Halogénures organiques

Applications 2-Nitro-5-fluorobenzoic Acid, Methyl Ester (cas# 393-85-1) is a compound useful in organic synthesis.

Applications 1-(1,1-Dimethylethyl)-4-iodo-2,5-dimethoxy-benzene is an intermediate used to prepare heterocyclic tyrosine kinase inhibitors.
References Spada, A., et al.: PCT Int. Appl., WO 9220642 A1 19921126 (1992)

Applications 3-Cyano-6,7-dihydro-4-trifluoromethyl-1,5H-cyclopenta-[b]-pyrid-2-one (cas# 371967-27-0) is a useful research chemical.

Applications methyl 4-(bromomethyl)-3-(tetramethyl-1,3,2-dioxaborolan-2-yl)benzoate (cas# 1626407-50-8) is a useful research chemical.

Applications (E)-3-(3-(Trifluoromethyl)phenyl)acrylic Acid is a reagent used in the preparation of new tacrine-cinnamic acid hybrids as cholinerase inhibitors against Alzheimer’s diseases.
References Chen, Y., et al.: J. Enzyme Inhib. Med. Chem., 33, 290 (2018)

Applications Chloromethyl Pivalate is used in the synthesis of oxazolines used in the preparation of imidazolium triflates. Also used in the synthesis of Src Kinase inhibitors used as anti-tumor agents.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Glorius, F. et al.: Chem. Comm., 22, 2704 (2002); Hennequin, L. et al.: J. Med. Chem., 49, 6465 (2006);

Applications 2-Bromo-4,6-dinitro-benzenamine is a useful reagent for preparing cinnamaldehyde analogs as as cyclooxygenase 1 and 2 inhibitors. Cinnamaldehyde analogs have anti-inflammatory activity.
References Patil, V. M., et al.: Curr. Drug Discov. Technol., 17, 154 (2020)

Applications 1,3-Dichloro-5-isocyanatobenzene is a reagent used in the synthesis of carbamate and aryl ether substituted pyrazinones as corticotropin releasing factor-1 receptor antagonists as well as the synthesis of novel triazolor pyridine derivatives.
References Ahuja, V. et al.: Bioorg. Med. Chem. Lett., Zhang, L. et al.: Turk. J. Chem., 39, 876 (2015);

Applications 2,2-difluoro-3-phenylpropanoic acid (cas# 142977-64-8) is a useful research chemical.

Applications 2-Fluorobenzoyl Chloride (cas# 393-52-2) is a compound useful in organic synthesis.

Applications 1,1-(Ethylenedioxy)-3-bromopropane is used in the synthesis of EGFR inhibitors. Also used in the synthesis of orally active agents of cancer and cell proliferation with quinoline substructures.
References Zhang, X. et al.: Arch. Pharm., 346, 44 (2013); Lee, Y. et al.: J. Med. Chem., 55, 10363 (2012);

Applications 1,6-Dibromopyrene

Applications Axitinib Iodo Tetrahydropyran is an analog of Axitinib (A794650). Axitinib (A794650) is a tyrosine kinase inhibitor. Axitinib is used in cancer therapy.
References Wasser, K., et al.: Eur. Radiol., 13, 80 (2003);Park, J., et al.: Clin. Cancer Res., 8, 1172 (2002); Bergers, G., et al.: J. Clin. Invest., 111, 1287 (2003);

Applications 2,2,2-Tribromoethyl Dichlorophosphate is a reagent for the synthesis of aryl trihaloethyl dihydrogen phosphates.
References Owen, G. R., et al.: Synthesis, 10, 704 (1974)

Applications 5-​Chloro-hexanoyl Chloride is an impurity of 5-chlorovaleroyl chloride.
References Tang, L., et al.: J. Pharm. Biomed. Anal., 53, 309 (2010)

Stability Extremely moisture sensitive
Applications Highly reactive cyclic phosphitylating reagent which provides fast coupling rates, and hydrolytic cleavage occurs more readily than with acyclic analogs.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Bannwarth,W. & Kung, E.: Tetrahedron Lett., 30, 4219 (1989)

Applications 2-Iodoheptafluoropropane is a useful synthetic intermediate. It is a reagent used to prepare a-trifluoromethyl carbonyl compounds and novel amino acids.
References Pham, P., et al.: Angewandte Chemie, 50, 6119 (2011); McNabb, S., et al.: Org. Lett., 6, 1911 (2004)

Applications 2,6-Dichloro-4-nitroanisole (cas# 17742-69-7) is a useful research chemical.

