Halogénures organiques

<p>Applications 1-Decylamine Hydrobromide is an intermediate forming the phosphatidylcholine-decylamine liposomal membranes.<br>References Kotynska, J., et al.: J. Bioenerget. Biomembrane., 40, 637 (2008);<br></p>

<p>Stability Hygroscopic<br>Applications 3-Bromo-1-(trimethylsilyl)-1-propyne is a reactant used in the preparation of a novel lipid mediator with anti-inflammatory activity. Also used in the preparation of (+)-Rubriflordilactone A, a natural nortriterpenoid.<br>References Goto, T. et al.: Tetrahedron., 71, 8320 (2015); Goh, S. et al.: Angew. Chem. Int. Ed., 54, 12618 (2015);<br></p>

<p>Applications 2-Bromoacetamide<br></p>

<p>Applications 2-(3-Bromopropyl)-1,3-dioxolane is used as a reactant in the synthesis of compounds that act as therapeutic agents.<br>References Cochrane, Stephen A., et al.: Org. &amp; Biomol. Chem., 13(21), 6073-6081 (2015);Brown, Patrick D., et al.: Angewandte Chemie, I. E., 52(50), 13273-13275 (2013);Amat, Mercedes, et al.: Chem. Comm., 49(30), 3149-3151 (2013)<br></p>

<p>Applications 3-Bromobiphenyl is used as a reagent in the synthesis of benzenesulfonamide derivatives as 12-LOX inhibitors. 3-Bromobiphenyl is also used as a reagent in the preparation of pyrrolidine derivatives as GlyT1 inhibitors.<br>References Maloney, D.J., et al.: PCT Int. Appl. WO 2015054662 A1 20150416. Apr 16, 2015; Amberg, W., et al.: PCT Int. Appl. WO 2014140310 A1 20140918. Sep 18, 2014<br></p>

<p>Applications 4-(Dimethylamino)benzoyl chloride (cas# 4755-50-4) is a useful research chemical.<br></p>

<p>Applications 2-Bromo-1-(3,5-dihydroxyphenyl)ethanone (cas# 62932-92-7) is a useful reagent for the preparation of terbutaline analogs.<br>References Zhang, B., et al.: PCT Int. Appl. (2020), WO 2020107913 A1<br></p>

<p>Applications 4-(4-Chlorophenyl)-4-hydroxycyclohexanone (cas# 36716-71-9) is a compound useful in organic synthesis.<br></p>

<p>Applications (S)-2,3-dihydroxypropyl 4-Chlorobenzoate is a useful synthetic intermediate.<br></p>

<p>Impurity Terazosin EP Impurity A/ Doxazosin EP Impurity F /Alfuzosin EP Impurity B<br>Applications 4-Amino-2-chloro-6,7-dimethoxyquinazoline (Terazosin EP Impurity A) is an intermediate in the production on Terazosin. Alfuzosin EP Impurity B<br>References Shaw, Y., et al.: J. Med. Chem., 47, 4453 (2004), Mendes da Silva, J., et al.: Bioorg. Med. Chem., 16, 7254 (2008),<br></p>

<p>Applications 3-(Aminomethyl)-4-fluorophenol Hydrobromide is derived from 2-Fluoro-5-methoxybenzaldehyde, which is versatile reactant used in the solid-phase synthesis of BODIPY dyes and development of an immunoglobulin fluorescent sensor.<br>References Vendrell, M., et al.: Chem. Commun., 47, 8424 (2011);<br></p>

<p>Applications Diethyl Bromodifluoromethylphosphonate is a highly efficient and environmentally benign difluorocarbene precursor. It can be used as a reagent in the synthesis of benzindolone structural scaffolds for inhibition of lumazine synthase.<br>References Zafrani, Y., et al.: Tetrahedron, 65, 5278 (2009); Talukdar, A., et al.: Bioorg. Med. Chem., 18, 3518 (2010)<br></p>

<p>Applications 1,1-dimethylguanidine hydrochloride (cas# 22583-29-5) is a useful research chemical.<br></p>

<p>Applications 4-Fluorobenzophenone is a Wittig reagent.<br>References Buschauer, A., J. Med. Chem., 32, 1963 (1989); Yamataka, H., et al.: J. Org. Chem., 53, 3877 (1988)<br></p>

<p>Applications 5-[1-Hydroxy-2-(2,4,5-trifluorophenyl)ethylidene]-2,2-dimethyl-1,3-dioxane-4,6-dione is an impurity of the DPP-IV inhibitor Sitagliptin (S491000).<br>References Ye, F. et al.: Hech. Huax., 18, 767 (2010); Ahn, J.H, et al.: Bioorg. Med. Chem. Lett., 17, 2622 (2007);<br></p>

