Halogénures organiques

Applications An antimalarial; antirheumatic; lupus erythematosus suppressant. It is a COVID19-related research product.
References Yarden, Y., et al.: Nature, 323, 226 (1986), Seifert, R., et al.: J. Biol. Chem., 264, 8771 (1989), Gahl, W., et al.: Mol. Genet. Metab., 76, 234 (2002), Card, J., et al.: Toxicol. Sci., 75, 169 (2003),

Applications Dichloroacetonitrile is commonly used with gas chromatography-mass spectrometry instrument to evaluate and quantify the common halogenated disinfection by products using the headspace technique.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Montesinos, I., et al.: J. Chromatogr. A., 1310 113 (2013)

Applications 3,6-Dichloro-2-hydroxybenzoic acid (cas# 3401-80-7) is a useful research chemical.

Applications N-(4-Chlorobenzyl)-1-(5-nitrothiophen-2-yl)methanamine is an analogue of GSK 4112 (G797700) which is a synthetic ligand for REV-ERBα, a member of the nuclear receptor superfamily that functions as a receptor for the porphoryin heme. GSK 4112 mimics the action of heme acting as agonist and suppresses the expression of REV-ERBα target genes involved in gluconeogenesis.
References Kojetin, D. et al.: ACS Chem. Biol., 6, 131 (2011); Grant, D. et al.: ACS Chem. Biol., 5, 925 (2010)

Applications Tetrachlorohydroquinone is a chlorinated hydroquinone compound used as an analytical standard.

Stability Moisture Sensitive
Applications 2-Chloro-5-(1-chloro-1,3-dihydro-3-oxo-1-isobenzofuranyl)-benzenesulfonyl Chloride is a useful synthetic intermediate.

Applications 2-Chloro-4,5-dinitro-toluene (cas# 56136-79-9) is a compound useful in organic synthesis.

Applications Methoxylamine is a methoxime derivative used as internal standard for Prostaglandin assays by gas chromatography-mass spectrometry.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Herold, D.A. et al.: Prostaglandins, 33, 599 (1987);

Applications Isotope labelled Trifluoroacetic Acid used as a solvent in a variety of organic synthesis and chemical processes. Used in the synthesis of anticancer agents as well as phospholipase D inhibitors.
E0
References Scott, S. et al.: Nat. Chem. Biol., 5, 108 (2009); Minko, T. et al.: Cancer. Chemother. Pharmacol., 50, 143 (2002);

Applications 1-Chloro-2-(α-chlorophenylmethyl)benzene is used as a reagent in the synthesis of bifonazole analogs which have antibacterial and antifungal activities. It is also used in the preparation of diphenylpiperazine N-type calcium channel inhibitors.
References El Hage, S., et al.: Arch. Pharm., 344, 402 (2011); Pajouhesh, H., et al.: Bioorg. Med. Chem. Lett., 20, 1378 (2010)

Stability Light Sensitive
Applications p-(2-Bromo)vinyl Anisole (cas# 6303-59-9) is a compound useful in organic synthesis.

Impurity Lamotrigine USP Related Compound B/ Lamotrigine EP Impurity E
Applications 2,3-Dichlorobenzoic Acid (Lamotrigine USP Related Compound B) is the key intermediate for antiepileptic drug Lamotrigine (L173250) and other pharmaceuticals for the treatment of central nervous system (CNS) disorders and disease.
References Liao Q., et al.: JingXi. Huagong., 36, 18 (2006); Qadeer, G., et al.: J. Brazilian. Chem. Soc., 18, 1176 (2007); Pellon, R.F., et al.: Syn. Commun., 37, 1853 (2007); Wang, J.F., et al.: Thermochimica. Acta., 512, 118 (2011);

Applications 2-Phenylacetimidamide hydrochloride (cas# 2498-46-6) is a useful research chemical.