Applications 7-Chloro-6-sulfamoylisatoic Anhydride is an intermediate in the synthesis of 2-Amino-4-chloro-5-sulfamoyl-o-benzotoluidide (A604420) and in the synthesis of 3-Aryl- and 3-​aralkyl-​1,​2,​3,​4-​tetrahydro-​4-​oxo-​6-​quinazolinesulfonamides.
References Shetty, B., et al.: J. Med. Chem., 13, 886 (1970);

Impurity Fluorouracil EP Impurity E
Applications Used for the experimental and clinical treatment of neoplastic and viral diseases. Fluorouracil EP Impurity E.
References Yu, H., et al.: J. Biol. Chem., 268, 15935 (1993), Staleva, L., et al.: Mutat. Res., 370, 81(1996), Harris, V., et al.: J. Mol. Biol., 326, 1389 (2003)

Applications 3-(Dibenzo[b,e]oxepin-11(6H)-ylidene)-N,N-diethylpropan-1-amine Hydrochloride (E/Z Mixture) is an intermediate in synthesizing N-Diethylnordoxepin Salt (D468115), a compound useful in organic synthesis.

Applications 5-Acetoxy-3-chloro-2-pentanone (cas# 13051-49-5) is a compound useful in organic synthesis.

Applications 3-Chlorocatechol is a useful reagent for synthesizing novel benzotropolones as Atg4B inhibiting autophagy blockers.
References Tanc, M., et al.: Bioorg. Chem., 87, 163 (2019)

Applications 5-(Trifluoromethyl)indolin-2-one is a useful reagent for the preparation of 3-Chloro-α-carbolines.
References Tian, S., et al.: Synlett, 29, 949 (2018)

Applications 2-Chloro-4-fluoro-5-sulfamoylbenzoic Acid is used as a reagent in the synthesis of N-benzyl-N'-(4-piperidinyl)urea CCR5 antagonists as anti-HIV-1 agents.
References Duan, M., et al.: Bioorg. Med. Chem. Lett., 20, 7401 (2010)

Applications 3,5-Difluoro-4-hydroxybenzoic acid

Applications 7-Chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine-1,1-dioxide is used in the preparation of antihypertensive agents.
References Topliss, J. G., et al.: Journal of Medicinal Chemistry, 6, 122 (1963);

Stability Air Sensitive
Applications 1,​2-​Diamino-​4-​(trifluoromethoxy)​benzene is a useful synthetic compound.

Applications Diethyl Bromodifluoromethylphosphonate is a highly efficient and environmentally benign difluorocarbene precursor. It can be used as a reagent in the synthesis of benzindolone structural scaffolds for inhibition of lumazine synthase.
References Zafrani, Y., et al.: Tetrahedron, 65, 5278 (2009); Talukdar, A., et al.: Bioorg. Med. Chem., 18, 3518 (2010)

Stability Hygroscopic
Applications (2S)-Tetrahydro-2-furanmethanamine Hydrochloride is a stereoisomeric salt of Tetrahydro-2-furanmethanamine (T293545) which is used in the synthesis of novel topoisomerase I targeting anti-cancer agents with mild to potent cytotoxic activity. Tetrahydro-2-furanmethanamine (T293545) is also used in the discovery and synthesis of orally bioavailable stearoyl-CoA desaturase 1 inhibitors.
References Lopez-Rodriguez, M. et al.: 44, 4504 (2001); Liu, G. et al.: J. Med. Chem., 50, 3086 (2007);

Applications 3-Chlorobenzyl Cyanide is a useful synthetic intermediate. It was used to design EGFR Tyrosine Kinase Inhibitors. It can also be used to synthesize imidoyl thioureas as non-nucleoside reverse transcriptase inhibitors.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Traxler, P., et al.: J. Med. Chem., 42, 1018 (1999); Ludovici, D., et al.: Bioorg. Med. Chem. Lett., 11, 2225 (2001)

