Halogénures organiques

Impurity Isoconazole Nitrate EP Impurity B
Applications 2,4-Dichloro-β-[(2,6-dichlorophenyl)methoxy]benzeneethanamine (Isoconazole Nitrate EP Impurity B) is used in the synthesis of novel triazole compounds showing antitubercular activity.
References Kim, S. et al.: Bioorg. Med. Chem. Lett., 22, 6844 (2012);

Applications 1H,1H,6H-Decafluorohexan-1-ol is a useful intermediate for the telomerization of tetrafluoroethylene with methanol using hydrogen peroxide.
References No, V. B., et al.: Zh. Org. Khim., 12, 1825 (1976)

Applications 4,6-Dibromo-2,3-dichloroaniline is a bromination product of dichloro-substituted aniline. 4,6-Dibromo-2,3-dichloroaniline is used in the preparation of benzothiazoles.
References Gruzdev, I.V. et al.: Rus. J. Appl. Chem., 84, 1748 (2011); Paramasivam, R.: Ind. J. Chem. Sec. B Org. Med. Incl. Med. Chem., 26B, 930 (1987);

Applications 3,4-Dichloro-2-fluoroaniline

Applications 2,3-Dibromoaniline is a useful reactant in organic synthesis.
References Buszek, Keith R., et al.: Org. Let., 9(21), 4135-4137 (2007);Wang, Dong, et al.: React. & Func. Polymers, 105, 114-121 (2016)

Applications 3-(Aminomethyl)-4-fluorophenol Hydrobromide is derived from 2-Fluoro-5-methoxybenzaldehyde, which is versatile reactant used in the solid-phase synthesis of BODIPY dyes and development of an immunoglobulin fluorescent sensor.
References Vendrell, M., et al.: Chem. Commun., 47, 8424 (2011);

Applications 2-(4-Fluoro-2-hydroxyphenyl)isonicotinic acid

Applications 1,1-dimethylguanidine hydrochloride (cas# 22583-29-5) is a useful research chemical.

Applications 4-Fluorobenzophenone is a Wittig reagent.
References Buschauer, A., J. Med. Chem., 32, 1963 (1989); Yamataka, H., et al.: J. Org. Chem., 53, 3877 (1988)

Applications 2,4-dichlorobromobenzene

Applications 5-[1-Hydroxy-2-(2,4,5-trifluorophenyl)ethylidene]-2,2-dimethyl-1,3-dioxane-4,6-dione is an impurity of the DPP-IV inhibitor Sitagliptin (S491000).
References Ye, F. et al.: Hech. Huax., 18, 767 (2010); Ahn, J.H, et al.: Bioorg. Med. Chem. Lett., 17, 2622 (2007);

Applications TRIMETHYL(BROMODIFLUOROMETHYL)SILANE (cas# 115262-01-6) is a useful research chemical.

Applications 2-Bromo-4-aminobenzoic Acid (cas# 2486-52-4) is a compound useful in organic synthesis.

Applications (1R,3S)-3-(4-Bromophenyl)cyclopentanamine is used in the synthesis of pharmaceutical agents.

Applications This compound is an impurity in the synthesis of Etoricoxib (E934100), a specific inhibitor of COX-2. It is also used in the synthesis of selective GlyT1 inhibitors.
References Pinard, E. et al.: J. Med. Chem., 53, 4603 (2010); McGeer, P.L., et al.: Exp. Gerontol., 37, 925 (2002), Chenevard, R., et al.: Circulation, 107, 405 (2003);

Applications 4-Aminocatechol Hydrochloride is an acidic salt form of 4-Aminocatechol (A603280). 4-Aminocatechol is a phenol derivative with inhibitory activity against matrix metalloproteinase (MMP).
References Rubino, M.T. et al.: Arch. Pharm., 344, 557 (2011);

Applications tert-Butyl-(3-iodo-1,1-dimethyl-propoxy)-dimethyl-silane (cas# 105262-85-9) is used as a reagent in the preparation of Methyl Acetoacetate.
References Heslin, J. C., et al.: J. Chem. Soc. [Perkin 1]. 6, 1417 (1988)

Applications 1,5-Diiodo-3-oxopentane (cas# 34270-90-1) is a compound useful in organic synthesis.

