Halogénures organiques

Applications 4-Chloro-3-fluorobenzoic Acid is a very useful precursor. It is a reagent used to synthesize 6-Hydroxy Albaconazole (H761395) which is a metabolite of Albaconazole (A511450), an antifungal agent as neuroprotectant.
References Pujol, I., et al.: J. Antimicrob. Chemother., 39, 163 (1997), Gilgado, F., et al.: J. Clin. Microbiol., 43, 4930 (2005), Raad, I., et al.: Clin. Infect. Dis., 42, 1398 (2006), Nucci, M., et al.: Clin. Microbiol. Rev., 20, 695 (2007),

Applications A cell-permeable, selective and irreversible PPARγ antagonist (IC50 = 3.3 nM, 32 nM, and 2 µM for PPARγ, PPARα, and PPARδ, respectively). Reported to covalently modify a cysteine residue in the binding site of PPAR. At a concentration of 10 µM, also acts as an agonist of human pregnane X receptor (PXR) and farnesoid X receptor (FXR). Does not activate liver X receptor-a (LXRa), retinoic acid receptor (RAR), retinoid X receptor-a (RXRa) and thyroid receptors a and b (TRa and TRb
References Huang, J.T., et al.: Nature, 400, 378 (1999), Wilson, T.M., et al.: J. Med. Chem., 43, 527 (2000), Leesnitzer, L.M., et al.: Biochemistry, 41, 6640 (2002)

Applications Adenine Hydrochloride can be utilized in uses for enhanced detection of hydrogen peroxide with platinized microelectrode arrays for analyses of mitochondria activities. It can also be used for biological use in method for producing Cordyceps sinesis by fermentation.
References Ben-Amor, S., et al.: Electrochim. Acta., 126, 171-178 (2014); Jia, J., et al.: Faming Zhuanli Shenqing, CN 101407767 A 20081117 (2008);

Stability Air Sensitive, Moisture Sensitive
Applications 3-Hexyl Chloroformate is a potential impurity in the synthesis of Dabigatran Etexilate Mesylate (D100150); a nonpeptide and direct thrombin inhibitor. Antithrombotic.
References Zheng, Y., et al.: Org. Process Res. Dev., 18, 744 (2014); Hauel, N., et al.: J. Med. Chem., 45, 1757 (2002); Mungall, D., et al.: Curr. Opin. Invest. Drugs, 3, 095 (2002); Stangier, J., et al.: J. Clin. Pharmacol., 45, 555 (2005)

Applications 4-Fluoro-a-oxo-benzenepropanoic acid (cas# 7761-30-0) is a useful research chemical.

Applications (3-Bromopropyl)triphenylphosphonium Bromide is used in rearrangement reactions of cyclic organic molecules and in organic synthesis.
References Kippo, T. et al.: J. Am. Chem. Soc., 135, 632 (2013); Shi, M. et al.: J. Am. Chem. Soc., 128, 7430 (2006);

Applications (Chloromethyl)cyclohexane is a common chemical reagent used in the synthesis of imidazole inhibitors of cytokine release which suppresses the response to tumor necrosis factor.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Laufer, S. et al., J. Med. Chem., 45, 1695 (2002); Rabinowitz, M. et al.: J. Med. Chem., 44, 4252 (2001);

Applications 4-Fluoro-3-nitrobenzenesulfonyl chloride is a used in the preparation of potent Bcl-2/Bcl-xL inhibitors with strong in vivo antitumor activity.
References Zhou, Haibin., et al.: J. Med. Chem., 55, 6149 (2012);

Applications 3-Acetylbenzoyl Chloride is used in the synthesis of aminimdes as potential CNS acting agents. Also, it is an intermediate used in the synthesis of 3-[(Dimethylamino)carbonyl]phenol (D461635), which can be used in the synthesis of novel purine and bicyclic pyrimidine, which are factor Xa inhibitors, and also have high selectivity over thrombin and trypsin.
References Capuano, B., et al.: Aust. J. Chem., 60, 673-684 (2007); Buckman B. O., et al.: Bio. Med. Chem. Let., 8, 2235 (1998)

Applications 3-(Chloromethyl)-2,4,6-trimethylbenzoic Acid (cas# 52411-49-1) is a useful research chemical.