Stability Moisture Sensitive
Applications 4-Chloro-3-nitrobenzoyl Chloride (cas# 38818-50-7) is a compound useful in organic synthesis.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package

Applications Chlorthiamid

Stability Hygroscopic
Applications Heptafluorobutyric Acid (HFBA) is used in reversed-phase chromatography.
E0
References Satake, I., et al.: Biopolymers, 15, 2263 (1976), Aso, K., et al.: Biosci. Biotech. Biochem., 56, 755 (1992), Cecchi, T., et al.: J. Chromatogr., 1216, 1789 (2009),

Applications (S)-2-Aminobutanoic Acid Hydrochloride is an intermediate in the synthesis of Levetiracetam (L331500), which is used as an anticonvulsant.
References Gower, A.J., et al.: Eur. J. Pharmacol., 222, 193 (1992); Kasteleijn-Noist Trenite, D.G.A., et al.: Epilepsy Res., 25, 225 (1996); Patsalos, P.N., et al.: Pharmacol. Ther., 85, 77 (2000)

Applications Dimethyldimyristylammonium Chloride is used as a surfactant.
References Cipiciani, A., et al.: Austr. J. Chem., 44, 1505 (1991); Hueck, H., et al.: Appl. Microbiol., 14, 308 (1966)

Applications Shows some anti-viral activity due to the adamantane structure. In addition it shows anti-microbial activity and cytotoxic application.
References Aigami, K. et al.: J. Med. Chem., 18, 713 (1975); Aigami, K. et al.: J. Pharm. Res., 4, 1407 (2011);

Stability Moisture Sensitive
Applications Pentafluorobenzoyl Chloride is a useful analytical reagent in the derivatization amphetamines as well as other primary amines.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Koster, E. et al.: Analyst, 127, 598 (2002);

Stability Light Sensitive
Applications 3-Chlorocyclohexene (cas# 2441-97-6) is a useful research chemical.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package

Applications 4,6-Dichloronicotinic acid

Applications 5-IODO-A-85380 Dihydrochloride is a highly potent and subtype-selective agonist for AChR α4β2 and AChR α6β2.
References Koren, A.O., et al.: J. Med. Chem., 41, 3690-3698 (1998); Muhkin, A.G., et al.: Mol. Pharmacol., 57, 642-649 (2000); Mogg, A.J., et al.: Neuropharmacology, 47, 848-859 (2004);

Impurity Isoconazole Impurity 6
Applications α-(Chloromethyl)-2,4-dichlorobenzyl alcohol is used in the synthesis of monocyclic nitroimidazole analogs of econazole. Isoconazole Impurity 6.
References Lee, S., et al.: Bioorg. Med. Chem. Lett., 21, 1515 (2011);

Applications 1H,1H,2H-Perfluoro-1-decene (cas# 21652-58-4) is a useful research chemical.

Stability Light Sensitive
Applications 2-​(Perfluorodecyl)​ethyl Acrylate is used as a reagent in the preparation of repellent finishes on cotton.
References El-Shafei, A. et al.: J. Coat. Tech. Res., 12, 681 (2015);

Applications Hexachloroethane is a highly efficient chlorinating agent in the preparation of chlorosilanes from hydrosilanes.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Pongkittiphan, V., et al.: Tetrahedron Lett., 50, 5080 (2009)

Applications Ethylamine Hydrochloride a chemical used in various chemical organic syntheses and biological studies.
References Miller, M.M. et al.: Bioorg. Med. Chem. Lett., 22, 6503 (2012); Yasui, K. et al.: Prot. Sci., 19, 486 (2010);

Applications p-Toluidine Trifluoroacetamide (cas# 350-96-9) is a compound useful in organic synthesis.

Applications Butylamine Hydrochloride is a miscellaneous reagent used in the synthesis of benzamides for the synthesis of various drugs and polymers.
References Bantreil, X. et al.: Eur. J. Org. Chem., 2015, 416 (2015);

Applications 3-Iodobenzoic Acid (cas# 618-51-9) is a compound useful in organic synthesis.

