Toxicologie

Applications Labelled Tamsulosin. Specific α1-adrenoceptor antagonist. Used in the treatment of benign prostatic hypertrophy.
References Kawabe, K., et al.: J. Urol., 144, 908 (1990), Abrams, P., et al.: Br. J. Urol., 76, 325 (1995), Michel, M.C., Expert Opin. Pharmacother., 5, 151 (2004),

Applications 2,3,4,5,6-Pentachlorobenzeneamine is a chemical in pesticides used to protect crops from various fungus and bacterium.
References Gartrell, M. et al.: J. Assoc. Off. Anal. Chem., 68, 1163 (1985); Renner, G. et al.: App. Env. Microbio. 46, 765 (1983);

Applications Terbufoxon Sulfoxide is a metabolite of Terbufoxon (T109075), a pesticide used in the protection of fruit and vegetable crops against insects. Acetylcholinesterase inhibitor.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Rahman, Md. M. et al.: Food Chem., 133, 604 (2012); Stojan, J. et al.: Biochem., 5599 (2008); Polgar, L. et al.: J. Chrom. A., 1249, 83 (2012);

Stability Hygroscopic
Applications A partially reversible gastric proton pump inhibitor.
References Moda, T., et al.: Lett. Drug Des. Discov., 4, 502 (2007), Belaz, K., et al.: J. Pharm. Biomed. Anal., 47, 81 (2008),

Applications The active labelled carboxylic acid metabolite of Ebastine.
References Hashizume, T., et al.: Drug Metab. Dispos., 29, 798 (2001), Hashizume, T., et al.: J. Pharmacol. Exp. Ther., 300, 298 (2002), Matsumoto, S., et al.: Xenobiotica, 33, 615 (2003), Chaikin, P., et al.: Br. J. Clin. Pharmacol., 59, 346 (2005),

Applications 4,4'-Dichlorodiphenyldichloroethane - d8 is a synthetic organochlorine insecticide. 4,4'-Dichlorodiphenyldichloroethane- d8 is a metabolite of 4,4'-Dichlorodiphenyltrichloroethane - d8 (D434197). 4,4'-Dichlorodiphenyldichloroethane - d8 is a probable carcinogen (Group B2).
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Tao, S. et al.: Environ. Sci. Technol., 39, 2494 (2005); Zhou, Q. et al.: J. Chrom. A, 1216, 6680 (2009); Weiderpass, E. et al.: Cancer Epidemiol. Biomark. Prev,., 9, 487 (2000)

Stability Not Stable in hot solution
Applications Muscarinic receptor antagonist. Bronchodilator.
References Haddad, E.-B., et al.: Mol. Pharmacol., 45, 899 (1994), Donohue, J. F., et al.: Chest, 122, 47 (2002), Profita, M., et al.: Allergy, 60, 1361 (2005), Dusser, D., et al.: Eur. Respir. J., 27, 547 (2006),

Stability Moisture Sensitive
Applications Fensulfothion Oxon is a metabolite of the insecticide fensulfonthion (F265490), an inhibitor of cholinesterase activity.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Rainsford, K.D., et al.: Pest. Biochem. Physiol., 8, 302 (1978); Iverson, F., et al.: Can. J. Biochem., 54, 918 (1976);

Applications Trimethadione is an anticonvulsant and antiepileptic agent used in the treatment of pregnant women. Prenatal exposure to anti-epileptic drugs (AEDs) has indicated increased risk of major or minor congenital malformation.
References Ahir, B. et al.: Toxicol. Vitro., 28, 948 (2014); Pastore, V. et al.: Bioorg. Med. Chem., 21, 841 (2013);

Applications 4,4'-Dichlorodiphenyltrichloroethane is a synthetic organochlorine insecticide. 4,4'-Dichlorodiphenyltrichloroethane functions by opening sodium ion channels in the insects’ neurons, causing them to fire spontaneously which in turn leads to death. 4,4'-Dichlorodiphenyltrichloroethane is banned for agricultural use in North America, it is still commonly used in some countries and particularly as a means of malaria control.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Balkew, M. et al.: Paras. Vect., 3, No pp. given (2010); Kikankie, C.K. et al.: Malaria J., 9, No pp. given. (2010); Battu, R.S. et al.: Sci. Total Environ., 78, 173 (1989);

Applications Bispyribac is used as a herbicide for the prevention and control of weeds.
References Alister, C., et al.: Crop Prot., 25, 202 (2006), Chandi, G., et al.: J. Food Eng., 79, 592 (2007), Wilkowska, A., et al.: Food Chem., 125, 803 (2011),

Applications It is a major metabolite of Nicotine in humans. Carcinogen.
References Byrd, G., et al.: Drug Metab. Dispos., 20, 192 (1992), Benowitz, N., et al.: Br. J. Clin. Pharmacol., 51, 53 (2001), Hanioka, N., et al.: Xenobiotica, 31, 687 (2001), Ethell, B., et al.: Biochem. Pharmacol., 65, 1441 (2003), Yamanaka, H., et al.: Eur. J. Pharm. Sci., 22, 419 (2004),

Applications Pre and post emergence foliar absorbed herbicide for winter weed control in cereal crops; carotenoid biosynthesis inhibitor.
References Conte, E., et al.: J. Agric. Food Chem., 46, 4766 (1998),

Stability Hygroscopic
Applications A metabolite of NNAL.
References Hecht, S.S., et al.: Chem. Res. Toxicol., 14, 555 (2001)

Applications N-Methyltaurine can be used as a counter ion in the formation of soaps.
References Miyahara, Reiji, et al.: J. of Oleo Sci., 50(10), 823-830 (2001)

Applications A glucuronide metabolite of Chlorpyrifos (C425300).
References Barron, M.G., et al.: Environ. Toxicol. Chem., 12, 1469 (1993), Tang, J., et al.: Drug Metab. Dispos., 29, 1201 (2001),

Applications A reversible monoamine oxidase inhibitor.
References Wiesel, F.A., et al.: Eur. J. Clin. Pharmacol., 28, 89 (1985), Burkard, W.P., et al.: J. Pharmacol. Exp. Ther., 248, 391 (1989)