Toxicologie

<p>Applications A labelled selective cyclooxygenase-2 (COX-2) inhibitor. Anti-inflammatory. Used in the treatment of familial adenomatous polyposis.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Simon, L.S., et al.: Arthritis Rheum., 41, 1591 (1998), Silverstein, F.E., et al.: J. Am. Med. Assoc., 284, 1247 (2000), Steinbach, G., et al.: N. Engl. J. Med., 342, 1946 (2000),<br></p>

<p>Stability Hygroscopic<br>Applications A metabolite of Carnitine.<br>References Huang, Z., et al.: Anal. Biochem., 199, 98 (1991), Friolet, R., et al.: J. Clin. Invest., 94, 1490 (1994), Rashed, M., et al.: Pediatr. Res., 38, 324 (1995), Costa, C., et al.: J. Lipid Res., 38, 173 (1997),<br></p>

<p>Applications Benzamide is a compound that is widely used as a starting material for various organic syntheses and reactions. Benzamide derivatives are prevalent in the pharmaceutical industry, for example Raclopride (R070800), a Dopamine (D533780) D-2 agonist that is used to treat patients with Parkinson’s Disease. Benzamide derivatives are also used in chemistry, for example N-nitrophenyl benzamide derivatives are used as chromosensors to detect cyanide in aqueous environments.<br>References Ehrin, E., et al.: Int. J. Appl. Rad. Isot., 36, 269 (1985); Sun, Y., et al.: Tetrahedron, 65, 3480 (2009); Terai, M., et al.: Eur. J. Pharm., 173, 177 (1989)<br></p>

<p>Impurity Ipratropium EP Impurity E<br>Applications N-Isopropyl Noratropine is a Noratropine derivative, an intermediate in the production of Ipratropium.<br>References Simms, P., et al.: J. Pharm. Biomed. Anal., 17, 841 (1998),<br></p>

<p>Applications Labelled 7α-Hydroxy-4-cholesten-3-one (H825130). 7α-Hydroxy-4-cholesten-3-one is a metabolite of Cholesterol (C432501).<br>References Connor, W., et al.: J, Clin. Invest., 48, 1363 (1969),<br></p>

<p>Applications Tenivastatin Calcium is derived from Simvastatin (S485000), which is a synthetic derivative of a fermentation product of Aspergillus terreus. A competitive inhibitor of HMG-CoA reductase. A synthetic analog of Lovastatin. Antilipemic. Simvastatin, the drug, is sold under the trade name Zocor.<br>References Hoffman, W.F., et al.: J. Med. Chem., 29, 849 (1986), Mol, M.J., et al.: Lancet, 2, 936 (1986)<br></p>

<p>Impurity Azithromycin EP Impurity E<br>Applications A metabolite of Azithromycin. Azithromycin Impurity E<br>References Bright, G., et al.: J. Antibiotics., 41, 1029 (1988), Amacher, D., et al.: Antimicrob. Agents Chemother., 35, 1186 (1991), Peters, D., et al.: Drugs, 44, 750 (1992),<br></p>

<p>Impurity Rocuronium EP Impurity C<br>Applications 17-Desacetyl Rocuronium Bromide (Rocuronium EP Impurity C) is a metabolite of Rocuronium (R639500), in human plasma.<br>References Kleef, U., et al.: J. Chromatogr., 621, 65 (1993), Proost, J., et al.: Br. J. Anaesth., 85, 717 (2000),<br></p>

<p>Applications Semisynthetic labelled Erythromycin derivative. Antibacterial.<br>References Jones, R.N., et al.: Antimicrob. Agents Chemother., 24, 209 (1983), Barry, A.L., et al.: Eur. J. Clin. Microbiol., 5, 536 (1986), Grassi, C., et al.: Chemioterapia, 6, 41 (1987),<br></p>

