Toxicologie

Applications Alodane (cas# 2550-75-6) is a compound useful in organic synthesis.

Applications Triclosan O-β-D-Glucuronide is a metabolite of the bacteriostat, Triclosan (T774250).
References Moss, T. et al.: Food Chem. Toxicol., 38, 361 (2000); Wu, J. et al.: Sepu, 27, 724 (2009);

Applications Vasodilator (coronary).
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Hay, D., et al.: Br. J. Pharmacol., 76, 103 (1982), Tanaka, T., et al.: Biochemistry, 24, 5281 (1985), Rampe, D., et al.: Pharmacol. Exp. Ther., 265, 1125 (1993),

Applications Labelled analogue of Flucloxacillin, a semisynthetic penicillin.
References Markovich, M. et al.: Antibiot. Med. Biotekhnol., 31, 603 (1986); Rahman, M. et al.: Biochem. Pharmacol., 46, 1721 (1993); Silva, D. et al.: Med. Biol. Res., 37, 963 (2004);

Applications N-Desmethyl Terbinafine Hydrochloride is a metabolite of Terbinafine (T107500), an orally active, antimycotic allylamine related to naftifine.
References Humbert, H., et al.: Pharam. Drug Dispos., 19, 417 (1998); Vickers, A., et al.: Drug Metab. Dispos., 27, 1029 (1999); Iverson, S., et al.: Chem. Res. Toxicol., 14, 175 (2001)

Applications A metabolite of Demeton-S (D231360).
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Szeto, S.Y., et al.: J. Agric. Food Chem., 30, 1082 (1982),

Applications Desethyldesisopropyl Atrazine is a metabolite of Atrazine (A794600).
References Adams, N., et al.: J. Agric. Food Chem., 38, 1411 (1990), Abbas, R., et al.: Toxicol. Appl. Pharmacol., 147, 15, (1997), Cooper, R., et al.: Toxicol. Sci., 2000, 53, 297 (2000), Hossain, M., et al.: Toxicology, 248, 52 (2008),

Applications Labelled Diclofenamide, a potent carbonic anhydrase inhibitor. Diclofenamide may provide a therapeutic strategy in the inhibition of the human cytosolic isoforms I and II and transmembrane tumor-associated isoenzymes IX and XII. Diclofenamide has been shown to be is effective in the prevention of episodic weakness in both hypokalemic periodic paralysis (HypoPP) and potassium-sensitive periodic paralysis (PSPP).
References Brzozowski, Z. et al.: Eur. J. Med. Chem., 46, 3656 (2010); Tawil, R. et al.: Ann. Neurol., 47, 46 (2000); Casey, J. et al.: J. Med. Chem., 47, 2337 (2004);

Applications Diofenolan is a pesticide, an insect growth regulator. Diofenolan has been developed as a Juvenile hormone agonist for insect pest control
References Fan, C., et al.: J. AOAC Int., 98, 130 (2015); Abe, R., et al.: Aquat. Toxicol., 159, 44 (2015)

Applications A drug used to treat tuberculosis.
References Marrero-Ponce, Y., et al.: Bioorg. Med. Chem., 13, 2881 (2005),

Applications 2-Oxo Clopidogrel-d3 is he labelled analogue of 2-Oxo Clopidogrel (O869990). The essential intermediate metabolite from which the active metabolite of Clopidogel is formed.
References eliste, R., et al.: Thromb. Res., 48, 403 (1987); Savi, P., et al.: Biochem. Pharmacol., 44, 527 (1992); Herbert, J., et al.: Cardiovasc Drug. Rev., 11, 180 (1993); Sugidachi, A., et al.: B. J. Pharmacol., 132, 47 (2001)

Applications 1-Hydroxypyridine-2-thione Zinc is a fungicide; used in preparation of UV antibacterial and mildew-proof topcoat with better yellowing resistance and wear resistance.
References Feng, S., et al.: Faming Zhuanli Shenqing, (2021);

