Halogénures organiques

<p>Applications [2-(4-Fluorophenyl)cyclopropyl]amine hydrochloride is a synthetic intermediate in the preparation of thiazolinone 4-monosubstituted quinolines as CDK1-Cyclin B inhibitors for use as anti-cancer agents.<br>References Tsai, T.Y., et al.: Bioorg. Med. Chem., 17, 2388 (2009); Vallgaarda, J., et al.: J. Med. Chem., 39, 1485 (1996);<br></p>

<p>Applications Hexachloroethane is a highly efficient chlorinating agent in the preparation of chlorosilanes from hydrosilanes.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Pongkittiphan, V., et al.: Tetrahedron Lett., 50, 5080 (2009)<br></p>

<p>Applications N-(4-Bromopheneethyl-phthalimide is a building block used in the preparation of N-phenylethylindole carboxamides for structure activity relationship study of allosteric modulators of CB1 receptor.<br>References Piscitelli, F., et al.: J. Med. Chem., 55, 5627 (2012);<br></p>

<p>Applications 7-bromohept-1-yne (cas# 81216-14-0) is a useful research chemical.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications 2-Bromo-1-(3,5-dihydroxyphenyl)ethanone (cas# 62932-92-7) is a useful reagent for the preparation of terbutaline analogs.<br>References Zhang, B., et al.: PCT Int. Appl. (2020), WO 2020107913 A1<br></p>

<p>Applications 1-Iodohexane (cas# 638-45-9) is a compound useful in organic synthesis.<br></p>

<p>Applications 2-Chloro-N-(methylsulfonyl)acetamide acts as a reagent for the preparation of piperazinylquinolonecarboxamides as antivirals. Solid phase preparation of peptidines, glycine-amidine-based oligomers.<br>References Vastl, J., et al.: Chem. Sci., 7, 3317 (2016); Schohe-Loop, R., et al.: PCT Int. Appl. (2006), WO 2006008046 A1 20060126<br></p>

<p>Applications o-Bromophenoxyacetic acid<br></p>

<p>Applications 9-Fluorenylmethyl tosylate is a useful reagent in the synthesis of Se-​(9-​Fluorenylmethyl) selenoesters and amino thioacids.<br>References Crich, D., et al.: Org. Lett., 9, 4423-26 (2007); Fecourt, F., et al.: Org. Lett., 15, 3758-61 (2013);<br></p>

<p>Applications (1S,2S,3R,5S)-3-Amino-5-(2-hydroxyethoxy)cyclopentane-1,2-diol Hydrochloride is used in the synthesis of Ticagrelor (T437700), the first reversible oral P2Y12 receptor antagonist, provides faster, greater, and more consistent ADP-receptor inhibition than Clopidogrel. Used in the treatment of acute coronary syndromes (ACS).<br>References Matetzky, S., et al.: Circulation, 109, 3171 (2004); Bassand, J., et al.: Eur. Heart J., 28, 1598 (2007); Jakubowski, J., et al.: Cardiovasc. Drug Rev., 25, 357 (2007)<br></p>

<p>Applications Triethylamine Hydrochloride is a hydrochloride salt of triethyllamine (T775740). Triethylamine is used as a competing base for the separation of acidic basic and neutral drugs by reverse-phased high-performance liquid chromatography (HPLC). Triethylamine induces visual disturbances (such as foggy vision) in humans, and is also used in industry as a quenching agent in the ozonolysis of alkenes (e.g. (E)-2-Pentene [P227315]). Triethylamine is used in the purification of drugs which are pharmacologically or chemically similar through separation in reverse-phase HPLC (2).Drinking water contaminant candidate list 3 (CCL 3) compound as per United States Environmental Protection Agency (EPA). Environmental contaminants; Food contaminants.<br>References 1. Akesson B. et al.: Int Arch Occup Environ Health. 1986;57(4):297-302. 2. Roos RW. et al.: J Chromatogr. 1986 Dec 24;370(3):403-18.<br></p>