Applications 4-(4-FLUOROPHENYL)-1,3-THIAZOLE (cas# 383145-29-7) is a useful research chemical.

Applications Methyl 4-(trifluoromethoxy)benzoate

Applications 5-Chloro-2-fluorobenzoic Acid (cas# 394-30-9) is a compound useful in organic synthesis.

Applications Methyl 2-Chloro-6-(trifluoromethyl)nicotinate (cas# 1073129-57-3) is a useful research chemical.

Applications 4-Chloro-4'-hydroxybiphenyl (cas# 28034-99-3) is a useful research chemical.

Stability Hygroscopic
Applications (2,4-difluorophenyl)hydrazine is a reactant in the preparation of 1a,2,5,5a-tetrahydro-1H-2,3-diaza-cyclopropa[a]pentalen-4-carboxamides as potent and selective CB2 receptor agonists.
References Han, S., et. al.: Bioorg. Med. Chem. Lett., 25, 322 (2015)

Applications (1-Bromoethenyl)-benzene is a useful synthetic intermediate. It is a reactant used to synthesize Potassium (1-Phenylcyclopropyl)trifluoroborate (P698400). It can also be used in the synthesis of substituted cyclopentenones.
References Zhang, L., et al.: J. Am. Chem. Soc., 128, 1442 (2006)

Applications (1S)-4-Bromo-2,3-dihydro-1H-inden-1-amine is used to prepare sphingosine 1 phosphate receptor modulators useful in treatment of S1P1-associated diseases.
References Boehm, M., et al.: PCT Int. Appl., WO 2012158550 A2 20121122 (2012)

Applications 1-Decylamine Hydrobromide is an intermediate forming the phosphatidylcholine-decylamine liposomal membranes.
References Kotynska, J., et al.: J. Bioenerget. Biomembrane., 40, 637 (2008);

Applications Octachlorocyclopentene (cas# 706-78-5) is a useful research chemical.

Stability Light and Moisture Sensitive
Applications A photoaffinity reagent.
References Hatanaka, Y. et al: Bioorg. Med. Chem., 2, 1367 (1994); Hatanaka, Y. et al: J. Org. Chem., 59, 383 (1994); Hatanaka, Y. et al: Bioorg. Med. Chem. 2, 1367 (1994)

Applications 3,6-Difluoro-2-(trifluoromethyl)-benzenamine is a useful building block in the synthesis of various pharmaceuticals.

Applications (3α,5β,7α)-24-Iodo-cholane-3,7-diol Diformate is an intermediate used in the synthesis of 3α,7α-Dihydroxycoprostanic Acid-d3 (D452517), which is a labelled analogue of 3α,7α-Dihydroxycoprostanic Acid (D452515), a precursor of Cholic Acid (C432600), it undergoes side chain oxidation during the synthesis of bile acids. It was found that Zellweger’s syndrome patients have abnormal mitochondrial structure, the organelle that is responsible for the side chain oxidation, and as a consequence, excess amounts of 3α,7α-Dihydroxycoprostanic Acid.
References Hanson, R. F., et al.: Science (Washington, DC, U. S.), 203, 1107 (1979)

Applications (±)-Tetrahydrofurfuryl Bromide is a general chemical reagent used in the synthesis of tubulin polymerization inhibitors.
References Colley, H. et al.: J. Med. Chem., 58, 9309 (2015);

Applications 4-Hydroxybenzamidine, Hydrochloride (cas# 38148-63-9) is a compound useful in organic synthesis.

