Toxicologie

Applications Moexiprilat Hydrochloride is an angiotensin converting enzyme (ACE) inhibitor; dimethoxy analog of Quinapril. Antihypertensive.
References Klutchko, et al.: J. Med. Chem., 29, 1953 (1986), Edling, O., et al.: J. Pharmacol. Exp. Ther., 275, 854 (1995), Stimpel, M., et al.: Cardiology, 87, 313 (1996),

Applications A N-nitroso compound of the triazine pesticides Simazine.
References Bakkan, G., et al.: J. Med. Chem., 43, 4534 (2000), Serra, J., et al.: Chem. Res. Toxicol., 14, 1535 (2001),

Applications Labelled Pipamperone (P475200). Antipsychotic.
References Steinijans, V., et al.: Eur. J. Clin. Pharm., 24, 127 (1983), Luhmann, I., et al.: Arzneim.-Forsch., 42, 1069 (1992), Hauck, W., et al.: J. Biopharm. Stat., 7, 87 (1997),

Applications Pymetrozine is a pyridine azomethine antifeedant. Pymetrozine is used as insecticide.
References Pennington, D., et al.: Environ. Sci. Technol., 39, 1119 (2005), Fenoll, J., et al.: Int. J. Food Sci. Technol., 44, 1034 (2009),

Applications Spirotetramat Metabolite BYI08330-mono-hydroxy can be used in analytical study of chemometric-​assisted QuEChERS extraction method for the residual analysis of thiacloprid, spirotetramat and spirotetramat's four metabolites in pepper.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Li, S., et al.: Food Chem, 192, 893 (2016)

Applications Used as an antiandrogen, antineoplastic (hormonal). (94%d4; 5.7%d3, 0.1%d1, no d0)
References Tucker, H., et al.: J. Med. Chem., 31, 954 (1988), Cockshott, I.D., et al.: Eur. Urol., 18, Suppl. 3, 10 (1990), Cockshott, I., et al.: Br. J. Clin. Pharm., 36, 339 (1993), McKillop, D., et al.: Xenobiotica, 25, 623 (1995),

Applications rel-(4R,5R)-5-(4-Chlorophenyl)-4-methyl-2-thiazolidinone is a useful building block and has been used in the synthesis of hexythiazox (H298500).
References Lou, J.; et al.: Nongyao, 47, 328 (2008).

Applications BTUM is uesed as a dye developer for direct thermal paper.
References Takahashi, Y., et. al.: IS&T’s Int. Congr. Ad Non-impact print. Tech., 10, 349 (1994)

Stability Hygroscopic
Applications A sodium-glucose transporter 2 inhibitor.
References Kasichayanula, S. et al.: Diabetes, Obesity and Metabolism 13, 47 (2011)

Applications Butyrophenone derivative having neuroleptic activity, used as an antipsychotic.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Shimoda, K., et al.: Pharmacol. Toxicol., 83, 164 (1998), Sekine, Y., et al.: Eur. J. Clin. Pharmacol., 55, 583 (1999), Oka, T., et al.: Life Sci., 76, 225 (2004), Fujikawa, M., et al.: Prog. Neuro-Psychopharmacol. Biol. Psych., 32, 755 (2008),

Applications 5β-Androsterone β-D-Glucuronide is a glucuronide metabolite of Testosterone (T155000).
References Weusten, J., et al.: J. Steroid Biochem., 32, 689 (1989), Antignac, J., et al.: Steroids, 70, 205 (2005),

Stability Not stable in solution
Applications Flazasulfuron, is a Trifluoro-pyridine derivative acting as a pesticide.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Deng, H., et al.: Zhejiang Huagong, 42, 1 (2011);

Applications Thiamine Monophosphate Dihydrate is a derivative compound of Thiamine Pyrophosphate Chloride (T344070). Thiamine pyrophosphate is a cofactor used to catalyze various biochemical reactions.
References Andrews, F.H. et al.: Biochem., 52, 3028 (2013); Mueller, C.R., et al.: Org. Biomolec. Chem., 11, 2000 (2013); Haag, N., et al.: J. Neurosci., 32, 17842 (2012); Nemeria, N., et al.: Biochem., 51, 7940 (2012);

