Halogénures organiques

<p>Applications A cell-permeable, selective and irreversible PPARγ antagonist (IC50 = 3.3 nM, 32 nM, and 2 µM for PPARγ, PPARα, and PPARδ, respectively). Reported to covalently modify a cysteine residue in the binding site of PPAR. At a concentration of 10 µM, also acts as an agonist of human pregnane X receptor (PXR) and farnesoid X receptor (FXR). Does not activate liver X receptor-a (LXRa), retinoic acid receptor (RAR), retinoid X receptor-a (RXRa) and thyroid receptors a and b (TRa and TRb<br>References Huang, J.T., et al.: Nature, 400, 378 (1999), Wilson, T.M., et al.: J. Med. Chem., 43, 527 (2000), Leesnitzer, L.M., et al.: Biochemistry, 41, 6640 (2002)<br></p>

<p>Stability Moisture Sensitive<br>Applications n-Octyl Chloroformate is a chemical reagent used in the synthesis of surfactants derived from N-alkoxycarbonyl amino acids. Also used n the preparation of piperazinyl-glutamate-pyridines used as orally bioavailable P2Y12 antagonists in platelet aggregation.<br>References Kawase, T. et al.: J. Oleo. Sci., 59, 191 (2010); Parlow, J. et al.: Bioorg. Med. Chem. Lett., 19, 4657 (2009);<br></p>

<p>Stability Hygroscopic<br>Applications 2-Amino-5-Ethylphenol Hydrochloride (cas# 149861-22-3) is a useful research chemical.<br></p>

<p>Applications 4-bromo-1,1-difluorobutane (cas# 1457946-33-6) is a useful research chemical.<br></p>

<p>Applications 4-Bromobenzotrifluoride is an aromatic compound that is used as a reagent to synthesize Bergenin (B318650), a compound that originates in Mallotus japonicus that exhibits hepatoprotective and antioxidant effects. 4-Bromobenzotrifluoride is also used as a reagent to prepare (±)-Preclamol, a partial dopamine D2 agonist that is used to treat Parkinson’s disease.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Lim, H., et al.: Pharmacology, 63, 71 (2001); Parkan, K., et al.: Chem. Eur. J., 20, 4414 (2014); Pirtosek, Z., et al.: Clin. Neuro., 16, 550 (1993); Takahashi, H., et al.: Bioorg. Med. Chem., 11, 1781 (2003); Vasdev, N., et al.: Synapse, 60, 314 (2006)<br></p>

<p>Applications Formamidine Hydrobromide is used as a reactant in the synthesis of organometal halide perovskites (OHPs).<br>References Shi, Yifei, et al.: ACS App. Mat. &amp; Interfaces, 10(11), 9849-9857 (2018)<br></p>

<p>Applications (2-Fluorophenoxy)acetic acid<br></p>

<p>Stability Moisture Sensitive<br>Applications N-Phenylbis(trifluoromethanesulfonamide) is used in the enantioselective synthesis of β-amino acids via the Mannich reaction. Used in the synthesis of sphingosine 1-phosphate-1 receptor agonists useful in pharmaceutical application.<br>References Asano, M. et al.: Tetra. Asymm., 24, 449 (2013);<br></p>

<p>Applications 4-Fluoro-2-formylphenylboronic acid<br></p>

<p>Applications N-​Methylcyclopropanami​ne Hydrochloride can be used as reactant/reagent in preparation of substituted benzazinones as antibacterial compounds.<br>References Jin, Q., et al.: PCT Int. Appl., WO 2017098440 A1 20170615 (2017)<br></p>

<p>Applications 4-Fluoro-2-(hydroxymethyl)phenylboronic Acid is a compound used in the preparation of 4,5-dihydro-1H-pyrazole derivatives as cholesterol 24 hydroxylase inhibitors.<br>References Kaku, T., et al.: Preparation of 4,5-dihydro-1H-pyrazole derivatives as cholesterol 24 hydroxylase inhibitors, WO 2010110400 (2010);<br></p>

<p>Applications 2-Fluoro-4-(methylsulfonyl)benzoic acid<br></p>

<p>Applications 4-[4-(trifluoromethyl)phenyl]butan-2-one (cas# 57132-19-1) is used in the study for syntheses and behavioral evaluations of fluorinated and silylated analogs of raspberry ketone as attractants for melon fly.<br>References Casana-Giner, V., et al.: J. Entomol. Sci. 38, 111 (2003)<br></p>

<p>Applications 2,5-Difluoro-1,4-phenylenediboronic acid, pinacol ester<br></p>