<p>Applications 3-(trifluoromethyl)oxetan-3-ol (cas# 1403676-72-1) is a useful research chemical.<br></p>

<p>Applications 2,2-Diiodopropane is used in studying the Raman effect (isomerism rotation) and is used as a reagent in some synthetic preparations.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Kahovec, L., et al: Z. Physik. Chem., B47, 48 (1940); Charette, A., et al: Synlett, 1, 176 (2002)<br></p>

<p>Applications 2,4,6-Tribromotoluene acts as a reagent in the synthesis of non-proteinogenic α-amino acids.<br>References Lecointe, L., et al.: J. Pept. Res., 55, 300 (2000)<br></p>

<p>Applications 2,6-Dichlorobenzyl Alcohol is a useful reagent in organic synthesis.<br>References Ren, Shishuai, et al.: Dalton Transactions, 47(12), 4352-4359 (2018);He, Wei, et al.: Org. &amp; Biomol. Chem., 16(10), 1659-1666 (2018);Stoit, Axel R., et al.: Bioorg. &amp; Med. Chem. Let., 28(3), 459-465 (2018)<br></p>

<p>Applications 3-​[2-​(Trifluoromethyl)​phenyl]​propionic Acid is a reactant used in the synthesis of small molecule inhibitors of anthrax toxin.<br>References Williams, J. et al.: Bioorg. Med. Chem., 22, 419 (2014);<br></p>

<p>Applications 2-amino-1-(4-fluorophenyl)propan-1-ol (cas# 109515-15-3) is a useful research chemical. Also, it is an intermediate used in the synthesis of p-Fluoro-4-methylaminorex (F791850), which is a derivative of Aminorex (A629200), an anorectic stimulant drug of the 2-amino-5-aryl oxazoline class. Aminorex has been shown to have locomotor stimulant effects similar to Methamphetamine (M258795).<br>References Poos, G., et al.: J. Med. Chem., 6, 266 (1963), Watson, A., et al.: Res. Vet. Sci., 45, 411 (1988), Russell, B., et al.: Pharmacol. Biochem. Behav., 51, 375 (1995),<br></p>

<p>Applications 2-Fluorophenyl cyclopentyl ketone (cas# 111982-45-7) is a useful research chemical.<br></p>

<p>Applications 2-Fluoropropiophenone (cas# 446-22-0) is a compound useful in organic synthesis.<br></p>

<p>Applications (2-Bromoethyl)benzene is used in the synthesis of sulforaphane derivatives used as potential antitumor agents. As well, used in the synthesis of 1,2-benzisothiazol-3-one derivatives as potent caspase-3-inhibitors.<br>References Hu, K. et al.: Eur. J. Med. Chem., 64, 529 (2013); Liu, D. et al.: Bioorg. Med. Chem., 21, 2960 (2013);<br></p>

<p>Applications 3-(2-Chloroethynyl)-2,2-dimethylcyclopropanecarboxylic Acid is a useful intermediate for the preparation of pesticidal and insecticidal formulations.<br>References Farooq, S., et al.: From Ger. Offen. (1980), DE 2925570 A1 19800117; Nishida, N., et al.: From Jpn. Kokai Tokkyo Koho (2002), JP 2002069039 A 20020308<br></p>

<p>Applications 2,2-Difluoro-1,3-benzodioxole is used in the synthesis of Kv3 inhibitors as well as in the preparation of renin inhibitors.<br></p>

<p>Applications 4-Fluorobenzophenone is a Wittig reagent.<br>References Buschauer, A., J. Med. Chem., 32, 1963 (1989); Yamataka, H., et al.: J. Org. Chem., 53, 3877 (1988)<br></p>

<p>Applications 2-Bromo-4-aminobenzoic Acid (cas# 2486-52-4) is a compound useful in organic synthesis.<br></p>