<p>Applications Triclosan is used as bactericide and preservative for cosmetic and detergent compositions (1). Broadly used as an antiseptic and disinfectant (2).This compound is a contaminant of emerging concern (CECs). Drinking water contaminant candidate list 3 (CCL 3) compound as per United States Environmental Protection Agency (EPA). Environmental contaminants; Food contaminants.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References 1. Lindström, A. et al.: Environ. Sci. Technol. 2002 Jun 1;36(11):2322-9. 2. Ruszkiewicz, J. et al.: J. Toxicol. Environ. Health B. Crit. Rev. 2017;20(2):104-117.<br></p>

<p>Applications N-Desmethyl Ulipristal Acetate is the N-monodemethylated analogue and metabolite of the selective progesterone receptor modulator Ulipristal Acetate (U700810). N-Desmethyl Ulipristal Acetate contributes significantly to the antiprogestational activity of its parent compound.<br>References Attardi, B.J. et al.: J. Steroid Biochem. Mol. Biol., 88, 277 (2004);<br></p>

<p>Applications Metalaxyl-M is an isomer of Metalaxyl (M258740), an agricultural fungicide. Phenylamide fungicide or use in food crops, shrubs and turf.<br>References Al-Alam, J. et al.: Anal. Bioanal. Chem., 409, 5157 (2017);<br></p>

<p>Applications A phosphocholine ester metabolite of the immunosuppressant macrolide SDZ RAD (also known as Everolimus E945400) which is an analog of the parent drug Rapamycin (R124000).<br>References Zollinger, M. et al.: Drug. Metab. Disp., 36, 1457 (2008); Kovarik, J. M., et al.: Clin. Pharmacol. Ther., 69, 48 (2001);<br></p>

<p>Applications 6β-Hydroxy-3α,5α-cycloandrostan-17-one is a degredation product of Dehydroepiandrosterone Sodium Sulfate (S673250), an active agent in the preparation of a pharmaceutical for the treatment of asthma or other respiratory diseases.<br>References Ishihara, T., et al.: Drug. Develop. Indust. Pharmacy., 5, 263 (1979); Sollman, P.B., et al.: J. Org. Chem., 28, 3559 (1963); Van Renterghem, P., et al.: Steroids., 75, 1047 (2010);<br></p>

<p>Impurity Carvedilol EP Impurity B; Carvedilol Impurity B; Carvedilol USP B<br>Applications Carvedilol Bis-carbazole (Carvedilol EP Impurity B; Carvedilol Impurity B; Carvedilol USP B) is an impurity from the process of Carvedilol (C184625).<br></p>

<p>Stability Hygroscopic<br>Applications Fluorescein-Cadaverine is a fluorescein derivative used in the preparation of biologically active fluorescent-labeled vitamin K analogues and monitoring of their subcellular distribution.<br>References Suhara, Y. et al.: Tetrahedron, 64, 8789 (2008);<br></p>

<p>Stability Hygroscopic<br>Applications Octenidine is an antiseptic (topical). Octenidine is a cationic surfactant and bis-(dihydropyridinyl)-decane derivative.<br>References Slee, A.M., et al.: Antimicrob. Agents Chemother., 23, 531 (1983), Ghannoum, M.A., et al.: J. Antimicrob. Chemother., 25, 237 (1990), Allen, M., et al.: Microbiology, 152, 989 (2006), Ojha, A., et al.: Mol. Microbiol., 66, 468 (2007),<br></p>

<p>Applications A degradation and metabolic intermediate of Betamethasone (B3270000).<br></p>

<p>Applications Daclatasvir, inhibits the HCV protein NS5A, and thus can be used as a drug candidate for the treatment of hepatitis C (HCV).<br>References Gao, M., et al.: Nature, 465(7294), 96 (2010); Bell, T. W., Chem. Med. Chem., 5(10), 1663 (2010);<br></p>

<p>Stability Unstable in DMSO solution<br>Applications Chlorimuron-ethyl is used in weed control method as herbicide.<br>References Sada, Y., et al.: PCT Int. Appl. 45 pp. (2020)<br></p>

<p>Applications Tropine derivative with anticholinergic activity. Antispasmodic; used in treatment of urinary incontinence.<br>References Antweiler, H., et al.: Arzneim.-Forsch., 16, 1581 (1966), Lux, G., et al.: Fortschr. Med., 96, 2113 (1978), Madersbacher, H., et al.: Br. J. Urol., 75, 452 (1995), Zinner, N.R., et al.: Expert Opin. Pharmacother., 6, 1409 (2005),<br></p>

