Composés Organiques Chiraux

Stability Hygroscopic
Applications Docetaxel (D494420) injection impurity A.
References Vasu Dev, R., et al.: J. Pharm. Biomed. Anal., 40, 614 (2006),

Impurity Timolol EP A; Timolol BP Impurity A; Timolol USP Related Compound A
Applications Antihypertensive; antiarrhythmic (class II); antianginal; antiglaucoma agent.Timolol EP A; Timolol BP Impurity A; Timolol USP Related Compound A
References Wasson, et al.: J. Med. Chem., 15, 651 (1972), Franciosa, et al.: Clin. Pharmacol. Ther., 13, 138 (1972), Heel, R.C., et al.: Drugs, 17, 38 (1979), Rofman, B.A., et al.: Hypertension, 2, 643 (1980), Mazzo, D.J., et al.: Anal. Profiles Drug Subs., 16, 641 (1987),

Applications Mitomycin (M371900) impurity.
References Siegel, D., et al.: Biochemistry, 31, 7879 (1992), Kontou, M., et al.: Oncogene, 21, 2406 (2002),

Impurity Docetaxel EP Impurity D
Applications 7-Epi-10-oxo Docetaxel (Docetaxel EP Impurity D) is a Docetaxel (D494420) injection impurity D.
References Hanna, I., et al.: Cancer Res., 60, 3440 (2000), Bournique, B., et al.: Br. J. Clin. Pharmacol., 52, 53 (2001), McFadyen, M., et al.: Biochem. Pharmacol., 62, 207 (2001), Vasu Dev, R., et al.: J. Pharm. Biomed. Anal., 40, 614 (2006),

Impurity Tadalafil EP Impurity B
Applications Tadalafil (T004500) analog. Tadalafil Impurity (6S,12aS)
References Daugan, A., et al.: J. Med. Chem., 46, 4533 (2003), Jiang, W., et al.: Bioorg. Med. Chem., 12, 1505 (2004),

Impurity Tadalafil EP Impurity C
Applications The (6S)-cis-enantiomer of Tadalafil (T004500). Tadalafil Impurity (6S,12aR)
References Aldridge, J., et al.: Br. Med. J., 318, 669 (1999), Daugan, A., et al.: J. Med. Chem., 46, 4533 (2003), Vredenbregt, M., et al.: J. Pharm. Biomed. Anal., 40, 840 (2006),

Impurity Tadalafil EP Impurity A
Applications The (6R)-cis-enantiomer of Tadalafil (T004500). Tadalafil Impurity (6R,12aS)
References Aldridge, J., et al.: Br. Med. J., 318, 669 (1999), Daugan, A., et al.: J. Med. Chem., 46, 4533 (2003), Vredenbregt, M., et al.: J. Pharm. Biomed. Anal., 40, 840 (2006),

Stability Hygroscopic
Applications Deoxypyridinoline Chloride Trihydrochloride Salt a collagen cross-links agent. A primary reference material for the monitoring of bone metabolism.
References Heaney, R., et al.: J. Bone Miner. Res., 5, 1135 (1990), Hannon, R., et al.: J. Bone Miner. Res., 13, 1124 (1998), Coudray, C., et al.: Eur. J. Nutr., 42, 91 (2003), Abrams, S., et al.: Am. J. Clin. Nutr., 82, 471 (2005),

Applications A new calcium sensing receptor ligand demonstrating potent calcilytic activity.
References Ray, N., et al.: J. Bone Miner. Res., 12, 24 (1997), Sato, M., et al.: J. Med. Chem., 42, 1 (1999),Rodan, G., et al.: Science, 289, 1508 (2000), Goltzman, D., et al.: Nat. Rev. Drug Discov., 1, 784 (2002), Petrel, C., et al.: J. Biol. Chem., 279, 18990 (2004),

Applications A potent novel activators of large-conductance Ca2+-activated K+ channel.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Imaizumei, Y. et al.: Mol. Pharmacol., 62, 836 (2002); Chang, S. et al.: AM. J. Physiol., 298, F1416 (2010);

Applications GDC 0152 is a peptidomimetic small molecule antagonist of inhibitor of apoptosis (IAP) proteins with antitumor activity.
References Yue, Q., et. al.: Drug Metab. Dispos., 41, 508 (2013)

Stability Very Hygroscopic
Applications 2-O-α-D-Glucosylglycerol is used to prepare glycoglycerolipid analogs active as antitumor-promoters the influence of the anomeric configuration.
References Colombo, D., et al.: Eur. J. Med. Chem., 35, 1109 (2000);

Stability Hygroscopic
Applications (±)-17-Methyl-morphinan-3-ol Hydrobromide is a racemic mixture of Dextrorphan Tartrate Salt (D299485) and Levorphanol Tartrate (L376500). Dextrorphan Tartrate Salt and Levorphanol Tartrate are orally active synthetic morphine analogs and analgesics (narcotic). Levorphanol Tartrate is a controlled substance.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Tallarida, R., et al.: Life Sci., 45, 947 (1989); Netzer, R., et al.: Eur. J. Pharmacol., 238, 209 (1993); Mao, J., et al.: Pain, 67, 361 (1996); Chow, L., et al.: J. Biomed. Sci., 11, 717 (2004); Randall, L.O., et al.: J. Pharmacol. Exp. Ther., 99, 163 (1950); Dajani, E., et al.: Eur. J. Pharmacol., 34, 105 (1975); Winpenny, J., et al.: Drugs, 8, 416 (2005),

Applications Repaglinide impurity.
References Grell, W., et al.: J. Med. Chem., 41, 5219 (1998),

Stability Hygroscopic
Applications 4-Desacetamido-4-chloro Andarine is a Selective Androgen Receptor Modulator (SARM) that has potential use for treatment of androgen related diseases such as muscle wasting and osteoporosis. 4-Desacetamido-4-chloro Andarine also a derivative of Andarine (A637470), a non-steroidal SARM that is used by athletes to enhance performance.
References Jones, A., et al.: Endocrinology, 150, 385 (2009); Marhefka, C., et al.: J. Med. Chem., 47, 993 (2004); Thomas, A., et al.: Rapid Comm. Mass Spec., 24, 1124 (2010)

Applications Desacetyl Forskolin is an analogue of Forskolin (F701800). Desacetyl Forskolin was tested for its ability to activate rat brain adenylate cyclase, activate detergent-solubilized rat brain adenylate cyclase, increase cyclic AMP in intact S49 wild-type cells, and inhibit the binding of 3H-forskolin to rat brain membranes.
References Desouza, N., et al.: Med. Res. Rev., 3, 201 (1983); Seamon, K., et al.: J. Med. Chem., 26, 436 (1983); Seguin, E., et al.: Planta Medica, 54, 4 (1988);

Applications N-Jasmonyl-L-Isoleucine (Mixture of Diastereomers) is a plant horomone.
References Chen, Y., Chen, Z.: J. Separation Sci., 36, 892 (2013)

Applications Bisabolene is a sesquiterpene and can be extracted from oregano and other aromatic plants. It may be a potential anticancer agent that can induce apoptosis in A549 cancer cell line.
References Grosso, N. R., et al.: Argent., Pat. Appl. AR 90961 A1 20141217 (2014); Yfanti, P., et al.: Am J Plant Sci. 6, 2092 (2015)

Applications Biosynthetic precursor of Sphingosine. Inhibits protein kinase C.
References Merrill, A.H. Jr., et al.: Biochemistry, 28, 3138 (1989)