<p>Applications (2-Chloroethoxy)methyl Chloride (cas# 1462-33-5) is a compound useful in organic synthesis.<br></p>

<p>Applications This compound is an impurity in the synthesis of Etoricoxib (E934100), a specific inhibitor of COX-2. It is also used in the synthesis of selective GlyT1 inhibitors.<br>References Pinard, E. et al.: J. Med. Chem., 53, 4603 (2010); McGeer, P.L., et al.: Exp. Gerontol., 37, 925 (2002), Chenevard, R., et al.: Circulation, 107, 405 (2003);<br></p>

<p>Applications tert-Butyl-(3-iodo-1,1-dimethyl-propoxy)-dimethyl-silane (cas# 105262-85-9) is used as a reagent in the preparation of Methyl Acetoacetate.<br>References Heslin, J. C., et al.: J. Chem. Soc. [Perkin 1]. 6, 1417 (1988)<br></p>

<p>Applications 2,4-Dichloroquinazoline has been used as a reactant for the preparation of 1-methyl-1H-imidazole derivatives as Jak2 inhibitors.<br>References Su, Q., et. al.: J. Med. Chem., 57, 144 (2014)<br></p>

<p>Applications 4-fluorobutanoic acid (cas# 462-23-7) is a useful research chemical.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications 5-Bromopentylboronic Acid<br></p>

<p>Applications Bromomethyl Methyl Ether acts as a reagent in the synthesis and evaluation of hydroxymethyl-aminocyclitols as glycosidase inhibitors, preparation of pyridine derivatives for minimizing CYP2C9 inhibition for cancer therapy. Also a reagent in the discovery of GBT 440, an orally bioavailable R state stabilizer of sickle cell Hb.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Trapero, A., et al.: J. Org. Chem., 80, 3512 (2015); Zak, M., et al.: J. Med. Chem., 59, 8345 (2016); Metcalf, B.; et al.: ACS Med. Chem. Lett., 8, 321 (2017)<br></p>

<p>Applications tert-butyl 2-(4-(bromomethyl)phenyl)acetate (cas# 77292-91-2) is a useful research chemical.<br></p>

<p>Applications N1-(3,4-Dichlorophenyl)-1,3-propanediamine is a compound being used in the synthesis of novel amide-based biaryl complexes which can act as allosteric binding site antagonists of NR1A/NR2B NMDA receptors.<br>References Mosley, C.A., et al.: Bioorg. Med. Chem. Lett., 17, 6463-6480 (2009)<br></p>

<p>Applications 3-(Difluoromethoxy)nitrobenzene (cas# 22236-07-3) is a useful research chemical.<br></p>

<p>Applications 2,4-dibromo-1-iodobenzene (cas# 19393-94-3) is a useful research chemical.<br></p>

<p>Impurity Isoconazole Nitrate EP Impurity B<br>Applications 2,4-Dichloro-β-[(2,6-dichlorophenyl)methoxy]benzeneethanamine (Isoconazole Nitrate EP Impurity B) is used in the synthesis of novel triazole compounds showing antitubercular activity.<br>References Kim, S. et al.: Bioorg. Med. Chem. Lett., 22, 6844 (2012);<br></p>

<p>Applications 2-Chloro-3-hydroxybenzoic acid (cas# 51786-10-8) is a useful research chemical.<br></p>

<p>Applications Intermeidate in the preparation of many GABA modulators<br>References Stafford, J., et al.: Bioorg. Med. Chem. Lett., 12, 3215 (2002), Fadeyi, O., et al.: Bioorg. Med. Chem. Lett., 18, 4172 (2008),<br></p>

<p>Stability Hygroscopic<br>Applications 4-Aminophenylboronic Acid Hydrochloride is a reagent used for the synthesis of colorimetric and fluorescent nanosensor based on B, N, S-codoped carbon dots (BNS-CDs).<br>References Liu, Y., et al.: ACS Appl. Mater. Interfaces, 9, 12663-12672 (2017)<br></p>

