Toxicologie

Applications 2-Oxo Clopidogrel-d3 is he labelled analogue of 2-Oxo Clopidogrel (O869990). The essential intermediate metabolite from which the active metabolite of Clopidogel is formed.
References eliste, R., et al.: Thromb. Res., 48, 403 (1987); Savi, P., et al.: Biochem. Pharmacol., 44, 527 (1992); Herbert, J., et al.: Cardiovasc Drug. Rev., 11, 180 (1993); Sugidachi, A., et al.: B. J. Pharmacol., 132, 47 (2001)

Applications Cyhalodiamide is a diamide insecticide and an agrochemical compound.
References Zhang, Y., et al.: Int. J. Agric. Biol., 19, 1421 (2017); Xing, J., et al.: Nongyao, 54, 842 (2015)

Applications Octanoic Acid-13C4 is an isotopic analog of Octanoic Acid (O237880), which is found naturally in the milk of various mammals. Its esters can be used in perfumery and also in the manufacture of dyes. It is also an antimicrobial pesticide used as a food contact surface sanitizer. Caprylic acid is also used in the treatment of some bacterial infections.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Lide, D. R., et al.: CRC Handbook chem. Phys., 70th Ed. (1990); Beare-Rogers, J., et al.: Pue Appl. Chem., 73 (4), 685 (2001);

Stability Hygroscopic
Applications The main metabolite of Omeprazole.
References Renberg, L., et al.: Drug Metab. Dispos., 17, 69 (1989), Calabresi, L., et al.: Pharmacol. Res., 49, 493 (2004), Yin, O., et al.: J. Clin. Pharmacol., 44, 582 (2004),

Impurity Abacavir API
Applications Abacavir (Abacavir API) is a carbocyclic 2'-deoxyguanosine nucleoside reverse transcriptase inhibitor and an anti-HIV drug used to treat HIV infection (1). Intracellular enzymes convert Abacavir to its active form, carbovir-triphosphate (CBV-TP), which then selectively inhibits HIV reverse transcriptase by incorporating into viral DNA (2). Abacavir is metabolized in the liver by uridine diphosphate glucuronyltransferase and alcohol dehydrogenase resulting in inactive glucuronide and carboxylate metabolites, respectively.
References (1) Jackson, A., et al.: Antivir Ther. 17, 19 (2012) (2) Yuen, G. J., et al.: Clin Pharmacokinet. 47, 351 (2008)

Applications Stereoisomer to Darunavir (D193500), a second generation HIV-1-protease inhibitor; structurally similar to amprenavir. Antiviral. It is a COVID19-related research product.
References Koh, Y., et al.: Antimicrob. Agents Chemother., 47, 3123 (2003), Arasteh, K., et al.: AIDS, 19, 943 (2005), Surleraux, D.L.N.G., et al.: J. Med. Chem., 48, 1813 (2005),

Applications A metabolite of Ceftiofur (C244700), which is microbiologic active.
References Washburn, K., et al.: J. Vet. Pharm. Ther., 28, 247 (2005),

Impurity Minocycline Hydrochloride EP Impurity A
Stability Hygroscopic
Applications 4-Epi Minocycline (Minocycline EP Impurity A) is an impurity of Minocycline.
References Naidong, W., et al.: J. Pharm. Biomed. Anal., 13, 905 (1995)

Applications Cytidine 5’-Diphosphate Ethanolamine Disodium Salt is an analog of Cytidine 5’-Diphosphate with an important role in the metabolism of phospholipides.
References Trotter, P., et al.: J. Biol. Chem., 270, 6062 (1995), Janssen, M., et al.: Yeast, 16, 641 (2000), Henneberry, A., et al.: Mol. Biol. Cell, 12, 511 (2001), Boumann, H., et al.: Biochemistry, 42, 3054 (2003),

Applications: 5-Ethyl-2-thiouracil is a modified nucleobase and a versatile reactant used in the synthesis. It was used as a reactant in the inhibition of Hepatitis B virus (HBV) replication.
References Semaine, W., et al.: J. Med. Chem., 49, 2049 (2006);

Applications 2-Hydroxy-2,3-tetrahydrofuranyl Entecavir is an impurity of Entecavir (E558900).

Stability Light, Moisture and temperature sensitive
Applications Third generation cephalosporin antibiotic. Antibacterial.
References Brodie, A., et al.: Antimicrob. Agents Chemother., 17, 876 (1980), Richards, D.M., et al.: Drugs, 29, 105 (1985), Abounassif, M.A., et al.: Anal. Profiles Drug Subs., 19, 95 (1990),

Applications N-(2-(2,4,6-TRICHLOROPHENOXY)ETHYL)PROPAN-1-AMINE (cas# 67747-01-7) is a useful research chemical.

Applications Morphine is the principle alkaloid of opium.
References Buchwald, M.E., et al.: J. Pharmacol. Exp. Ther., 71, 197 (1941); Muhtadi, F.J., et al.: Anal. Profiles Drug Subs., 17, 259 (1988);

Applications Spinetoram J is a component of Spinetoram (S683650), a compound that belongs to the spinosyn family of insecticides and shows potential of natural products research. Useful in cannabis testing kits as a component of pesticide mixes (P698240).
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Kirst H. A.: J. Antibiot., 63, 101-111 (2010)

Applications Fluazinam is a broad spectrum fungicide. Fluazinam is commonly used for control of Sclerotinia blight and other soilborne pathogens of peanut as well for the control of potato blight.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Smith, F.D. et al.: Peanut Sci., 19, 115 (1992); Roques, J.-F. et al.: Phytoma, 460, 48 (1994); Platt, H.W. et al.: Tests Agrochem. Cult., 15, 36 (1994);

Applications 5-Chloro-3-methyl-4-nitro-1H-pyrazole (CMNP) is a pyrazole-derived plant growth regulator used as a citrus abscission agent.
References Barcelo, J., et al.: J. Plant Nutr., 13, 1 (1990), Delessert, C., et al.: Plant Mol. Biol., 55, 165 (2004), Both, M., et al.: The Plant Cell, 17, 2107 (2005),

Applications Bitertanol is a foliar-applied triazole fungicide used to protect tropical and subtropical crops in agriculture, in particular bananas. Bitertanol has effects on behavior that are similar to those of psychomotor stimulants.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Allen, A.R. et al.: Neurotoxicol. Teratol., 15, 237 (1993); Scheinpflug, H. et al.: Pflanzsensch.-Nach., 34, 8 (1981);