Toxicologie

<p>Stability Moisture Sensitive<br>Applications Phosphoric acid diethyl ester is an organophosphate that is usually found in pesticides and is known to induce changes in male hormone profile by decreasing serum testosterone and inhibin B levels. Phosphoric acid diethyl ester is also known to negatively affect the health of women and newborns living in agricultural communities.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Aguilar-Garduno, C., et al.: Toxicology, 307, 55 (2013); Huen, K., et al.: Environ. Res., 117, 8 (2012)<br></p>

<p>Applications Bicyclomycin benzoate is a polar metabolite with activity against Gram negative bacteria.<br></p>

<p>Applications Pyribenzoxim can be used in biological study of production of acetolactate synthase inhibitor herbicide tolerant Brassica napus mutants.<br>References Ruiter, R., et al.: U.S. Pat. Appl. Publ., US 20150089682 A1 20150326 (2015)<br></p>

<p>Applications Cymoxanil-d3 (methoxy-d3) (CAS# 2140803-92-3) is a useful isotopically labeled research compound of Cymoxanil(C988995). Cymoxanil is a fungicide applied as a seed treatment or as a foliar application to the plants to control late blight.<br>References Dhingani, J. C., et al.: J. Pure. App. Microbiol., 6, 1683 (2012); Bakirici, G.T., et al.: Food. Chem., 135, 1901 (2012);<br></p>

<p>Applications Labelled Entecavir. An oral antiviral drug used in the treatment of hepatitis B infection. A guanine analogue that inhhibits all three steps in the viral replication process.<br>References Innaimo, S.F., et al.: Antimicrob. Agents Chemother., 41, 1444 (1997), Honkoop, P., et al.: Expert Opin. Invest. Drugs, 12, 683 (2003), Chang, T.-T., et al.: N. Engl. J. Med., 354, 1001 (2006),<br></p>

<p>Applications Metribuzin DK is a selective triazine herbicide used in the control of broadleaf weeds. Used in the protection of vegetable and fruit crops. Pesticide.<br>References Xie, Y. et al.: Microchem. J., 133, 468 (2017);<br></p>

<p>Stability Hygroscopic<br>Applications Isotope labelled 1,6-Anhydro-β-D-glucopyranose (A648100), an compound that have been proven to be a valuable synthon for the preparation of various biologically important and structurally diverse products (e.g. rifamycin S, indanomycin, thromboxane B2, (+)-biotin, tetrodotoxin, quinone, and macrolide antibiotics) as well as for modified sugars.<br>References Fraser-Reid, B., et al. J. Am. Chem. Soc. 106, 731 (1984); Edwards, M.P., et al. J. Org. Chem. 49, 3503 (1984); Kelly, A.G., and Roberts, J.S. J. Chem. Soc., Chem. Commun. 228, (1980); Ogawa, T., et al. Carbohydr. Res. 57, C31 (1977); Isobe, M., et al. Tetrahedron Lett. 28, 6485 (1987);<br></p>

<p>Applications Propazine<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications Florasulam is a triazolopyrimidine sulfonamide compound that is used as a post emergence herbicide. Florasulam is often used to control dandelion populations in wheat fields.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Krieger, M., et al.: J. Agr. Food Chem., 48, 3710 (2000); Li, Z., et al.: Bull. Environ. Cont. Toxicol., 90, 280 (2013)<br></p>

<p>Applications Perindoprilat-d4 is the isotope labelled analog of Perindoprilat (P287531); an angiotensin-converting enzyme (ACE) inhibitor and antihypertensive.<br>References Pascard, C., et al.: J. Med. Chem., 34, 663 (1991)<br></p>

<p>Applications A fat-metabolism stimulator. Antioxidant.<br>References Plotzker, R., et al.: Am. J. Med. Sci., 283, 79 (1982), Evans, J., et al.: Diabetes Technol. Ther., 2, 401 (2000), Konrad, D., et al.: Diabetes, 50, 1464 (2001), Lockhart, B., et al.: Brain Res., 855, 292 (2000),<br></p>

<p>Applications Diethanolamine similar to triethanolamine (T775580) is used as a surfactant. It also has the potential to be a corrosion inhibitor by means of chemisorption. This is the labelled analog.<br>References Bhajiwala, H.M et al.: Bull. Electrochem., 17, 441 (2001); Yu, J. et al.: Thin. Solid. Films., 379, 7 (2000);<br></p>

