Toxicologie

Applications T-705RTP-13C5 Sodium Salt is a labeled salt derivative of T-705 (F103350) which has activity against the lethal H5N1 influenza A viruses.
References Yousuke, F., et al.: Antimicrob Agent Chemother., 49, 981 (2005); Kiso, M., et al.: Proc. Natl. Acad. Sci. U.S.A., 107, 882 (2010)

Applications Diphenyl Phosphate is an organophosphate diester and metabolite of the flame retardant Triphenyl Phosphate (T808990) and also a metabolite of 2-Ethylhexyl diphenyl phosphate.
References Cooper, E.M. et al.: Anal. Bioanal. Chem., 401, 2123 (2011); Nishimaki-Mogami, T. et al.: Arch. Toxicol., 61, 259 (1988);

Applications 2-Chloro-N-(4'-chloro-5-hydroxy[1,1'-biphenyl]-2-yl)-3-pyridinecarboxamide is a biscalid (B675850) metabolite that is used as a pesticide or for pesticide tolerance in certain commodities.
References Joyner, S., et al.: Federal Register, 75, 29901 (2010); Environmental Protection Agency.: Federal Register, 68, 44640 (2003)

Applications 8-Epitacrolimus is a new l-pipecolic acid macrolide lactone, an important immunosuppressive drug that blocks T cell proliferation in vitro by inhibiting the generation of several lymphokines, especially IL-2. 8-Epitacrolimus is also an Epimer of Tacrolimus (F370000).
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Skytte, D.M., et al.: J. Nat. Prod.,73, 776 (2010); Rokaw, M.D., et al.: Am. J. Physiol., 271, C194 (1996); Knoll, G.A., and Bell, R.C.: Brit. Med. J., 318, 1104 (1999);

Applications N-Isopropyl quaternary salt of Atropine. Nonselective muscarinic acetylcholine receptor antagonist; bronchodilator.
References Groeben, H., et al.: Anesthesiology, 85, 867 (1996), Haddad, et al.: Br. J. Pharmacol., 127, 413 (1999), Barnes, P. J., et al.: Chest, 117, 63S (2000),

Applications δ-Ketoendrin is an isomerization product of Endrin (E555530), a chlorinated hydrocarbon insecticide that produces hepatic and neurologic toxicity. Endrin is also known to produce hyperexcitability of the human central nervous system that could result in convulsions. δ-Ketoendrin is an endocrine disrupting compound that has been found in human fetal and newborn tissues.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Burton, W.B., Pollard, G.E.: B. Environ. Contam. Tox., 12, 113 (1974); Bagchi, M., et al.: Arch. Env. Contam. Toxicol., 23, 1 (1992); Coble, Y., et al.: JAMA, 202, 489 (1967); Eisler, R. & Edmunds, P.: Trans. Am. Fish. Soc., 95, 153 (1966); Cappiello, A., et. al.: Anal. Bioanal. Chem., 406, 2779 (2014)

Applications 3-Isopropylphenyl Methylcarbamate is a potential human-safe insecticide against the malaria mosquito.
References Hartsel, J. A., et al.: Bioorg. Medicinal Chem. Lett., 22, 4593 (2012); Naik, P. K., et al.: SAR QSAR Environ. Res., 20, 551 (2009); Shang, Z., et al.: Nongyaoxue Xuebao, 2, 17 (2000)

Applications Metolachlor OA is a derivative of Metolachlor (M338700), a selective pre-emergence herbicide. Drinking water contaminant candidate list 3 (CCL 3) compound as per United States Environmental Protection Agency (EPA), environmental, and food contaminants.
References 1. McGahen, L. et al.: J. Agric. Food Chem. 1978 26 (2), pp 414–4192. Chesters, G. et al.: Rev. Environ Contam Toxicol. 1989;110:1-74.

Applications Glyphosate-13C,15N is the labelled analogue of Glyphosate (G765000), which is used as a herbicide.
References Davis, V., et al.: Weed Sci., 57, 494 (2009), Bellaloui, N., et al.: J. Agric. Food Chem., 57, 9050 (2009),

Applications 5β-Dihydrocortisol, is a derivative of Cortisol (H714615), which is a steroid hormone, more specifically a glucocorticoid, produced by the zona fasciculata of the adrenal gland.
References Vigore, L., et al.: Cancer Ther., 6, 699 (2008), Puurunen, J., et al.: J. Clin. Endocrinol. Metab., 94, 1973 (2009), Lemos, D., et al.: J. Endocrinol., 201, 275 (2009), Chen, S., et al.: Am. J. Physiol., 296 (2009),

Applications Semisynthetic labelled Erythromycin derivative. Antibacterial.
References Jones, R.N., et al.: Antimicrob. Agents Chemother., 24, 209 (1983), Barry, A.L., et al.: Eur. J. Clin. Microbiol., 5, 536 (1986), Grassi, C., et al.: Chemioterapia, 6, 41 (1987),

Applications Triclosan is used as bactericide and preservative for cosmetic and detergent compositions (1). Broadly used as an antiseptic and disinfectant (2).This compound is a contaminant of emerging concern (CECs). Drinking water contaminant candidate list 3 (CCL 3) compound as per United States Environmental Protection Agency (EPA). Environmental contaminants; Food contaminants.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References 1. Lindström, A. et al.: Environ. Sci. Technol. 2002 Jun 1;36(11):2322-9. 2. Ruszkiewicz, J. et al.: J. Toxicol. Environ. Health B. Crit. Rev. 2017;20(2):104-117.

Applications 1,4-Dihydro-4-oxo-3-quinolinecarboxylic Acid Ethyl Ester has been studied as a novel influenza endonuclease inhibitor. They also function as high-affinity ligands at the benzodiazepine site of brain GABAA receptors.
References Baughman, B. et al.: ACS. Chem. Biol., 7, 526 (2012); Gaurav, A. et al.: Medicin. Chem. Res., 20, 192 (2011);

Applications Disodium Salt of 3-Methylphosphinicopropionic Acid, the major metabolite of Glufosinate (G596950), used as herbicide.
References Royer, A., et al.: Anal. Chem., 72, 3826 (2000), Muller, B., et al.: Pestic. Manag. Sci., 57, 46 (2001), Duke, S., et al.: J. Agric. Food Chem., 51, 340 (2003),

Applications A new, oral, small-molecule Tyrosine Kinase Inhibitor (TKI) for the treatment of CML. Antineoplastic. It is a COVID19-related research product.
References Lombardo, L.J., et al: J. Med. Chem., 47, 6658 (2004), Shah, N. P., et al.: Science, 305, 399 (2004), O’Hare, T., et al.: Curr. Opin. Genet. Dev., 16, 92 (2006),

Stability Hygroscopic
Applications Propoxycarbazone sodium salt
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package

Applications Paraquat Monopyridone Iodide is a metabolite of Paraquat (P191900), a commonly used heribicide.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Fuke, C., et al.: Arch. Toxicol., 70, 504 (1996); