Halogénures organiques

Applications TRIMETHYL(BROMODIFLUOROMETHYL)SILANE (cas# 115262-01-6) is a useful research chemical.

Applications (3Z)-7-Bromo-3-heptene is an intermediate used in the synthesis of (Z)-γ-Jasmolactone (J210470), which is a compound that has a fruity, flowery and sweet taste and is commonly used as a fruit flavouring agent to enhance the peach flavour in a variety of food items.
References Clososki, G., et al.: Synth. Comm., 34, 817 (2004); Coelho, G., et al.: Hand. Fruit Veg. Flav., No vol. given, 211 (2010); Missio, L. & Comasseto, J.: Tetrahedron: Asymm., 11, 4609 (2000); Wamhoffa, H. & Gribbleb, G.: Adv. Hetero. Chem., 106, 185 (2012)

Applications 2-Fluorobenzenenitrile (cas# 394-47-8) is a compound useful in organic synthesis.

Applications 4-Bromo-3-hydroxyphenylboronic Acid (cas# 1701448-16-9) is a useful research chemical.

Applications 2,3-Dibromoaniline is a useful reactant in organic synthesis.
References Buszek, Keith R., et al.: Org. Let., 9(21), 4135-4137 (2007);Wang, Dong, et al.: React. & Func. Polymers, 105, 114-121 (2016)

Applications 5-Amino-2-chlorobenzenesulfonamide (cas# 2015-19-2) is a compound useful in organic synthesis.
References Somers, F., et al.: Pharm. Pharmacol. Commun., 6, 89 (2000), D'Ambrosio, K., et al.: J. Med. Chem., 51, 3230 (2008),

Applications 4,6-Dibromo-2,3-dichloroaniline is a bromination product of dichloro-substituted aniline. 4,6-Dibromo-2,3-dichloroaniline is used in the preparation of benzothiazoles.
References Gruzdev, I.V. et al.: Rus. J. Appl. Chem., 84, 1748 (2011); Paramasivam, R.: Ind. J. Chem. Sec. B Org. Med. Incl. Med. Chem., 26B, 930 (1987);

Applications Chlorosulfates were used to esterify several carboxylic acids.
References Binderup, E., et al.: Synth. Commun., 14, 857 (1984).

Applications Collidine-hydrogen fluoride complex (approx 1:2 collidine:HF) (cas# 45725-47-1) is a useful research chemical.

Applications 2-BROMO-9,9-DIOCTYL FLUORENE (cas# 302554-80-9) is a useful research chemical.

Applications 4-(2-Amino-3,3-dimethyl-1-oxobutyl)benzonitrile hydrochloride is used as a reagent to synthesize phenyloxobutanylpyridinylpiperazinecarboxamide derivatives, compounds that have TRPA1 receptor antagonistic properties.
References Svensson, M. & Weigelt, D. Preparation of Phenyloxobutanylpyridinylpiperazinecarboxamide Derivatives for Use as TRPA1 Receptor Antagonist. PCT Int. Appl. 2012050512. Apr 19, 2012.

Applications D-NG-Nitroarginine Methyl Ester Hydrochloride is inactive stereoisomer of L-NAME NOS inhibitor. Also, it reduces the necrotic and hypersensitive response of tobacco induced by Ralstonia solanacearum.
References Chou, C., et al.: Plant Pathol. Bull., 15, 97-105 (2006)

Applications A useful synthetic intermediate.

Applications 3-Bromo-4,5-difluorobenzoic Acid is a useful synthetic intermediate.

Applications N-[(2,4-Difluorophenyl)methylene]-2,4-difluoro-benzenemethanamine is derived from 2,4-Difluorobenzylamine (D450850), which acts as a reagent for the design of pyrazole derivatives as non-nucleoside heptatitis B virus inhibitors. It is also used as a reagent in the preparation, HIV antiviral activity, SAR, and molecular modelling of hydroxypyridonecarboxylic acids as HIV reverse transcriptase inhibitors.
References Jia, H., et al.: Eur. J. Med. Chem., 123, 202 (2016); Kankanala, J., et al.: J. Med. Chem., 59, 5051 (2016)

Stability Hygroscopic
Applications (±)-Tetrahydroxypavinane Hydrochloride is a useful synthetic intermediate.

