Toxicologie

Stability Very Very Hygroscopic
Applications Quetiapine is a dibenzothiazepine antipsychotic commonly used as monotherapy for patients with major depressive disorder and schizophrenia.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Cutler, A., et al.: J. Clin. Psych., 70, 526 (2009); Kapur, S., et al.: Arch. Gen. Psych., 57, 553 (2000); Peuskens, J. & Link, C.: Acta. Psych. Scand., 96, 265 (1997)

Applications Hexaflumuron is an benzoylphenylurea based chitin synthesis inhibitor used against Ephestia figulilella.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Sun, C.X., et al.: Bull. Environ. Contamin. Toxicol., 89, 868 (2012); Khajepour, S., et al.: J. Insect. Sci., 12, 102 (2012);

Applications An impurity of Rifampamycin (R508000).

Applications Ametryn is a methylthiotriazine based herbicide which inhibits photosynthesis and other enzymatic processes. Ametryn is used to control broadleaf weeds and annual grasses in pineapple, sugarcane and bananas.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Kasozi, G.N. et al.: Environ. Pollut., 169, 12 (2012); Megersa, N., et al.: 29, 789 (2012)

Applications Clonidine is an α2-Adrenergic agonist. Antihypertensive; analgesic for neuropathic pain.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Roach, A.G., et al.: J. Pharmacol. Exp. Ther., 227, 421 (1983); Glassman, A.H., et al.: Science, 226, 864 (1984); Abounassif, A.M., et al.: Anal. Profiles Drug Subs. Excip., 21, 109 (1992);

Impurity Clarithromycin EP Impurity J
Applications Erythromycin A Oxime (Roxithromycin Impurity C) (Clarithromycin EP Impurity J) is the major metabolite of Roxithromycin and an intermediate of Azithromycin. Antibacterial agent. Roxithromycin impurity C.
References Ferrero, J., et al.: Drug Metab. Dispos., 18, 441 (1990), Gase, C., et al.: J. Antibiot., 44, 313 (1991), Markham, A., et al.: Drugs, 48, 297 (1994), Jarukamjorn, K., et al.: J. Pharm. Pharmacol., 50, 515 (1998),

Stability Hygroscopic
Applications (R,R)-Ethambutol-d4 Dihydrochloride is the isotope labelled analog of (R,R)-Ethambutol Dihydrochloride (E889805); a compound that shows antitumor properties when complexed with platinum. Also an isomer of Ethambutol (E889800) which is an antibacterial (tuberculostatic).
References Coluccia, M. et al.: Anticanc. Res., 11, 281 (1991); Wilkinson, et al.: J. Med. Chem., 5, 835 (1962); Kulig, et al.: Diss. Pharm. Pharmacol., 23, 463 (1971); Lee, C.S., et al.: Anal. Profiles Drug Subs., 7, 231 (1978)

Applications Phenthoate is an organothiophosphate insecticide used against lepidoptera and houseflies.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Strempel, S., et al.: Envrion. Toxicol. Chem., 32, 1187 (2013); Zhao, Q. et al.: Anal. Bioanal. Chem., 405, 4765 (2013);

Applications Estrogenic mycotoxin produced by Fusarium fungi commonly found in grains. One of a group of compounds known as resorcylic acid lactones.Environmental contaminants; Food contaminants
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Tanaka, T., et al.: J. Agric. Food Chem., 36, 979 (1988), Hamilton, S., et al.: Anticancer Res., 16, 3597 (1996), Hecht, S., et al.: Cancer Lett., 150, 49 (2000), Hussein, H., et al.: Toxicology, 167, 101 (2001), Lim, H., et al.: J. Immunol., 175, 4180 (2005),

Applications Clocortolone Acetate is an intermediate in the synthesis of Clocortolone (C583800), an corticosteroid used in the treatment of skin inflammmation and other skin conditions arising for dermatoses.
References Rehm, K. et al.: Pharmaz. Zeit., 127, 888 (1982);

Applications A degradation and metabolic intermediate of Dexamethasone (D298800). A Dexamethasone enol aldehyde as inflammation inhibitor.
References Weiss, G., et al.: J. Clin. Endocrinol. Metab., 43, 696 (1976), Hirschmann R., et al.: Steroids, 57, 579 (1992),

Applications A metabolite of Baclofen (c).
References Ault, B., et al.: Eur. J. Pharmacol., 71, 357 (1981),

Applications Sodium channel blocker, local anesthetic.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Wilson, T.D., et al.: Anal. Profiles Drug Subs., 19, 59 (1990), McClellan, K.J., et al.: Drugs, 56, 355 (1998),

Stability Hygroscopic
Applications An intermediate in the production of Rosuvastatin (R700500) derivatives.