Applications Cyhalodiamide is a diamide insecticide and an agrochemical compound.
References Zhang, Y., et al.: Int. J. Agric. Biol., 19, 1421 (2017); Xing, J., et al.: Nongyao, 54, 842 (2015)

Applications Controlled substance (opiate). Used in treatment of opioid dependence.
References Bishara, R.H., et al.: Anal. Profiles Drug Subs., 3, 365 (1974), Senay, E.C., et al.: Int. J. Addict., 20, 803 (1985), Inturrisi, C.E., et al.: Clin. Pharmacol. Ther., 41, 392 (1987), Sees, K.L., et al.: J. Am. Med. Assoc., 283, 1303 (2000),

Applications Labelled Dicloxacillin (D436650). A semi-synthetic antibiotic related to Penicillin. Antibacterial.
References Chalikian, T., et al.: J. Mol. Biol., 260, 588 (1996), Kharakoz, D., et al.: Biochemistry, 36, 10276 (1997), Taboada, P., et al.: Langmuir, 16, 3175 (2000),

Applications Labelled Robenidine (R639000). Robenidine is used as a coccidiostat.
References Kantor, et al.: Science, 373, 168 (1970), Wong, et al.: Biochem. Biophys. Res. Commun., 46, 621 (1972)

Applications Roflumilast-N-oxide is the active metabolite of Roflumilast (R639700).
References Chiba, M., et al.: Drug Metab. Dispos., 25, 1022 (1997), Jarvis, B., et al.: Drugs, 59, 891 (2000),

Applications A labelled Desfuroyl Ceftiofur-related metabolite that have the potential to be microbiologic active in swine muscle, kidney, liver and fat.
References Gilbertson, T., et al.: J. Agric. Food Chem., 43, 229 (1995), Olson, S., et al.: Vet. Pharmacol. Therap., 21, 112 (1998), Hornish, R., et al.: Curr. Top Med. Chem., 2, 717 (2002),

Stability Very Hygroscopic
Applications Labelled Oseltamivir Acid (O700980). Oseltamivir Acid is a metabolite of Oseltamivir (O701000). It is a COVID19-related research product.
References Oliyai, R., et al.: Pharm. Res., 15, 1300 (1998), Kim, C.U., et al.: Med. Chem. Res., 8, 392 (1998), Hayden, F.G., et al.: N. Engl. J. Med., 341, 1336 (1999), Treanor, J.J., et al.: J. Am. Med. Assoc., 283, 1016 (2000)

Applications Oseltamivir Acid Hydrochloride is a metabolite of Oseltamivir (O701000), an orally active inhibitor of influenza virus neuraminidase; converted in vivo to the active acid metabolite. An antiviral drug. It is a COVID19-related research product.
References Oliyai, R., et al.: Pharm. Res., 15, 1300 (1998); Kim, C.U., et al.: Med. Chem. Res., 8, 392 (1998); Hayden, F.G., et al.: N. Engl. J. Med., 341, 1336 (1999); Treanor, J.J., et al.: J. Am. Med. Assoc., 283, 1016 (2000)

Applications L-3,6-Bis(β-chloroethyl)-2,5-diketopiperazine (cas# 1333325-25-9) is a compound useful in organic synthesis.

Applications Antibacterial (tuberculostatic).
References Weiner, I.M., et al.: J. Pharmacol. Exp. Ther., 180, 411 (1972), Feldner, E., et al.: Anal. Profiles Drug Subs., 12, 433 (1983)

Applications 6-Hydroxy Warfarin β-D-Glucuronide Disodium Salt Hydrate, is a metabolite of Warfarin (W498500) in humans.
References Barbato, F., et al.: J. Pharm. Sci., 86, 225 (1997), Kavana, M., et al.: Biochemistry, 42, 10238 (2003), Franco, A., et al.: Environ. Toxicol. Chem., 28, 458 (2009),