Applications (2,4-Difluorophenoxy)acetic acid

Applications 2,4-Difluorophenylboronic Acid is used as a reagent in suzuki-miyaura coupling reactions such as in the synthesis of enantiomerically pure 3,3'-bis-arylated BINOL derivatives. Also used in the synthesis of highly efficient phospherescent iridium (III) complexes which are used for light-emiiting diodes.
References Qu, B., et al.: J. Org. Chem., 81, 745 (2016); Tao, P., et al.: Adv. Funct. Mater., 26, 881 (2016);

Applications Methyl 4-Chlorobenzoate is a reactant used in the synthesis of ataxia-telangiectasia mutated (ATM) kinase, a target for novel radiosensitizing agents. As well, used as a reactant in the synthesis of aminopyridine functionalized polyacrylonitrile fibers.
References Min, J. et al.: J. Med. Chem., 59, 559 (2016);

Applications Methyl 2-Bromopropionate is used in the synthesis of poly(ADP-Ribose)polymerase inhibitors derived from benzoxazin-3-one. Also used in the synthesis of 5-HT2C antagonists affecting serotonin levels.
References Gangloff, A et al.: Bioorg. Med. Chem. Lett., 23, 4501 (2013); Zhao, G. et al.: Bioorg. Med. Chem. Lett., 23, 3914 (2013);

Applications 2-Bromo-4-chloro-6-nitroanisole

Stability Hygroscopic
Applications 4-Aminophenylboronic Acid Hydrochloride is a reagent used for the synthesis of colorimetric and fluorescent nanosensor based on B, N, S-codoped carbon dots (BNS-CDs).
References Liu, Y., et al.: ACS Appl. Mater. Interfaces, 9, 12663-12672 (2017)

Applications N-[(4-fluorophenyl)methyl]prop-2-enamide (cas# 1046471-60-6) is a useful research chemical.

Applications 4-Chloro-N'-hydroxybenzimidamide

Applications ETHYL 4-AMINO-2-FLUOROBENZOATE (cas# 73792-06-0) is a useful research chemical.

Applications 4-Bromo-2-fluorobenzamide is used as a reagent to synthesize tricyclic dihydroquinazolinones, compounds that act as anti-obesity agents. 4-Bromo-2-fluorobenzamide is also used as a reagent to synthesize imidazole pyrimidine amides, compounds that act as cyclin-dependent kinase inhibitors.
References Ahmad, S., et al.: Bioorg. Med. Chem. Lett., 20, 1128 (2010); Jones, C., et al.: Biororg. Med. Chem. Lett., 18, 6486 (2008)

Applications 4-Chlorodifluoromethoxyaniline has been used as a reactant for the preparation of arylphthalazines as a potent and orally bioavailable inhibitor of VEGFR-2.
References Duncton, M. A. J., et. al.: Bioorg. Med. Chem., 17, 731 (2009)

Applications 2,4-Dichloroquinazoline has been used as a reactant for the preparation of 1-methyl-1H-imidazole derivatives as Jak2 inhibitors.
References Su, Q., et. al.: J. Med. Chem., 57, 144 (2014)

Applications 4-Bromotoluene is used as a reagent in the preparation of aromatic diselenides which are useful for generating anticancer lead compounds.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Rizvi, M.A., et al.: Bioorg. Med. Chem. Lett., 24, 3440 (2014); Leung, C., et al.: Angew Chem., Int. Ed., 52, 766 (2013)

Applications 4-Bromophenyl disulfide
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package