<p>Applications 3-Fluoro-5-(trifluoromethyl)phenylacetic Acid used as a synthetic intermediate in the preparation of kinase inhibitors and agonists.<br></p>

<p>Applications Methyl 4-Chlorobenzoate is a reactant used in the synthesis of ataxia-telangiectasia mutated (ATM) kinase, a target for novel radiosensitizing agents. As well, used as a reactant in the synthesis of aminopyridine functionalized polyacrylonitrile fibers.<br>References Min, J. et al.: J. Med. Chem., 59, 559 (2016);<br></p>

<p>Applications 4-Chloro-7-nitro-2,1,3-benzothiadiazole (cas# 2207-29-6) is a useful research chemical.<br></p>

<p>Applications 2-Bromo-4-chloro-6-nitroanisole<br></p>

<p>Applications tert-Butyl 2,2,2-trichloroacetimidate is used in the conversion of alcohols and carboxylic acids to their respective ethers and esters.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Wessel, H., et al.: J. Chem. Soc., Perkin Trans. 1, 2251 (1985); Armstrong, A., et al.: Tetrahedron Lett., 29, 2483 (1988)<br></p>

<p>Applications 1-(5-Bromo-2-pyridyl)ethanone is a reagent used to synthesize substituted pyridin-3-yl)phenyloxazolidinones as antibacterial agents with reduced activity against monoamine oxidase A.<br>References Reck, F., et al.: J. Med. Chem., 50, 4868 (2007)<br></p>

<p>Applications 3-Fluorophenylmethylboronic acid pinacol ester<br></p>

<p>Applications 9-Anthracenylmethyl Chloride is a derivative of Anthracene (A678400) which is an important source of dyestuffs. It is a reagent for the protection of carboxylic acids, alcohols, phenols and thiols as their 9-anthrylmethyl derivatives, which are stable to mild acid or base, but specifically cleaved by NaSMe.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Kornblum, N., et al.: J. Am. Chem. Soc., 96, 590 (1974)<br></p>

<p>Applications This compound is an impurity in the synthesis of Etoricoxib (E934100), a specific inhibitor of COX-2. It is also used in the synthesis of selective GlyT1 inhibitors.<br>References Pinard, E. et al.: J. Med. Chem., 53, 4603 (2010); McGeer, P.L., et al.: Exp. Gerontol., 37, 925 (2002), Chenevard, R., et al.: Circulation, 107, 405 (2003);<br></p>

<p>Applications tert-Butyl-(3-iodo-1,1-dimethyl-propoxy)-dimethyl-silane (cas# 105262-85-9) is used as a reagent in the preparation of Methyl Acetoacetate.<br>References Heslin, J. C., et al.: J. Chem. Soc. [Perkin 1]. 6, 1417 (1988)<br></p>

<p>Applications 5-Iodo-2-aminoindane<br></p>

<p>Applications Reagent used in the preparation of cyclopropane derivatives.<br>References Antipenko, L., et al.: Chem. Pharm. Bull., 57, 580 (2009), Kumar, A., et al.: Bioorg. Med. Chem., 17, 5285 (2009),<br></p>

<p>Applications 2,3-Dibromopropene is used in preparation of Quaternary Ammonium Salt derivatives for use as Trimethylamine production inhibitors.Also, used in preparation of Boron containing compounds as Phosphodiesterase PDE4 inhibitors.<br>References Nudel, K., et al.:PCT Int. Appl., (2020); Strohbach, Joseph W., et al.: PCT Int. Appl., (2020);<br></p>

<p>Applications Dibromoacetic Acid is a halogenated disinfection byproduct. Dibromoacetic Acid was found to induce apoptotic changes and hydroxyl radical formation in human peripheral blood mononuclear cells (PBMCs). Dibromoacetic Acid also found to exhibit carcinogenic activity in which mice and rats were exposed to drinking water containing different concentrations of Dibromoacetic Acid that resulted in increased incidences of mononuclear cell leukemia, malignant mesothelioma, hepatocellular neoplasms, and hepatoblastoma.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Michalowicz, J., et al.: Toxicol. In Vitro 29, 1416 (2015); Natl Toxicol Program Tech Rep Ser. 537, 1 (2007)<br></p>

<p>Applications 3-Chlorocatechol is a useful reagent for synthesizing novel benzotropolones as Atg4B inhibiting autophagy blockers.<br>References Tanc, M., et al.: Bioorg. Chem., 87, 163 (2019)<br></p>

