Toxicologie

<p>Applications 5-Chloro-3-methyl-4-nitro-1H-pyrazole (CMNP) is a pyrazole-derived plant growth regulator used as a citrus abscission agent.<br>References Barcelo, J., et al.: J. Plant Nutr., 13, 1 (1990), Delessert, C., et al.: Plant Mol. Biol., 55, 165 (2004), Both, M., et al.: The Plant Cell, 17, 2107 (2005),<br></p>

<p>Applications Bitertanol is a foliar-applied triazole fungicide used to protect tropical and subtropical crops in agriculture, in particular bananas. Bitertanol has effects on behavior that are similar to those of psychomotor stimulants.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Allen, A.R. et al.: Neurotoxicol. Teratol., 15, 237 (1993); Scheinpflug, H. et al.: Pflanzsensch.-Nach., 34, 8 (1981);<br></p>

<p>Applications Nebivolol (N387896) metabolite.<br></p>

<p>Applications Labelled Bosentan (B675900). A mixed endothelin receptor antagonist. Used as a vasodilator. Antihypertensive.<br>References Clozel, M., et al.: J. Pharmacol. Exp. Ther., 270, 228 (1994), Gutsch, G., et al.: Cardiovasc. Drugs Ther., 10, 717 (1996), Weber, C., et al.: Clin Pharmacol. Ther., 60, 124 (1996), Krum, H., et al.: N. Engl. J. Med., 338, 784 (1998)<br></p>

<p>Stability Hygroscopic<br>Applications A new nitrification inhibitor to be used on solid and in liquid fertilizers and slurry.<br></p>

<p>Stability Hygroscopic<br>Applications β-Nicotyrine-d3, is the labeled analogue of β-Nicotyrine (N445002), which is an alkaloid derived from the dehydrogenation of nicotine and its analog, nornicotine. An alkaloid occurring in cigaret smoke.<br>References Swain, M.L., et al.: J. Am. Chem. Soc., 71, 1341 (1949);<br></p>

<p>Stability Light Sensitive<br>Applications A PAH metabolite having a toxic effect on fish bone metabolite. Also, it is used as a marker of the carcinogenic potency of the polycyclic aromatic hydrocarbons (PAH) mixture. A genotoxic agent.<br>References Ebright, R., et al.: Cancer Res., 46, 2349 (1986), Morito, K., et al.: Biol. Pharm. Bull., 24, 351 (2001), Billiard, S., et al.: Toxicol. Sci., 92, 526 (2006),<br></p>

<p>Applications Ethylmorphine impurity.<br>References Pfeifer, S., et al.: Pharmazie, 27, 648 (1972),<br></p>

<p>Stability Hygroscopic<br>Applications 2-Hydroxy-4’,5-diacetamido-diphenyl Ether is used in the synthesis of novel benzimidazoles as potent inhibitors of TIE-2 anf VEGFR-2 tyrosine kinase receptors. Angiogenesis therapeutic agent.<br>References Hasegawa, M. et al.: J. Med. Chem., 50, 4453 (2007);<br></p>

<p>Stability Hygroscopic<br>Applications Acarviosin is a part of the potent α-amylase inhibitor, Acarbose (A123500), an anti-diabetic drug used to treat type 2 diabetes mellitus (1,2,3).<br>References (1) Shibata, Y., et al.: Carbohydrate. Res., 228, 377 (1992) (2) Raimbaud, E., et al.: Carbohydrate. Res., 227, 351 (1992) (3) Geng, P., et al.: Carbohydr Res. 343, 882 (2008)<a href="https://www.ncbi.nlm.nih.gov/pubmed/18294624PMID" target="_blank" rel="noreferrer noopener">https://www.ncbi.nlm.nih.gov/pubmed/18294624PMID</a>: 18294624<br></p>

<p>Applications A natural product with significant antitumor activities.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Sah, N., et al.: J. Biol. Chem., 278, 20593 (2003), Lu, D., et al.: J. Int. Med. Res., 32, 488 (2004), Yunmbam, M., et al.: Oncol. Rep., 11, 833 (2004), Shao, S., et al.: Cell Biol. Int., 32, 893 (2008),<br></p>

<p>Applications N-(6-Chloro-3-pyridylmethyl)-N’-cyano-acetamidine is an Acetamipride-Metabolite. It also performs insecticidal and neuroblocking activities in animals.<br>References Kiriyama, K., et al.: J. Pest. Sci., 28, 17 (2003); Gbylik-S., et al.: J. Chromatogr. B: Analyt. Technol. Biomed. Life Sci., 990, 132 (2015)<br></p>

