Toxicologie

<p>Applications 2,3,4,5,6-Pentachlorobenzeneamine is a chemical in pesticides used to protect crops from various fungus and bacterium.<br>References Gartrell, M. et al.: J. Assoc. Off. Anal. Chem., 68, 1163 (1985); Renner, G. et al.: App. Env. Microbio. 46, 765 (1983);<br></p>

<p>Applications Aminoethoxyvinyl Glycine Hydrochloride is an ethylene synthesis inhibitor that is used as a plant growth regulator.<br>References Tsantili, E., et. al.: Sci. Hortic-Amsterdam, 140, 26 (2012); Cetinbas, M., Butar, S.: Eur. J. Hortic. Sci., 78, 126 (2013); Centibas, M., et. al.: Sci. Hortic-Amsterdam, 147, 1 (2012)<br></p>

<p>Stability Hygroscopic<br>Applications Auristatin F is an antimitotic auristatin derivative that has been shown as a potent antitumor agent.<br>References Doronina S.O., et al.: Bioconjugate Chem., 17, 114-124 (2006);<br></p>

<p>Applications Terbutryn-d5 (ethyl-d5) (CAS# 1219804-47-3) is a useful isotopically labeled research compound.<br></p>

<p>Applications A labelled isotpe of Isopropyl 1-(1-phenylethyl)-1H-imidazole-5-carboxylate (I485580). A short-acting intravenous anaesthetic agent used for dislocated joints, tracheal intubation, cardioversion and electroconvulsive therapy.<br>References Goetz, E., et al.: Anaesthesist, 23, 331 (1974), Chang, Z. L., et al.: Anal. Profiles Drug Subs., 12, 191 (1983),<br></p>

<p>Applications Herbicide.<br>References Oehler, D.D., et al.: J. Agric. Food Chem., 28, 685 (1980),<br></p>

<p>Applications (E)-Thiothixene is an antipsychotic agent used in the treatment of psychological disorders.<br>References Andorn, A. et al.: Brain Res., 971, 66 (2003); Seeman, P. et al.: Mol. Pharmacol. 28, 391 (1985);<br></p>

<p>Applications 2-Amino-4,6-dimethoxypyrimidine is used in the making of herbicidal compositions.<br>References Hanagan, M. A., et al.: Bioactive Heterocyclic Compound Classes, 39, (2012); Wei, W., et al.: Bioorg. Med. Chem. Lett., 27, 3365 (2017); Ma, Y., et al.: Heterocycles, 92, 829 (2016); Carles, L., et al.: J. Hazard. Mater., 354, 42 (2018)<br></p>

<p>Applications It is an antiepileptic.<br>References Burchall, J., et al.: Mol. Pharmacol., 1, 126 (1965), Cody, V., et al.: J. Med. Chem., 25, 427 (1982)<br></p>

<p>Applications (R)-Diclofop-methyl is a stereo-isomer of Diclofop-methyl(D431555) which isused as the active ingredient in many herbicides that are used to control weed growth in plants such as wheat and wild oats.<br>References Marzouk, E., et al.: J. Appl. Sci. Res., 9, 4907 (2013)<br></p>

<p>Applications Bupirimate is a pyrimidine based fungicide with protective and curative activity for the control of fungal diseases by interfearing with nucleic acid synthesis.<br>References Belmonte, V. N., et al.: J. Chromatograph. A., 1264, 110 (2012); Attallah, E.R., et al.: J. Food. Agri. Envrion., 10, 755 (2012);<br></p>

<p>Applications Phosalone is a organophosphate compouund used as insecticide and acaricide. Phosalone is a weak inhibitor of acetylcholinesterase.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Munj, A.Y., et al.: Pestol., 36, 35 (2012); Andrascikova, M., et al.: Food. Add. Contamin. Chem. Anal. Control. Exposure. Risk. Assess., 30, 286 (2013);<br></p>

