Toxicologie

Applications Phenothrin is a pesticide used in the control of pests and insects. It is used in cannabis testing kits as a component of pesticide mixes (P698240).
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Wang, Y. et al.: Chemopshere, 90, 848 (2013); Hirahara, Y. et al.: Japan. J. Toxicol. Env. Health, 44, 451 (1998);

Applications Methoprene, is a juvenile hormone (JH) analog which can be used as an insecticide that acts as a growth regulator. Useful in cannabis testing kits as a component of pesticide mixes (P698235).
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Xiao-li, M., et al.: Nongyao, 52, 380 (2013); Anon.IP.com Journal, 12, 9 (2012);

Applications Levofloxacin-d3, is the labeled analogue of Levofloxacin (L360000), an antibiotic used against gram-negative organisms.
References Kato, M., et al.: Arzneim.-Forsch., 42, 365 (1992), North, D.S., et al.: Pharmacotherapy, 18, 915 (1998), Hwang, D.G., et al.: Br. J. Ophthalmol., 87, 1004 (2003),

Applications Labelled Cefuroxime (C248050). Antibacterial.
References O’Callaghan, C.H., et al.: Antimicrob. Agents Chemother., 9, 511 (1976), Norrby, R., et al.: J. Antimicrob. Chemother., 3, 355 (1977), Brogden, R.N., et al.: Drugs, 17, 233 (1979), Wozniak, J.R., et al.: Anal. Profiles Drug Subs., 20, 209 (1991),

Applications NN703 (Tabimorelin) is an orally active growth hormone (GH) secretagogue intended for use as an alternative to daily injections of GH. In vitro studies in human liver microsomes have indicated that NN703 is a mechanism-based inhibitor of CYP3A4.
References Fabre, G., et al.: Biochem. Pharmacol., 37, 4389 (1988), Thummel, K., et al.: Clin. Pharmacol. Ther., 59, 491 (1996), Yu, D., et al.: J. Clin. Pharmacol., 39, 1203 (1999),

Applications Labelled Folpet (F402000). Agricultural fungicide.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Cohen, S., et al.: Crit. Rev. Toxicol., 40, 531 (2010), Wong, J., et al.: J. Agric. Food Chem., 58, 5884 (2010),

Applications A β1 selective aryloxypropanolamine andrenergic antagonist. Used in the treatment of a variety of cardiovascular disorder.
References McGourty, J.C., et al.: Br. J. Clin. Pharmacol. 20, 555 (1985), Lennard, M.S., et al.: Biochem. Pharmacol., 35, 2757 (1986),

Applications Anidulafungin, is a semisynthetic echinocandin that inhibits glucan synthase, an enzyme important in the formation of (1→3)-β-D-glucan, a major fungal cell wall component, and thus is used as antifungal drug.
References Denning, D. W., et al.: J. Antimicrob. Chemother, 40, 611 (1997); Vazquez, J. A., et al.: Clin. Ther., 27(6), 657 (2005);

Applications Bictegravir-15N, d2 is the labeled version of Bictegravir, which is a novel, potent inhibitor of HIV-1 integrase with an IC50 of 7.5 nM.
References Tsiang M. et al.: Antimicrob Agents Chemother. 2016 Nov 21;60(12):7086-7097;

Applications 2'-O-Methyl Uridine-d3 is an isotope labelled compound of 2'-O-Methyl Uridine (M338200), a uridine analog used for the preparation of antiviral nucleoside derivatives as inhibitors of subgenomic hepatitis C virus RNA replication.
References Gratzner, H., et al.: Science, 218, 474 (1982), Jarvis, T., et al.: J. Biol. Chem., 271, 29107 (1996), Pavco, P., et al.: Clin. Cancer Res., 6, 2094 (2000),

Applications β-Cypermethrin is a pyrethroid compound that is used as an insecticide to eliminate unwanted pests from crop fields. β-Cypermethrin has been advertised to be safe for humans despite the fact that considered a possible human carcinogen.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Chen, S., et al.: Appl. Micro. 94, 505 (2012); Li, Z., et al.: Bull. Env. Cont. Toxicol., 80, 335 (2008)

Applications A metabolite of Imipramine (I465980).
References Magdalou, J., et al.: J. Biol. Chem., 257, 13624 (1982), Orzechowski, A., et al.: Carcinogenesis, 15, 1549 (1994), Hawes, E., et al.: Drug Metab. Dispos., 26, 830 (1998),

Applications Bromothalonil can be used in biological study of comparison and validation of an in vitro skin sensitization strategy using a data set of 33 chemical references.Environmental toxin on US EPA Toxic Release Inventory list (TRI) list.
References Clouet, E., et al.: Toxicology In Vitro, (2017)

Applications The active labelled metabolite of the antibacterial dye, Sulfamidochrysoidine. Inhibits folic acid synthesis in prokaryotes. Antibacterial.
References Colebrook, L., et al.: Lancet, 233, 1291 (1937), Dye, C., et al.: Nat. Rev. Microbiol., 7, 81 (2009), Isik, S., et al.: Bioorg. Med. Chem., 17, 1158 (2009),

Applications (+)-Irinotecan is a Topo I inhibitor.