<p>Applications 2,6-Diisopropylnaphthalene, is a building block used for the synthesis of more complex compounds. 2,6-Diisopropylnaphthalene (2,6-DIPM) is also used in the manufacturing of pesticide products intended to prevent sprouting of stored potatoes.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Beaver, R. G., et al.: American Journal of Potato Research, 80, 311 (2013);<br></p>

<p>Applications (R)-Quizalofop Ethyl is a post-emergence herbicide for control of grassy weeds in broad-leaved crops. Herbicide.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Corbett, T., et al.: Cancer Res., 42, 1707 (1982), Branda, R., et al.: Biochem. Pharmacol., 38, 3521 (1989), Corbett, T., et al.: J. Exper. Therap. Oncol., 1, 95 (1996),<br></p>

<p>Applications Labelled Dodecyl Phthalate (D525380). Dodecyl Phthalate is used in the preparation of Cytarabine (C998100) derivatives as anticancer agents.<br>References Aoshima, M., et al.: Cancer Res., 36, 2726 (1976), Wang, N., et al.: Bioorg. Med. Chem. Lett., 15, 4064 (2005), Marie-Helene, G., et al.: Bioorg. Med. Chem., 2009, 17, 6340 (2009),<br></p>

<p>Applications n-Pentyl 4-Hydroxybenzoate-2,3,5,6-d4 (CAS# 1219798-66-9) is a useful isotopically labeled research compound.<br></p>

<p>Applications A metabolite of the fluorinated quinolone antibacterial Ciprofloxacin.<br></p>

<p>Applications Biotin Sulfone, is derivative of Biotin (B389040), which is a growth factor present in minute amounts in every living cell, and plays an indispensable role in numerous naturally occurring carboxylation reactions.<br>References du Vigneaud, et al.: J. Biol. Chem., 146, 475 (1942), Traub, et al.: Nature, 178, 649 (1956), Siegel, H., et al.: Experienta, 37, 789 (1981), Vesely, D.L., Science, 216, 1329 (1982), Hugues, M., et al.: Biochemistry, 31, 12 (1992),<br></p>

<p>Stability Hygroscopic<br>Applications A metabolite of the sedative drug Detomidine.<br>References Salonen, J.S., et al.: Eur. J. Drug Metab. Pharmacokinet., 17, 13 (1992),<br></p>

<p>Applications An oleic acid synthetic analog that is an effective non-toxic anticancer drug with a wide spectrum against different types of cancer. An antihypertensive.<br>References Llado, V. et al.: J. Cell. Molec. Med., 14, 659 (2010); Alemany, R. et al.: J. Lip. Res., 47, 1762 (2006); Martinez, J. et al.: J. Pharmacol. Exp. Therap., 315, 466 (2005);<br></p>

<p>Impurity Betamethasone Dipropionate EP Impurity G<br>Applications Betamethasone Tripropionate (Betamethasone Dipropionate EP Impurity G) is a Betamethasone (B327000) related compound.<br>References Grootveld, M., et al.: Biochem. Pharmacol., 37, 271 (1988), Chen, B., et al.: Steriods, 74, 30 (2009), Mikami, E., et al.: J. Pharm. Biomed. Anal., 28, 261 (2002),<br></p>

<p>Applications S-Ramelteon Metabolite M-II is a metabolite of Ramelteon in serum (M-II).<br>References Karim, A., et al.: J. Clin. Pharmacol., 44, 1210 (2004); Prescott, E., et al.: Drug Metab. Rev., 36, 203 (2004); Kato, K., et al.: Neuropharmacology, 48, 301 (2005); Karim, A., et al.: J. Clin. Pharmacol., 46, 140 (2006)<br></p>

<p>Applications Potassium bromide is an ionic compound that is commonly used in chemistry to form a pellet that can be used to analyze a number of compounds by means of infrared spectroscopy. Potassium bromide is also used as an anticonvulsant to treat refractory seizures in humans and dogs.<br>References Kirkland, J.: Anal. Chem., 27, 1537 (1955); Korinthenberg, R., et al.: J. Child Neuro., 22, 414 (2007); Wilberley, S., et al.: Anal. Chem., 29, 210 (1957); Yohn, S., et al.: J. Am. Vet. Med. Ass., 201, 468 (1992)<br></p>

