Halogénures organiques

Applications 6-Bromo-2-napthoic Acid is used in the preparation of Adapalene, a synthetic aromatic retinoid with specificity for RARβ and RARγ receptors.
References Milanese, A. et al.: Bioorg, Chem., 39, 151 (2011);

Stability Moisture Sensitive
Applications Tris(1-chloro-2-propyl) Phosphate is a flame retardant of low hydrolytic stability, used in polyurethane (PU) rigid and flexible foam, PVC, EVA, phenolics and epoxy resin.
References Grump, D., et al.: Toxicol. Sci., 126, 140 (2012); Paciorek, S.J., et al.: J. Porous. Mater., 19, 161 (2012);

Applications 1-Bromo-1,1-dichloro-2-propanone is a disinfection byproduct in drinking water.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Krasner, S., et al.: Environ. Sci. Technol., 40, 7175 (2006); Richardson, S., et al.: Water Air Soil Poll., 123, 95 (2000)

Applications 2,6-Dichlorophenol is a reagent used in the synthesis of α-chloroesters and chlorophenols as well as chlorinated pharmaceutical compounds such as the anti-HIV agent chloropeptin I.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Deng, H. et al.: J. Am. Chem. Soc., 125, 9032 (2003); Hoke, J. et al.: App. Cat. B. Env., 1, 285 (1992); Reynolds, N. et al.: J. Am. Chem. Soc., 127, 16406 (2005);

Stability Moisture Sensitive
Applications 4-(Iodoacetylamino)phenol is used as an analytical reagent in absolute quantitation of NAPQI-modified rat serum albumin by LC-MS/MS in vivo.
References LeBlanc, A., et al.: Chem. Res. Toxicol., 27, 1632 (2014);

Applications 1-Bromo-2-(bromomethyl)-4,5-dimethoxybenzene is used in the synthesis of novel histone deacetylase 1 inhibitors (HDAC 1). Also used in the synthesis of antibacterial gemifloxacin derivatives.
References Sun, Q. et al.L: Bioorg. Med. Chem. Lett., 23, 3295 (2013); Feng, L. et al. Eur. J. Med. Chem., 55, 125 (2012);

Applications 1,2,4-Triaminobenzene Dihydrochloride is a useful reagent for making multicolor fluorescent carbon dots that can be detected via white-​light-​emitting diodes and water.
References Kumari, R., et al.: Langmuir, 36, 5287 (2020)

Stability Moisture Sensitive
Applications 2-Chloro-5-(1-chloro-1,3-dihydro-3-oxo-1-isobenzofuranyl)-benzenesulfonyl Chloride is a useful synthetic intermediate.

Applications Intermediate in the synthesis of Linezolid (L466500).

Applications Used as a reactant in the preparation of pyrimidinone ribosides and analogs that show anti-tumor properties.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Driscoll, J.S. et al.: J. Med. Chem., 34, 3280 (1991); Pan, L. et al.: J. Pharm. Biomed. Anal., 52, 589 (2010);

Applications 3,3,4,4,5,5,6,6,7,7,8,8,8-Tridecafluorooctane-1-sulphonic Acid is an aliphatic compound for fluorinated surfactant synthesis.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Weiss-Errico, M. et al.: J Hazard Mat. 329, 57, 2017 (2017); Munoz, G. et al.: Env. Sci. Tech., 51, 1231 (2017);

Applications Nitrosyl Tetrafluoroborate is a reagent in the formation of miRNA-34a-conjugated magnetic nanovectors which shows therapeutic effects by inhibiting cellular migration and invasion through CD44 gene suppression.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Lee, H., et al.: J. Nanosci. Nanotechnol., 16, 12939-12946 (2016);

Applications (S)-4,4-Difluoro-N-(3-oxo-1-phenylpropyl)cyclohexanecarboxamide acts as a reagent in the synthesis of CCR5 antagonists which are used in HIV therapy and may also be relevant for the treatment of graft-vs.-host disease and Staphylococcus aureus infection.
References Asano, S., et al.: ACS Med. Chem. , 5, 133 (2014)

Applications Iodine Monobromide is an electrophile used in preparation of polyketide structural units via eletrophile-induced methoxy transfer.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Liu, K., et al.: Org. Lett., 8, 5393 (2006).

