Toxicologie

<p>Stability Light Sensitive<br>Applications (1R)-trans-γ-Cyhalothrin is an isomer of λ-Cyhalothrin (C988980), which is used as an insecticide.<br>References Bhavani, B., et al.: Pestol., 33, 42 (2009), Patial, A., et al.: Env. Ecol., 27, 320 (2009), Schleier, J., et al.: J. Med. Entomol., 46, 693 (2009), Yang, D., et al.: Toxicol. App. Pharmacol., 237, 49 (2009),<br></p>

<p>Applications Ivosidenib is a first-in-class mutant IDH1 inhibitor for the treatment of IDH1 mutant cancers.<br>References Popovici-Muller, J., et al.: ACS Medicinal Chemistry Letters, 9, 300 (2018);<br></p>

<p>Applications Isotope labelled Cyclopropylmethyl Bromide is a reagent used in the synthesis of human dihydroorotate dehydrogensase inhibitors which are based on azole scaffolds. In addition it is used in the preparation of ([11C]CMDC) for PET imaging of mGlur2 which has been a proposed target in the treatment of schizophrenia.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Sainas, S. et al.: Eur. J. Med. Chem., 129, 287 (2017); Ma, Y. et al.: Bioorg. Med. Chem., 25, 1014 (2017);<br></p>

<p>Applications Nodakenin (CAS# 495-31-8) is a useful research chemical compound.<br></p>

<p>Applications This product is deuterated at the 1 position and on the ajacent methyl. The 1 position is the benylic position of the bis(trifluoromethyl) phenyl. This compound has a mixture of 1 to 4 deuterium atoms, there is no detectable unlabeled material.Aprepitant is a structurally novel substance P neurokinin 1 (NK1) receptor antagonist. In vitro studies using human liver microsomes indicate that aprepitant is metabolised primarily by CYP3A4 with minor metabolism by CYP1A2 and CYP2C19, and no metabolism by CYP2D6, CYP2C9, or CYP2E1.<br>References Hale, J.J., et al.: J. Med. Chem., 41, 4607 (1998), Campos, D., et al.: J. Clin. Oncol., 19, 1759 (2001), Van Belle, S., et al.: Cancer, 94, 3032 (2002), Majumdar, A.K., et al.: J. Clin. Pharmacol., 46, 291 (2006),<br></p>

<p>Impurity Fluconazole EP Impurity B / Fluconazole USP Related Compound A<br>Applications 4-Defluoro-4-(1H-1,2,4-triazol-1-yl) Fluconazole (Fluconazole EP Impurity B) is an impurity of the antifungal agent Fluconazole (F421000).<br>References Ramesh, B. et al.: J. Pharm. Res., 4, 1401 (2011); Al-Rimawi, F.: Jor. J. Chem., 4, 357 (2009);<br></p>

<p>Applications Metazosulfuron is a herbicide used in paddy fields to control annual and perennial weeds.<br>References Lee, I., et. al.: The Korean Soc. Weed Sci., 31, 308 (2011)<br></p>

<p>Applications N-Oleoyl Taurine which belongs to the class of N-Acyl Taurines were detected in beta cells of Langerhans islets causing insulin secretion results beta cell dysfunction in type 2 diabetes<br>References Aichler, M., et al.: Cell Metab., 25, 1334-1347 (2017)<br></p>

<p>Applications N-Isopropyl-3,4-dimethyl-2,6-dinitroaniline is a dinitro herbicides.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Chen, Y., et al.: Green Chemistry, 15, 91 (2013)<br></p>

<p>Applications An intermediate in the preparation of HIV-integrase inhibitors<br>References Itoh, F., et al.: Chem. Pharm. Bull., 43, 230 (1995), Summa, V., et al.: J. Med. Chem., 51, 5843 (2008),<br></p>

<p>Applications N-Acetyl Cefixime is the N-acetylated analogue and impurity of the third generation cephalosporin antibiotic, Cefixime (C242800).<br></p>