Applications Labelled Deshydroxyethoxy Ticagrelor analog of Ticagrelor (T437700) an antiplatelet agent, and preventative in the treatment of heart attacks, myocardial infarction, and other pulmonary diseases.
References Zhang, H. et al.: Bioorg. Med. Chem. Lett., 22, 3598 (2012);

Applications Bis-(1-Chloro-2-propyl)phosphate is the metabolite of organic flame retardants.
References Schindler, B. et al.: Anal. Bioanal. Chem., 395, 1167 (2009);

Applications Herbicide, active by perturbing cell membranes
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Hollender, J., et al.: Environ. Sci. Technol., 43, 7862 (2009), Bollman, S., et al.: Weed Technol., 23, 264 (2009), Goudarzi, N., et al.: J. Agric. Food Chem., 57, 7153 (2009),

Applications Imazapic can be used in analytical and biological studies of residue analysis and determination of imidazolinone herbicides in sunflower and soil by GC-MS.
References Ozcan, C., et al.: Chromatographia, 80, 941 (2017)

Applications Valproic Acid-d15 β-D-Glucuronide, is the labeled analogue of Valproic Acid β-D-Glucuronide (V094760), a metabolite of Valproic acid.
References Rudy, A., et al.: J. Pharmacol. Exp. Ther., 259, 1133 (1991), Nagai, K., et al.: J. Antimicrob. Chemother., 39, 295 (1997), Yamamura, N., et al.: Drug Metab. Dispos., 27, 724 (1999)

Applications A mixture of 2 metabolites of butadiene. The isomeric ratio has been determine to be approximately 1:1 based on proton nmr integration.
References Barnsley, E.A., et al.: Biochem. J., 100, 362 (1966),

Applications Piperonyl Butoxide-d9 is a deuterated analog of Piperonyl Butoxide an Insecticide synergist, especially for pyrethroids and rotenone. Also used in Cannabis testing.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Jiang, W., et al.: J. Econ. Entomol., 103, 1365 (2010), Markussen, M., et al.: Pest. Biochem. Physiol., 98, 50 (2010),

Applications Tetradifon is an acaricide and ovicide. Also, Tetradifon possessed nephrotoxic by promoting kidney morphometric and functional damage and depleting renal antioxidant defense system in rats.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Badraoui, R., et al.: Exp Toxicol Pathol., 64, 645-50 (2012);

Applications An anti-inflammatory and analgesic agent. Anesthetic (local).
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Reynolds, et al.: Br. J. Anaesth., 43, 33 (1971), Tullar, et al.: J. Med. Chem., 14, 891 (1971), Aberg, G., et al.: Acta Pharmacol. Toxicol., 31, 273 (1972),

Applications Sedative, hypnotic.Controlled substance (depressant).
References Lomen, P., et al.: J. Int. Med. Res., 4, 55 (1976), Allens, G.S., et al.: J. Int. Med. Res., 6, 343 (1978), Pakes, G.E., et al.: Drugs, 22, 81 (1981)

Applications Aminopyralid is used as a herbicide for control weeds and arthropods.
References Mitich, L., et al.: Weed Technol., 14, 231 (2000), Berisford, Y., et al.: Weed Sci., 54, 391 (2006), Westra, P., et al.: Proc. Weed Sci. Soc. America, 49, 407 (2009),

Applications Spinetoram L is an impurity of Spinetoram (S683650), Spinetoram belongs to spinosyn family of insecticides and shows potential of natural products research.
References Kirst H. A.: J. Antibiot., 63, 101-111 (2010)

Applications Non-absorbable semisynthetic Rifamycin antibiotic.
References Brufani, M., et al.: J. Antibiot., 37, 1611 (1984), Gillis, J.C., et al.: Drugs, 49, 467 (1995), Huang, D.B., et al.: J. Infection, 50, 97 (2005),

Applications (±)-Fluazifop-d4 is a labeled analogue of (±)-Fluazifop (F407430), a grass-selective herbicide which inhibits acetyl-CoA carboxylase in sensitive plant species.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Walker, K.A., et. al.: Biochem. J., 254, 307 (1988); Hajslova, J., et. al.: J. Chrom., 438, 55 (1988)

Applications Xanthine derivative with diuretic, cardiac stimulant and smooth muscle relaxant activities; isomeric with theobromine. Small amounts occur in tea. Bronchodilator.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Cohen, J.L., et al.: Anal. Profiles Drug Subs., 4, 466 (1975), Svedmyr, K., et al.: Allergy, 37, 111 (1982),

Applications cis-1-(3-Chloroallyl)-3,5,7-triaza-1-azoniaadamantantane Chloride is a quaternary ammonium salt used as a preservative in many cosmetics and industrial substances.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Marouchoc, S.: Cosm. Sci. Technol. Series, 1, 143 (1984); Cheng, J., et al.: J. Toxicol. Cutan. Ocul. Toxicol., 14, 287 (1995);

Applications Bromethalin is used to protect plants from insect pests. Is attractant, chemosterilant and rodenticide for mice pest control.
References Leland, J., et al.: PCT Int. Appl., (2019); Gries, G., et al.: PCT Int. Appl., (2017);