Applications Tigoloyl Chloride is used in the polymerization of propylene as well as through a Freidel-Crafts reaction for the preparation of permethylindenyl complexes of transition metals. As well, it is primarily used as a reagent in the enantioselective synthesis of dihydropyrans.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References O'Hare, D. et al.: Organometallics, 11, 48 (1992); Kaminsky, W. et al.: J. Organomet. Chem., 487, 181 (1995); Evans, D. A. et al.: J. Am. Chem. Soc., 122, 1635 (2000);

Applications 4-Fluorobenzamide

Applications 3-Bromotetrahydrofuran

Applications 3-Fluoro-5-trifluoromethylbenzonitrile is a reagent used in the synthesis of cholesteryl ester transfer protein (CETP) inhibitors in the treatment of high cholesterol. Also used in the preparation of substituted pyrimidines with dithioacetals for antimicrobial activity.
References Qiao, J. et al.: J. Med. Chem., 58, 9010 (2015); Gami, S. et al.: J. Hetero. Chem., 52, 751 (2015);

Applications 2,2-BIS(3-AMINO-4-HYDROXYPHENYL)HEXAFLUOROPROPANE (cas# 83558-87-6) is a useful research chemical.

Applications 2-Fluoro-5-iodobenzonitrile is a compound commonly used in synthetic chemistry and is also used as a reagent to synthesize 1-alkyl-1H-indazoles. 2-Fluoro-5-iodobenzonitrile reacts with sodium sulfide to produce mercaptobenzonitriles.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Liu, H., et al.: Tetrahedron, 19, 3907 (2013); Taldone, T., et al.: Tetrahedron Lett., 53, 2548 (2012)

Applications Methyl trans-4-Bromo-2-butenoate is used as a reagent in the synthesis of several organic compounds including that of dimethoxy ketals and ketones via electrochemical oxidative decarboxylation of malonic acids.
References Ma, X., et al.: Org. Lett., 17, 4690 (2015);

Applications Used as a general reagent in acylation reactions. A byproduct formed in treated waters, and found in marine life.
E0
References Zuckermann, R.N. et al.; J. Am. Chem. Soc., 115, 10646 (1992); Bull, R., et al.: Toxicol. Appl. Pharmacol., 182, 55 (2002), Mitch, W., et al.: Water Sci. Technol., 2, 191 (2002),

Applications 3-Chlorobenzoyl Chloride is used in the synthesis of isoquinoline derivatives as potent CRTH2 antagonists in treatment of allergies. Also used in the synthesis of anticancer 2-phenzainamine derivatives.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Nishikawa-Shimono, R. et al.: Bioorg. Med. Chem., 21, 7674 (2013); Gao, X. et al.: Eur. J. Med. CHem., 69, 1 (2013);

Applications 6-Bromo-8-fluoro-2,4-dihydro-1,4-benzoxazin-3-one is a reactant in preparation of benzoxazinone derivatives as potent and selective nonsteroidal mineralcorticoid receptor antagonists.
References Hasui, T., et al.: J. Med. Chem., 54, 8616 (2011);

Applications 3,5-Diiodothyropropionic acid is an ionotropic analog of L-thyroxine.

Applications cyclopent-2-en-1-amine hydrochloride (cas# 91469-54-4) is a useful research chemical.

Applications 4-Chloroiodobenzene is used as a reagent in the synthesis of Clothiapine (C588550); an atypical antipsychotic of the dibenzothiazepine chemical class that has shown efficacy in treatment-resistant schizophrenic patients.
References Schmutz, J., et al.: Helvetica Chimica Acta 50, 245 (1967); Geller, V., et al.: Schizophrenia Research 80 (2-3), 343 (2005)

Applications 4-Nitrobenzyl Bromide is used in the synthesis of di and tri-substituted azoles. Also used in the preparation of N6-Benzyladenosine-5’-uronamides as selective A3 adenosine agonists.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Gallo-Rodriguez, C. et al.: J. Med. Chem., 37, 636 (1994); Appukkuttan, P. et al.: Org. Lett., 6, 23 (4223);

Stability Moisture Sensitive
Applications BROMO-PEG3-BROMIDE (cas# 31255-10-4) is a useful research chemical.

