Toxicologie

Applications K+-selective ionophoric cyclodepsipeptide; potassium ionophore which uncouples oxidative phosphorylation, induces apoptosis in murine thymocytes, inhibits NGF-induced neuronal differentiation and antagonizes ET-induced vasoconstriction. Used as insecticide, nematocide.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Ivanov, et al.: Biochem. Biophys. Res. Commun., 34, 803 (1969), Duax, et al.: Science, 176, 911 (1972),

Impurity Aztreonam
Applications Ethanol Ring-opened Aztreonam is an Aztreonam (A965200) in-house impurity 1. Aztreonam is the first totally synthetic monocyclic β-lactam antibiotic.
References Sykes, R.B., et al.: Antimicrob. Agents Chemother., 21, 85 (1982), Florey, K., et al.: Anal. Profiles Drug Subs., 17, 1 (1988),

Applications (S)-7,8-Dihydroxy Efavirenz is a metabolite of (S)-Efavirenz (E425000); a nonnucleoside HIV-1 reverse transcriptase inhibitor.
References Young, S. D., et al.: Antimicrob. Ag. Chemother., 39, 2602 (1995); Deng, Y., et al.: J. Sep. Sci., 38, 1529 (2015)

Applications Eugenol-glucuronide is a metabolite of Eugenol (E938640) formed in isolated rat hepatocytes.
References Thompson, David C., et al.: Chemico-Bio. Inter., 77(2), 137-47 (1991)

Applications A deuterated 4-chloro Bupropion (B689625) analogue used in the preparation of compounds for indirect dopamine agonist pharmacotherapy for treating cocaine, methamphetamine, nicotine, and other drugs of abuse addiction.
References Carroll, F.I. et al.: J. Med. Chem., 52, 6768 (2009);