Applications Phenyl chloroformate is a corrosive liquid that is used to synthesize Urazole, a five membered heterocyclic compound that reacts with aldoses to form α and β pyranosides and furanosides. Phenyl chloroformate is also used as a reagent to prepare Sorafenib (S676850), a multikinase inhibitor that targets the tumour and tumour vasculature in patients with melanoma.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Boettecher, B. & Meister, A.: Anal. Biochem., 138, 449 (1984); Chai, W., et al.: Tetrahedron Lett., 53, 3514 (20112); Eisen, T., et al.: Brit. J. Cancer, 95, 581 (2006); Kolb, V., et al.: J. Mol. Evol., 38, 549 (1994); Llovet, J., et al.: Engl. J. Med., 359, 378 (2008)

Stability Hygroscopic
Applications N-​Ethyl-​α-​methyl-​3-​(trifluoromethyl)​-benzeneethanamine hydrochloride has been used in case studies for the study of impulsivity, motor skills, and anxiogenic effects in the neuroscience community.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Whitney, K.N., et al.: Exp. Clin. Psychopharm., 21, 345-54 (2013); Arrant, A.E., et al.: Neuropharmacology, 65, 213-22 (2013)

Applications 2,6-Dibromo-4-fluorophenol

Applications o-tert-Butyl-α-chlorotoluene is a useful research reagent for the competitive chloromethylation of alkylbenzenes.
References Takezawa, T., et al.: Nippon Kagaku Kaishi 6, 1047 (1989); Hu, Y. L., et al.: J. Chil. Chem. Soc., 55, 97 92 (2010); Pinnell, R. P., et al.: Tetrahedron Lett., 25, 3511 (1984)

Applications 4-Bromo-2,2-diphenylbutyric Acid (cas# 37742-98-6) is a compound useful in organic synthesis.

Stability Moisture Sensitive
Applications 4,4'-Dimethoxytrityl Chloride (cas# 40615-36-9) is a compound useful in organic synthesis.

Applications Difluoroacetic acid
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package

Stability Volatile
Applications 1,2-Dichlorotrifluoroethyl trifluoromethyl ether (cas# 2356-53-8) is a useful research chemical.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package

Applications 3,5-Dichloro-4-(1,1,2,2-tetrafluoroethoxy)aniline (cas# 104147-32-2) is a useful research chemical.

Impurity Amiodarone EP Impurity H / Amiodarone USP Related Compound H
Stability Moisture Sensitive, Hygroscopic
Applications 2-Chloro-N,N-diethylethylamine Hydrochloride (Amiodarone EP Impurity H) is a related compound of Amiodarone, a non-selective ion channel blocker.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Bonati, M., et al.: J. Pharm. Sci., 73, 829 (1984), Plomp, T.A., Anal. Profiles Drug Subs., 20, 1 (1991), Chow, M., et al.: Ann. Pharmacother., 30, 637 (1996), Singh, B.N., et al.: Clin. Cardiol., 20, 608 (1997)

Applications 1,1,1,2,2,3,3,4,4,5,5,6,6,7,7,8,8-Heptadecafluoro-10-iododecane

Applications Tetrabromophthalic Anhydride is a brominated flame retardant used as additives in plastics to decrease the rate of combustion of these materials, leading to greater consumer safety.
References El-Fouly, M., et al.: Environ. Toxicol. Chem., 13, 1581 (1994), Fowles, J., et al.: Toxicology , 86, 49 (1994),

Applications 2-Chloro-N-phenylacetamide is used as a reagent in the synthesis of indolylmethylene benzo[h]thiazolo[2,3-b]quinazolinones which exhibit anticancer and antimicrobial activities in vitro.
References Gali, R., et al.: Bioorg. Med. Chem. Lett., 24, 4239 (2014)

Applications 1-(4-Amino-3,5-dichlorophenyl)-2-ethanone (cas# 37148-48-4) is a compound useful in organic synthesis.