<p>Applications Benzyltriphenylphosphonium bromide is a useful reactant and reagent for organic reactions and synthesis.<br>References Hajra, S., et al.: Chem. Comm., 47, 3981-82 (2011); Smith, M.J., et al.: Org. Lett., 2011, 13, 3396-98;<br></p>

<p>Applications Ethyl 8-bromooctanoate is a useful research reagent for organic synthesis and other chemical processes.<br>References Shao, M., et al.: Bioorg. Med. Chem. Lett., 27, 4051 (2017); Wang, L., et al.: Chin. J. Chem., 32, 157 (2014)<br></p>

<p>Applications 4-Benzyloxy-1-bromobutane<br></p>

<p>Stability Hygrscopic<br>Applications N-(2,6-Dimethylphenyl)-2,2-dichloroacetamide is an intermediate used to prepare Ranolazine (R122500), an antianginal agent.<br>References Aalla, S., et al.: Org. Proc. Res. Dev.,16, 748 (2012)<br></p>

<p>Applications 2-(2,2-Difluorobenzo[d][1,3]dioxol-5-yl)acetonitrile (cas# 68119-31-3) is a useful research chemical.<br></p>

<p>Applications 5-Acetoxy-3-chloro-2-pentanone (cas# 13051-49-5) is a compound useful in organic synthesis.<br></p>

<p>Applications Methyl 4-(trifluoromethoxy)benzoate<br></p>

<p>Applications (Chloromethyl)cyclopropane is a used as a reagent to synthesize 6-alkylamino-9-alkylpurines, compounds that have potential to be antipsychotic agents. (Chloromethyl)cyclopropane is also used as a reagent to prepare acylmorphinans, a class of compounds that have analgesic effects in rats.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Kelley, J., et al.: J. Med. Chem., 40, 3207 (1997); Mohacsi, E., et al.: J. Med. Chem., 28, 1177 (1985)<br></p>

<p>Applications Ethyl α-Bromo-β-phenylpropionate 90% (cas# 39149-82-1) is a compound useful in organic synthesis.<br></p>

<p>Stability Moisture Sensitive<br>Applications 4-Hydroxybenzenesulfonyl Chloride is useful for the preparation of amino acid derivatives with anticancer activity.<br>References Kim, S., et al.: PCT Int. Appl. (2020), WO 2020204548 A1<br></p>

<p>Applications 3-(Dibenzo[b,e]oxepin-11(6H)-ylidene)-N,N-diethylpropan-1-amine Hydrochloride (E/Z Mixture) is an intermediate in synthesizing N-Diethylnordoxepin Salt (D468115), a compound useful in organic synthesis.<br></p>

<p>Applications 4,5-Dichloro-2-nitroaniline<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Stability Light Sensitive, Volatile<br>Applications cis-1-Bromo-1-propene is generally used as a reactant in organic synthesis.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Aebly, Andrew H., et al.: Tetrahedron Let., 58(40), 3795-3799 (2017); Acharyya, Ranjan Kumar, et al.: J. of Org. Chem., 83(4), 2087-2103 (2018)<br></p>

<p>Applications 2-(Dimethylamino)-ethanesulfonyl Chloride Hydrochloride is derived from 2-(Dimethylamino)ethanethiol Hydrochloride (D461685), which is a starting material for the synthesis of Echothiophate Iodide (E325800). Echothiophate Iodide is an anticholinesterase drug.<br>References Ashani, Y., et al.: Biochem. Pharm., 30, 2593 (1981)<br></p>

<p>Applications 1-Bromopentane is a chemical reagent used in a multitude of organic syntheses. It is used iron-catalyzed alkylations of aromatic Grignard reagents via cross coupling. It is used in the synthesis of α,γ-diketo acids as reversible inhibitors of Hepatitis C virus NS5b RNA polymerase.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Cahiez, G. et al.: Angew. Chem. Int. Ed., 46, 4364 (2007); Summa, V. et al.: J. Med. Chem., 47, 14 (2004);<br></p>

<p>Stability Hygroscopic<br>Applications 3,5-Dimethylbenzoyl chloride<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications 4-chloro-1,2-dimethylbenzene (cas# 615-60-1) is a useful research chemical.<br></p>

<p>Applications Methyl 2-chloro-6-nitrobenzoate<br></p>

<p>Applications 3,5-Diamino-4-chlorobenzonitrile is used in the preparation of glycolic amide derivatives as allergy inhibitors and antiinflammatory agents<br>References Ban, M., et al.: Bioorg. Med. Chem., 6, 1069 (1998); Takasugi, H. et al.: J. Antibio., 36, 846 (1983); Ban, M. et al.: Bioorg. Med. Chem., 6, 1069 (1998);<br></p>