Applications 3,4-Difluoro-1-nitrobenzene was used in the synthesis of nitrogen-carbon-linked (azolylphenyl)oxazolidinones with antibacterial activities. It was also used in the preparation of (homo)piperazinylphenyl- and piperidinylphenyl-substituted oxazolidinones with antibacterial activities.
References Genin, M., et al.: J. Med. Chem., 43, 953 (2000); Das, B., et al.: Bioorg. Med. Chem. Lett., 15, 4261 (2005)

Stability Moisture Sensitive
Applications Dichloromethanesulfonyl Chloride is a useful reactant in organic synthesis.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Opitz, Guenter, et al.: Liebigs Annalen, (12), 2151-63 (1995);Serrano, Pedro, et al.: J. of Combi. Chem., 9(1), 43-52 (2007)

Applications Ethyl 2-fluoropropionate is used as a solvent for lithium secondary batteries. Ethyl-2-fluoropropionate is also used as a reagent to synthesize a series of potent Nicotinic Acid (N429250) receptor agonists for the treatment of dyslipidemia, a health condition characterized by high triglyceride levels.
References Grundy, S., et al.: Arch. Intern. Med., 162, 1568 (2002); Nambu, N., et al.: Electrochemistry, 80, 746 (2012); Qin, J., et al.: ACS Med. Chem. Lett., 2, 171 (2011)

Applications Carboxymethoxyamine Hemihydrochloride (cas# 2921-14-4) is a compound useful in organic synthesis.

Applications Alpha-(trifluoromethyl)styrene
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package

Applications 1-Chloro-4-(chlorophenylmethyl)benzene is used in the synthesis of novel benzhydrylpiperazine derivatives as cytotoxic compounds in the treatment of various cancers.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Gurdal, E. et al.: Drug Res., 63, 121 (2013); Yarim, M. et al.: Int. J. Mol. Sci., 13, 8071 (2013);

Applications (2-Chloroethoxy)methyl Chloride (cas# 1462-33-5) is a compound useful in organic synthesis.

Applications (+/-)-tert-Butyl 6-Chloro-5-hydroxy-3-oxohexanoate is an impurity in the synthesis of Rosuvastatin (R700500), a selective, competitive HMG-CoA reductase inhibitor. Antilipemic.
References Watanabe, M., et al.: Bioorg. Med. Chem., 5, 437 (1997), Lee, E., et al.: Clin. Pharmacol. Ther., 78, 330 (2005), Ferdinand, K.C., et al.: Am. J. Cardiol., 97, 229 (2006);

Applications 2,6-Dichlorobenzyl Alcohol is a useful reagent in organic synthesis.
References Ren, Shishuai, et al.: Dalton Transactions, 47(12), 4352-4359 (2018);He, Wei, et al.: Org. & Biomol. Chem., 16(10), 1659-1666 (2018);Stoit, Axel R., et al.: Bioorg. & Med. Chem. Let., 28(3), 459-465 (2018)

Applications 2-Iodophenylacetic acid is a synthetic intermediate that is widely used in the chemical, pharmaceutical and cosmetic industries. 2-Iodophenylacetic acid is also used as a reagent to synthesize Cepharanone B, a natural and potentially antineoplastic aristolactam that is found in Piper longum (a medicinal plant native to India).
References Kim, J., et al.: Org. Lett., 10, 3543 (2008); Philip, S., et al.: Curr. Sci., 78, 169 (2000); Soniya, E. & Das, M.: Plant Cell Tiss. Org. Cult., 70, 325 (2002)

Applications 4,5-Dichloro-1,3-benzothiazol-2-amine

Applications 3-(Methylamino)propanoic acid HCl

Applications Ethyl α-Bromo-β-phenylpropionate 90% (cas# 39149-82-1) is a compound useful in organic synthesis.

Applications 2-Chlorobenzenesulfonamide (cas# 6961-82-6) is a useful research chemical.