Applications 2-Chloroethyl Formate is a chemical reagent used in the hydrolysis of esters.
References Stefanidis, D. et al.: J. Am. Chem. Soc., 115, 6045 (1993);

Stability Air and Moisture Sensitive
Applications Diethyl Chlorophosphite is used in the synthesis of organophosphates and are considered anticholinesterase agents through observation in studies.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Segall, Y. et al.: Chem. Res. Toxicol., 16, 350 (2003);

Stability Light Sensitive
Applications (2E)-1,4-Dibromo-2-butene, is used as a reagent in the preparation of diaminoalkenes though copper-mediated diamination reaction.
References Martinez, C., et al.: Eur. J. Org Chem., 2014, 2017 (2014)

Applications 2,2-Difluoro-2-phenylacetic acid

Applications 2-Bromo-3,3-dimethyl-1-butanol is formed by use of N-bromosuccinimide and moist Me2SO.
References Dalton, D. R., et al.: J. Am. Chem. Soc., 90, 5498 (1968)

Applications Methyl 2-Chloro-1-cyclopentenecarboxylate is a versatile reactant that can be synthesized from Methyl 2-Cyclopentanonecarboxylate (M294705), which is used in the preparation of functionalized ketones.
References Mashima, K. et al.: J. Org. Chem., 59, 3064 (1994); Hamashima, Y. et al.: J. Am. Chem. Soc., 124, 11240 (2002);

Applications 3,4-Dimethylbenzotrifluoride could be a useful reagent for the preparation of bromodomain targeting degronimers for target protein degradation.
References Phillips, A. J., et al.: PCT Int. Appl. (2017) WO 2017197056 A1

Stability Moisture Sensitive
Applications 4-Morpholinylsulfur Trifluoride is a chemical reagent used in the preparation of proline analogs. Also used in the preparation of difluoropiperidines.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Mykhailiuk, P. et al.: Tetrahedron 67, 3091 (2011); Surmont, R. et al.: Synlett., 12, 1933 (2009);

Applications 4-(Trichloromethyl)benzonitrile, is a building block used in various chemical syntheis such as in preparation of Betrixaban (B329500), a novel anticoagulant, and an oral direct inhibitor of factor Xa (FXa) for use in the prevention of venous thromboembolism (VTE).
References Turpie, A.G.G. et al.: Thromb. Haemost., 101, 68 (2009); Gomez-Outes, A. et al.: Curr. Vasc. Pharmacol., 7, 309 (2009);

Applications 4-(Trifluoromethyl)benzhydrazide is a reagent used in the synthesis of benzoyl hydrazone derivatives displaying fungicidal activity.
References Zhang, J. et al.: Chinese Chem. Lett., 28, 1238 (2017);

Applications 2-Bromophenylacetic Acid is used as the starting material in the synthesis of 2,3,3a,12b-Tetradehydro Asenapine (T291630); a degredation product of Asenapine (A788000) which is a combined serotonin (5HT2) and dopamine (D2) receptor antagonist structurally related to Mianserin (M341500, HCl). Also used as an antipsychotic.
References Meltzer, H., et al.: J. Pharmacol. Exp. Ther., 251, 238 (1989); Schotte, A., et al.: Brain Res., 631, 191 (1993); Andree, B., et al.: Psychopharmacology, 131, 339 (1997); Richelson, E., et al.: Life Sci., 68, 29 (2000)

Applications 2-Amino-3,6-dichlorobenzoic Acid is a reagent used in the synthesis of 3-Kinase inhibitors with improved metabolic stability.
References Patel, L. et al.: J. Med. Chem., 59, 9228 (2016);

Stability Moisture Sensitive
Applications Methyl (chlorosulfonyl)acetate

Applications 1,5-Benzodiazepine Hydrochloride can be used in silver halide emulsion sensitized with a fused diazepine. Its free base form 1,5-Benzodiazepine (CAS 265-02-1) can be used in biological study of interaction of 1,4 and 1,5-benzodiazepines with GABAA receptors of rat cerebellum granule cells in culture.
References Nikas, P., et al.: J Mol Neurosci, 56, 768 (2013); Schwalenstocker, H.: U.S., US 4036649 A 19970719 (1997)