<p>Applications 4-methyl-2-(4-(trifluoromethyl)phenyl)thiazole-5-carboxylic acid (cas# 144059-86-9) is a useful research chemical.<br></p>

<p>Applications Droxicam is a non-steroidal anti-inflammatory drug.<br>References Lapeyre-Mestre, M., et. al.: Fundam. Clin. Pharm., 20, 391 (2006)<br></p>

<p>Applications A normal mammalian metabolite of Cortisone (C696500).<br>References Schneider, et al.: J. Biol. Chem., 183, 365 (1950), Barkemeyer, et al.: Appl. Microbiol., 8, 237 (1960),<br></p>

<p>Impurity Ritonavir EP Impurity N<br>Applications 4-Dehydroxy-5-Hydroxy Ritonavir (Ritonavir EP Impurity N) is an impurity of the selective HIV protease inhibitor Ritonavir (R535000). It is a COVID19-related research product.<br>References Kempf, D.J. et al.: J. Med. Chem., 41, 602 (1998); Mekapati, S.B. et al.: J. Enzyme Inhib., 16, 185 (2001);<br></p>

<p>Stability Sample is unstable in solution<br>Applications Erythromycin A N-oxide is a facile metabolite of erythromycin A.<br></p>

<p>Impurity Ambroxol EP Impurity B Hydrochloride<br>Stability Hygroscopic<br>Applications Ambroxol Cyclic Impurity is a metabolite as well as an impurity of the bronchosecretolytic drug, Ambroxol (A575900).<br>References Hammer, R. et al.: Arzneim.-Forsch., 28, 899 (1978); Nieder, M. et al.: HRC &amp; CC, 9, 561 (1986); Huq, F. et al.: J. Pharmacol. Toxicol., 3, 147 (2008);<br></p>

<p>Stability Hygroscopic<br>Applications The optically active isomer of Carvedilol (C184625), a nonselective ß-adrenergic blocker with a1-blocking activity. An antihypertensive used in the treatment of congestive heart failure.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Hirohashi, M., et al.: Arzneim.-Forsch., 40, 735 (1990),<br></p>

<p>Applications Fenfluthrin can be used in agricultural use and as analyte in analytical/biological study of retrospective screening of relevant pesticide metabolites in food using liquid chromatography high resolution mass spectrometry and accurate-​mass databases of parent molecules and diagnostic fragment ions.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Polgar, L., et al.: J. Chromatogr. A., 1249, 83-91 (2012)<br></p>

<p>Applications A labelled nonsteroidal anti-inflammatory drug (NSAID); activity resides primarily in the (S)-isomer.<br>References Busson, M., et al.: J. Int. Med Res., 14, 53 (1986), Meade, E.A., et al.: J. Biol. Chem., 268, 6610 (1993), Davies, N.M., et al.: Clin. Pharmacokinet., 34, 101 (1998),<br></p>

<p>Applications Aminosteroid, competitive neuromuscular blocker.<br>References Magorian, T., et al.: Anesthesiology, 79, 913 (1993), Wicks, T.C., et al.: J. Am. Assoc. Nurse Anesth., 62, 33 (1994)<br></p>

<p>Applications A Rosuvastatin (R700500) intermediate as HMG-CoA reductase inhibitor.<br>References Beck, et al.: J. Med. Chem., 33, 52 (1999),<br></p>

<p>Applications Analgesic.<br>References Haddad, P., et al.: Drugs, 62, 1649 (2002), Chiu, P., et al.: J. Pharmacol. Sci., 95, 311 (2004), Dubin, A., et al.: J. Biomol. Screen, 10, 168 (2005),<br></p>

<p>Stability Reacts with DMSO<br>Applications A metabolite of Cyclophosphamide (C988580).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Bohnenstengel, F., et al.: Eur. J. Clin. Pharmacol., 51, 297 (1996), Busse, D., et al.: J. Clin. Oncol., 15, 188 (1997), Roy, P., et al.: Drug Metab. Dispos., 27, 655 (1999),<br></p>

<p>Applications Veratramine is useful as signal transduction inhibitor for treating tumors.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Imamura, L., et al.: J. Trad. Med., 12, 129 (1995), Ingolfsdottir, K., et al.: Antimicrob. Agents. Chemother., 1997, 41, 215 (1997), Tezuka, Y., et al.: J. Nat. Prod., 61, 1397 (1988)<br></p>

<p>Applications An Epinephrine (E588585) derivative formed in injection solutions and eye drops during sterilization and storage of L-Epinephrine Bitartrate.<br>References De Mol, N.J. et al.: Pharmac. Week., 117, 1 (1982); Liu, C. et al.: Yao. Fen. Zaz., 2, 200 (1982);<br></p>

<p>Applications Labelled 5-FU, a potent antineoplastic agent in clinical use. Also an inhibitor of DNA synthesis.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Rudy, B.C., et al.: Anal. Profiles Drug Subs., 2, 221 (1973), Miyashita, O., et al.: Chem. Pharm. Bull., 29, 3181 (1981), Hansen, R.M., et al.: Cancer Invest., 9, 637 (1991),<br></p>

<p>Stability Hygroscopic<br>Applications L-Penicillamine Hydrochloride is a salt form of L-Penicillamine (P2230005). L-Penicillamine is a metabolite of penicillin. L-Penicillamine is used in the treatment of Wilson’s disease, Cystinuria, Scleroderma and arsenic poisoning.<br>References Marti-Prats, L., et al.: Neurosci. Lett., 483, 143 (2010), Singh, A., et al.: J. Pharm. Sci., 99, 3931 (2010), Everette, J., et al.: J. Agric. Food Chem., 58, 8139 (2010),<br></p>

<p>Applications Teflubenzuron is an benzoylphenylurea chitin synthesis inhibitor used to control a wide range of insect pests and mites in fruit, vegetable, cereal and seed crops. Teflubenzuron is used in cannabis testing kits as a component of pesticide mixes (P698240).<br>References Carro, A.M., et al.: J. Separat. Sci., 35, 2866 (2012); Brock, T.C.M., et al.: Environ. Sci. Pollu. Res., 19, 3610 (2012);<br></p>

<p>Stability Hygroscopic<br>Applications 5-Aminoimidazole-4-carboxamide Lactose Adduct is a lactose adduct of 5-Aminoimidazole-4-carboxamide (A611690), a metabolite of Temozolomide (T017775).<br>References Jaeken, J., et al.: Lancet, 2, 1058 (1984), Baggott, J., et al.: Biochem. J., 236, 193 (1986), Baggott, J., et al.: Arch. Dermatol., 135, 813 (1999)<br></p>

<p>Applications A metabolite of polycyclic aromatic hydrocarbons in humans.<br>References Jacob, J., et al.: Xenobiotica, 12, 45 (1982), Becher, G., et al.: Cancer Lett., 17, 301 (1983), Hoffmann, D., et al.: Cancer Treat. Res., 72, 1 (1995), Einolf, H., et al.: Chem. Res. Toxicol., 10, 609 (1997),<br></p>

<p>Applications Bone metabolism modulator; inhibits bone resorption while maintaining bone formation. Antiosteoporotic.<br>References Buehler, J., et al.: Bone, 29, 176 (2001), Henrotin, Y., et al.: J. Bone Miner. Res.,16, 299 (2001), Meunier, P.J., et al.: N. Engl. J. Med., 350, 459 (2004),<br></p>

<p>Stability Hygroscopic<br>Applications Orally active acyclic labelled nucleoside with inhibitory activity towards several herpes viruses. Antiviral.<br>References Collins, P., et al.: J. Antimicrob. Chemother., 5, 431 (1979); Matsumoto, H., et al.: Chem. Pharm. Bull., 36, 1153 (1988); Whitley, R.J., et al.: N. Engl. J. Med., 327, 782 (1992)<br></p>

<p>Applications Cyclizine is a piperazine derivative with anti-emetic activity that is useful in the prevention and treatment of nausea and vomiting associated with motion sickness. Antiemetic.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Kuntzman, R., et al.: J. Pharmacol. Exp. Ther., 158, 332 (1967), Walker, R., et al.: Eur. J. Pharm. Sci., 4, 301 (1996), Dumasia, M., et al.: Xenobiotica, 32, 795 (2002),<br></p>

<p>Applications Isopyridoxal Hydrochloride is an active vitamer of the B6 complex in humans, and a metabolite standard in the determination of all seven vitamin B6-related compounds. It is also a metabolite in a pyridoxine degradation pathway by soil bacteria.<br>References Edwards, P., et. al.: Clinica Chimica Acta: Int. J. Clin. Chem., 190, (1990); Lee, Y. C., et. al.: J. Bio. Chem., 261, (1986); Argoudelis, C. J.: J. Chromatogr. A, 790, (1998)<br></p>