Stability Hygroscopic
Applications Mesalazine-d3, is the labeled analogue of Mesalazine (M258100), the active metabolite of Sulfasalazine (S699084). Anti-inflammatory (gastrointestinal).
References Friedman, G., et al.: Am. J. Gastroenterol., 81, 141 (1986), Tursi A., Expert Opin. Pharmacother., 6, 69 (2005)

Applications Avermectin B1a, a natural product derived from the soil actinomycete Streptomyces avermitilis, is an antiparasitic agent that paralyzes nematodes without causing hypercontraction or flaccid paralysis.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Lofgren, C.S., et al.: J. Econ. Entomol., 75, 798 (1982); Kass, I.S., et al.: P. Natl. Acad. Sci. USA, 77, 6211 (1980); Fritz, L.C., et al.: P. Natl. Acad, Sci. USA, 76, 2062 (1979);

Applications Labelled Clopidogrel, an antithrombotic.
References Mills, D.C.B., et al.: Arterioscler. Thromb., 12, 430 (1992), Feuerstein, G., et al.: Exp. Opin. Invest. Drugs, 4, 425 (1995)

Stability Moisture Sensitive
Applications Melphalan Hydrochloride is used in combined intravitreal chemotherapy with topotecan hydrochloride for viable vitreous seeding from retinoblastoma. Also, it is an anti-cancer chemotherapy drug.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Ghassemi, F., et al.: JAMA Ophthalmol., 132, 936-941 (2014); Gao, L. P., et al.: Adv. Mater. Res., 781-784, 993-998 (2013);

Applications Tetrabromobisphenol S is a brominated flame retardant (BFR) and a derivative of Bisphenol-S. It can be used as a herbicide to control weeds such as Digitaria, Cyperus microiria, and Echinochloa crusgalli in cucumbers, tomatoes, and white radish.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Wang, X.M., et al.: Anal. Chim. Acta, 753, 1 (2012); Liaw, D.-J., et al.: Angew. Makromol. Chem., 199, 171 (2003); Takamatsu, H., et al. Sulfones as herbicides. Jpn. Kokai Tokkyo Koho. JP 53109942 A 19780926. Sep 26, 1978

Impurity Prilocaine USP Related Compound A
Applications o-Toluidine Chloride is a carcinogenic and toxic aromatic amine contained in hair dye, henna and dyed hair samples. Prilocaine USP Related Compound A
References El-Bayoumy, K., et al.: Cancer Res., 46, 6064 (1986), Turesky, R., et al.: Chem. Res. Toxicol., 16, 1162 (2003), Andrew, A., et al.: Int. J. Cancer, 109, 581 (2004), Pinheiro, H., et al.: Dyes Pigments, 61, 121 (2004), Kirkland, D., et al.: Mutat. Res., 588, 88 (2005),

Applications Pre-emergence herbicide for use in rice and other food crops.
References Jurney, W., et al.: J. Neurosci., 22, 6019 (2002), Yap, C., et al.: J. Cell Biol., 180, 827 (2008),

Stability Hygroscopic
Applications Clencyclohexerol-d10 is a labelled analog of Clenbuterol, a β-agonist which can be used as a growth promoter in farm animals.
References Maistro, S., et al.: Lancet, 346, 180 (1995); Vanoosthuyze, K., et al.: J. Agric. Food Chem., 45, 3129 (1997); Fiori, M., et al.: Anal. Chim. Acta, 529, 207 (2005); Salquebre, G., et al.: J. Anal. Toxicol., 31, 114 (2007);

Applications Antimicrobial agent used as a substitute for chlorophenols in industrial applications.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Martin, I.D., et al.: Arch. Environ. Contam. Toxicol., 24, 381 (1993), Reemtsma, T., et al.: Environ. Sci. Technol., 29, 478 (1995),

Applications Phorate Sulfone is a metabolite of Phorate (85%, P353500) which is a non-biocumulative organophosphate used as an insecticide and acaricide. Phorate is an inhibitor of acetylcholinesterase and pseudocholinesterase.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Pandey, G.C. et al.: Ind. J. Comp. Anim. Physiol., 6, 1 (1988); Henderson, M.C. et al.: Biochem. Pharmacol., 68, 959 (2004); Peter, J.V. et al.: NeuroToxicology, 29, 335 (2008);

Applications Fomesafen is a protoporphyrinogen oxidae (PPO) inhibitor.
References Peng, X., et al.: Faming Zhuanli Shenqing (2018), CN 107836452 A 20180327