Applications Nonadecanoyl Chloride is a useful synthetic intermediate. It is used to prepare 5-acyl-2-hydroxymethylpyrroles with P388 cytotoxicities. It is also used to synthesize 3-hydroxy-2-octadecylindole.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Nabbs, B., et al.: Bioorg. Med. Chem. Lett., 9, 505 (1999); Clawson, R., et al.: Tetrahedron, 65, 8786 (2009)

Applications 4-Fluoro-a-oxo-benzenepropanoic acid (cas# 7761-30-0) is a useful research chemical.

Applications CHLOROMETHYL ISOBUTYRATE (cas# 61644-18-6) is a useful research chemical.

Applications 4-Bromo-2,6-difluorobenzonitrile

Stability Unstable in solution. Small amounts of precipitate should have no effect on use.
Applications 1-Chloro-N,N-2-trimethylpropenylamine acts as a reagent in the synthesis and antitumor activity of (-)-bassianolide in human cancer cells through cell cycle arrest. Enantioselective total synthesis of nannocystins A and A0 as elongation factor 1 inhibitors. Total synthesis of (-)-caprazamycin A with antibacterial activity against Mycobacterium tuberculosis (TB) via diastereoselective aldol reaction.
References Mun, B., et al.: Bioorg. Chem., 69, 64 (2016); Huang, J., et al.: Org. Lett., 18, 4702 (2016); Nakamura, H., et al.: Angew. Chem., Int. Ed., 54, 3136 (2015)

Applications 1-Iodopropane is used in the synthesis of a new class of cesium selective ionophores. Also used to preparation of secondary amines and diamines.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Casnati, A. et al.: J. Am. Chem. Soc., 117, 2767 (1995); Fukuyama, T. et al.: Tetrahedron Lett., 38, 5831 (1997);

Applications 1-Chloro-2-nitrobenzene is a useful synthetic intermediate. It was used in the synthesis of 1-hydroxybenzotriazole derivatives. Reaction of 1-chloro-2-nitrobenzene with dinitrogen pentoxide in dichloromethane is strongly catalysed by H-Faujasite-720.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Fathalla, M., et al.: J. Chem. Soc. Pak., 33, 324 (2011); Claridge, R., et al.: J. Chem. Soc. Perkin Trans. II, 9, 1815, (1999)

Applications Used as a general reagent in acylation reactions. A byproduct formed in treated waters, and found in marine life.
E0
References Zuckermann, R.N. et al.; J. Am. Chem. Soc., 115, 10646 (1992); Bull, R., et al.: Toxicol. Appl. Pharmacol., 182, 55 (2002), Mitch, W., et al.: Water Sci. Technol., 2, 191 (2002),

Applications Tetrabromobisphenol A Diglycidyl Ether is a brominated flame retardant (BFR) with good stability and a thermal decomposition temperature over 300°.
References Oleszek S., et al.: Waste Manag., 33, 1835 (2013); Jia, X., et al.: Henan Daxue Xuebao, Ziran Kexueban, 36, 44 (2006)

Applications N-​Methylaniline Trifluoroacetate is regent used in organic synthesis, functioning as an α-methylating agent for ketones and activates internucleodecoupling upon removal.
References Nikolaev, V. et al.: E-Eros. Encyc. Reag. Org. Synth, 1, (2001); Wallace, D. et al.: Tetrahedron Lett., 54, 4425 (2013);

Applications 3,5-Diiodothyropropionic acid is an ionotropic analog of L-thyroxine.

Applications Lusutrombopag (cas# 153203-80-6) is a useful research chemical.

Applications Ethyl trans-2-(4-aminocyclohexyl)acetate, HCl

Applications 3-(2,2,2-trifluoroethoxy)prop-1-yne (cas# 1481-06-7) is a useful research chemical.

Applications (2-Carboxyethyl)-triphenylphosphonium Chloride (cas# 36626-29-6) is a compound useful in organic synthesis.