Halogénures organiques

Applications 2-Fluoro-5-(trifluoromethyl)aniline has been used as a reactant for the synthesis of 5,6,7-trimethoxy-N-phenyl(ethyl)-4-aminoquinazoline derivatives with anticancer activities.
References Zhang, Y., et. al.: Eur. J. Med. Chem., 66, 335 (2013)

Stability Extremely Moisture Sensitive
Applications Hexylphosphonic Dichloride acts as a reagent for the preparation of enantiomeric phosphonates which are inhibitors of cholesterol esterase.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Gillespie, S. G., et al.: Phosphorus, Sulfur Silicon Relat. Elem., 122, 205 (1997)

Applications 3-[3-(Trifluoromethyl)-3H-diazirin-3-yl]benzenemethanamine is a useful synthetic organic compound.

Stability Moisture Sensitive, Toxic
Applications Benzyl Chloromethyl Ether is a reagent in the preparation of benzoyl-hydroxypyrimidine-diones, which are dual inhibitors of HIV reverse transcriptase and integrase.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Tang, J., et al.: Bioorg. Med. Chem. Lett., 21, 2400 (2011); Berkley, S., et al.; Nat. Med. 16, 981 (2010)

Applications 5-[3-(Trifluoromethoxy)phenyl-2-Furancarboxylic Acid is the structural analogue of 5-[2-(Trifluoromethoxy)phenyl]-2-furancarboxylic Acid (T790925), a reactant used in the preparation of (phenyl)-N-[(mercapto)(pyrrolyl)triazolyl]furancarboxamide and (phenoxy)-N-[(mercapto)(pyrrolyl)triazolyl]acetamide derivatives as herbicides.
References Xue, S., Lu, C.: Youji Huaxue, 28, 1083 (2008)

Applications Methyl-2-bromo-4-bromomethylbenzoate

Applications 2-Chloro-3,4-dihydroxybenzoic acid (cas# 87932-50-1) is a useful research chemical.

Applications 3,5-Difluorobenzoic Acid can be used as reactant/reagent in Rh(III)-catalyzed regioselective heterocyclization of benzoic acids with acrylates to give phthalides with water as the solvent
References Zhu, Y., et al.: Eur J Org Chem, 2017, 806 (2017)

Applications Octafluoroadiponitrile (cas# 376-53-4) is a useful research chemical.

Applications 4-[(2-chloroacetyl)amino]benzoic acid (cas# 4596-39-8) is a useful research chemical.

Applications 4,4'-Dichlorobenzhydrol is used as a dummy template for the synthesis of molecularly imprinted liquid magnetic microspheres.
References Qiao, F., et al.: J. Sep. Sci., 39, 1310-1315 (2016)

Applications 9-Fluorenone is a polycyclic aromatic ketone that has photosensitizing properties and also has the ability to undergo electrochemical polymerization. 9-Fluorenone is used in industry as an initiator in visible-light cured resin systems. 9-Fluorenone has potentially toxic effects on humans, as exposure can cause DNA mutations.
References Cihaner, A., et al.: J. Elec. Chem., 568, 151 (2004); Li, Y., et al.: J. Biomed. Mater. Res. Part B-A, 84, 58 (2008); Okamoto, H., et al.: Org. Lett., 13, 2758 (2011)

Applications trans-2-(Chloromethyl)cyclohexanemethanol is an impurity of Lurasidone Hydrochloride (L474920), an antipsychotic used for treatment of schizophrenia.
References Ishiyama, T., et al.: Eur. J. Pharmacol., 572, 160 (2007); Cole, P., et al.: Drugs of the Fut., 33, 316 (2008)

Applications 3-Chloro-4-fluorophenylacetic Acid is a useful intermediate for organic synthesis.
References Baltzly, R., et al.: J. Org. Chem., 26, 2353 (1961); Feng, Q., et al.: Adv. Synth. Catal., 356, 1697 (2014)

Applications (4-Carboxybutyl)triphenylphosphonium Bromide (cas# 17814-85-6) is a compound useful in organic synthesis.

Applications (2S)​-N-​(3-​chloro-​4-​fluorophenyl)​-​2-​[[[(tetrahydro-​1,​1-​dioxido-​3-​thienyl)​amino]​carbonyl]​amino]​-​Propanamide is a useful building block and research chemical.