Applications 1,5-Dibromopentane is used as an alkylating agent in organic synthesis. 1,5-Dibromopentane is also used as a reagent to synthesize benzo[b]xanthone derivatives, compounds that have potential anticancer activity.
References Luo, L., et al.: J. Serb. Chem. Soc., 78, 1301 (2013); Royer, G. & Klotz, I.: J. Am. Chem. Soc., 91, 5885 (1969)

Stability Temperature sensitive - closes readily. Store at -80°C
Applications Used for isolating bases by means of Reinecke's salt.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Dudley, H., et al.: Biochem. J., 27, 157 (1933),

Applications 2-Bromopentane is a compound useful in organic synthesis, that has been used in the meta-selective C-H bond alkylation with Ruthenium catalysts.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Hofmann, N., Ackermann, L.: J. Am. Chem. Soc., 135, 5877 (2013)

Applications 2-Chloro-2,3-Dimethyl Butane (cas# 594-57-0) is a useful research chemical.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package

Applications Isotope labelled Trifluoroacetic Acid used as a solvent in a variety of organic synthesis and chemical processes. Used in the synthesis of anticancer agents as well as phospholipase D inhibitors.
E0
References Scott, S. et al.: Nat. Chem. Biol., 5, 108 (2009); Minko, T. et al.: Cancer. Chemother. Pharmacol., 50, 143 (2002);

Applications DL-2,4-Diaminobutyric Acid Dihydrochloride (cas# 65427-54-5) is a useful research chemical.

Applications 2,3,4,6-Tetrachlorotoluene is a tetra-chlorinated derivative of toluene that is often used as a reference standard.

Applications 2,4,6-Tribromophenyl Acetate (cas# 607-95-4) is a compound useful in organic synthesis.

Stability Unstable in Solution
Applications 2-(Trimethylsilyl)ethoxymethyl chloride is mostly used in organic synthesis to protect hydroxyl functionalities.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Lipshutz, B. & Miller, T.: Tetrahedron Lett., 30, 7149 (1989); Wada, T., et al.: Tetrahedron Lett., 36, 1683 (1995)

Applications Methyl 6-aminohexanoate is used as a reagent to synthesize straight chain hydroxamates, compounds that act as inhibitors of Human Histone Deacetylase (HDAC) that have the potential to treat cancer. Methyl 6-aminohexanoate is also sometimes used as a spacer unit for peptide synthesis.
References Matthews, S., et al.: J. Chem. Soc. Chem. Commun., 17, 1809 (1995); Remiszewski, S., et al.: J. Med. Chem., 45, 753 (2002)

Applications 4'-(Trifluoromethyl)-3-biphenylcarboxylic Acid functions as a reagent in the scalable development of GPR40 receptor agonist AMG 837. A potential antidiabetic agent.
References Houze, J. B., et al.; Bioorg. Med. Chem. Lett., 22, 1267 (2012); Walker, S. D., et al.: Org. Process Res. Dev., 15, 570 (2011)

Applications 2,6-Difluorobenzamide (CAS# 18063-03-1) is a useful building block used in the synthesis of (E)-3-methyleneisoindolin-1-ones via oxidative annulation acrylates.
References Laha, J. K.; et al.: J. Org. Chem., 82, 7346 (2017).

Applications 2-(Bromomethyl)benzonitrile is an intermediate in the synthesis of Alogliptin (A575425), an oral antihyperglycemic agent that is a selective inhibitor of the enzyme dipeptidyl peptidase-4 (DPP-4). Antidiabetic agent.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Lai, Z., et. al.: Eur. J. Med. Chem., 83, 547 (2014); Lynn, F., et al.: Diabetes, 50, 1004 (2001); Trumper, A., et al.: J. Endocrinol., 174, 233 (2002); Vollmer, K., et al.: J. Clin. Endocrinol. Metab., 94, 1379 (2009)

Stability Light Sensitive
Applications 2-​(Perfluorodecyl)​ethyl Acrylate is used as a reagent in the preparation of repellent finishes on cotton.
References El-Shafei, A. et al.: J. Coat. Tech. Res., 12, 681 (2015);

Applications N-[(4-chlorophenyl)methyl]cyclopentanamine is a useful reagent for the preparation of γ-​lactams.
References Fujii, T., et al.: Tetrahedron Letters, 61, 152276 (2020)

Applications 2,2,2-Trichloroacetamide was an aliphatic halogenated DBP precursor identified in drinking water treatment; a pollutant.
References Zhang, Y., et al.: J. Environ. Sci. (Beijing, China), 58, 322 (2017)

Applications 2,4,5-Trichloroaniline is a chlorinated aniline used in the preparation of azo dyes, insecticides, herbicides as well as in antiviral agents.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Kreutzberger, A. et al.: Arch. Pharm., 320, 37 (1987); Lee, K.S. et al.: Han. Nong. Hakh., 22, 109 (1979); Peters, A.T. et al.: Dyes Pigm., 30, 291 (1996);

Applications Bromocyclobutane
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package