<p>Applications Methyl Chlorooxoacetate is used as a reagent in organic synthesis of several compounds including that of coumarin-based probes which fluoresce in response to detection of Pi in cell culture and Caenorhabditis elegans. Also used in the synthesis of phenanthrene β-diketo acids which is being studied as potential HIV-1 integrase inhibitors.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Wang, H., et al.: Dyes Pigments, 120, 293 (2015); Sharma, H., et al.: Bioorg. Med. Chem. Lett., 23, 6146 (2013);<br></p>

<p>Applications 2-Chloro-5-chlorosulfonylbenzoic Acid (cas# 137-64-4) is a compound useful in organic synthesis.<br></p>

<p>Applications Methyl 2-Bromopropionate is used in the synthesis of poly(ADP-Ribose)polymerase inhibitors derived from benzoxazin-3-one. Also used in the synthesis of 5-HT2C antagonists affecting serotonin levels.<br>References Gangloff, A et al.: Bioorg. Med. Chem. Lett., 23, 4501 (2013); Zhao, G. et al.: Bioorg. Med. Chem. Lett., 23, 3914 (2013);<br></p>

<p>Applications N-(4-bromo-2-thienyl)-carbamic Acid 1,1-Dimethylethyl Ester, is an intermediate for the synthesis of bicyclic inhibitors of ROCK protein kinsae.<br>References Hahmann, C. et al.: Cell. Mol. Life Sci., 67, 171 (2010);<br></p>

<p>Applications 2-fluoropropanedioic acid (cas# 473-87-0) is a useful research chemical.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications Methyl 6-Chloronicotinate is used in the determination of Acetamiprid (A150800) and its metabolites in crop and soil.<br>References Tokieda, M., et al.: Nippon Noyaku Gakkaishi, 24, 115 (1999)<br></p>

<p>Applications Cyclopent-3-enamine hydrochloride (cas# 91469-55-5) is a useful research chemical.<br></p>

<p>Applications 2-(2-Chlorophenyl)-cyclohexanone is a reactant that is used in the preparation of benzofurans via palladium-phosphine-catalyzed intramolecular enolate O-arylation of α-arylketones.<br>References Willis, M.C., et al.: Tetrahedron, 62, 11513 (2006)<br></p>

<p>Applications 4-(Trifluoromethoxy)benzoic Acid is a substituted benzoic acid used in the preparation of a various biologically active compounds such as antifungal and antimalarial agents.<br>References Jiang, Y. et al.: Bioorg. Med. Chem. Lett., 21, 4471 (2011); Herrin, T.R. et al.: J. Med. Chem., 18, 1216 (1975);<br></p>

<p>Applications 4-Bromo-A23187 is an ionophore that transports Zn2+ and Mn2+ with high selectivity over Ca2+.<br>References Park, J. Genevieve, et al.: Methods in Mol. Bio., 1071, 29-47 (2014);Erdahl, Warren L., et al.: Biochem., 35(43), 13817-13825 (1996)<br></p>

<p>Applications 4-Bromo-2,5-dichloro-benzonitrile is a useful synthetic intermediate.<br></p>

<p>Applications 4-Fluorophenethylamine hydrochloride (cas# 459-19-8) is a useful research chemical.<br></p>

<p>Stability Moisture Sensitive<br>Applications 2,4-Difluoro-3-formylphenylboronic acid<br></p>

<p>Stability Hygroscopic<br>Applications 3-Bromo-1-(trimethylsilyl)-1-propyne is a reactant used in the preparation of a novel lipid mediator with anti-inflammatory activity. Also used in the preparation of (+)-Rubriflordilactone A, a natural nortriterpenoid.<br>References Goto, T. et al.: Tetrahedron., 71, 8320 (2015); Goh, S. et al.: Angew. Chem. Int. Ed., 54, 12618 (2015);<br></p>