Applications methyl 2,4-dichlorothiazole-5-carboxylate (cas# 861708-66-9) is a useful research chemical.

Applications 6-Destrifluoromethyl-5-trifluoromethyl Bendoflumethiazide is an impurity of Bendroflumethiazide (B133500), a thiazide diuretic that is used to treat patients with Arterial Hypertensive Disease. Bendroflumethiazide works by blocking sodium reabsorption in the distal tubules within the kidneys.
References Borgström, L., et al.: J. Pharmacokinet. Biop., 8,431 (1981); Castillo, A., et al.: FASEB J., 23, 805 (2009); Greible, H., et al.: Arch. Intern. Med., 110, 34 (1962); Hallin, L. & Hansson, L.: J. Cardiovasc. Pharm., 5, 1083 (1983)

Stability Very Very Moisture sensitive
Applications Chloroformic Acid Chloromethyl Ester is used as a reagent in the synthesis of carbamates and carbonates.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Safadi, M. et al.: Pharm. Res. 10, 1350 (1993); Loren, J.C. et al.: Synlett, 18, 2847 (2005);

Applications 4-​Hydrazinobenzoic acid hydrochloride (cas# 24589-77-3) is a useful research chemical.

Applications pentan-2-amine hydrochloride (cas# 76716-21-7) is a useful research chemical.

Applications 2-Chloro-3,4-dimethoxy-β-nitrostyrene is an intermediate in the synthesis of high affinity D1 dopamine receptor ligand.
References Tarantino, P. A., et al.: Toxicol. App. Pharmacol., 27, 507 (1974);

Applications N-(Trifluoroacetyl)hexanolamine (cas# 40248-34-8) is a compound useful in organic synthesis.

Applications Ethyl 6-(4-chlorophenoxy)hexanoate is used as an intermediate in the preparation of (aryl)-N-(oxooxazolidinyl)-amides as potent quorum-sensing inhibitors of Pseudomonas aeruginosa.
References Jiang, K., et al.: Eur. J. Med. Chem., 194, 112252 (2020);

Applications 5-Fluoronicotinamide

Stability Light and Moisture sensitive
Applications (Diacetoxyiodo)benzene is a hypervalent iodine reagent that is used in conjunction with catalytic amount of sodium azide in acetonitrile, which enables oxidative decarboxylation of 2-aryl carboxylic acid into the corresponding aldehydes, ketones and nitriles.
References Telvekar, V.N., et al.: Synlett., 2778 (2012); Liu, W.B., et al.: Beilstein. J. Org. Chem., 8, 244 (2012);

Applications Methyl 3-(bromomethyl)cyclobutanecarboxylate (cas# 89892-95-5) is a useful research chemical.

Stability Hygroscopic
Applications 3-(Dimethylamino)propionic Acid Hydrochloride is a useful reagent for the preparation of biological active small molecules.
References Salado, I. G., et al.: J. Med. Chem., 57, 2755 (2014)

Applications 2,2,5,5-Tetramethylthiazolidine-4-carbonyl Chloride Hydrochloride is an intermediate in the synthesis of D,L-Penicillamine O-Lactose Adduct (P223020), which is an impurity of D-Penicillamine (P223000), a Penicillin metabolite used in the treatment of Wilson’s disease, Cystinuria, Scleroderma and arsenic poisoning.
References Marti-Prats, L., et al.: Neurosci. Lett., 483, 143 (2010); Singh, A., et al.: J. Pharm. Sci., 99, 3931 (2010); Everette, J., et al.: J. Agric. Food Chem., 58, 8139 (2010);

Applications A 3-aryl substituted Azetidine (A813000) used in the preparation opioid receptor modulators.

Applications 2-Bromo-1-cyclopropylethanone is an intermediate used to prepare pyrrolo[2,1-f]purine-2,4-dione and imidazo[2,1-f]purine-2,4-dione derivatives as potent and selective human A3 adenosine receptor antagonists. It is also used to synthesize indolizine derivatives incorporating a cyclopropylcarbonyl group against Hep-G2 cancer cell line.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Baraldi, P., et al.: J. Med. Chem., 48, 4697 (2005); Shen, Y., et al.: Eur. J. Med. Chem., 45, 3184 (2010)

Stability Hygroscopic
Applications TRISPHENYL(3,3,3-TRIFLUOROPROP-1-YL)PHOSPHONIUM IODIDE (cas# 128622-15-1) is a useful research chemical.