<p>Stability Light Sensitive<br>Applications Tacalcitol Monohydrate is used as a vitamin D analog used in combination with Imatinib (G407000) in the therapy of non-small cell lung cancer. It is a COVID19-related research product.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Schindler, T., et al.: Science, 289, 1938 (2000), Drucker, B.J., et al.: N. Engl. J. Med., 344, 1031 (2001),<br></p>

<p>Applications Protected Irinotecan metabolite.<br></p>

<p>Applications Labelled Mefenamic acid metabolite.<br>References Besunder, J., et al.: Clin. Pharmacokinet., 14, 261 (1988), Smith, P., et al.: Drug Metab. Dipos., 18, 639 (1990), Kraus, D., et al.: Clin. Pharmacol. Ther., 54, 351 (1993), Sato, J., et al.: Biol. Pharm. Bull., 16, 811 (1993),<br></p>

<p>Applications Prazosin Hydrochloride Dihydrate (Terazosin EP Impurity K) is an antihypertensive. α1-Adrenergic blocker.<br>References Jaillon, P., et al.: Clin. Pharmacokinet., 5, 365 (1980), Russell, I.J., et al.: J. Rheumatol., 12, 94 (1985), Kostek, L.J.: Anal. Profiles Drug Subs., 18, 351 (1989),<br></p>

<p>Applications Clascoterone is being developed as a topical cream by Cassiopea for androgen-​dependent skin disorders.<br>References Dhillon, S., et al.: Drugs, 80, 1745 (2020)<br></p>

<p>Applications Labelled S-Verapamil (V124991). Both isomers inhibit the p-glycoprotein efflux pump in multidrug resistant tumor cells.<br>References Peroutka, S., et al.: J. Ann. Neurol, 23, 500 (1988), Eliason, J.F., et al.: Int. J. Cancer, 46, 113 (1990),<br></p>

<p>Applications Alphaxalone-d5 (major) is the labeled analogue of Alphaxalone (A575530), an anesthetic used on animals.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Gieseg, M.A., et. al.: New Zeal. Vet. J., 62, 103 (2014);<br></p>

<p>Applications 2’-Des(1-hydroxy-1-methylethyl)-2’-carboxy Montelukast Bissodium Salt is an impurity of Montelukast Sodium Salt (M568000), a selective leukotriene D4-receptor antagonist. Used as an antiasthmatic.<br>References Labelle, M., et al.: Bioorg. Med. Chem. Lett., 5, 283 (1995); Jones, T.R., et al.: Can. J. Physiol. Pharmacol., 73, 191 (1995); Markham, A. and Faulds, D.: Drugs, 56, 251 (1998)<br></p>

<p>Applications 4,4'-DDE - d8 is a metabolite of DDT - d8 (D434197), a synthetic organochlorine insecticide that functions by opening sodium ion channels in the insects’ neurons, causing them to fire spontaneously which in turn leads to death. 4,4'-DDE - d8 has shown to have endocrine disrupting effects on gonadotropin hormones in pituitary gonadotrope cells.<br>References Saschenbrecker, P.W.: Can. J. Comp. Med., 37, 203 (1973); Balkew, M. et al.: Paras. Vect., 3, No pp. given (2010); Kikankie, C.K. et al.: Malaria J., 9, No pp. given. (2010); Battu, R.S. et al.: Sci. Total Environ., 78, 173 (1989); Zhou, J., et. al.: Environ. Toxicol. Phar., 37, 1194 (2014)<br></p>

<p>Applications A reactive metabolite of Lapatinib (L175800) which is associated with various drug toxicities. Lapatinib is metabolized mainly by P450 3A4 to form O- and N-dealkylated metabolites.<br>References He, K., et al.: Chem. Res. Toxicol., 11, 252 (1998), Rusnuk, D., et al.: Cancer Res., 61, 7196 (2001), Li, X., et al.: Drug Metab. Dispos., 37, 1242 (2009),<br></p>