<p>Impurity Beclomethasone Dipropionate EP Impurity H<br>Applications Beclomethasone 17-Propionate (Beclomethasone Dipropionate EP Impurity H) is an active metabolite of Beclomethasone Dipropionate (BDP).<br>References Soria, I., et al.: Biopharm. Drug Dispos., 19, 297 (1998), Harrison, L., et al., J. Pharm. Pharmacol., 51, 1235 (1999), Daley-Yates, P., et al.: Br. J. Clin. Pharm., 51, 400 (2001).<br></p>

<p>Applications Disodium Salt of 3-Methylphosphinicopropionic Acid, the major metabolite of Glufosinate (G596950), used as herbicide.<br>References Royer, A., et al.: Anal. Chem., 72, 3826 (2000), Muller, B., et al.: Pestic. Manag. Sci., 57, 46 (2001), Duke, S., et al.: J. Agric. Food Chem., 51, 340 (2003),<br></p>

<p>Applications N-Acetyl-S-(3-hydroxypropyl-1,1,2,2,3,3-D6)cysteine Dicyclohexylammonium Salt is labelled N-Acetyl-S-(3-hydroxypropyl)cysteine Dicyclohexylammonium Salt (A179075), which is a metabolite of halopropanes.<br>References Barnsley, E.A.: Biochem. J., 100, 362 (1966)<br></p>

<p>Applications A chloroacetanilide herbicide used on vegetable crops.<br>References Matthies, M., et al.: Environ. Sci. Technol., 43, 9223 (2009); Hollender, J., et al.: Environ. Sci. Technol., 43, 7862 (2009); Dresen, S., et al.: Anal. Bioanal. Chem., 396, 2425 (2010); Liu, B., et al.: J. Agric. Food Chem., 58, 2673 (2010);<br></p>

<p>Applications Macitentan-d4 is an isotopic form of Macitentan (M105005). Macitentan, is an orally active endothelin receptor antagonist used for pulmonary arterial hypertension.<br>References Emoto, N. Ensho to Men'eki, 20, 487 (2012);<br></p>

<p>Applications Fenfluthrin can be used in agricultural use and as analyte in analytical/biological study of retrospective screening of relevant pesticide metabolites in food using liquid chromatography high resolution mass spectrometry and accurate-​mass databases of parent molecules and diagnostic fragment ions.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Polgar, L., et al.: J. Chromatogr. A., 1249, 83-91 (2012)<br></p>

<p>Applications Labelled Ticagrelor (T437700), the first reversible oral P2Y12 receptor antagonist, provides faster, greater, and more consistent ADP-receptor inhibition than Clopidogrel. Used in the treatment of acute coronary syndromes (ACS).<br>References Matetzky, S., et al.: Circulation, 109, 3171 (2004), Bassand, J., et al.: Eur. Heart J., 28, 1598 (2007), Jakubowski, J., et al.: Cardiovasc. Drug Rev., 25, 357 (2007),<br></p>

<p>Applications ω-Hydroxy-DEET is a metabolite of DEET (D228500), an insect repellant commonly used to prevent contact with mosquitoes.<br>References Constantino, L. &amp; Iley, J.: Xenobiotica, 29, 409 (1999); Syed, Z. &amp; Leal, W.: P. Natl. Acad. Sci. USA, 105, 13598 (2008)<br></p>

<p>Stability Hygroscopic<br>Applications N-(2-Ethyl-6-methylphenyl)-N-(2-sulfoacetyl)-L-alanine is a pesticide metabolite that is a pollutant found in in surface water and groundwater.<br>References Reemtsma, T., et al.: J. Chromatogr. A, 1271, 95 (2013); Hand, L., et al.: Environ. Toxicol. Chem., 35, 1401 (2016);<br></p>