Applications The major metabolite of Deflazacort.
References Bernareggi, A., et al.: J. Pharma. Biomed. Anal., 5, 177-81 (1987), Assandri, A., et al.: Xenobiotica, 13(3), 185 (1983), Martinelli, E., et al.: Drug Metab. Dispos., 7, 335 (1979),

Applications Perindoprilat is an angiotensin-converting enzyme (ACE) inhibitor and antihypertensive.
References Pascard, C., et al.: J. Med. Chem., 34, 663 (1991)

Applications Atazanavir-d6 is the isotope labelled analog of Atazanavir (A790051); an azapeptide HIV protease inhibitor. Atazanavir has also been investigated as potential treatment of human immunodeficiency virus (HIV) and for anticancer purposes.
References Musial, B.L., et al.: Am. J. Health Syst. Pharm., 61, 1365 (2004); Wood, R., et al.: J. Acquir. Immune Defic. Syndr., 36, 684 (2004)

Applications Trestolone acetate is a derivative of Trestolone (T719600), a synthetic androgen used as a potential hormonal male contraceptive method that induces a state of temporary infertility.
References Garcia-Becerra, R., et al.: Reproduction., 143, 211 (2012); Attardi, B.J., et al.: J. Steroid. Biochem. Molec. Biol., 122, 212 (2010)

Impurity Ambroxol EP Impurity B Hydrochloride
Stability Hygroscopic
Applications Ambroxol Cyclic Impurity is a metabolite as well as an impurity of the bronchosecretolytic drug, Ambroxol (A575900).
References Hammer, R. et al.: Arzneim.-Forsch., 28, 899 (1978); Nieder, M. et al.: HRC & CC, 9, 561 (1986); Huq, F. et al.: J. Pharmacol. Toxicol., 3, 147 (2008);

Stability Hygroscopic
Applications The optically active isomer of Carvedilol (C184625), a nonselective ß-adrenergic blocker with a1-blocking activity. An antihypertensive used in the treatment of congestive heart failure.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Hirohashi, M., et al.: Arzneim.-Forsch., 40, 735 (1990),

Applications A labelled nonsteroidal anti-inflammatory drug (NSAID); activity resides primarily in the (S)-isomer.
References Busson, M., et al.: J. Int. Med Res., 14, 53 (1986), Meade, E.A., et al.: J. Biol. Chem., 268, 6610 (1993), Davies, N.M., et al.: Clin. Pharmacokinet., 34, 101 (1998),

Applications Prednisolone 21-β-D-Glucuronide Sodium Salt is a metabolite of Prednisolone (P703740).
References Hutzler, J., ET AL.: Drug Metab. Dispos., 30, 355 (2002), Sugiyama, D., et al.: J. Biol. Chem., 278, 43489 (2003), Hagenbuch, B., et al.: Xenobiotica, 38, 778 (2008),

Applications Lumichrome is a derivative of Riboflavin (R415000), a vitamin with a key role in maintaining cellular function and health in human and animals. Dyes and metabolites.
References Rajamani, S., et al.: Mol. Plant. Microbe. Interact., 21, 1184 (2008); Unna, K., et al.: J. Pharmacol. Exp. Ther., 76, 75 (1942), Rivlin, et al.: N. Engl. J. Med., 283, 463 (1970), Al-Shammary, F.J., et al.: Anal. Profiles Drug Subs., 19, 429 (1990),

Impurity Anastrozole Monoamide Impurity
Applications Anastrozole Monoamide is a derivative of Anastrozole (A637425), an aromatase inhibitor. Used as an antineoplastic.
References Plourde, P.V., et al.: Breast Cancer Res. Treat., 30, 103 (1994), Buzdar, A.U., et al.: Cancer, 79, 730 (1997)

Applications Amcinonide (A576150) analog as glucocorticoid receptor agonists for the treatment of inflammation and allergic conditions.
References Woodford, R., et al.: Curr. Ther. Res., 26, 301 (1979),

Stability Moisture Sensitive
Applications Oxyfedrine acts as a vasodilator affecting the coronary base flow.
References Baraka, Y. et al.: J. Drug Res., 12, 161 (1980);

Stability Hygroscopic, Temperature Sensitive
Applications Gemcitabine Triphosphate is a phosphorylated metabolite of Gemcitabine (G305000), an antineoplastic agent.
References Kennedy., E.P., et al.: J. Biol. Chem., 222, 193 (1956),