Applications A metabolite of Ceftiofur (C244700), which is microbiologic active.
References Washburn, K., et al.: J. Vet. Pharm. Ther., 28, 247 (2005),

Applications Propiconazole is a systemic foliar fungicide. Agricultural fungicide. Useful in cannabis testing kits as a component of pesticide mixes (P698235).
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Child, R., et al.: Plant Growth Regul., 13, 203 (1993), Jaleel, C., et al.: Plant Sci., 171, 271 (2006), Jaleel, C., et al.: Pestic Biochem. Physiol., 91, 170 (2008),

Applications Methyl Trithion, is used as an insecticide in biological studies to determine the effect on agriculture. Also, this compound was used evaluate the repellency in deer mouse and house mouse to determine the toxicity.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Burden, G.S., et al.: J. Econ. Entomol., 61, 1565 (1968); Schafer, E. W., et al.: Arch. Environ. Con. Tox., 14, 111, (1985)

Applications Guthoxon is an organophosphorus anticholinesterase pesticide.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Murphy, S., et al.: Toxicol Appl Pharmacol, 12, 22 (1968); Wong, J., et al.: J. Agric. Food Chem., 55, 1117 (2007);

Applications Lercanidipine-d3 is a labeled dihydropyridine calcium channel blocker.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Bianchi, G., et al.: Pharmacol. Res., 21, 193 (1989); Rimoldi, E., et al.: Acta Therap., 200, 23 (1994)

Stability Light Sensitive, Temperature Sensitive
Applications Anhydrochlortetracycline is the anhydro analogue and impurity of Chlortetracycline (C426500). Anhydrochlortetracycline is an antimicrobial and antibacterial.
References Diana, J. et al.: J. Pharmac. Biomed. Anal., 39, 523 (2005); Sanniez, W.H.K. et al.: J. Pharmac. Sci., 69, 5 (1980); Oliva, B. et al.: Antimircob. Agents Chemother., 36, 913 (1992);

Stability Moisture Sensitive
Applications TEPP functions as the first man-made organophosphate cholinesterase inhibitor. Also used in the evaluation of in silico models for the identification of respiratory sensitizers.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Petroianu, G. A.: Pharmazie, 70, 427 (2015); Dik, S., et al.: Toxicol. Sci., 142, 385 (2014)

Applications Terfuboxon is a pesticide used in the protection of fruit and vegetable crops against insects. Acetylcholinesterase inhibitor.
References Rahman, Md. M. et al.: Food CHem., 133, 604 (2012); Stojan, J. et al.: Biochem., 5599 (2008);

Applications N-(2-(2,4,6-TRICHLOROPHENOXY)ETHYL)PROPAN-1-AMINE (cas# 67747-01-7) is a useful research chemical.

Applications Morphine is the principle alkaloid of opium.
References Buchwald, M.E., et al.: J. Pharmacol. Exp. Ther., 71, 197 (1941); Muhtadi, F.J., et al.: Anal. Profiles Drug Subs., 17, 259 (1988);

Applications Endosulfan is an insecticide that poses health risks to humans and animals that acquire it through ingestion, inhalation, and percutaneous contact. Despite its potential risks, it is still being widely used all around the globe to protect cotton, sugarcane, and vegetable crops.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Bhalerao, T. & Puranik, P.: Int. Biodeter. Biodegr., 59, 315 (2007); Kalender, S., et al.: Toxicology, 202, 227 (2004); Naqvi, S. & Vaishnavi, C.: Comp. Biochem. Phys. C, 105, 347 (1993)

Applications Normorphine is a metabolite of Morphine (M652290). This is a controlled substance (opium derivative). Analgesic (narcotic).
References Coffman, B., et al.: Drug Metab. Dispos., 25, 1 (1997), Hanks, G., et al.: Br. J. Cancer, 84, 587 (2001), Projean, D., et al.: Xenobiotica, 33, 841 (2003), Dale, O., et al.: Br. J. Clin. Pharmacol., 58, 156 (2004),

