Toxicologie

Applications 9-(2-Hydroxypropyl)adenine-13C5 is an intermediate used in the synthesis of rac Tenofovir-13C5 (>90%) (T018501), which is he isotope labelled analog of Tenofovir (T018500); an acyclic phosphonate nucleotide analogue and reverse transcriptase inhibitor. Also used as an anti-HIV agent and antiviral.
References Shaw, J.-P., et al.: Pharm. Res., 14, 1824 (1997); Wyles, D., et al.: Clin Infect. Dis., 40, 174 (2005); Peng, J., et al.: J. Clin. Pharmacol., 46, 265 (2006); Seminari, E., et al.: J. Antimicrob. Chemother., 60, 831 (2007)

Stability Hygroscopic
Applications Intermedine is an unsaturated monoester pyrrolizidine alkaloid that is extracted from the seeds of Amsinckia intermedia, a tarweed that causes enzootic hepatic cirrhosis in horses and hard liver disease in cattle. Intermedine is also a diastereomer of Lycopsamine (L487525), a pyrrolizidine alkaloid that is found in honey and in comfrey (a topical anti-inflammatory agent used to treat patients with arthritis and gout).
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Culvenor, C., et al.: J. Agr. Food Chem., 29 958 (1981); Janes, D., et al.: Nat. Prod. Comm., 7, 861 (2012); Li, Y. & Stermitz, F.: J. Nat. Prod., 51, 1289 (1988); McCulloch, E.: Am. Vet. Med. Assoc., 96, 5 (1940); Pawar, R., et al.: J. Sep. Sci., 33, 200 (2010)

Applications 4-Methyl-1,2,3-Thiadiazole-5-Carboxylic Acid (cas# 18212-21-0) is a useful research chemical.

Applications An Efavirenz (E425000) impurity.

Applications Artemether- 13C, d3, is the labeled analogue of Artemether (A777400), which is a derivative of Artemisinin (A777500). Antimalarial, used to treat strains of malaria which are multi-drug resistant.
References Hombhanje, F., et al.: Pharma., 3, 3581 (2010), Michael, O., et al.: Malaria J., 9, 335 (2010), Cesar, I., et al.: J. Pharm. Biomed. Anal., 54, 114 (2011),

Impurity Cefuroxime Axetil EP Impurity A
Applications Δ2-Cefuroxime Axetil (Cefuroxime Axetil EP Impurity A) is an oral prodrug of Cefuroxime (C248060), an injectable second generation cephalosporin with an excellent antibacterial activity. This ester is applied in therapy as a mixture of the R and S diastereoisomers.
References Nguyen, N., et al.: Pharm. Res., 8, 893 (1991), Stoeckel, K., et al.: Antimicrob. Agents Chemother., 42, 2602 (1998), Scott, L., et al.: Drugs, 61, 1455 (2001),

Applications Ethofumesate is a herbicide.

Stability Hygroscopic
Applications Isomalathion is a major impurity in the synthesis of Malathion (M111000), a commonly used insecticide.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Josse, R et al.: Chem. Bio., Interact., 209, 76 (2014); Buratti, F. et al.: J. Biochem. Mol. Toxicol., 19, 406 (2009);

Applications (1R,2S)-rel-2-Phenylcyclopropanamine Sulfate is a monoamine oxidase inhibitor (MAOI), synthesized into a functioning anti-depressant.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Birkenhager, T. et al.: J. Clin. Psych., 65, 1505 (2004); van Haelst, I. et al.: J. CLin. Psych., 73, 1109 (2012);

Applications 2,4,5-Trichlorophenol-d2 is the labelled analogue of 2,4,5-Trichlorophenol (T774145), which is used as a broad range pesticide against insects, fungi, vegetation and bacteria. It has become a common environmental contaminant and probable human carcinogen.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Amer, S. et al.: Cytologia, 39, 633 (1974); Xu, X. wt l.: Occup. Environ. Med., 68, 557 (2011); Sinclair, C.J. et al.: Environ. Sci. Technol., 37, 4617 (2003);

Applications Norapomorphine Glucuronidate is a metabolite of Amomorphine (A727500). Amomorphine is a dopamine (D1 and D2) receptor agonist. Emetic. Antiparkinsonian.
References Neumeyer, J.L., et al.: J. Pharm. Sci., 59, 1850 (1970), Ginos, J.Z., et al.: J. Med. Chem., 18, 1194 (1975), Muhtadi, F.J., et al.: Anal. Profiles Drug Subs., 20, 121 (1991),

Applications (3S,5S)-Dihydroxy Simvastatin is a derivtive of Simvastatin (S485000). Simvastatin is a synthetic derivative of a fermentation product of Aspergillus terreus. A competitive inhibitor of HMG-CoA reductase. A synthetic analog of Lovastatin. Antilipemic. Simvastatin, the drug, is sold under the trade name Zocor.
References Hoffman, W.F., et al.: J. Med. Chem., 29, 849 (1986), Mol, M.J., et al.: Lancet, 2, 936 (1986)