<p>Applications Bis-(1-Chloro-2-propyl)phosphate is the metabolite of organic flame retardants.<br>References Schindler, B. et al.: Anal. Bioanal. Chem., 395, 1167 (2009);<br></p>

<p>Applications Chlorethoxyfos is an organophosphorous pesticide/insecticide.<br>References Li, S., et al.: Toxicology In Vitro, 56, 93 (2019); Yi, X., et al.: Sepu, 34, 1097 (2016); Can, A., et al.: Toxicol. Lett., 230, 434 (2014)<br></p>

<p>Applications Clindamycin Palmitate is a semi-synthetic antibiotic with high bioavailability. Clindamycin Palmitate is an antibacterial.<br>References Platzer, D., et al.: J. Pharm. Biomed. Anal., 41, 84 (2006),<br></p>

<p>Impurity Azithromycin EP Impurity L<br>Applications Azithromycin N-Oxide (Azithromycin EP Impurity L) is an Azithromycin (A927000) impurity. A degradation products of Azithromycin.<br>References Anon., et al.: Pharmaeuropa, 13, 750 (2001),<br></p>

<p>Applications Darunavir intermediate, a potent inhibitor of HIV-1 protease.<br>References Debouck, C., et al.: Drug Dev. Res., 21, 1 (1990), Krohn, A., et al.: J. Med. Chem., 34, 3340 (1991), Sham, H., et al.: Antimicrob. Agents Chemother., 42, 3218 (1998),<br></p>

<p>Applications 1,1,3,3,5,5,7,7,9,9,11,11-DODECAMETHYLHEXASILOXANE (cas# 995-82-4) is a useful research chemical.<br></p>

<p>Applications Labelled Dimethomorph (D460530). Agricultural fungicide.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Lu, X., et al.: Phytopathol., 100, 1162 (2010), Schafer, R., et al.: Environ. Sci. Technol., 45, 1665 (2011),<br></p>

<p>Applications Labelled Fenthion, an organothiophosphate insecticide. Fenthion is also a potent acaricide.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Pati, B.R. et al.: Plant Soil, 80, 215 (1984); Barros, A.T. et al.: Vet. Parasitol., 96, 243 (2001); Kyriakidis, N.V. et al.: Food Chem., 91, 241 (2005);<br></p>

<p>Applications Triallate is a pesticide.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Schneider, M., et al.: J. Environ. Qual., 42, 844 (2013); Busi, R., et al.: Pest Manag. Sci., 69, 1379 (2013)<br></p>

<p>Stability Hygroscopic<br>Applications Oseltamivir 5-Desamino 5-(2-Formyl 5-Hydroxymethylpyrrol-1-yl) is derived from Oseltamivir Phosphate (O701000), which is an orally active inhibitor of influenza virus neuraminidase; converted in vivo to the active acid metabolite. An antiviral drug. It is a COVID19-related research product.<br>References Oliyai, R., et al.: Pharm. Res., 15, 1300 (1998), Kim, C.U., et al.: Med. Chem. Res., 8, 392 (1998), Hayden, F.G., et al.: N. Engl. J. Med., 341, 1336 (1999), Treanor, J.J., et al.: J. Am. Med. Assoc., 283, 1016 (2000)<br></p>

<p>Stability Unstable in Solution<br>Applications Iodosulfuron is a weed management herbicide used in crop protection.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Bro, E. et al.: Sci. Total Env., 521, 315 (2015); Gandy, M. et al.: Org. Biomol. Chem., 13, 5586 (2015);<br></p>

<p>Stability Hygroscopic<br>Applications Pizotifen Malate is an anti migraine drug.<br>References Serna-Jimenez. et al.,Int. J. Pharm. 492, 223-232(2015);<br></p>

<p>Applications Flutriafol is a systemic fungicide of the triazole class. Flutriafol has broad spectrum fungicidal activity and is used to control effectively cereal powdery mildew, cloud disease, leaf spot disease and rust disease.<br>References Gozzo, F. et al.: Pest. Biochem. Physiol., 40, 68 (1991); Cao, W. et al.: Jing. Huag. Zhong., 36, 33 (2006); Evans, V.J. et al.: BCPC Conf. Pests Dis., 1, 511 (2000);<br></p>