Applications Methyl 3-chlorosulfonylthiophene-2-carboxylate

Applications 2-(2-Chlorophenyl)-cyclohexanone is a reactant that is used in the preparation of benzofurans via palladium-phosphine-catalyzed intramolecular enolate O-arylation of α-arylketones.
References Willis, M.C., et al.: Tetrahedron, 62, 11513 (2006)

Stability Moisture Sensitive, reacts with Moisture in the air
Applications 1,3-Benzodioxole-5-carbonyl chloride (cas# 25054-53-9) is a useful research chemical.

Applications 6-Chloro-1-benzofuran-2-carboxylic Acid is used to prepare cis-diaminocyclohexane derivatives as factor Xa inhibitors. It is also used to synthesize tachykinin NK2 receptor antagonists.
References Bioorg. Med. Chem., 17, 8206 (2009); Gensini, M., et al.: ChemMedChem, 5, 65 (2010)

Stability Light Sensitive
Applications α-Bromopropiophenone (cas# 2114-00-3) is a compound useful in organic synthesis.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package

Applications A new labelled substituted pyridazinone with tuberculostatic action.
References Wright, L., et al.: J. Antimicrob. Chemother., 12, 317 (1983), Choi, W., et al.: Anal. Biochem., 219, 368 (1994), Zacchino, S., et al.: J. Nat. Prod., 62, 1353 (1999), Urbina, J., et al.: Bioorg. Med. Chem., 8, 691 (2000),

Applications 1,3-Dichloro-5,5-dimethylhydantoin is used as a reagent in the synthesis of macrolactonolides which can be used as potential antiinflammatory drugs.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Tomaskovic, L., et al.: Bioorg. Med. Chem., 21, 321 (2013)

Applications Bromotrimethylsilane is used as a reagent in the synthesis of α-carboxy nucleoside phosphonate analogs as HIV reverse transcriptase-targeting agents.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Keane, S.J., et al.: J. Org. Chem., ahead of print (2014)

Applications 3-Aminophthalic Acid Hydrochloride Dihydrate (cas# 1852533-96-0) is a useful research chemical.

Applications 2-Bromo-2-(2-chlorophenyl)acetic Acid is used as an intermediate in the preparation of biologically active compounds such as the antithrombotic Clopidogrel (C587250).
References Chen, J. et al.: Hech. Huax., 18, 586 (2010);

Applications 4,5-Dichloroveratrole (cas# 2772-46-5) is a useful research chemical.

Applications 3-chloro-5-fluoro-2-hydroxybenzoic acid (cas# 4068-62-6) is a useful research chemical.

Applications N-(2-Chloroprop-2-en-1-yl)-2,3-dihydro-1H-inden-1-amine is related to the drug Rasagiline(R126030). Rasagiline is used to increase the availability of dopamine at striatal receptors as a method to treat Parkinson’s disease.
References Youdim, M.B.H., et al.: Br. J. Pharmacol., 132, 500 (2001); Finberg, J.P., Rambam Maimonides Med. J., 1 (2010)

Applications 3-Fluorobenzyl Bromide is a substituted benzyl bromide used as a reagent in the preparation of wide range of biologically active compounds such as antidiabetic drugs, anti-virals and anti-cancer agents.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Zhang, Y. et al.: Eur. J. Med. Chem., 53, 356 (2012); Wang, L.-J. et al.: Bioorg. Med. Chem. Lett., 22, 3473 (2012);

Applications 4-Fluoro-2-(hydroxymethyl)phenylboronic Acid is a compound used in the preparation of 4,5-dihydro-1H-pyrazole derivatives as cholesterol 24 hydroxylase inhibitors.
References Kaku, T., et al.: Preparation of 4,5-dihydro-1H-pyrazole derivatives as cholesterol 24 hydroxylase inhibitors, WO 2010110400 (2010);

Applications Methyl 5-cyano-2-fluorobenzoate

Applications (3-trans-Chloroallyl)oxyamine is used as a reagent in the preparation of 5-(dioxabicyclohept-6-yl)cyclohexenone oxime ether as hericides and plant growth regulators.
References Rheinheimer, J., et al.: PCT Int. Appl., 1998:490643 (1998)

Applications 1-(4-Bromophenyl)ethane-1,2-diol is used as a reactant in the regioselective palladium-catalyzed O,S rearrangement of cyclic thiocarbonates.
References Mahy, William, et al.: Euro. J. of Org. Chem., 2017(43), 6441-6444 (2017)

Stability Air Sensitive
Applications 4-IODO-2-NITROANILINE (cas# 20691-72-9) is a useful research chemical.

Applications A derivative of dioxane.

Applications 4-Bromo-2-(trifluoromethyl)benzoic acid

Applications Methyl 2-chloro-6-nitrobenzoate

Applications 4-[4-(trifluoromethyl)phenyl]butan-2-one (cas# 57132-19-1) is used in the study for syntheses and behavioral evaluations of fluorinated and silylated analogs of raspberry ketone as attractants for melon fly.
References Casana-Giner, V., et al.: J. Entomol. Sci. 38, 111 (2003)

Applications N-(3-Bromopropyl)phthalimide is used in synthesis of several organic compounds including that of flavonoid derivatives which act as selective ABCC1 modulators with potential use as pharmacological tools for investigation of the role of ABCC1. It is also used in the synthesis of Hederagenin which is a triterpene template for the development of new antitumor compounds.
References Obreque, B., et al.: Eur. J. Med. Chem., 109, 124 (2016); Rodriguez-Hernandez, D., et al.: Eur. J. Med. Chem., 105, 57 (2015);

Stability Hygroscopic
Applications 2-[2-(2-Chloroethoxy)ethoxy]ethanol is used in the preparation of ethylene glycol based amino acids. 2-[2-(2-Chloroethoxy)ethoxy]ethanol is also used in the preparation of polymers for direct and amplified DNA detection.
References Slama, J. et al.: Biochemistry, 19, 4595 (1980); Tansil, N.C. et al.: Chem. Comm., 47, 1533 (2011);

Stability Moisture Sensitive
Applications 3,5-Dinitrobenzoyl Chloride was used as a derivatization agent for high performance liquid chromatographic analysis of several compounds including polyamines and acteylated derivatives, taurine and hypotaurine and biogenic amines in fermented foods. It was also used in the synthesis of several organic compounds including that of a novel starch derivative which has adsorption property for creatinine and may therefore be useful in treatment of renal failure.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Kirschbaum, J., et al.: J. Chromatogr A., 881, 517 (2000); Wongyai, S., et al.: Biomed. Chromatogr., 2, 254 (1988); Masuoka, N., et al.: J. Chromatogr B., 660, 31 (1994); Jiu-gao, Y., et al.: Acta Pharm. Sin., 38, 191 (2003);

Applications 5-Chloro-4-nitro-2,1,3-benzoselenadiazole (cas# 20718-46-1) is a compound useful in organic synthesis.
References Turesky, R., et al.: J. Agric. Food Chem., 53, 3248 (2005),

Applications 3-(Cbz-Amino)-5-fluorophenylboronic acid

Applications 4-(4-Chlorophenyl)-2-butanone has been used as a reactant in the preparation of diarylheptanoids as tumor necrosis factor-α (TNF-α) inhibitors.
References Dhuru, S., et. al.: Bioorg. Med. Chem. Lett., 21, 3784 (2011)

Applications Methyl 5-chloropentanoate (cas# 14273-86-0) is a useful research chemical.

Stability Light Sensitive
Applications Cis-1-Bromo-2-ethoxyethylene

Applications methyl 3-chloro-4-hydroxyphenylacetate (cas# 57017-95-5) is a useful research chemical.

Stability Moisture Sensitive
Applications 3,4-Dimethoxybenzoyl Chloride is a benzoyl chloride derivative used in the preparation of a variety of biologically active compounds such as bronchodilators
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Sharma, R.L. et al.: ARKIVOC, 10, 233 (2009);