Applications Labelled Fenthion Sulfone (F278015). Fenthion Sulfone is a metabolite of the organothiophosphate insecticide Fenthion (F278000).
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Oh, C., et al.: Bull Environ. Contam. Toxicol., 78, 314 (2007); Wang, W., et al.: Anal. Chim. Acta, 602, 211 (2007);

Applications Cilostazol-d4 is the labeled analogue of Cilostazol (C441500), a potent phosphodiesterase III A (PDE3A) inhibitor (IC50=0.2uM) and inhibitor of adenosine uptake. Has antimitogeni, antithrombotic, vasodilatory and cardiotonic properties in vivo. Also affects lipid levels in vivo.
References Suri, A., et al.: J. Clin. Pharmacol., 38, 144 (1998); Park, S.-W., et al.: Am. J. Cardiol., 84, 511 (1999); Tsuchikane, E., et al.: Circulation, 100, 21 (1999)

Applications Vinblastine-d3 Methiodide is the labeled analogue of Vinblastine Methiodide (V314015), an adduct of Vinblastine (V314000), an antitumor alkaloid isolated from periwinkle, Vinca rosea Linn., Apocynaceae; inhibits microtubule assembly. An antineoplastic.
References Dorman, D.E., Paschal, J.W.: Org. Magnetic Resonance, 8, 413 (1976); Lu, C., et al.: Cancer Research, 39, 3575 (1979); Gobbi, P.G., et al.: J. Clin. Oncol., 14, 527 (1996); Muhtadi, F.J., et al.: Anal. Profiles Drug Subs. Excip., 21, 611 (1992)

Applications Ritonavir O-Sulfate is a metabolite of Ritonavir (R535000); a selective HIV protease inhibitor. It is a COVID19-related research product.
References Daluge, S., et al.: Antimicrob. Agents Chemother., 38, 1590 (1994); Ammaranond, P., et al.: J. Clin. Virol., 26, 153 (2003), Harrigan, P., et al.: J. Infect. Dis., 191, 339 (2005); Miller, J., et al.: Bioorg. Med. Chem. Lett., 16, 1788(2006); Denissen, J.F., et al.: Drug Metab. Dispos., 25, 489 (1997)

Applications A labelled imidazole, a versatile heterocycle used in the preparation of various biologically active compounds such as the amino acid histidine and is present in many antifungal medication. It is also used extensively as a corrosion inhibitor on transition metals such as copper.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Arispe, N. et al.: Biophys. J., 95, 4879 (2008); Troesken, E.R. et al.: Endo. Res., 30, 387 (2004); Otmacic Curkovic, H. et al.: Corr. Sci., 51, 2342 (2009);

Applications N7-Des[2-(1H-tetrazol-1-yl)acetyl]-N7-(tert-butylcarbonyl) Cefazolin Sodium Salt is an impurity of the semi-synthetic antibiotic Cefazolin (C242500).

Applications 7-methoxy-4-phenyl-1,2-dihydroquinolin-2-one (cas# 30034-43-6) is a useful research chemical.

Applications 4-(1,1-Dimethylpropyl)-β-methylbenzenepropanol is a useful synthetic intermediate in the synthesis of Amorolfine Hydrochloride (A634170); a morpholine antifungal drug and topical solution for the treatment of toenail infections.
References Rotta, I., et al.: JAMA Dermatol., 149, 341 (2013); Espinel-Ingroff, A., et al.: Antimicrob. Agents Ch., 26, 5 (1984); Zhang, S., et al.: Faming Zhuanli Shenqing. CN 103288768 A 20130911. Sep 11, 2013

Applications A novel metabolite of Phenazopyridine (P313751).
References Bailey, K., et al.: Drug Metab. Dispos., 11, 277 (1983), Thomas, B. H., et al.: J. Pharm. Sci., 79, 321 (1990), Thomas, B.H., et al.: Xenobiotica, 23, 99 (1993),

Applications Androstenedione (A637550) analog, an aromatase inhibitor.
References Marsh, D.A., et al.: J. Med. Chem., 28, 788 (1985),

Applications Isopropyl 2-Furoate is used in the preparation of heteroarenecarboxylates.
References Luo, Wenkun. et al., Org. Lett. 22, 2093-2098(2019);

Applications Marbofloxacin N-oxide is a metabolite of Marbofloxacin (M197000); a fluorinated quinolone antibacterial.
References Gruet, P., et al.: Vet. Rec., 140, 199 (1977); Lefebvre, H.P., et al.: J. Vet. Pharmacol. Ther., 21, 453 (1998); Schneider, M., et al.: J. Diary Sci., 87, 202 (2004)