Impurity Rosuvastatin EP Impurity C (Calcium Salt)
Stability Hygroscopic
Applications 5-Oxo Rosuvastatin (Rosuvastatin EP Impurity C (Calcium Salt)) is a Rosuvastatin (R700500) impurity.
References Endo, A., et al.: J. Antibiot., 32, 852 (1979), Beck, G., et al.: J. Med. Chem., 33, 52 (1990), Koga, T., et al.: Lipids, 30, 775 (1995),

Applications Isopyridoxal Hydrochloride is an active vitamer of the B6 complex in humans, and a metabolite standard in the determination of all seven vitamin B6-related compounds. It is also a metabolite in a pyridoxine degradation pathway by soil bacteria.
References Edwards, P., et. al.: Clinica Chimica Acta: Int. J. Clin. Chem., 190, (1990); Lee, Y. C., et. al.: J. Bio. Chem., 261, (1986); Argoudelis, C. J.: J. Chromatogr. A, 790, (1998)

Applications AICAR is a nucleoside analogue that is able to enter nucleoside pools and is able to significantly increase levels of adenosine during periods of ATP breakdown. Adenosine-regulating agents (ARAs) have been recognized for therapeutic potential in myocardial ischemia. Cardioprotective.
References Mullane, K., et al.: Trends Cardiovasc Med., 3, 227 (1993), Browne, G.J., et al.: J. Biol. Chem., 279, 13, 12220 (2004)

Applications A metabolite of Mifepristone.
References Heikinheimo, O., et al.: J. Steroid Biochem., 26, 279 (1987), Brogden, R., et al.: Drugs, 45, 384 (1993), Shi, Y., et al.: Contraception, 48, 133 (1993), Jang, G., et al.: Biochem. Pharmacol., 52, 753 (1996), Gainer, E., et al.: Steroids, 68, 1005 (2003),

Impurity Rosuvastatin EP Impurity B
Stability Hygroscopic
Applications A diastereomer of Rosuvastatin (R700500) used for treatment, prevention and combination therapy of lipid-related disorders. Rosuvastatin EP Impurity B

Applications A metabolite of Mifepristone.
References Heikinheimo, O., et al.: J. Steroid Biochem., 26, 279 (1987), Brogden, R., et al.: Drugs, 45, 384 (1993), Shi, Y., et al.: Contraception, 48, 133 (1993), Jang, G., et al.: Biochem. Pharmacol., 52, 753 (1996), Gainer, E., et al.: Steroids, 68, 1005 (2003),

Applications Diamino-5-phenylthiazole Hydrobromide is an phenylthiazole derivative used in the preparation of antiallergic and antiinflammatory agents.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Ban, M. et al.: Bioorg. Med. Chem., 6, 1069 (1998);

Stability Hygroscopic
Applications Fencamfamine is a CNS stimulant. This is a controlled substance (stimulant).
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Hotovy, R., et al.: Arzneim.-Forsch., 11, 20 (1961), DeLucia, R., et al.: Gen. Pharmacol., 21, 161 (1990), Planeta, C., et al.: Pharmacol. Biochem. Behav., 50, 35 (1995),

Applications Controlled substance. CNS stimulant. The more potent isomers of Methylphenidate. The threo enantomers have shown that the pharmacological activity residues predominantly in the d-threo enantiomer.
References Greenblatt, E.N., et al.: J. Pharmacol. Exp. Ther., 131, 115 (1961), Padmanabhan, G.R., et al.: Anal. Profiles Drug Subs., 10, 473 (1981), Kuczenski, R., et al.: J. Pharmacol. Exp. Ther., 296, 876 (2001), Pelham, W.E., et al.: J. Consult. Clin. Psychol., 61, 506 (1993), Srinivas, N.R., et al.: Pharm. Res., 10, 14 (1993),

Applications 5-(4-Fluorophenyl)-2,3-dihydro-3-(1-methylethyl)-2-oxo-N,4-diphenyl-1-[2-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-1H-pyrrole-3-carboxamide is a photodegradation product of Atorvastatin (A791750).
References Cermola, F., et al.: Tetrahedron., 62, 7390 (2006);

Applications Prednival was used in the study of inflammation-inhibiting activity of steroids.
References Bodor, N., et al.: J. Med. Chem., 26, 318 (1983); Stouch, T., et al.: J. Med. Chem., 29, 2125 (2986);