Halogénures organiques

<p>Applications 4-Cyano-3,5-difluorophenylboronic acid<br></p>

<p>Applications 1-(2,3-dichlorophenyl)ethanone (cas# 56041-57-7) is a useful research chemical.<br></p>

<p>Applications 2,2-Difluoro-2-phenylacetic acid<br></p>

<p>Applications 1-Bromo-4-nitrobenzene is part of a group of compounds that have the ability to stimulate the microbial degradation of polychlorinated biphenyls (PCBs), rendering them less harmful to the environment, animals and humans. 1-Bromo-4-nitrobenzene is also an electron-poor arene that has genotoxic effects on humans.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References DeWeerd, K. &amp; Bedard, D.: Env. Sci. Tech., 33, 2057 (1999); Huang, Q., et al.: J. Env. Sci., 8, 103 (1995); Imperato. G., et al.: Adv. Synth. Cat. 348, 2243 (2006)<br></p>

<p>Applications Reagent used in the preparation of Levofloxacin.<br>References Sidique, S., et al.: Bioorg. Med. Chem. Lett., 19, 5773 (2009),<br></p>

<p>Applications 2,3-Dimethylbutyl Chloroformate is used to prepare phenyl(piperazinylphenyl)pyrazolo[1,5-a]pyrimidinylamine derivatives for use as Lck inhibitors.<br>References Buehlmayer, P., et al.: PCT Int. Appl. (2008), WO 2008037459 A1 20080403<br></p>

<p>Applications 4-Bromo-1-butyne is used in the regioselective preparation and CDC25 phosphatase inhibition activity SAR of triazolobenzylidene-thiazolopyrimidines via parallel click chemistry between azidobenzylidene-thiazolopyrimidines and alkynes<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Duval, R., et al.: J. Comb. Chem., 11, 947 (2009)<br></p>

<p>Stability Hygroscopic<br>Applications 1-(4,5-Dihydro-2-thiazolyl)-3-azetidinethiol Hydrochloride is used as a reagent in the synthesis of Tebipenem Tetrahydrate (T012840); the active metabolite of Tebipenem Pivoxil (T012900) that shows excellent bactericidal activity against β-lactamase-nonproducing, ampicillin-resistant isolates.<br>References Nakashima, M. et al.: Nip. Kag. Ryo. Gak., 57, 90 (2009); Kishii, K. etal.: Antimicrob. Agents Chemother., 54, 3970 (2010); Xu, Z., et al.: Yaoxue Xuebao, 48, 993 (2013); Hazra, S., et al.: Biochem., 53, 3671 (2014); Li, H., et al.: Int. J. Antimicrob. Ag., 43, 92 (2014)<br></p>

<p>Applications 2,6-Dimethoxybenzoyl Chloride is used in the synthesis of penicillins and cephalosporins.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Newall, C. et al.: Comp. Med. Chem., 2, 609 (1990); Kanao, M. et al.: J. Med. Chem., 25, 1358 (1982);<br></p>

<p>Applications 3,4-Dimethylbenzotrifluoride could be a useful reagent for the preparation of bromodomain targeting degronimers for target protein degradation.<br>References Phillips, A. J., et al.: PCT Int. Appl. (2017) WO 2017197056 A1<br></p>

<p>Applications Decabromobiphenyl is a flame retardant and a standard for environmental testing and research.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References EPA. Method 1668, (EPA 821-R-00-002) (1999); Zeng, L., et al.: Environ. Sci. Technol. 48, 12586 (2014)<br></p>

<p>1,1-Dichlorodimethyl ether is a chemical compound that is used as an intermediate in the synthesis of trifluoroacetic acid from hydrochloric acid and methanol. This chemical has also been shown to inhibit inflammation by inhibiting the release of inflammatory cytokines, including epidermal growth factor (EGF) and interleukin-8 (IL-8). It may be used to treat chronic cough and chronic bronchitis. 1,1-Dichlorodimethyl ether inhibits the production of EGF by blocking the binding of EGF to its receptor on the surface of cells. The molecule also has an inhibitory effect on IL-8 production via inhibition of protein kinase C. The 1,1-dichlorodimethyl group is a reactive oxygen species that can react with other molecules such as DNA or proteins, leading to damage or even cell death.</p>