<p>Stability Light Sensitive<br>Applications Maytansine inhibits in vitro polymerization of tubulin and is used in the treatment of advanced breast cancer.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Remillard, S., et. al.: Science, 189, 1002 (1975); Prota, A.E., et. al.: P. Natl. Acad. Sci. USA, 111, 13817 (2014)<br></p>

<p>Stability Hygroscopic<br>Applications N,N-Diethyltryptamine Hydrochloride is a derivative of Tryptamine (T894600). Tryptamine is a monoamine alkaloid found in plants and is commonly used in the preparation of biologically active compounds such as neurotransmitters and psychedelics.<br></p>

<p>Applications Flometoquin is a pesticide. It is also used in other insecticidal compositions containing flometoquin and anabasine as active ingredients. An agrochemical compound.<br>References Anon.: Fain Kemikaru, 41, 34 (2012); Anon.: IP.com J., 12, 19 (2011); Ren, T., et al.: From Faming Zhuanli Shenqing (2014), CN 103814939 A 20140528; Jeanmart, S., et al.: Bioorg. Med. Chem., 24, 317 (2016)<br></p>

<p>Applications Potent inhibitor of Phosphatidylinositol 3-kinase (PI3K)<br></p>

<p>Stability Hygroscopic<br>Applications Deuterated, Memantine (M218000) which is used as an antiparkinsonian and antispasmodic.<br>References Rohde, H., et al.: Fortschr. Med., 100, 2023 (1982), Kornhuber, J., et al.: Eur. J. Pharmacol., 166, 589 (1989), Gortelmeyer, R. and Erbler, H.: Arzneimittel-Forsch., 42, 904 (1992)<br></p>

<p>Stability Hygroscopic<br>Applications MCPA-L-carnitine is a derivative of L-Carnitine (C184110); an essential cofactor of fatty acid metabolism required for the transport of fatty acids through the inner mitochondrial membrane.<br>References Mitchell, M.E., et al.: Am. J. Clin. Nutr., 31, 293 (1978); Lango, R., et al.: Cardiovasc. Res., 51, 21 (2001); Vaz, F.M., et al.: Biochem. J., et al.: 361, 417 (2002); Karlic, H., et al.: Nutrition, 20, 709 (2004)<br></p>

<p>Applications D-p-Hydroxyphenylglycinamide is an activated side chain precursor and is an intermediate in the synthesis of 3-(4-Hydroxyphenyl)-2(1H)-pyrazinone (H951260), which is a potential impuritiy of the penicillins, ampicillin and amoxicillin, which have not been reported previously. 3-(4-Hydroxyphenyl)-2(1H)-pyrazinone impurity may be formed during the semi-synthetic preparation of these antibiotics or upon their degradation.<br>References Munro, A., et al.: J. Pharm. Sci., 67, 1197 (1978); Lebelle, M., et al.: J. Pharm. Pharmacol., 31, 441 (1979); Gabor, E., et al.: PCT Int. Appl., WO 2004111241 A1 20041223 (2004)<br></p>

<p>Applications Anthracene is obtained from coal tar. It is an important source of many dyes.This compound is a contaminant of emerging concern (CECs)<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications ent-Entecavir is an enantiomeric impurity of the antiviral drug Entecavir (E558900).<br>References Ruediger, E. et al.: Tetrahed. Lett., 45, 739 (2004): Bisacchi, G.S. et al.: Bioorg. Med. Chem. Lett., 7, 127 (1997);<br></p>

<p>Applications Alloxydim-sodium can be used to prepare methods and formulas for prevention of downward migration of agricultural materials, as well as, controlling of herbicide resistant or tolerant weeds.<br>References Essig, K., et.al., PCT Int. Appl., 84,(2020); Kraus, H., et.al., PCT Int. Appl., 75,(2019);<br></p>

<p>Applications JNJ 42041935 is a selective hypoxia-inducible factor (HIF) prolyl hydroxylase (PHD) enzyme inhibitor. It can potentially be used for the treatment of inflammation-induced anemia.<br>References Barrett, T., et al.: Mol. Pharmacol., 79, 910 (2011); Thirstrup, K., et al.: Pharmacol. Res., 64, 268 (2011);<br></p>