Applications 5-Amino-2-chloro-4-fluorophenol is a reagent involved in the design and structure of potent vascular endothelial growth factor (VEGF) receptor tyrosine kinase inhibitors.
References Hennequin, L. F., et al.: J. Med. Chem., 42, 5369-5389 (1999);

Applications N-(4-Bromopheneethyl-phthalimide is a building block used in the preparation of N-phenylethylindole carboxamides for structure activity relationship study of allosteric modulators of CB1 receptor.
References Piscitelli, F., et al.: J. Med. Chem., 55, 5627 (2012);

Applications 2,6-Difluorobenzyl chloride

Stability Light Sensitive, Moisture Sensitive
Applications 2-Bromo-1-(1,3-thiazol-2-yl)ethanone

Applications 1-Bromo-4-(2-bromoethyl)benzene

Applications 2,2-Dihydroxy-3,5,5-bromobiphenyl is a useful building block and reactant.

Applications (1-Fluorovinyl)methyldiphenylsilane acts as a reagent for the preparation of fluoro C-glycosyl asparagine from C-formyl glucoside by fluorovinylation and Claisen rearrangement for the construction of α-amino acid moiety.
References Usuki, Y., et al.: ITE Lett. Batter., New Technol. Med., 7, 63 (2006)

Applications 4-​Chloro-​3-​sulfobenzoic acid is a useful chemical for the preparation of pyridinylbiphenylcarboxamide derivatives for the use as nervous system agents.
References Wei, Z.L., et al.: PCT Int. Appl. 199pp. Patent 2009 CODEN:PIXXD2;

Applications Benzyl 2-Chloroethyl Ether is used in the synthesis of phosphane ligands with novel linker units that are complexed with rhodium to be used as building blocks for dendrimer catalysts. Also used in the formation of 2,6-diphenylpyrazine molecule derivatives which display cytotoxic properties.
References Findeis, R. et al.: Eur. J. Inorg. Chem., 1, 99 (2003); Dias, N. et al.: Eur. J, Med. Chem., 40, 1206 (2005);

Applications Di-[2-(2,3-dichlorophenyl)aminoethyl]amine is prepared from 1-Bromo-2,3-dichlorobenzene(B687435) and Diethylenetriamine (D444255). 1-Bromo-2,3-dichlorobenzene is a reagent used in the preparation of selective nonpeptidic inhibitors of striatal-enriched protein tryosine phosphatase.
References Baguley, T.D., et al.: J. Med. Chem., 56, 7636 (2013)

Applications 2,2-difluoroacetamide is a useful research chemical for the preparation of dihydroperfluoroalkyl amines and other fluoro derivatives.
References Vyazkov, V. A., et al.: Fluorine Notes, 65 (2009); Gontar, A. F., et al.: Fluorine Notes, 64 (2009); Englin, M. A., et al.: Zhurnal Obshchei Khimii, 33, 2963 (1963)

Applications Heptadecanoyl Chloride is an aliphatic reagent used in organic synthesis such as thiazole based amides for gelation study. Chloride derivative of Heptadecanoic Acid (H281030), a saturated fatty acid and occurs as a trace component of the fat in ruminants.
References Yadav, P. et al.: New J. Chem., 39, 721 (2015); Beare-Rogers., et al.: Pure. Applied. Chem., 73, 685 (2001);

Applications 4-(4-Chlorophenyl)-4-hydroxycyclohexanone (cas# 36716-71-9) is a compound useful in organic synthesis.

Applications 2-(3-Bromo-4-(trifluoromethoxy)phenyl)-2,2-difluoroacetic acid

Stability Hygroscopic
Applications Methylbenzethonium Chloride is an anti-leishmanial agent, in the treatment of leishmaniasis, a zoonotic infection affecting people in tropical regions.
References El-On, J. et al.: Exp. Parasitol., 116, 156 (2007); Peniche, A. et al.: Antimicrob. Agents. Chemother., 58, 78 (2014);

Applications 4-Fluoro-2-(hydroxymethyl)phenol can be used in preparation of naphthyridine derivatives as chemokine receptor antagonists useful in the treatment of pain.
References Wang, X., et al.: PCT Int. Appl., WO 2013010453 A1 20130124 (2013)