Stability Hygroscopic
Applications Pyraclostrobin is a fungicide for use in seed grass and food crops. Useful in cannabis testing kits as a component of pesticide mixes (P698240).
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Gyldenkaerne, S., et al.: Pestic Sci., 55, 1210 (1999), Pennington, D., et al.: Environ. Sci. Technol., 39, 1119 (2005), Wang, S., et al.: Food Control., 18, 731 (2007),

Applications Rimantadine-d4 Hydrochloride is an isotope labeled version of Rimantadine Hydrochloride, an antiviral agent.
References Hayden, F.G., et al.: Antimicrob. Ag. Chemother., 19, 226 (1981), Zlydnikov, D.M., et al.: Rev. Infect. Dis., 3, 408 (1981),

Applications Rosuvastatin Calcium (R,S,R)-Diastereomer is a degradation product of rosuvastatin.
References Shah, R. P., et al.: Anal. Bioanal. Chem., 405, 3215 (2013; ,Litvic, M.,et al.: J. Photochem. Photobiol. A. Chem., 252, 84 (2013)

Applications Dazomet is a as fumigant used for the control of brown root rot disease. Dazomet was shown to be a possible agent in preventing pest incursion in agriculture, gardening and agroforestry.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Fu, C.H., et al.: Pest. Mange. Sci., 68, 959 (2012); Liberatore, L., et al.: Water. Air. Soil Poll., 223, 4751 (2012); Sande, D., et al.: Int. J. Enviro. Res. Pub. Health., 8, 4649 (2011);

Stability Extremely Hygroscopic
Applications Nabam (Hydrate) is used a fungicide.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Virk, K.S., Gemawat, P.D.: Pesticides, 15, 25 (1981)

Stability Hygroscopic
Applications Estriol 3-O-β-D-Glucuronide Sodium Salt is a metabolite found in the urine of pregnant women.
References Simkins, A., Worth, H.G.J., Anals Clin. Biochem., 12, 233 (1975)

Applications Nebivolol (N387896) metabolite.

Applications Propyzamide-d3 (phenyl-2,4,6-d3) (CAS# 1219805-79-4) is a useful isotopically labeled research compound.

Applications Labelled Tolvaptan. It is a selective, competitive arginine vasopressin V2 receptor antagonist used to treat hyponatremia (low blood sodium levels) associated with congestive heart failure, cirrhosis, and the syndrome of inappropriate antidiuretic hormone (SIADH).
References Paterna, S., et al.: Eur. J. Heart Fail, 2, 305 (2000), Udelson, J., et al.: Circulation, 104, 2417 (2001), Goldsmith, S., et al.: J. Am. Coll Cardiol., 46, 1785 (2005), Schrier, R., et al.: N. Engl. J. Med., 355, 2099 (2006),

Applications Agricultural fungicide.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Corrales, M., et al.: Food Chem. Toxicol., 48, 3471 (2010), Lagunas-Allue, L., et al.: Anal. Bioanal. Chem., 398, 1509 (2010), Wong, J., et al.: J. Agric. Food Chem., 58, 5897 (2010),

Stability Hygroscopic
Applications β-Nicotyrine-d3, is the labeled analogue of β-Nicotyrine (N445002), which is an alkaloid derived from the dehydrogenation of nicotine and its analog, nornicotine. An alkaloid occurring in cigaret smoke.
References Swain, M.L., et al.: J. Am. Chem. Soc., 71, 1341 (1949);

Applications Etoxazole is a acaricide/insecticide that works via chitin biosynthesis inhibition for the control of mites. Used as a standard for Pesticide detection. Useful in cannabis testing kits as a component of pesticide mixes (P698235).
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Wise, J.C., et al.: Arthropod. Manage. Test., 36, 1 (2011); Kleinstreuer, N.C., et al.: Environ. Health. Perspect., 119, 1596 (2011); Polgar, L., et al.: J. Chromatograph. A., 1249, 83 (2012);