<p>Applications An isotopically Labelled metabolite of Itraconazole, an orally active antimycotic structurally related to Ketoconazole. It is a COVID19-related research product.<br>References Saag, M., et al.: Antimicrob. Agents Chemother., 32, 1 (1988), Haria, M., et al.: Drugs, 51, 585 (1996), Kousoulos, C., et al.: Anal. Bioanal. Chem., 384,199 (2006),<br></p>

<p>Stability Hygroscopic<br>Applications One of the bioactive forms of Riboflavin. Nutritional factor found in milk, eggs, malted barley, liver, kidney, heart, leafy vegetables. Richest natural source is yeast. Minute amounts present in all plant and animal cells. Vitamin (enzyme cofactor).<br>References Unna, K., et al.: J. Pharmacol. Exp. Ther., 76, 75 (1942), Rivlin, et al.: N. Engl. J. Med., 283, 463 (1970), Al-Shammary, F.J., et al.: Anal. Profiles Drug Subs., 19, 429 (1990),<br></p>

<p>Applications Fingolimod is a novel immune modulator that prolongs allograft transplant survival in numerous models by inhibiting lymphocyte emigration from lymphoid organs.<br>References Brinkmann, V., et al.: Transplantation, 72, 764 (2001), Brinkmann, et al.: J. Biol. Chem., 277, 24, 21453 (2002), Mtaloubian, M., et al.: Nature, 427, 355 (2004),<br></p>

<p>Applications Isoprothiolane is a dithiolane pesticide. Isoprothiolane is commonly used in agriculture as a fungicide to control planthoppers and blast disease in rice plants.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Chin, K.M.: Malay. Agric. J., 50, 221 (1975); Ikeda, Y. et al.: Biosci. Biotech. Biochem., 57, 288 (1993); Nakamura, H.: Rev. Plant Prot. Res., 10, 1 (1977); Reddy, A.P.K. et al.: Pesticide, 22, 21 (1988);<br></p>

<p>Applications A new indicator for the determination of organic acid anhydrides by the morpholine method.<br>References Ruch, J.E., et al.: Anal. Chem., 47, 2057 (1975),<br></p>

<p>Applications Analgesic.<br>References Haddad, P., et al.: Drugs, 62, 1649 (2002), Chiu, P., et al.: J. Pharmacol. Sci., 95, 311 (2004), Dubin, A., et al.: J. Biomol. Screen, 10, 168 (2005),<br></p>

<p>Applications An endogenous estrogen metabolite, risk-factor for development of breast cancer.<br>References Beral, V., et al.: Lancet, 362, 419 (2003), Nelson, R., et al.: Clin. Chem., 50, 373 (2004), Malekinejad, H., et al.: J. Agric. Food Chem., 54, 9785 (2006),<br></p>

<p>Applications Veratramine is useful as signal transduction inhibitor for treating tumors.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Imamura, L., et al.: J. Trad. Med., 12, 129 (1995), Ingolfsdottir, K., et al.: Antimicrob. Agents. Chemother., 1997, 41, 215 (1997), Tezuka, Y., et al.: J. Nat. Prod., 61, 1397 (1988)<br></p>

<p>Impurity Betamethasone Dipropionate EP Impurity D<br>Applications Betamethasone 21-acetate-17-propionate (Betamethasone Dipropionate EP Impurity D) is a related compound of Betamethasone dipropionate (B327005).<br>References Grootveld, M., et al.: Biochem. Pharmacol., 37, 271 (1988), Chen, B., et al.: Steriods, 74, 30 (2009), Mikami, E., et al.: J. Pharm. Biomed. Anal., 28, 261 (2002),<br></p>

<p>Stability Hygroscopic<br>Applications A labelled metabolite of Bisphenol A.<br>References Zalko, D., et al.: Drug Metab. Dispos., 26, 28 (1998), Matthews, J., et al.: Chem. Res. Toxico., 14, 149 (2001), Kinjo, J., et al.: Biol. Pharm. Bull., 27, 185 (2004), Murata, M., et al.: Biochemistry, 43, 2569 (2004),<br></p>

<p>Stability Hygroscopic<br>Applications Benfotiamine-Amide is an analog of Benfotiamine, which is a Vitamin B1 analog. Synthetic S-acyl derivative of Thiamine (T344185).<br>References Stracke, H., et al.: Exper. Clin. Endocrinol., Diabetes, 116, 600 (2008), Gohil, V., et al.: Nat., Biotechnol., 28, 249 (2010),<br></p>

