.
References Liu, G., et al.: J. Mat. Sci., Mat. Med., 22, 601 (2011)

Stability Moisture Sensitive
Applications Trifluoromethanesulfonic Anhydride is a strong electrophile used in chemical synthesis for introducing the triflyl group.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Cai, D. et al.: Org. Synth., 10, 112 (2004);

Applications 2,6-Diiodophenol is a useful reactant in organic synthesis.
References Gebara, Karimi S., et al.: Tetrahedron Let., 52(22), 2849-2852 (2011);Lv, Chunjie, et al.: Org. Let., 20(7), 1919-1923 (2018)

Applications (2S)​-N-​(3-​chloro-​4-​fluorophenyl)​-​2-​[[[(tetrahydro-​1,​1-​dioxido-​3-​thienyl)​amino]​carbonyl]​amino]​-​Propanamide is a useful building block and research chemical.

Stability Extremely moisture sensitive
Applications Highly reactive cyclic phosphitylating reagent which provides fast coupling rates, and hydrolytic cleavage occurs more readily than with acyclic analogs.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Bannwarth,W. & Kung, E.: Tetrahedron Lett., 30, 4219 (1989)

Applications PV8 (Hydrochloride), is similar to alpha-pyrrolidinophenone (alpha-PVP) which is an analog of pyrovalerone (psychoactive compound). PV8 (hydrochloride) differs from alpha-PVP as it has hexaphenone in place of the pentiophenone portion of the compound.
References Staack, R.F., et al.: Curr. Durg Metab., 6, 259 (2005); Meyer, M.R., et al.: Curr. Drug Metab. 11, 468 (2010)

Applications 3-Bromoanisole is a compound useful in organic synthesis and other chemical processes. It is an intermediate used for pharmaceuticals, perfumes and agrochemicals.
References Hura, N., et al.: ACS Omega, 3, 1955 (2018); Srinivas L. K., et al.: Bioorg. Med. Chem. Lett., 28, 778 (2018); Yoon, D., et al.: ACS Med. Chem. Letters, 8, 1336 (2017)

Applications 4-Bromobutyric Acid is used in the preparation of analgesic and anti-inflammatory agents as nitroalkyl ethers. It is also used in the synthesis of Autotaxin (ENPP2) inhibitors, used in tissue fibrosis regulation, cancer cell invasion and metastasis.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Anzini, M. et al.: J. Med. Chem., 56, 4821 (2013); Kawaguchi, M. et al.: ACS Chem. Biol. et al.: 8, 1713 (2013);

Applications tert-Butyl Bromoacetate is a halogenated t-butyl acetate commonly used as an alkylating agent. tert-Butyl Bromoacetate is used in the synthesis of collagenase inhibitors.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Steinman, D.H. et al.: Bioorg. Med. Chem. Lett., 8, 2087 (1998); Fray, M.J. et al.: J. Med. Chem., 46, 3514 (2003): Neri, P. et al.: J. Org. Chem., 59, 3880 (1994);

Applications (4-Isopropoxyphenyl)hydrazine hydrochloride (cas# 104033-62-7) is a useful research chemical.

Applications METHYL 2-HYDROXY-4-IODOBENZOATE (cas# 18179-39-0) is a useful research chemical.

Applications Reagent used in Phthalimidooxy alylation.
References Yoda, R., et al.: Chem. Pharm. Bull., 42, 686 (1994), Kim, M., et al.: Bioorg. Med. Chem. Lett., 6, 2077 (1996),

Applications 4-Cyanophenylhydrazine Hydrochloride (cas# 2863-98-1) is a compound useful in organic synthesis.

Applications 4-bromo-2-(morpholin-4-yl)benzonitrile (cas# 1260762-06-8) is a useful research chemical.

Applications 6,7-Dichloro-1-tetralone (cas# 25095-57-2) is a useful research chemical.

Applications 4-Bromo-3-hydroxyphenylboronic Acid (cas# 1701448-16-9) is a useful research chemical.

Applications 3-Chlorobenzotrifluoride
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package

Stability Very unstable to water and protic solvents.
Applications N,N-Dimethylmethyleneiminium chloride (cas# 30354-18-8) is a useful research chemical.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package

Applications TRIMETHYL(BROMODIFLUOROMETHYL)SILANE (cas# 115262-01-6) is a useful research chemical.

Applications 4-(Dimethylamino)butanal Hydrochloride is the HCl salt of D492530, which was one of the reagents in discovery of a novel series of quinolone a6 nicotinic acetylcholine receptor agonists.
References McDonald, I., et al.: Bioorganic Med. Chem. Lett., 23, 1684 (2013).