Applications Methyl 2-Bromomethylbenzoate is a reactant in the preparation of Methyl 2-((4-(2-(2-methylphenoxy)acetyl)piperazin-1-yl)methyl)benzoate with neuroprotective activity.
References Zhong, Y., et. al.: Chin. J. Struct. Chem., 33, 1096 (2014)

Applications Copper Hexafluorosilicate is a useful compound in metal-organic material synthesis.
References Nugent, P., et al.: Natrue, 495, 80 (2013);

Applications Phenyl N-​(2-​Chloro-​4-​hydroxyphenyl)​carbamate is a reagent used in the prepartion of quinoline-carboxamide compounds including Lenvatinib (L329400), an orally active inhibitor of multiple receptor tyrosine kinases including VEGF, FGF and SCF receptors.
References Wang, N. et al.: Faming Zhuanli Shenqing (2017), CN 106632033 A 20170510.

Applications 2-​Amino-​3-​chloro-​5-​trifluoromethylpyrid​ine acts as a reactant in the synthesis of novel imidazo[1,2-a]pyridine-coumarin hybrid molecules as inhibitors of NS5B in potential treatment of Hepititis C.
References vManvar, P. et al.: Tetrahedron 72, 1293 (2016);

Applications 1,3,5-TRIMETHYL-1,3,5-TRIS(3,3,3-TRIFLUOROPROPYL)CYCLOTRISILOXANE (cas# 2374-14-3) is a useful research chemical.

Applications Dabsyl Chloride is used for HPLC amine derivatization to detect proteins and other molecules.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Romero, R. et al.: Chromatograph., 51, 404 (2000); Ikeda, M. et al.: Amino Acids., 8, 401 (1995):

Applications 3-chloro-N-(3-hydroxyphenyl)propanamide (cas# 50297-40-0) is a useful research chemical.

Applications 1-Bromobenzene, is used as a general reagent in palladium-catalyzed reactions and in the synthesis of Grignard reagents.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Miyaura, N. et al.: Synth. Commun., 11, 513 (1981); Nahm, S. et al.: Tetra. Lett., 22, 3815 (1981);

Applications 3-[3-(trifluoromethyl)phenyl]propan-1-amine (cas# 104774-87-0) is a useful research chemical.

Applications 4-Bromo-2,2-diphenylbutyric Acid (cas# 37742-98-6) is a compound useful in organic synthesis.

Applications 2,6-Dichloro-4-(trifluoromethyl)aniline is used in the synthesis of GABA receptor antagonists and insecticides.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Sammelson, R. et al.: Bioorg. Med. Chem., 12, 3345 (2004); Huang, W. et al.: Bioorg. Med. Chem., 14, 8280 (2006);

Applications DL-2,4-Diaminobutyric Acid Dihydrochloride (cas# 65427-54-5) is a useful research chemical.

Stability Air Sensitive
Applications 2-(2,4-Diaminophenoxy)ethanol Dihydrochloride

Applications N-[(4-chlorophenyl)methyl]cyclopentanamine is a useful reagent for the preparation of γ-​lactams.
References Fujii, T., et al.: Tetrahedron Letters, 61, 152276 (2020)

Stability Hygroscopic
Applications 3-[[[2-[(Diaminomethylene)amino]-4-thiazolyl]methyl]thio]propanimidamide hydrochloride (cas# 76833-47-1) is a useful research chemical.

Stability Hygroscopic
Applications Perfluorobutylphosphonic Acid, is a surfactant or antifoaming agent.

Stability Volatile
Applications 5-Fluoro-1-pentyne use as a reactant/reagent for preparation of glutamic acid-based peptidomimetic prostate-specific membrane antigen binding agents for imaging use.
References Wang, E., et al.: PCT Int. Appl., WO 2013028664 A1 20130228 (2013)

Stability Unstable in Aqueous Solution
Applications 1-(4-Chlorophenyl)-3-(dimethylamino)propan-1-one Hydrochloride

Applications Intermediate in the preparation of imidazole antifungal agents.
References Albet, C. et al.; J. Pharmaceut. Biomed. 10, 205 (1992); Raga, M. et al.; Eur. J. Med. Chem. 21, 329 (1986)

Applications 2-(2-bromo-4,5-dimethoxyphenyl)ethan-1-amine hydrochloride (cas# 103275-23-6) is a useful research chemical.