<p>Stability Hygroscopic<br>Applications A metabolite of Digoxin (Dx) (D446575).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Fujii, Y., et al.: Clin. Chem., 37, 476 (1991), Salphati, L., et al.: Xenobiotica, 29, 171 (1999), Song, S., et al.: Drug Metab. Dispos., 27, 689 (1999),<br></p>

<p>Applications Lidocaine-d6 Hydrochloride is the labeled analogue of Lidocaine Hydrochloride, a local anesthetic; antiarrhythmic (class IB). Long-acting, membrane stabilizing agent against ventricular arrhythmia. Originally developed as a local anesthetic.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Duce, R., et al.: J. Pharmacol. Exp. Ther., 179, 580 (1971), Kronberg, G.H., et al.: J. Med. Chem., 16, 739 (1973), Groningsson, K., et al.: Anal. Profiles Drug Subs., 14, 207 (1985), Davies, P.S., et al.: Drugs, 64, 937 (2004),<br></p>

<p>Applications (-)-Carbovir, is a nucleoside/nucleotide reverse transcriptase inhibitor (NRTI) caused mitochondrial toxicity in human hepatoma carcinoma cell.<br>References Suo, Z., et al.: J. Biol. Chem., 273, 27250 (1998), Ray, A., et al.: Antimicrob. Agents Chemother., 48, 1089 (2004), Lynx, M., et al.: Biochem. Pharmacol., 71, 1342 (2006),<br></p>

<p>Applications A metabolite of Testosterone (T155000).CONTROLLED SUBSTANCE<br>References Brandon, E., et al.: Toxicol. Appl. Pharmacol., 189, 233 (2003), Froehlich, A., et al.: Drug Metab. Dispos., 33, 1532 (2005), Schmelzer, E., et al.: Xenobiotica, 6, 693 (2006), Jasmund, I., et al.: Biomol. Eng., 24, 59 (2007),<br></p>

<p>Stability Hygroscopic<br>Applications 3-Hydroxyhexadecanoylcarnitine Inner Salt is a derivative of Carnitine, essential cofactor of fatty acid metabolism; required for the transport of fatty acids through the inner mitochondrial membrane. Synthetized primarily in the liver and kidney; highest concentrations found in heart and skeletal muscle. Dietary sources include red meat, dairy products, beans, avocado. Also 3-Hydroxyhexadecanoylcarnitine works similar to the endogenous non-toxic molecule L-Carnitine (C184110) whose bioavailablity is improved due to the transport systems in place for Carnitine.<br>References Mitchell, M.E., et al.: Am. J. Clin. Nutr., 31, 293 (1978), Lango, R., et al.: Cardiovasc. Res., 51, 21 (2001), Vaz, F.M., et al.: Biochem. J., et al.: 361, 417 (2002), Karlic, H., et al.: Nutrition, 20, 709 (2004), O. Piermatti. et al.: Bioorg. Med. Chem., 16, 1444 (2008);<br></p>

<p>Applications The major metabolite of Mosapride (M731000).<br>References Somogyi, A., et al.: Clin. Pharmacokinet., 8, 463 (1983), Cashman, J., et al.: Drug Metab. Dispos., 21, 587 (1993), Berkman, C., et al.: Biochem. Pharmacol., 50, 565(1995), Blake, B., et al.: Xenobiotica, 25, 377 (1995),<br></p>

<p>Applications A thienodiazepine derivative that possesses anxiolytic, skeletal muscle relaxant anticonvulsant, sedative properties as well as contributing to siginificant increase stage 2 NREM sleep. It binds to benzodiazepine site of the GABAA receptor where it acts as a full agonist resulting in enhanced GABA inhibitory effect at the GABAA receptor. Controlled Substance.<br>References Mandrioli, R. et al.: Curr.Drug Metab., 8, 827 (2008); Nakazawa, Y. et al.: Psychopharmacol., 44, 165 (1975); Yakushiji, T. et al.: Br. J. Pharmacol., 98, 735 (1989);<br></p>