<p>Applications Isometheptene Maleate belongs to a group of sympathomimetic amine and shows very little antihypertensive activity. Isometheptene Maleate is used as an antispasmodic drug.<br>References Vidrio, H. et al.: J. Pharmacol. Exp. Therap., 187, 308 (1973); Taylor, W.G. et al.: Drug Metab. Disp., 5, 564 (1977);<br></p>

<p>Applications 2,4'-Dichlorobenzophenone is used in the synthesis of triarylcarbinol analogs of fenarimol as potent inhibitors of Trypanosoma cruzi. It can also be used to prepare fatty acid amide hydrolase inhibitors.<br>References Keenan, M., et al.: J. Med. Chem., 55, 4189 (2012); Roughley, S., et al.: Bioorg. Med. Chem. Lett., 22, 901 (2012)<br></p>

<p>Applications A novel semi-synthetic taxane with antitumor activity used for the treatment of castration-resistant prostate cancer. A microtubule inhibitor.<br>References Agarwal, N. et al.: Fut. Oncol., 7, 15 (2011); Mita, A. et al.: Clin. Cancer Res., 15, 723 (2009); Figg, W.D. et al.: Cancer Biol. Ther., 10, 1233 (2010);<br></p>

<p>Applications Dopamine D2-receptor antagonist with anticholinesterase activity. Gastroprokinetic.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Iwanaga, Y., et al; Jpn. J. Pharmacol., 56, 261 (1991), Mushiroda, T., et al.: Drug Metab. Dispos., 28, 1231 (2000),<br></p>

<p>Applications 1,8-Naphthoic Anhydride is used in the synthesis of napthalimide analogues as anticancer agents.<br>References Verma, M. et al.: Eur, J, Med. Chem., 68 (2013); Quintana-E,. et al.: Bioorg, Med. Chem., 21, 6484 (2013);<br></p>

<p>Applications Chlorthiamid<br></p>

<p>Applications Benzyldecyldimethylammonium Chloride is a biocide.<br>References Lee, M., et al.: Appl. Micro. Biotech., 87, 1109 (2010); Campanac, C., et al.: Antimicrob. Agents Ch., 46, 1469 (2002); Shen, J., et al.: Anal. Chem., 62, 116 (1990)<br></p>

<p>Applications Amcinonide (A576150) analog as glucocorticoid receptor agonists for the treatment of inflammation and allergic conditions.<br>References Woodford, R., et al.: Curr. Ther. Res., 26, 301 (1979),<br></p>

<p>Applications S-Form of Dropropizine. Cough suppressive phenylpiperazine derivative. Antitussive.<br>References Noel, P.R.B., et al.: Arzneim.-Forsch., 19, 1246 (1969), Cartwright, K., et al.: J. Pharm. Pharmacol., 23, Suppl., 247S (1971), Moreo, GC., et al.: Gazz. Med. Ital., 140, 409 (1981),<br></p>

<p>Applications Benzthiazide is a diuretic, antihypertensive agent.<br>References Mollica, J., et al.: J. Pharm. Sci., 58, 635 (1969), Chienthavorn, O., et al.: J. Pharm. Biomed. Anal., 36, 477 (2004),<br></p>

<p>Applications O-Desethyl Dapagliflozin is derivative of antidiabetic drug Dapagliflozin (D185370), which is sodium-glucose transporter 2 inhibitor.<br>References Kasichayanula, S., et al.: Diabetes, Obesity and Metabolism 13, 47 (2011); Xu, G., et al.: J. Med. Chem., 57, 1236 (2014);<br></p>

<p>Applications trans-Permethrin is the trans isomer of Permethrin (P288500) which is a common synthetic pyrethoid insecticide with low mammalian toxicity.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Itaya, N., et al.: ACS Sym. Ser., 42, 45 (1977); Elliott, M., et al.: Nature, 246, 169 (1973);<br></p>

<p>Applications Sitagliptin is a trizolopyrazine dipeptidyl peptidase IV inhibitor. Sitagliptin has recently been approved for the therapy of type II diabetes.<br>References Kim, D., et al.: J. Med. Chem. 48, 141 (2005), Ahren, B., et al.: Eur. J. Pharmacol. 521 164 (2005), Bergman, A., et al: Clin. Ther. 28, 55 (2006)<br></p>