<p>Applications Protected Paclitaxel metabolite.<br></p>

<p>Applications Methiozolin is commonly used in herbicidal mixtures. it is a bluegrass selective herbicide.<br>References Auler, T., et al.: PCT Int. Appl., 51 (2020); Kim, J., et al.: J. Agric. Food. Chem., 67, 13534-13543 (2019)<br></p>

<p>Stability Hygroscopic<br>Applications 4-Hydroxybutyryl-L-carnitine Chloride, is an aryl carnitine, which is an important metabolite used as a diagnostic tool for detecting inherited metabolic disorders. Antibodies can be raised against L-carnitine and other carnitine-related compounds to measure the quantity of L-carnitine in biological samples and serum.<br></p>

<p>Applications Isotope labelled 1’-Hydroxy Midazolam (H948424), metabolite of Midazolam (M343000).<br>References Dundee, J., et al.: Drugs, 28, 519 (1984), Galetin, A., et al.: Drug Metab. Dispos., 30, 1512 (2002), Uchaipichat, V., et al.: Drug Metab. Dispos., 34, 449 (2006), Lewis, B., et al.: Biochem. Pharmacol., 73, 1463 (2007),<br></p>

<p>Applications Malathion (Diethyl-d10) is used as one of the substances for the clean-up step in post-harvest pesticide residue analysis.<br>References Ucles, A., et al.: Talanta, 144, 51 (2015)<br></p>

<p>Applications (S,2E,6E)-Dehydroxy Pitavastatin is an impurity of Pitavastatin (P531000), a competitive inhibitor of HMG-CoA reductase and antilipemic agent.<br>References Aoki, T., et al.: Arzneim.-Forsch., 47, 904 (1997), Yamada, I., et al.: Xenobiotica, 33, 789 (2003), Park, S., et al.: Clin. Ther., 27, 1074 (2005),<br></p>

<p>Applications A labelled metabolite of Cortisol.<br>References Abel, S., et al. J. Steroid Biochem. Mol. Biol., 45, 445 (1993), Yates, C., et al.: Pharm. Res., 20, 1794 (2003),<br></p>

<p>Stability Hygroscopic<br>Applications A mixture of 2 labelled metabolites of Styrene.<br>References Ryan, A., et al.: Drug Metab. Dispos., 5, 363 (1977), Delbressine, L., et al.: Xenobiotica, 11, 589 (1981), Truchon, G., et al.: J. Anal. Toxicol., 14, 227 (1990),<br></p>

<p>Applications Testosterone Octanoate-d15 is the isotope analog of Testosterone Octanoate. Testosterone Octanoate is a metabolite of tesosterone (T155000), which is used in biological studies to determine the hemolytic and lipophilic activity of this anabolic steroid.<br>References Biagi, G.L., et al.: J. Med. Chem., 13, 944 (1970); Biagi, G. L., et al.: J. Med. Chem., 18, 873 (1975)<br></p>

<p>Applications Ethylester-m-fexofenadine is a drug analog of Fexofenadine (F322470).<br></p>

<p>Applications Triazophos-D5 is the labeled form of Triazophos(T767595). Triazophos is an organophosphorus insecticide.<br>References Bhosale, B., et al.: Pestol., 33, 38 (2009), Dash, D., et al.: J. Entomol. Res., 33, 105 (2009), Hu, Y., et al.: J. Agric. Food Chem., 58, 2801 (2010),<br></p>

<p>Applications 2-Oxo-7a-hydroxy Clopidogrel is an impurity found in clopidogrel (C587250).<br></p>

<p>Applications 4-Bromoaniline is a brominated aniline used as a building block in the preparation or pharmaceutial and organic compounds.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Abdel-M. et al.: J. Org. Chem., 61, 3849 (1996); Sridhar, S.. et al.: Eur. J. Med. Chem., 36, 615 (2001);<br></p>

<p>Applications A dinitroanilie heribicide used for the control of a wide range annual grass and broadleaf weeds in crops such as groundnuts, tobacco, lettuce, turf, alfalfa, clover, watermelons and sweet melons.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Bradley, M.R. et al.: Exp. Horticult., 29, 35 (1977); Harvey, R.G. et al.: Weed Sci., 25, 256 (1977); Grichar, W.J. et al.: Peanut Sci., 20, 126 (1993);<br></p>