<p>Applications N-(4-Chlorophenyl)-2,6-Difluorobenzamide (cas# 122987-01-3) is a useful research chemical.<br></p>

<p>Applications 2-Chloro-3-hydroxybenzoic acid (cas# 51786-10-8) is a useful research chemical.<br></p>

<p>Applications 1,3-Diiodobenzene is a common chemical reagent used in the synthesis of multinuclear complexes of large porphyrinoids. Also used in the synthesis of small molecular probes as sensors with low viscosity values.<br>References Miguel, D. et al.: Org. Lett., 17, 2844 (2015);<br></p>

<p>Applications Benzyltrimethylammonium dichloroiodate is used in the mechanism of oxidation.<br>References Srinivasan, N., et al.: Tetrahedron, 30, 419 (1974), Sankhla, R., et al.: J. Chem. Res., 0465 (2002),<br></p>

<p>Stability Air Sensitive<br>Applications 4-IODO-2-NITROANILINE (cas# 20691-72-9) is a useful research chemical.<br></p>

<p>Applications Amino(3-​chlorophenyl)​acetic Acid functions as intermediate useful in the preparation of synthetic penicillins, also used in the structure-activity relationship examination of several drugs containing the benzyl moiety, their roles in biochemical and pharmacological processes.<br>References Hansch, C., et al.: J. Med. Chem., 13, 957 (1970); Holdrege, C. T., et al.: Can. (1975), CA 966853 A2 19750429;<br></p>

<p>Applications Ammonium Bromide is used as a bromide activated chloramine biocide for effective control of volatile fatty acids and catalase and biofilm elimination in paper making industry. Also applied in biopharmaceuticals and dosage form designs.<br>References Bharati, S., et al.: Appita J., 56, 426 92003); Torosian, G., et al.: Am. J. Hosp. Pharm., 30, 716 (1973)<br></p>

<p>Applications 1,4-Dichloro-2-butyne used in the synthesis of 1,4-disubstituted 1,2,3-triazoles. Also, it is used in the approach of the 20S-camptothecin family of antitumor agents.<br>References Feldman, A. et al.: Org. Lett., 6, 3897 (2004); Josien, H. et al.: Chem. Eur. J., 4, 67 (1998);<br></p>

<p>Applications 2,5-Difluorophenylacetic acid has been used in the synthesis of 2,2-dimethyl-4-(2,5-difluorophenyl)-5-[4-(aminosulfonyl)phenyl]-3(2H)-furanone.<br>References Chin, O., et al.: J. Pharm., 44, 138 (2013)<br></p>

<p>Applications (3,3-Difluorocyclobutyl)methanamine hydrochloride (cas# 1159813-93-0) is a useful research chemical.<br></p>

<p>Applications 4-Chlorobenzyl bromide<br></p>

<p>Applications 2-(1,3-Dioxolan-2-yl)ethyltriphenylphosphonium Bromide (cas# 86608-70-0) is a useful research chemical.<br></p>

<p>Stability Extremely moisture sensitive<br>Applications Highly reactive cyclic phosphitylating reagent which provides fast coupling rates, and hydrolytic cleavage occurs more readily than with acyclic analogs.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Bannwarth,W. &amp; Kung, E.: Tetrahedron Lett., 30, 4219 (1989)<br></p>

<p>Applications 12-Bromo-1-aminododecane, Hydrobromide (cas# 14502-45-5) is a compound useful in organic synthesis.<br></p>

<p>Applications 2-Chloro-5-chlorosulfonylbenzoic Acid (cas# 137-64-4) is a compound useful in organic synthesis.<br></p>

<p>Applications 3-Fluoropropan-1-ol is used as a reagent to synthesize fluorinated amino acids (e.g. DL-erythro-4-Fluoroglutamine [F591630]). 3-Fluoropropan-1-ol is also used as a reagent to synthesize labelled N-desmethyl-loperamide analogues, compounds that have potential use as imaging radiotracers.<br>References Bao, X. &amp; Duliang, L.: Tetrahedron Lett., 54, 1412 (2013); Drouet, F., et al.: Eur. J. Org. Chem., 2014, 1195 (2014)<br></p>

<p>Applications 3-Aminophthalic Acid Hydrochloride Dihydrate (cas# 1852533-96-0) is a useful research chemical.<br></p>