Applications p-Trifluoromethylphenyl is used in the synthesis of P2Y1 antagonists and antithrombotic agents. Also, used in the synthesis of potent myeloid cell leukemia inhibitors.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Chao, H. et al.: J. Med. Chem., 56, 1704, 2013; Friberg, A. et al.: J. Med. Chem., 56, 15 (2013);

Stability Hygroscopic
Applications DOTA-NHS-ester Hexafluorophosphate TFA Salt is used as a reagent in the preparation of metal or radiometal-labeled-urea- and carbamate-based PSMA inhibitors for PSMA-targeted imaging and radiotherapy.
References Ray, S., et al.: PCT Int. Appl. (2015), WO 2015171792 A1 20151112

Applications 1-Bromo-2-(4-bromophenyl)ethylene (contains cis isomer) (cas# 778641-02-4) is a compound useful in organic synthesis.

Stability Hygroscopic
Applications Benzyltrimethylammonium chloride (cas# 56-93-9) is a useful research chemical.

Applications Perfluorodecyl iodide is used to prepare 3,5-bis(perfluorodecyl)phenylboronic acid, "green" catalyst for the direct amide condensation reaction. It is also used to synthesize 3-(perfluorodecyl)prop-1-ene.
References Ishihara, K, et al.: Synlett., 9, 1371 (2001); Ryu, I., et al.: Tetrahedron Lett., 42, 947 (2001)

Applications 2-Chloroethyl Methyl Ether is used as a reagent in the synthesis of Piperonyl Methoxyethyl Ether (P490475); a selective inhibitor of the cytochrome P450-dependent monooxygenase from the housefly.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Motoyama, N., et al.: Rev. Pestic. Toxicol., 1, 173 (1991)

Applications 2,4,5,6-Tetrachloro-m-xylene, is an intermediate for the synthesis of pesticides and metabolites. It can also be used for the preparation of Quinol nitrates.
References Suzuki, H., et al.: J. Chem. Soci. Comm., 51 (1957); Snyder, J. L., et al.: Anal. Chem., 64, 1940 (1992);

Stability Light Sensitive
Applications Methyl 2-Iodobenzoate is used as a reagent in the synthesis of Montelukast Sodium Salt (M568000); a selective leukotriene D4-receptor antagonist that is used as an antiasthmatic. Methyl 2-Iodobenzoate is also used as a reagent in the synthesis of isoquinolinone-based tricycles as polyribose polymerase-1 inhibitors.
References Bollikonda, S., et al.: J. Org. Chem., 80, 3891 (2015); Labelle, M., et al.: Bioorg. Med. Chem. Lett., 5, 283 (1995); Jones, T.R., et al.: Can. J. Physiol. Pharmacol., 73, 191 (1995); Markham, A. and Faulds, D.: Drugs, 56, 251 (1998); Chen, J., et al.: Bioorg. Med. Chem. Lett., 24, 2669 (2014)

Applications p-Toluoyl chloride is an aromatic compound used as a reagent to synthesize (+)-Yashabushitriol, a plant metabolite that is naturally found in the male flowers of Alnus sieboldiana matsum. p-Toluoyl chloride is also used as a reagent to prepare derivatives of Desloratadine (D290250). Desloratadine is a selective H1-receptor antagonist that has anti-inflammatory effects and is used to treat patients with allergic rhinitis.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Berger, W.. et al.: Ann. All. Asth. Immun., 89, 485 (2002); Fang, Z., et al.: Tetrahedron Lett., 54, 6834 (2013); Feldman, K. & Simpson, R.: Tetrahedron Lett., 30, 6985 (1989); Mu, S., et al.: Chin. Chem. Lett., 24, 531 (2013)

Applications 4-Bromo-2,6-diisopropylaniline is used as a reactant in the preparation of hyperbranched ethylene oligomers.
References Wiedemann, T., et. al.: J. Am. Chem. Soc., 136, 2078 (2014)