<p>Stability Hygroscopic<br>Applications Labelled analogue of Cloxacillin, an antibiotic that belongs to the group of the isoxazolylpenicillins. Cloxacillin is used to treat infections caused by species of staphylococci that produce beta-lactamase due to its inhibitory effects on beta-lactamase binding.<br>References Gibbs, D.L. et al.: Curr. Microbiol., 2, 239 (1979); Dmitrova, D. et al.: Farmat., 48, 28 (2001); Craven, N. et al.: Res. Vet. Sci., 29, 57 (1980);<br></p>

<p>Applications Mandestrobin is a novel fungicide having a methoxyacetamid structure. Mandestrobin also shows safer profiles for human health and the environment.<br>References Hirotomi, D., &amp; Kiguchi, S.: PCT Int. Appl., WO 2017026526 A1 20170216 (2017)<br></p>

<p>Applications Pyridaben is a pyridazinone derivative used as an insecticide and acaricide. In the European Union, Pyridaben has been authorized for use as an insecticide and acaricide from 1 May 2011. In Germany, Austria and Switzerland, no plant protection products containing this active substance are authorized. Pyridaben is a colorless solid that is practically insoluble in water. Useful in cannabis testing kits as a component of pesticide mixes (P698235).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Wadleigh, R., et al.: J. Chem. Ecol.,14, 1279 (1988), Hirata, K., et al.: J. Pestic. Sci., 20, 177 (1995), Chen, F., et al.: J. Entomol. Sci., 42, 296 (2007),<br></p>

<p>Applications 16alpha-Hydroxy-17beta-estradiol-2,4-d2 (CAS# 53866-32-3) is a useful isotopically labeled research compound.<br></p>

<p>Applications Tembotrione is one of the pesticides found in surface waters. It can also be found as pesticide residues in fruits and vegetables.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Moschet, C., et al.: Environ. Sci. Technol., 48, 5423 (2014); Wang, J., et al.: J. Agric. Food Chem., 62, 10375 (2014);<br></p>

<p>Applications Nicergoline-d3 is the labeled analogue of Nicergoline(N394550), a drug used for age-dependent cognitive impairment such as Alzheimers disease and other types of dementia.<br>References Caraci, F., et. al.: Brain Res., 1047, 30 (2005); Mizuno, T., et. al.: Brain Res., 1066, 78 (2005)<br></p>

<p>Applications A metabolite of Clomipramine.<br>References McTavish, D., et al.: Drugs, 39, 136 (1990), Chauret, N., et al.: Drug Metab. Dispos., 25, 1130 (1997), Gex-Fabry, M., et al.: Ther. Drug Monit., 22, 701 (2000), Herrera, D., et al.: J. Clin. Pharmacol., 40, 1488 (2000),<br></p>

<p>Applications 2,3,5-Trichloropyridin-4-amine (cas# 28443-69-8) is a useful research chemical.<br></p>

<p>Applications A metabolite of Chlorpyrifos (C425300).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Barron, M.G., et al.: Environ. Toxicol. Chem., 12, 1469 (1993), Tang, J., et al.: Drug Metab. Dispos., 29, 1201 (2001),<br></p>

<p>Applications Labelled antilipemic.<br>References Fuccella, L.M., et al.: Clin. Pharmacol. Ther., 28, 790 (1980), Lovisolo, P.P., et al.: Pharmacol. Res. Commun., 13, 151 (1981), Aktories, K., et al.: Arzneim.-Forsch., 33, 1525 (1983), Boatman, P., et al.: J. Med. Chem., 51, 7653 (2008), Rigazio, S., et al.: Am. J. Physiol., 295, E413 (2008),<br></p>

<p>Impurity Ezetimibe Ketone (USP)<br>Applications Phase-I metabolite of Ezetimibe (E975000).<br>References Shah, V., et al: J. Pharm. Sci., 17, 1551 (2000), Van Heek, M., et al.: Br. J. Pharmacol., 134, 409 (2001), Watts, G., et al.: Clin. Sci.,103, 595 (2002), Ghosal, A., et al.: Drug Metab. Dispos., 32, 314 (2004), Sistla, R., et al.: J. Pharm. Biomed. Anal., 39, 517 (2005),<br></p>

<p>Applications rac cis-Paroxetine N-Methyl is an impurity formed in the synthesis Paroxetine (P205750) related compounds.<br>References Gangula, S., et al.: Syn. Commun., 42, 3344 (2012);<br></p>