Toxicologie

Applications Ketoconazole N-​Oxide is an impure analogue of Ketoconazole (K186000) which inhibits cytochrome P-450 dependent steps in the biosynthesis of steroid hormones in vivo. Antimetastatic and antineoplastic activity. Orally active 5-lipoxygenase and thromboxane synthase inhibitor.
References Lambert, A., et al.: Biochem. Pharmacol., 35, 3999 (1986), Van Wauwe, J.P. and Janssen, P.A.J., J. Med. Chem., 32, 2231 (1989), Nardone, P.A., et al.: . Surg. Res., 44, 425 (1988), Tucker, W.F.G., et al.: Br. Med. J., 293, 882 (1986)

Stability Hygroscopic
Applications Iso Desloratadine Hydrochloride Salt is a degradation product of Desloratadine (D290250).
References Anon, et al.: J. Biol. Chem., 266, 15575 (1991), Piwinski. et al.: J. Med. Chem., 34, 457 (1991),

Applications A methylated analog of Zonisamide (Z700000) with anticonvulsant activity.
References Uno, H., et al.: J. Med. Chem., 22, 180 (1979)

Applications (S)-(-)-Ofloxacin-d3 (N-methyl-d3) (CAS# 2208780-63-4) is a useful isotopically labeled research compound.

Applications 3-Chloro-6-(chloromethyl)benzene-1,2,4,5-d4 is an isotope-labeled analog of 4-Chlorobenzyl Chloride (C364730), which is a benzylchloride derivative used in the preparation of various biologically active compounds such as bronchodilators and antibacterial agents.
References Adams, M. et al.: Synth. Comm., 29, 2419 (1999); Foroumadi, A. et al.: Arch. Pharm. Res., 30, 138 (2007);

Applications (±)-Carvedilol-d4 (ethyl-d4) (CAS# 1133705-56-2) is a useful isotopically labeled research compound.

Applications An impurity of Norethindrone Acetate (N675990).

Applications Nitroethane-2,2,2-d3 (CAS# 1219802-04-6) is a useful isotopically labeled research compound.

Impurity Rosuvastatin Formyl Impurity
Applications Rosuvastatin intermediate.
References Watanabe, M., et al.: Bioorg. Med. Chem., 5, 437 (1997),

Stability Hygroscopic
Applications Fluorescein-Cadaverine is a fluorescein derivative used in the preparation of biologically active fluorescent-labeled vitamin K analogues and monitoring of their subcellular distribution.
References Suhara, Y. et al.: Tetrahedron, 64, 8789 (2008);

Applications (±)-Zopiclone-d3 (N-methyl-d3) (CAS# 1398066-10-8) is a useful isotopically labeled research compound.