<p>Applications Bromotrimethylsilane is used as a reagent in the synthesis of α-carboxy nucleoside phosphonate analogs as HIV reverse transcriptase-targeting agents.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Keane, S.J., et al.: J. Org. Chem., ahead of print (2014)<br></p>

<p>Applications 1-Decylamine Hydrobromide is an intermediate forming the phosphatidylcholine-decylamine liposomal membranes.<br>References Kotynska, J., et al.: J. Bioenerget. Biomembrane., 40, 637 (2008);<br></p>

<p>Applications 3-chloro-5-fluoro-2-hydroxybenzoic acid (cas# 4068-62-6) is a useful research chemical.<br></p>

<p>Applications N-(2-Chloroprop-2-en-1-yl)-2,3-dihydro-1H-inden-1-amine is related to the drug Rasagiline(R126030). Rasagiline is used to increase the availability of dopamine at striatal receptors as a method to treat Parkinson’s disease.<br>References Youdim, M.B.H., et al.: Br. J. Pharmacol., 132, 500 (2001); Finberg, J.P., Rambam Maimonides Med. J., 1 (2010)<br></p>

<p>Applications 6-Bromo-2-picoline is a halogenated pyridine derivative used is a building block in the preparation of nitrogen containing heterocyclic compounds.<br>References Long, G.V. et al.: J. Chem. Soc. Dalt. Trans. Inorg. Chem., 21, 3175 (1993); Uenishi, J. et al.: J. Org. Chem., 58, 4382 (1993);<br></p>

<p>Applications Methyl 2-Bromo-1-cyclopentenecarboxylate is a versatile reactant that can be derived from Cyclopentanone (C988395), which is a compound used in the synthesis of various simple and complex organic compounds. Cyclopentanone is also used in the synthesis of peptidase IV inhibitors for the treatment of type 2 diabetes.<br>References Imamoto, T. et al.: J. Am. Chem. Soc., 112, 5244 (1990); Augeri, D. et al.: J. Med. Chem., 48, 5025 (2005);<br></p>

<p>Applications 4-Chloro-7-nitro-2,1,3-benzothiadiazole (cas# 2207-29-6) is a useful research chemical.<br></p>

<p>Applications 3-((2-Nitro-4-(trifluoromethyl)-phenyl)amino)propane-1,2-diol, (cas# 104333-00-8) is a useful research chemical.<br></p>

<p>Applications 3-Bromo-4,5-difluorobenzoic Acid is a useful synthetic intermediate.<br></p>

<p>Applications 1,1,1-Trichloromethanesulfonic Acid 1,1'-Anhydride is a derivative of 1,1,1-Trichloromethanesulfonic Acid a very strong acid used in protonation reactions, and as a catalyst in esterifications.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Howells, R. et al.: Chem. Rev., 77, 69 (2006);<br></p>

<p>Applications Methyl 5-cyano-2-fluorobenzoate<br></p>

<p>Applications 7-Chloro-4-oxo-4H-chromene-2-carboxylic acid (cas# 114741-22-9) is a useful research chemical.<br></p>

<p>Applications ethyl 4-aminopentanoate hydrochloride (cas# 119396-97-3) is a useful research chemical.<br></p>

<p>Applications 1,3,5-Tribromobenzene, is a reagent that can be used in the preparation of different inhibitors. It is also a substituted Bromobenzene, a general reagent in palladium-catalyzed reactions and in the synthesis of Grignard reagents.<br>References Miyaura, N. et al.: Synth. Commun., 11, 513 (1981); Nahm, S. et al.: Tetra. Lett., 22, 3815 (1981);<br></p>

<p>Applications 1,3-Dichloroacetone (cas# 534-07-6) is a compound useful in organic synthesis.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications 2-Fluorobenzenenitrile (cas# 394-47-8) is a compound useful in organic synthesis.<br></p>