Applications 3-Bromobiphenyl is used as a reagent in the synthesis of benzenesulfonamide derivatives as 12-LOX inhibitors. 3-Bromobiphenyl is also used as a reagent in the preparation of pyrrolidine derivatives as GlyT1 inhibitors.
References Maloney, D.J., et al.: PCT Int. Appl. WO 2015054662 A1 20150416. Apr 16, 2015; Amberg, W., et al.: PCT Int. Appl. WO 2014140310 A1 20140918. Sep 18, 2014

Applications 2-(2-Chloro-6-fluorobenzylthio)aniline

Applications 3,4-Dimethyl-benzamidine hydrochloride (cas# 112072-09-0) is a useful research chemical.

Applications 3-(Methylamino)-1-phenylpropan-1-one hydrochloride (cas# 2538-50-3) is a useful research chemical.

Applications Hydrobromide salt of Triphenylphosphine, used in the preparation of uridine derivatives as substrate donor analogs of UDP-sugars for glycosyltransferases. Also used in the preparation of tensioactive and antibacterial deoxyglycoside compounds via catalysis.
References Wandzik, I. et al.: Bioorg. Chem., 37, 211 (2009); Martins, A. et al.: Eur. J. Org. Chem., 2014, 1448, 2013

Stability Light and Temperature sensitive
Applications PFPA-silane is a functionalized perfluorophenyl azides for covalent immobilization of ultrathin polymer films.
References Mosbach, K., et al.: Biotechnology, 14, 163 (1996), Keren, K., et al.: Science, 297, 72 (2002), Lidstrom, M., et al.: Nature Rev. Microbiol., 1, 158 (2003),

Applications N-Hydroxybenzylamine Hydrochloride, is a versatile intermediate for the synthesis of various pharmaceutical compounds. It is used for the preparation of Ticagrelor (T437700) derivatives as novel antiplatelet agents.
References Zhang, H., et al.: Bioorg. Med. Chem. Lett., 22, 3598 (2012); Jakubowski, J., et al.: Cardiovasc. Drug Rev., 25, 357 (2007);

Applications methyl amino(2-bromophenyl)acetate hydrochloride (cas# 1219408-44-2) is a useful research chemical.

Applications Ethenesulfonyl chloride is a useful reactant for the preparation of oral quinoline-based ALDH1A1 inhibitors as potential antitumor agents.
References Yang, SM., et al.: J. Med. Chem., 61, 4883-4903 (2018);

Applications β-Chlorolactic Acid (cas# 1713-85-5) is a compound useful in organic synthesis.

Applications 4-Fluorobenzonitrile is used in the synthesis of flurenones, pharmaceutical prerequisites, as well as opiod receptor antagonists.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Wan, J. et al.: Org. Lett., 15, 2742 (2013); Kormos, C. et al.: J. Med. Chem., 56, 4551 (2013);

Applications N-(2-Azidoethyl) Cyclen is used in the synthesis of lanthanide cyclen derivative complexes.
References Szijjarto, C., et al.: Dalton Trans., 41, 7660 (2012)

Applications 2-Bromo-1-(2-ethoxyphenyl)ethanone is used as a reagent in the preparation of aroylfurans and aroylthiophenes which are used in the treatment of neoplastic and autoimmune diseases.
References Eberle, M., et al.: Preparation of aroylfurans and aroylthiophenes for treating neoplastic and autoimmune diseases, WO Patent 2005061476, Jul 7, 2005;

Applications 3-Bromothioanisole (cas# 33733-73-2) is a compound useful in organic synthesis.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package

Stability Moisture Sensitive
Applications Oleyl Chloride is used as a chemical reagent in the preparation of Vitamin E analogs as well as antiviral nucleoside phosphoramidate prodrugs used in the treatment of HIV and HBV.
References Cho, J. et al.: Bioorg. Med. Chem., 22, 6665 (2014); Iwata, R. et al.: Bioorg. Med. CHem. Lett., 25, 815 (2015);

Applications 4-(4-Chlorophenyl)but-3-en-2-one (cas# 3160-40-5) is a useful research chemical.