Applications 4-Amino-5-trifluoromethylbenzoic Acid (cas# 400-76-0) is a compound useful in organic synthesis.

Applications 2-Hydroxy-5-(trifluoromethoxy)phenylboronic acid

Applications Intermediate in the production of Folic Acid
References Jones, P., et al.: J. Med. Chem., 41, 3062 (1998), Uto, Y., et al.: Bioorg. Med. Chem., 16, 6042 (2008),

Applications 3-Fluoro-5-(trifluoromethyl)phenylacetic Acid used as a synthetic intermediate in the preparation of kinase inhibitors and agonists.

Applications Ethyl 4-Fluorophenylglyoxylate (cas# 1813-94-1) is a compound useful in organic synthesis.

Applications 2-Fluorophenacyl Chloride is 2-fluoro substituted α-chloro acetophenone used as a synthetic intermediate for neurologically active pharmaceutical compounds.

Applications Dibenzosuberyl Chloride is used in the synthesis of atypical tricyclic antidepressant as well as dibenzosuberyl-substituted tropines as ligands for acetylcholine-binding protein. Dibenzosuberyl Chloride is also used in the preparation of amino protecting group for solid phase peptide synthesis.
References Gerdes, K. et al.: Int. Elec. Conf. Synth. Org. Chem., 596 (2004); Noda, M. et al.: Shim. Hyor., 54, 223 (1997); Edink, E. et al.: Bioorg. Med. Chem. Lett., 22, 1448 (2012);

Applications 4-Fluoro-3-nitrobenzotrifluoride is an intermeidate used in the synthesis of 2-nitro-4-trifluoromethylphenylhydrazine, derivatization reagent for 1,2-diol compounds and oxo-steroids and [3-(2-nitro-4-trifluoromethylphenyl)aminophenyl]dihydroxyborane, derivatization reagent for 1,2-diol compounds and oxo-steroids.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Higashi, T., et al.: Anal. Sci., 18, 1301 (2002); Caci, E., et al.: Am. J. Physiol. Lung Cellular and Molecular Physiology, 285, L180 (2003)

Applications A phosphorylating agent.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Nachmansohn, et al.: Adv. Enzymology, 12, 259 (1951),

Applications 2,3-Dimethyl-3-butenoyl Chloride is an intermediate in the synthesis of (Z)-7-(((R)-2-Amino-2-carboxyethyl)thio)-2-(2,3-dimethylbut-3-enamido)hept-2-enoic Acid (A604435), which is an impurity of Cilastatin (C441100), prevents renal metabolism of penem and carbapenem antibiotics by specific and reversible dehydropeptidase I inhibition. Antibacterial adjunct.
References Finlay, K.R., et al.: Invest. Ophthalmol. Visual Sci., 24, 1147 (1983), Norrby, S.R., et al.: Antimicrob. Agents Chemother., 23, 300 (1983), Washburn, D.E., et al.: J. Antimicrob. Chemother., 12, 39 (1983),

Applications (E)-3-(3-(Trifluoromethyl)phenyl)acrylic Acid is a reagent used in the preparation of new tacrine-cinnamic acid hybrids as cholinerase inhibitors against Alzheimer’s diseases.
References Chen, Y., et al.: J. Enzyme Inhib. Med. Chem., 33, 290 (2018)

Applications 1,3-Dichloro-5-isocyanatobenzene is a reagent used in the synthesis of carbamate and aryl ether substituted pyrazinones as corticotropin releasing factor-1 receptor antagonists as well as the synthesis of novel triazolor pyridine derivatives.
References Ahuja, V. et al.: Bioorg. Med. Chem. Lett., Zhang, L. et al.: Turk. J. Chem., 39, 876 (2015);

Applications Z-2-Fluoro-3-(3-pyridyl)acrylic Acid (cas# 359435-42-0) is a compound useful in organic synthesis.

Applications Trimethyl-tetradecylammonium chloride,99% (cas# 4574-04-3) is a useful research chemical.