<p>Applications NS-398 is a selective Cox-2 inhibitor neuroprotective agent.<br></p>

<p>Applications Emamectin B1 Benzoate is a neurotoxic pesticidal compound. A potential anti-leukemia agent. Also applied in pesticidal screening and control techniques.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Li, H., et al.: Agr. Sci. Tech., 15, 1707 (2014); Tang, T., et al.: Zhiwu Baohu, 42, 222 (2016); Yun, X., et al.: Environ. Toxicol. Pharmacol., 52, 280 (2017)<br></p>

<p>Applications Physiological analog of vitamin B12 where the CN group is replaced with OH. Exists in aqueous solution as an equilibrium mixture of the hydroxy isomer and the ionic aqua isomer (aquacobalamin). Precursor of the coenzymes methylcobalamin and cobamamide. Coordination Compound. Vitamin (hematopoietic).<br>References Kaczka, E.A., et al.: Science, 112, 354 (1950), Friedrich, W., et al.: Vitamins, 837 (1988), Forsyth, J.C., et al.: Clin. Toxicol., 31, 277 (1993),<br></p>

<p>Applications Triterpenoid which can inhibit the proliferation of leukemia HL-60 cells.<br>References Cho, J., et al.: Pulmon. Pharmacol. Ther., 23, 190 (2010), Gohil, V., et al.: Nat. Biotechnol., 28, 249 (2010), Saha, S., et al.: J. Agric. Food Chem., 58, 434 (2010),<br></p>

<p>Applications Enzalutamide Carboxylic Acid is used as hormone therapies to prevent androgen-fuled growth of castrate-resistant prostate cancer.<br>References Tomasz, M.B., et al.: New Engl, J. Med., 424, 371 (2014);<br></p>

<p>Stability Moisture Sensitive<br>Applications Phoxim is an organophosphate insecticide. It is an analogous dimethyl ester and an organothiophosphate acaricide.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Lu, Y., et al.: Nature, 487, 362 (2012); Jokanovic, M., et al.: Arch. Toxicol., 70, 119 (1995); Wang, W., et al.: Pest. Biochem. Physiol., 84, 180 (2006)<br></p>

<p>Stability Light Sensitive, Temperature Sensitive<br>Applications A metabolite of all-trans Retinoic acid (R250200).<br>References Idres, N., et al.: Cancer Res., 61, 700 (2001), Taimi, M., et al.: J. Biol. Chem., 279, 77 (2004), Vermot, J., et al.: Science, 308, 563 (2005),<br></p>

<p>Applications Ranitidine-d6 is a labeled histamine H2-receptor antagonist which inhibits gastric acid secretion. Antiulcerative.<br>References Bradshaw, J., et al.: Brit. J. Pharmacol., 66, 464 (1979); Berstad, A., et al.: Scand. J. Gastroenterol, 15, 637 (1980); Hohnjec, M., et al.: Anal. Profiles Drug Subs., 15, 533 (1986)<br></p>

<p>Applications Atorvastatin impurity. Atorvastatin Methyl Ester<br>References Graul, A., et al.: Drugs Future, 22, 956 (1997),<br></p>

<p>Applications Isotope labelled N-Nitrosodiphenylamine (N525775), which is the N-nitroso analogue of diphenylamine that was once used as a rubber additive but is no longer due to undesirable carcinogenic effects (1). N-Nitrosodiphenylamine may have potential carcinogenic activity and is currently classified as a probable carcinogen by EPA with genetic toxicity (2,3).Drinking water contaminant candidate list 3 (CCL 3) compound as per United States Environmental Protection Agency (EPA), environmental, and food contaminants.<br>References 1. Boyland, D. et al.: Eur. J. Cancer. 1968. May;4(2):233-2342. Iversen, O. et al.: Eur. J. Cancer. 1980 May;16(5):695-8.3. McGregor, D. et al.: Mutat. Res. Rev. Gen. Toxicol. 1994 Jun:317(3):195-211<br></p>