<p>Applications A metabolite of Rosiglitazone.<br>References Balton, G.C., et al.: Xenobiotica, 26, 6, 627 (1996), Kim, K., et al.: J. Clin. Pharmacol., 45, 941 (2005), Kirchheiner, J., et al.: Clin. Pharmacol. Ther., 80, 657 (2006), O'Maille, G., et al.: J. Pharm. Biomed. Anal., 48, 934 (2008),<br></p>

<p>Impurity Ritonavir EP Impurity F<br>Applications Des(isopropylthiazolyl) Hydantoin Ritonavir (Ritonavir EP Impurity F) is a Ritonavir (R535000) derivative with potential use in the treatment of viral infections. Cytochrome P450 oxidase inhibitor. It is a COVID19-related research product.<br>References Daluge, S., et al.: Antimicrob. Agents Chemother., 38, 1590 (1994); Ammaranond, P., et al.: J. Clin. Virol., 26, 153 (2003);<br></p>

<p>Applications A Levamisole derivative<br>References Lewis, J., et al.: Mol. Pharmacol., 31, 185 (1987),<br></p>

<p>Applications (2R,4S)-Itraconazole is an enantiomer of Itraconazole (I937500), an orally active antimycotic structurally related to Ketoconazole. Antifungal. It is a COVID19-related research product.<br>References Espinel-Ingroff, A., et al.: Antimicrob. Agents Chemother., 26, 5 (1984), Heykants, J., et al.: Mycoses, 32, Suppl 1, 67 (1989), Sugar, A.M.,et al.: Curr. Clin. Top. Infect. Dis., 13, 74 (1993),<br></p>

<p>Impurity Lamivudine EP Impurity D<br>Stability Hygroscopic<br>Applications ent-Lamivudine (Lamivudine EP Impurity D) is an enantiomer of Lamivudine (L172500); an antiviral that inhibits HIV-reverse transcriptase.<br>References Pepe, G. et al.: Eur. J. Med. Chem., 31, 775 (1996); Marr, E. et al.: Antiviral Res., 28, 1 (1995); Parikh, U.M. et al.: Antimicrob. Agents Chemother., 49, 1139 (2005);<br></p>

<p>Impurity Clarithromycin EP Impurity L<br>Applications Clarithromycin (9Z)-Oxime (Clarithromycin EP Impurity L) is an impurity of Clarithromycin (C559750); a semi-synthetic macrolide antibiotic and derivative of Erythromycin (E650000).<br>References Esteban, J., et al.: Tetrahedron Lett., 45, 5563 (2004); Morgan, D., et al.: J. Chromatogr., 502, 351 (1990); Benson, C., et al.: Eur. J. Clin. Microbiol., 6, 173 (1987); Boyanova, L., et al.: J. Med. Microb., 61, 85 (2012); Lin, Z., et al.: Toxicol. Sci., 126, 114 (2012)<br></p>

<p>Applications Desmethylene seco-Benzoxadiazine Marbofloxacin is an impurity of Marbofloxacin (M197000); a fluorinated quinolone antibacterial.<br>References Gruet, P., et al.: Vet. Rec., 140, 199 (1977); Lefebvre, H.P., et al.: J. Vet. Pharmacol. Ther., 21, 453 (1998)<br></p>

<p>Applications 3-Cyano-6,7-dihydro-4-trifluoromethyl-1,5H-cyclopenta-[b]-pyrid-2-one (cas# 371967-27-0) is a useful research chemical.<br></p>

<p>Applications Bis(tributyltin) Oxide is an organotin compound used as a fungicide and molluscicide, particularly in wood preservation. Bis(tributyltin) Oxide was used as an active component in marine antifouling paints but is not longer used due to its toxicity and is considered a severe marine pollutant.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Laughlin, R.B.J. et al.: Environ. Sci. Technol., 20, 884 (1988); Polster, M. et al.: Ces.-Slov. Hyg., 15, 243 (1970);<br></p>

<p>Applications 2,5-Dichloro-1,3-benzenedicarbonitrile is a metabolite of the fungicide 2,4,5,6-tetrachloroisophthalonitrile (TPN) in soil.<br>References Sato, K., et al.: Biol. Fert. Soils, 3, 205 (1987)<br></p>