Stability Hygroscopic
Applications Labelled Gemcitabine, an antineoplastic.
References Hertel, L.W., et al.: Cancer Res., 50, 4417 (1990), Abbruzzese, J.L., et al.: J. Clin. Oncol., 9, 491 (1991), Ruiz, V.W.T., et al.: Biochem. Pharmacol., 46, 762 (1993),

Stability Hygroscopic
Applications 2-Hydroxy-4’,5-diacetamido-diphenyl Ether is used in the synthesis of novel benzimidazoles as potent inhibitors of TIE-2 anf VEGFR-2 tyrosine kinase receptors. Angiogenesis therapeutic agent.
References Hasegawa, M. et al.: J. Med. Chem., 50, 4453 (2007);

Applications Antilipemic; reducing lipid levels in the blood.
References Webb, S., et al.: Toxicol. Lett., 142, 157 (2003), Calabuig, C., et al.: Int. J. Pharm., 278, 111 (2004), El-Gindy, A., et al.: J. Pharm. Biomed. Anal., 43, 196 (2007),

Stability Hygroscopic
Applications Acarviosin is a part of the potent α-amylase inhibitor, Acarbose (A123500), an anti-diabetic drug used to treat type 2 diabetes mellitus (1,2,3).
References (1) Shibata, Y., et al.: Carbohydrate. Res., 228, 377 (1992) (2) Raimbaud, E., et al.: Carbohydrate. Res., 227, 351 (1992) (3) Geng, P., et al.: Carbohydr Res. 343, 882 (2008)https://www.ncbi.nlm.nih.gov/pubmed/18294624PMID: 18294624

Stability Hygroscopic
Applications Spermidine is a biogenic polyamine formed from putrescine. Spermidine is a precursor of Spermine. Spermidine is essential for both normal and neoplastic tissue growth.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Abraham, A.K., et al.: Eur. J. Biochem., 106, 257 (1980), Mach, M., et al.: Biochem. J., 202, 153 (1982), Thyss, A., et al.: Eur. J. Cancer Clin. Oncol., 18, 611 (1982),

Applications Loxoprofen-d3, is the labeled analogue of Loxoprofen (L472905), which is non-selective nonsteroidal anti-inflammatory drug (NSAID) that has been effective in reducing atherosclerosis in mice by reducing inflammation.
References Masahide H. et al.: J Clin Biochem Nutr., 47, 138 (2010); Noguchi, M. et al.: Biolog. Pharmac. Bull., 28, 2075 (2005); Hyun, J. et al.: Arch. Pharm. Res., 24, 541 (2001);

Applications DL-Panthenol is used in the topical treatment of skin disorders, such as minor irritations and skin burns. Also used in the strengthening and treatment of hair.
References Ebner F. et al.: Am J Clin Dermatol. 3, 427 (2002); Heldermann, M. et al.: SOFW J. et al.: 40, 44 (2012);

Applications Etomidate is a hypnotic. Neuroprotective & Neuroresearch Products
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Goetz, E., et al.: Anaesthesist, 23, 331 (1974), Chang, Z. L., et al.: Anal. Profiles Drug Subs., 12, 191 (1983),

Stability Unstable in Solution
Applications A psychotropic benzodiazepine derivative with hypnotic and anxiolytic properties. Controlled Substance.
References Sethy, V.H. et al.: Naun.-Schmeid. Atch. Pharmacol., 301, 157 (1978); Moore, S. et al.: Curr. Therap. Res., 29, 704 (1981); Gutierrez, S.F. et al.: Cien. Pharmac., 5, 37 (1995);

Applications Hexaflumuron is an benzoylphenylurea based chitin synthesis inhibitor used against Ephestia figulilella.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Sun, C.X., et al.: Bull. Environ. Contamin. Toxicol., 89, 868 (2012); Khajepour, S., et al.: J. Insect. Sci., 12, 102 (2012);