<p>Applications 4,6-Dinitro-2-methyl-d3-phenol (CAS# 1219804-69-9) is a useful isotopically labeled research compound.<br></p>

<p>Applications 2,4-Dimethylphenol is used both as a pesticide to ward of insects or other common pests from crops from crops as well as in the synthesis of anti-oxidant compounds due to the phenol moiety in the structure. This is a labelled analog.<br>References Liu, B. et al.: J. Agri. Chem., 58, 2673 (2010); Guillen, M. et al.: J. Agri. Chem., 47, 3016 (1999); Guillen, M. et al.: J. Agri. Chem., 46, 1276 (1999); Kim, S. et al.: J. Agri. Chem., 59, 4570 (2011);<br></p>

<p>Applications Methyl 3,6-dichloropyridine-2-carboxylate<br></p>

<p>Applications 2,3-Dichloropropanoic acid is an organochlorine herbicide<br>References Okochi, Yumiko, et al.: Kankyo Gijutsu, 26(4), 225-228 (1997)<br></p>

<p>Applications Protected Propofol metabolite.<br></p>

<p>Applications Tecloftalam is an agrochemical fungicide. Tecloftalam is used for the control of rice bacterial leaf blight.<br>References Nakagami, K. et al.: Nip. Noyak. Gak., 5, 511 (1980); Kirkpatrick, D. et al.: J. Agric. Food Chem., 29, 608 (1981); Takahi, Y. et al.: Jap. Past. Info., 46, 25 (1985);<br></p>

<p>Stability Hygroscopic<br>Applications Indigosol O is an indigo dye used for cotton.<br>References Ruggli, P., et al.: Helv. Chim. Acta, 23, 689 (1940),<br></p>

<p>Stability Moisture Sensitive<br>Applications Isodimethoate is an isomer of Dimethoate (D460505), which is an organophosphate insecticide. Isodimethoate is present in usual pesticide formulations of Dimethoate that is anticholinesterase which disables cholinesterase, an enzyme essential for central nervous system function and thus is neurotoxic for humans. Isodimethoate reacts with human red blood cell acetylcholinesterase (AChE) rendering part of AChE making it non-reactivatable.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Tripathy, N.K. et al.: Mut. Res. Gen. Toxicol. Test., 206, 351 (1988); Papp, A. et al.: Pest. Biochem. Physiol., 61, 21 (1998); Eyer, P., et al.: Biochem. Pharmacol., 75, 2045 (2008);<br></p>

<p>Applications Reagent used in the synthesis of herbicides.<br>References Mekenyan, O., et al.: Chem. Res. Toxicol., 10, 994 (1997), Brown, T., et al.: Environ. Sci. Technol., 42, 5202 (2008),<br></p>

<p>Applications Labelled Nabumetone. Anti-inflammatory. Antibacterial.<br>References Kumpulainen, H., et al.: J. Med. Chem., 49, 1207 (2006),<br></p>

<p>Applications Phosacetim is a toxic organophosphate compound which acts as an acetylcholinesterase inhibitor and is used as a rodenticide.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Rennison, B.: Pest. Sci., 8, 405 (1977); Ming, S., et al.: J. Anal. Toxicol., 12, 287 (1988)<br></p>

<p>Applications Estradiol 4-Carboxymethyl, is a metabolite of 17β-Estradiol (E888000). Estradiol is the major estrogen secreted by the premenopausal ovary.<br>References Bucala, R., et al.: J. Clin. Endocrinol. Metab., 60, 841 (1985), Telang, N., et al.: Anticancer Res., et al.: 11, 1021 (1991), Seeger, H., et al.: Med. Sci. Res., 26, 481 (1998), Bolton, J., et al.: Chem. Res. Toxicol., 13, 135 (2000),<br></p>