Toxicologie

Stability Hygroscopic
Applications Metoprolol Succinate is used in the treatment of patients suffering from chronic heart failure, as well as to treat blood pressure from mild hypertension. β-adrenoceptor antagonist or β-blocker.
References Yazici, H. et al Sci. World J., 608683/1, 7 (2013); Studinger, P. et al.: J. Clin. Hyper., 15, 910 (2013);

Applications Analgesic; sedative; anesthetic.Controlled substance (opiate).
References DeRossi, R., et al.: Vet. J., 178, 294 (2008), Hoecker, J., et al.: Anesthesiol., 109, 95 (2008), Fliri, A., et al.: J. Med. Chem., 52, 8038 (2009),

Stability Moisture Sensitive
Applications Phorate Oxon Sulfone is a major metabolite of Phorate (P353500), an inhibitor of acetylcholinesterase and pseudocholinesterase.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Boshoff, P.R., et al.: J. Agr. Food Chem., 27, 626 (1979),

Applications SB 242084 is a 5-HT2C receptor antagonist that displays 158- and 100-fold selectivity over 5-HT2A and 5-HT2B receptors respectively. SB 242084 displays selectivity over a range of other 5-HT, dopamine and adrenergic receptors.SB 242084 os a brain penetrant; exerts anxiolytic-like activity.
References Bromidge, et al.: J. Med. Chem., 40, 3494 (1997), Kennet, et al.: Neuropharmacology, 36, 609 (1997), Dalton, et al.: Psychopharmacology, 185, 45 (2006),

Applications An alkylated dipeptide reported to be 6000 to 10000 times sweeter than sucrose; structurally related to Aspartame. A non-nutritive sweetener.
References Ranney, R., et al.: J. Toxicol. Environ. Health, 2, 441 (1976), Padden, B.E., et al.: Anal. Chem., 71, 3325 (1999), Arai, H., et al.: Metabolism, 56, 115 (2007),

Applications Cefpodoxime Proxetil-d7 is the labelled form of Cefpodoxime Proxetil (C243860), an antibacterial. Cefpodoxime Proxetil is a broad spectrum, orally absorbed third generation cephalosporin, ester prodrug of the active free acid metabolite, Cefpodoxime (C243850).
References Fujimoto, K., et al.: J. Antibiot., 40, 370 (1987), Utsui, Y., et al.: Antimicrob. Agents Chemother., 31, 1085 (1987),

Applications Hexazinone is a herbicide. It functions by inhibiting photosynthesis and thus is a nonselective herbicide. Hexazinone is a pervasive groundwater contaminant, due to its high water solubility.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Kennedy, K., et al.: Weed Sci., 58, 317 (2010); Yanase, D., et al.: Pes. Biochem. Physio., 44, 60 (1992); Johnson, J., et al.: Tree Physio., 8, 371 (1991)

Applications Valifenalate is used in antibacterial compositions and method for controlling of plant disease with improved effect, fungicides preparation and phytosanitary treatments with fungicides.
References Gonnzalez-Alvarez, M., et al.: Food Chem., 131 826 (2012); Ogawa, M., et al.: PCT Int. Appl. (2016), WO 2016194971 A1 20161208

Applications It inhibits PDGFR tyrosine kinase with IC50=83nM. It is useful for the treatment of inflammation and as an anti-proliferative agent. Dual action VEGFR & Raf inhibitor.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Leuner, C., et al.: Eur. J. Pharm. Biopharm., 50, 47 (2000),

Applications Isotope labelled Bisphenol A β-D-Glucuronide is the glucuronide conjugate and metabolite of bisphenol A (B519495), an monomer used for policarbonate and epoxy resins.
References Zalko, D., et al.: Drug Metab. Dispos., 26, 28 (1998), Matthews, J., et al.: Chem. Res. Toxico., 14, 149 (2001), Kinjo, J., et al.: Biol. Pharm. Bull., 27, 185 (2004), Murata, M., et al.: Biochemistry, 43, 2569 (2004),

Applications Antineoplastic; non-selective steroidal aromatase inhibitor that prevents the conversion from androgen to estrogen. Used in in the treatment of familial male precocious puberty. An effective anti-tumor agent.
References Dunkel, L.: Mol. Cell. Endocrinol., 254, 207 (2006); Eugster, E. A.: Treat. Endocrinol., 3, 141 (2004); Holbeck, S.L. et al.: Mol. Cancer Therap., 9, 1451 (2010);

Stability Moisture Sensitive
Applications Fensulfothion Oxon Sulfone is a metabolite of the insecticide fensulfonthion (F265490), an inhibitor of cholinesterase activity.
References Solly, S.R.B., et al.: New. Zea. J. Agri. Res., 14, 88 (1971); Hansch, C., et al.: Biochem. Toxicol. Insectic. Proc., 33 (1970);

Applications A neonicotinoid; the active ingredient in certain neuro-active insecticides. Reports show that when exposed to neonicotinid pesticides honeybees have problems returning home after foraging and bumblebee colonies grow poorly and produce fewer queens. Imidacloprid is useful in cannabis testing kits as a component of pesticide mixes (P698240).
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Chauzat, M., et al.: Env. Entomol., 38, 514 (2009), Patial, A., et al.: Env. Ecol., 27, 320 (2009), Fernandez-Bayo, J., et al.: J. Agric., Food Chem., 57, 5435 (2009), Tomizawa, M., et al.: J. Med. Chem., 52, 3735 (2009), Chem. and Eng. News 90: 10 (2012)

Applications An isotopically labelled, orally active antimycotic structurally related to Ketoconazole.A representative lot was 88% d5, 12% d4 with no d0. It is a COVID19-related research product.
References Espinel-Ingroff, A., et al.: Antimicrob. Agents Chemother., 26, 5 (1984), Heykants, J., et al.: Mycoses, 32, Suppl 1, 67 (1989), Sugar, A.M., et al.: Curr. Clin. Top. Infect. Dis., 13, 74 (1993),

Applications Candesartan Cilexetil-d11 is the labeled analogue of Candesartan Cilexetil (C175580), is an ester prodrug; hydrolized in vivo to the active carboxylic acid. Used in treatment of congestive heart failure. Antihypertensive.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Shibouta, Y., et al.: J. Pharmacol. Exp. Ther., 266, 114 (1993), Ogihara, T., et al.: Clin. Ther., 16, 74 (1994)

Stability Hygroscopic
Applications Bialaphos Sodium Salt is a herbicide.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Mase, S.: Japan Pesticide Info., 45, 27 (1984)

Applications 2-Methyl-4,6-dinitrophenol is a powerful toxicant with a long history of use in agriculture as a herbicide.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Heusinkveld, H. J., et al.: Toxicol. Lett., 252, 62 (2016), Bettiol, C., et al.: Environ. Sci. Pollut. Res., 23, 7398 (2016)