<p>Applications Labelled Clopidogrel, an antithrombotic.<br>References Mills, D.C.B., et al.: Arterioscler. Thromb., 12, 430 (1992), Feuerstein, G., et al.: Exp. Opin. Invest. Drugs, 4, 425 (1995)<br></p>

<p>Applications A metabolite of Venlafaxine.<br></p>

<p>Applications A novel bile acid, an analogue of Cholic acid (C432600).<br>References Yamaga, N., et al.: J. Biochem., 116, 1123 (1994),<br></p>

<p>Stability Hygroscopic<br>Applications Disodium salt of Mosapride (M731000) derivative.<br>References Yoshida, N., et al.: Arch. Int. Pharmacodyn. Ther., 300, 51 (1989), Yatera, S., et al.: Japan. Pharmacol. Ther., 21, 21 (1993), Ruth, M., et al.: Aliment Pharmacol. Ther., 12, 35 (1998),<br></p>

<p>Impurity Irinotecan USP Related Compound E<br>Applications An anticancer drug, showed strong activity against various murine tumors. A Camptothecin (CPT) derivative as antineoplastic agent against drug-resistant tumors. Irinotecan USP Related Compound E.<br>References Brangi, M., et al.: Cancer Res., 59 5938 (1999), Miyake, K., et al.: Cancer Res., 59, 8 (1999) , Bom, D., et al.: J. Med. Chem., 43, 3970 (2000) , Gamcsik, M., et al.: Mol. Cancer Ther., 1, 11 (2001).<br></p>

<p>Applications A new Sildenafil (S435000) analogue.<br>References Balayssac, S., et al.: J. Pharm. Biomed. Anal., 50, 602 (2009),<br></p>

<p>Stability Hygroscopic<br>Applications A cell-permeable DNA-binding dye. Binds preferentially to DNA rich in adenine and thymine. Used in flow cytometry for measuring nuclear DNA content or for sorting isolated chromosomes.<br>References Jpeeesen, C, and Nielsen, P.E.: Eur. J. Biochem., 182, 437 (1989), Li,J., et al.: J. Exp. Biol., 200, 1499 (1997), Zaitsev, E.N., and Kowalczykowsi, S.C.: Nucl. Acids Res., 26(2), 650 (1998), Germ, M., et al.: Biochem. Biophys. Res. Commun., 261, 452 (1999),<br></p>

<p>Applications N,N-Dimethylnicotinamide-2-sulfonamide (cas# 112006-75-4) is a compound useful in organic synthesis.<br></p>

<p>Applications Naloxone-d5 3-β-D-Glucuronide is a labelled metabolite of Naloxone ((N285000). Narcotic antagonist.<br>References Scheurer, U., et al.: J. Pharmacol. Exp. Ther., 252, 1324 (1990), Yuan, C., et al.: Clin. Pharmacol. Ther., 59, 469 (1996), Ulens, C., et al.: Biochem. Pharmacol., 62, 1273 (2001), Comert, M., et al.: Eur. J. Pharmacol., 511, 183 (2005),<br></p>

<p>Applications Phosphonomethanol has been used in the investigation on the stereochemistry of 2-Hydroxyethylphosphonate Dioxygenase.<br>References Whitteck, J.T., et al.: J. Am. Chem. Soc., 133, 4236 (2011); Duca, J.S., et al.: Chem. Materials., 12, 3821 (2000);<br></p>

<p>Applications Labelled Clomiphene. Synthetic estrogen agonist-antagonist. Gonad-stimulating principle.<br>References Palopoli, F.P., J. Med. Chem., 10, 84 (1967), Ernst., et al.: J. Pharm. Sci., 65, 148 (1976), Baustian, C.L., et al.: Pharm. Biomed. Anal., 4, 237 (1986),<br></p>

<p>Stability Very Hygroscopic<br>Applications A benzoquidine diimine derivative useful as animal growth substance.<br>References Clark, R., et al.: J. Agric. Food Chem., 44, 3643 (1996), Sadowski, J., et al.: J. Med. Chem., 41, 332 (1998), Estrada, E., et al.: J. Med. Chem., 43, 1975 (2000),<br></p>