Applications 1,1-(Ethylenedioxy)-3-bromopropane is used in the synthesis of EGFR inhibitors. Also used in the synthesis of orally active agents of cancer and cell proliferation with quinoline substructures.
References Zhang, X. et al.: Arch. Pharm., 346, 44 (2013); Lee, Y. et al.: J. Med. Chem., 55, 10363 (2012);

Applications 5-Amino-2-chloroquinazolin-4(1H)-one is a synthetic reagent.

Applications 2-(3,4-Difluorophenyl)ethanamine

Applications 2,2,2-Tribromoethyl Dichlorophosphate is a reagent for the synthesis of aryl trihaloethyl dihydrogen phosphates.
References Owen, G. R., et al.: Synthesis, 10, 704 (1974)

Applications Ethoxyoxalyl Chloride has been used as a reactant in the preparation of oxyoxalamide derivatives as epoxide hydrolase inhibitors.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Kim, I., et. al.: Bioorg. Med., 22, 1163 (2014)

Stability Extremely moisture sensitive
Applications Highly reactive cyclic phosphitylating reagent which provides fast coupling rates, and hydrolytic cleavage occurs more readily than with acyclic analogs.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Bannwarth,W. & Kung, E.: Tetrahedron Lett., 30, 4219 (1989)

Applications α-(Aminomethyl)-2-(trifluoromethoxy)benzenemethanol is an analog of α-(Aminomethyl)-3-(trifluoromethoxy)benzenemethanol (A630745); a compound that is used as a reagent in the synthesis of potent and selective ethanolamine inhibitors of bacterial phenylalanyl tRNA synthetase. It is also used as a reagent in the synthesis of 1-aryl-2-((6-aryl)pyrimidin-4-yl)amino)ethanols as competitive inhibitors of fatty acid amide hydrolase.
References Jarvest, R.L., et al.: Bioorg. Med. Chem. Lett., 15, 2305 (2005); Keith, J.M., et al.: Bioorg. Med. Chem. Lett., 24, 1280 (2014)

Applications 2,5-Difluorophenylacetic acid has been used in the synthesis of 2,2-dimethyl-4-(2,5-difluorophenyl)-5-[4-(aminosulfonyl)phenyl]-3(2H)-furanone.
References Chin, O., et al.: J. Pharm., 44, 138 (2013)

Applications 2,6-Dichloro-4-nitroanisole (cas# 17742-69-7) is a useful research chemical.

Applications 3-Chlorobenzyl chloride (cas# 620-20-2) is a useful research chemical.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package

Applications Manganese(II) chloride monohydrate (cas# 64333-01-3) is a useful research chemical.

Applications 7-Chloro-6-sulfamoylisatoic Anhydride is an intermediate in the synthesis of 2-Amino-4-chloro-5-sulfamoyl-o-benzotoluidide (A604420) and in the synthesis of 3-Aryl- and 3-​aralkyl-​1,​2,​3,​4-​tetrahydro-​4-​oxo-​6-​quinazolinesulfonamides.
References Shetty, B., et al.: J. Med. Chem., 13, 886 (1970);

Applications 2-(Dimethylamino)-ethanesulfonyl Chloride Hydrochloride is derived from 2-(Dimethylamino)ethanethiol Hydrochloride (D461685), which is a starting material for the synthesis of Echothiophate Iodide (E325800). Echothiophate Iodide is an anticholinesterase drug.
References Ashani, Y., et al.: Biochem. Pharm., 30, 2593 (1981)

Applications 3-(Dibenzo[b,e]oxepin-11(6H)-ylidene)-N,N-diethylpropan-1-amine Hydrochloride (E/Z Mixture) is an intermediate in synthesizing N-Diethylnordoxepin Salt (D468115), a compound useful in organic synthesis.

Applications 3-Bromo-1-(2-octylphenyl)propan-1-one is a chemical useful in organic synthesis.

Applications (Chlorodifluoromethoxy)benzene

Applications 3-(4-FLUOROPHENYL)CYCLOPENTANONE (cas# 165591-10-6) is a useful research chemical.

Applications Trimethyl (2-N-t-Butoxycarbonylamino)ethylammonium Bromide is a compound useful in organic synthesis.

Applications Ethyl 8-bromooctanoate is a useful research reagent for organic synthesis and other chemical processes.
References Shao, M., et al.: Bioorg. Med. Chem. Lett., 27, 4051 (2017); Wang, L., et al.: Chin. J. Chem., 32, 157 (2014)