<p>Applications 6-O-Methyl-2',4''-bis-O-(trimethylsilyl)-9-[O-(1-ethoxy-1-methylethyl)oxime]-Erythromycin (CAS# 119665-62-2) is a derivative of erythromycin (E649950), an antibiotic.<br>References Koch, W.L., et al.: Anal. Profiles Drug Subs., 8, 157 (1979),<br></p>

<p>Stability Very unstable<br>Applications Cefixime Impurity is an impurity of Cefixime (C242800); an orally active third generation cephalosporin antibiotic.<br>References Kamimura, T., et al.: Antimicrob. Agents Chemother., 25, 98 (1984); Yamanaka, H., et al.: J. Antibiot., 38, 1738 (1985); Guay, D.R.P., et al.: Antimicrob. Agents Chemother., 30, 485 (1986)<br></p>

<p>Applications Hydroxy Velpatasvir is an impurity of antivaral drug Velpatasvir (V116000), which is a HCV NS5A inhibitor used to treat Hepatitis C.<br>References Feld, J. J., et al.: N. Engl. J. Med. 373, 2599 (2015); Gane, E. J., et al.: Gastroenterol., 151, 448 (2016);<br></p>

<p>Applications A D2/D4-Dopamine receptor antagonist. A serotonergic receptor antagonist. A dibenzoxazepine antipsychotic agent.<br>References Shen, Y., et al.: J. Biol. Chem., 268, 18200 (1993), Fiorella, D., et al.: Psychopharmacology, 121, 347 (1995), Glusa, E., et al.: Br. J. Pharmacol., 130, 692 (2000)<br></p>

<p>Applications 5-Bromo-2-nitrophenol is a halonitrophenol with antifungal activity.<br>References Gershon, H., et al.: Monatshefte fuer Chemie, 126, 1161 (1995)<br></p>

<p>Applications 3,4-O-(Diethylmethylidene) Shikimic Acid Ethyl Ester is a reactant used in the preparation of oseltamivir analogs as neuraminidase inhibitors against avian influenza virus.<br>References Kongkamnerd, J. et al.: Bioorg. Med. Chem., 20, 2152 (2012)<br></p>

<p>Applications Intermediate in the preparation of Testosterone metabolites.<br></p>

<p>Applications (rac)AIB-Precursor is used as a reagent in the preparation of cyclized sulfamoylarylamide derivatives for treatment of hepatitis B.<br>References Vendeville, S. M. H., et al.: PCT Int. Appl. 244pp. (2017)<br></p>

<p>Applications Propineb-d3 is the labeled analog of Propineb (P771450), which is used as a fungicide.<br>References Sharma, I.M., et. al.: J. Mycology Plant Pathology, 44, 92 (2014); Gupta, R.C., et. al.: Pestology, 37, 43 (2013)<br></p>

<p>Applications Hydroxynaphthoquinone derivative that inhibits mitochondrial electron transport. Antipneumocystic.<br>References Hudson, A.T., et al.: Drugs Exp. Clin. Res., 17, 427 (1991), Fry, M., et al.: Biochem. Pharmacol., 43, 1545 (1992), El-Sadr, W.M., et al.: N. Engl. J. Med., 339, 1889 (1998),<br></p>

<p>Applications 2,3-Dimethylbenzoquinone is a reagent in the preparation of hydroxycinnolines which has antifungal activity.<br>References Ryu, C., et al.: Bioorg. Med. Chem. Lett., 16, 1850 (2006)<br></p>

<p>Applications cis-2-(2,4-Dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolane-4-methanol Benzoate (Ester) is an intermediate in the synthesis of trans-2-​(2,​4-​Dichlorophenyl)​-​2-​(1H-​imidazol-​1-​ylmethyl)​-​1,​3-​dioxolane-​4-​methanol (D431560). trans-2-​(2,​4-​Dichlorophenyl)​-​2-​(1H-​imidazol-​1-​ylmethyl)​-​1,​3-​dioxolane-​4-​methanol is an impurity of Ketoconazole (K186000).<br>References Ryu, J., et al. Bull. Korean Chem. Soc., 24, 460 (2003)<br></p>

<p>Applications Docosanoyl Ethanolamide is saturated N-acylethanolamide.<br></p>