Applications Racemic Colchicine.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package

Applications Gabapentin Lactam-d6, is the labeled analogue of Gabapentin Lactam (G117275), that reduces protein aggregates and improves motor performance in a transgenic mouse model of Huntington’s disease. It opens mitochondrial ATP-dependent potassium channels.
References Zucker, B.,et al.: Naunyn Schmiedebergs Arch. Pharmacol., 370, 131 (2004)

Applications Abiraterone is a steroidal cytochrome P 450 17α-hydroxylase-17,20-lyase inhibitor (CYP17), is currently undergoing phase II clinical trials as a potential drug for the treatment of androgen-dependent prostate cancer.
References Denis, L., et al.: Cancer, 72, 3888 (1993); Potter, G.A., et al.: J. Med. Chem., 38, 2463 (1995); Denmeade, S., et al.: Nat. Rev., 2, 389 (2002); Scher, H., et al.: J. Clin. Oncol., 23, 8253 (2005);

Applications Dihydro Artemisinin (D448360) dimer with anticancer and antiprotozoal activity.
References Galal, A. et al.: Bioorg. Med. Chem., 17, 741 (2009); Beekman, A. et al.: Phytother. Res., 10, 140 (1996)

Applications Phenthoate is an organothiophosphate insecticide used against lepidoptera and houseflies.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Strempel, S., et al.: Envrion. Toxicol. Chem., 32, 1187 (2013); Zhao, Q. et al.: Anal. Bioanal. Chem., 405, 4765 (2013);

Applications A M1 muscarinic agonist designed as an innovative therapy for Alzheimer’s disease.
References Wanibuchi, F., et al.: Eur. J. Pharmacol., 187, 476 (1990), Court, J.A., et al.: Pharmacol. Ther., 52, 423 (1991), Ladner, C.J., et al.: J. Neuropathol. Exp. Neurol., 57, 719 (1998),

Applications A metabolite of Aflatoxin B1; a hepatocarcinogen in many animal models and probably a human carcinogen. It is produced by the predominant forms of cytochrome P 450 enzymes responsible for the biotransformation of AFB1. It shows potential predictive value as a marker for exposure and risk of dietary aflatoxins.Environmental contaminants; Food contaminants
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Mykkaenen, H., et al.: Int. J. Cancer, 115, 879 (2005); Van Vleet, T.R. et al.: J. Toxicol. Environ. Health, 65, 853 (2002);

Impurity Beclomethasone Dipropionate EP Impurity B
Applications Beclomethasone 21-Acetate 17-Propionate (Beclomethasone Dipropionate EP Impurity B) is an impurity of Beclomethasone Dipropionate (B131030).

Applications An oleic acid synthetic analog that is an effective non-toxic anticancer drug with a wide spectrum against different types of cancer. An antihypertensive.
References Llado, V. et al.: J. Cell. Molec. Med., 14, 659 (2010); Alemany, R. et al.: J. Lip. Res., 47, 1762 (2006); Martinez, J. et al.: J. Pharmacol. Exp. Therap., 315, 466 (2005);

Impurity Betamethasone Dipropionate EP Impurity G
Applications Betamethasone Tripropionate (Betamethasone Dipropionate EP Impurity G) is a Betamethasone (B327000) related compound.
References Grootveld, M., et al.: Biochem. Pharmacol., 37, 271 (1988), Chen, B., et al.: Steriods, 74, 30 (2009), Mikami, E., et al.: J. Pharm. Biomed. Anal., 28, 261 (2002),

Applications Betamethasone 17-Butyrate is an impurity of Clobetasone 17-Butyrate (C583550), an glucocorticoid used for anti-inflammatory purposes.

Applications A metabolite of Baclofen (c).
References Ault, B., et al.: Eur. J. Pharmacol., 71, 357 (1981),