Stability Moisture Sensitive
Applications Tris(1,1,3-tribromo-2,2-dimethylpropyl) phosphate (cas# 19186-97-1) is a useful research chemical.

Applications Intermediate for the synthesis of glucuronide conjugates of trans-Resveratrol
References Kitagawa, M., et al.: Chem. Pharm. Bull., 39, 2681 (1991), Keller, T., et al.: Chem. Pharm. Bull., 49, 1009 (2001),

Applications Ethyl 2-(2,6-Dichlorophenyl)acetate (cas# 90793-64-9) is a useful research chemical.

Applications 1-fluoro-3,3-dimethyl-1$l^{3},2-benziodoxole (cas# 1391728-13-4) is a useful research chemical.

Applications DOTA-4AMP, is a macrocyclic ligand used for preparation of magnetic resonance imaging contrast agents.
References Sun, X, et al.: Huaxue Tongbao, vol. 75, :21-26 (2012);

Applications 2,2-Dimethylbutanoyl chloride is a reagent that is used in the synthesis of 4α,5-Dihydro Simvastatin (D450010). 4α,5-Dihydro Simvastatin is an impurity in the synthesis of Simvastatin (S485000), a synthetic derivative of a fermentation product of Aspergillus terreus. A competitive inhibitor of HMG-CoA reductase. A synthetic analog of Lovastatin. Antilipemic. Simvastatin, the drug, is sold under the trade name Zocor.
References Hoffman, W.F., et al.: J. Med. Chem., 29, 849 (1986), Mol, M.J., et al.: Lancet, 2, 936 (1986),

Applications 4-(4-Fluorophenyl)aniline

Applications 9-Fluorenemethanol is used in the design and in the synthesis of novel type somatostatin analogs with antiproliferative activities on A431 tumor cells.
References Miyazaki, A., et al.: Tetrahedron Lett., 45, 6323 (2004)

Applications 2,3-Dichlorobenzal Chloride is used in the biological study of plant growth-promoting activity.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Kemp, M. S., et al.: Ann. Appl. Biol., 80, 311-15 (1975)

Applications N-​Methylcyclopropanami​ne Hydrochloride can be used as reactant/reagent in preparation of substituted benzazinones as antibacterial compounds.
References Jin, Q., et al.: PCT Int. Appl., WO 2017098440 A1 20170615 (2017)

Applications 2-Fluoro-4-(methylsulfonyl)benzoic acid

Applications 4-Fluoro-2-(trifluoromethl)benzonitrile is a reagent used in the synthesis of 5-substituted-1H-tetrazoles as antibacterials.
References Sivaguru, P. et al.: Tetrahedron Lett., 56, 2203 (2015); Shi, G et al.: Org. Lett., 17, 38 (2015);

Applications 2-Amino-4-trifluoromethoxyphenylboronic acid pinacol ester

Applications 5-Chloro-1-hexene is a reagent with difluoroacetic acid that results in the formation of 5-chloro-2-hexyl-2-d trifluoro-acetate and 1,4-chlorine shift.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Peterson, P. E., et al.: J. Am. Chem. Soc., 86, 4503-4 (1964)

Applications It is useful in photochromic materials.

Applications 1,3,5-Trichloro-2-nitrobenzene is a building block for organic synthesis.

Applications (4-(BROMOMETHYL)PHENYL)METHANOL (cas# 71831-21-5) is a useful research chemical.

Applications Colestipol Hydrochloride (cas# 37296-80-3) is a useful research chemical.

Applications 2-Fluoroanisole is a useful synthetic intermediate with antifungal activity.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Pinto, M. F. S., et al.: J. Mol. Struc.: Theochem., 539, 303-310 (2001)

Applications 2,3,5,6-Tetrachloro-p-xylene is a derivative of 2,3,5,6-Tetrachloro-4-methyl benzonitrile used as intermediates of pesticide with fluorine.
References Oliver, B.G., et al.: Environ. Sci. Technol., 19, 842 (1985), Boden, N., et al.: Tetrahedron Lett., 47, 8685 (1995),

Applications Methyl 2-(4-Bromophenyl)-2,2-dimethylacetate (cas# 154825-97-5) is a compound useful in organic synthesis.

Applications 2-Bromoethyl Methyl Ether was used as a reactant for the preparation of alkyl ethers of β-alkylcholine salts.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Major, R.T., Cline, J.K.: J. Am. Chem. Soc., 55, 2504 (1933)