Applications 2,4-Dimethylbenzenesulfonyl Chloride is used as a reagent in the synthesis of dimethyl benzimidazolones as potent and selective inhibitors of BRPF1 bromodomain. 2,4-Dimethylbenzenesulfonyl Chloride is also used as a reagent in the synthesis of quinazoline analogs as glucocerebrosidase inhibitors with chaperone activity for the treatment of Gaucher disease.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Demont, E.H., et al.: ACS Med. Chem. Lett., 5, 1190 (2014); Marugan, J.J., et al.: J. Med. Chem., 54, 1033 (2011)

Stability Moisture Sensitive
Applications 2,3-Dichloropropionyl Chloride is used as a reagent in the synthesis of 6-chloro-5-cyclohexyl-1-indancarboxylic acid, a potent analgesic, antipyretic, and antiinflammatory agent, and its related compounds.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Sawa, Y., et al.: Yakugaku Zasshi, 96, 653 (1976)

Applications 2,4-Difluorobenzoic Acid (cas# 1583-58-0) is a compound useful in organic synthesis.

Applications 4-Bromocyclohexanone is an organic building block, used as a reactant in the preparation of alkylbenzenes via nickel-catalyzed cross-coupling with arylfluorosilanes.
References Powell, D., Fu, G.: J. Am. Chem. Soc., 126, 7788 (2004);

Applications 4,4-diethylcyclohexan-1-amine hydrochloride (cas# 1087747-58-7) is a useful research chemical.

Applications prop-1-ene-2-sulfonyl chloride (cas# 874009-75-3) is a useful research chemical.

Applications 2-Chloroaniline is used in biological studies to evaluate the mutagenicity and carcinogenicity of Salmonella typhimurium.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Simmon, V.F., J. Natl. Cancer Inst., 62, 893 (1979)

Applications 2-Aminoacetohydrazide Hydrochloride has been used in the preparation of hydrazidones that exhibit antihypertensive activity.
References Cave, C., et. al.: Eur. J. Med. Chem., 29, 389 (1994)

Applications 2-Bromoethyl Methyl Ether was used as a reactant for the preparation of alkyl ethers of β-alkylcholine salts.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Major, R.T., Cline, J.K.: J. Am. Chem. Soc., 55, 2504 (1933)

Applications 1-chloroethyl acetate (cas# 5912-58-3) is a useful research chemical.

Applications 2,6-Diiodobenzene-1,4-diol is a metabolite of the antithyroid compound, Diacetyl-2,6-diiodoohydroquinone.
References Serif, George S., et al.: Biochem. Pharma., 12(8), 885-91 (1963)

Applications N-(4-Chlorophenyl)-2,6-Difluorobenzamide (cas# 122987-01-3) is a useful research chemical.

Applications 3-Bromo-4-isopropylbenzoic acid

Stability Very Moisture Sensitive
Applications Chlorotriphenylstannane is used in the synthesis of nanoparticles which bear triamide ligands.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Shariatinia, Z. et al.: Beil. J. Nanotech., 4, 94 (2013);

Applications 3-Aminobenzotrifluoride is a known human toxin that can cause bacterial mutation and hepatocyte unscheduled DNA synthesis.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Reinhold, D., et al.: T. ASAE, 49, 2077 (2006); Thompson, C., et al.: Environ. Mutagen., 5, 803 (1983)

Applications Substrate specificity of haloalkane dehalogenases.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Koudelakova, T., et al.: Biochem. J., 435, 345 (2011),

Applications 3-Bromopentane, is an organic building block used in various chemical synthesis. It can be used for cobalt-catalyzed ortho alkylation of aromatic Imines.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Gao, K., et al.: J. Amer. Chem. Soci., 135, 9279 (2013);

Stability Hygroscopic
Applications 4,4'-(Propane-1,3-diylbis(oxy))bis(benzene-1,3-diamine) tetrahydrochloride (cas# 74918-21-1) is a useful research chemical.

Applications 1,1,1-Trifluoro-2-iodoethane (cas# 353-83-3) is a compound useful in organic synthesis.

Applications 1-(4-CHLOROPHENYL)CYCLOBUTANAMINE HYDROCHLORIDE (cas# 1228878-71-4) is a useful research chemical.

Applications t-Butyl 4-bromobutanoate is a useful research chemical for organic synthesis and other chemical and pharmaceutical processes.
References Brudeli, B., et al.: Bioorg. Med. Chem., 18, 8600 (2010); Colak, S., et al.: Macromolecules, 41, 8436 (2008)