Applications Labelled Pholedrine (P352000). An α-adrenergic agonist. Antihypotensive.
References Glennon, R., et al.: J. Med. Chem., 23, 294 (1980), de Letter, E., et al.: J. Anal. Toxicol., 26, 113 (2002), Lin, D., et al.: J. Anal. Toxicol., 31, 109 (2007),

Applications Chrysanthemic Acid is an intermediate in the synthesis of Chrysanthemic Acid (C903440); Dimethrin is a pesticide, a pyrethroid insecticide. An acaricide for agricultural purposes.
References Ford, M G.: Pestic. Sci., 10, 39 (1979); Gan, W., et al.: Zhonghua Yufang Yixue Zazhi, 35, 13 (2001); Wright, F. C.: Southwestern Entomol., 5, 222 (1980);

Applications Procaine is a sodium channel blocker and inhibitor of a variety of processes.

Applications Etodroxizine is a piperazine antihistimine.
References Wolffgramm, J. et al.: Arzneim.-Forsch., 38, 885 (1988); Maurer, H. et al.: Fres. Zeitsch. Anal. Chem., 331, 744 (1988);

Applications A long-acting β2 adrenoreceptor agonist and bronchodilator, for the treatment of asthma and chronic obstructive pulmonary disease.
References Currie, G.P. et al.: Curr. Opin. Invest. Drugs., 7, 457 (2006); Naline, E. et al.: Eur. Resp. J., 29, 575 (2007); Roig, J. et al.: Open Resp. Med. J., 3, 27 (2009);

Applications Glycochenodeoxycholic-d5 Acid-3-O-β-glucuronide Disodium Salt is an isotope labelled compound of Glycochenodeoxycholic Acid-3-O-β-glucuronide Disodium Salt (G641275), used in steriod studies and also in the synthesis of conjugated and unconjugated bile acids.
References Goto, J., et al.: Chem. Pharm. Bull., 28, 1258 (1980)

Applications Flecainide is an antiarrhythmic (class IC).
References Hodess, A.B., et al.: J. Cardiovasc. Pharmacol., 1, 427 (1979), Somani, P., et al.: Clin. Pharmacol. Ther., 27, 464 (1980), Alessi-Severini, S., et al.: Anal. Profiles Drug Subs. Excip., 21, 169 (1992)

Applications Isotope labelled penconazole is an conazole based fungicide that works by inhibiting cell membrane ergosterol biosynthesis, thus stopping the development of fungi.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Sharma, H., et al.: J. Mycol. Plant. Pathol., 42, 494 (2012); Sen, K., et al.: Food. Chem. Toxicol., 50, 3990 (2012); Pitt, W.M., et al.: Plant Disease., 96, 1303 (2012);

Applications Labelled Gefitinib (G304000). Gefitinib is an antineoplastic.
References Anderson, N.G., et al.: Int. J. Cancer, 94, 774 (2001), Hirata, A., et al.: Cancer Res., 62, 2554 (2002), Kris, M.G., et al.: J. Am. Med. Assoc., 290, 2149 (2003), Tamura, K., et al.: Expert Opin. Pharmacother., 6, 985 (2005),

Applications Daminozide is a plant growth regulator used to improve crop quality and maximize yield.Used as a standard for Pesticide detection. Useful in cannabis testing kits as a component of pesticide mixes (P698240).
References Xiaoming, R., et al.: Field Crops Res, 149, 1-10 (2013)

Stability Hygroscopic
Applications A metabolite of Bufuralol, a β-Adrenergic blocker with peripheral vasodilating activity.
References Boobis, A.R., et al.: Biochem. Pharmacol., 34, 65 (1985), Yamazaki, H., et al.: Mol. Pharmacol., 46, 568 (1994), Mast, N., et al.: Biochem., 42, 14284 (2003),

Stability Hygroscopic
Applications Anesthetic (local); antiarrhythmic (class IB). Long-acting, membrane stabilizing agent against ventricular arrhythmia. Originally developed as a local anesthetic.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Duce, R., et al.: J. Pharmacol. Exp. Ther., 179, 580 (1971), Kronberg, G.H., et al.: J. Med. Chem., 16, 739 (1973), Groningsson, K., et al.: Anal. Profiles Drug Subs., 14, 207 (1985), Davies, P.S., et al.: Drugs, 64, 937 (2004),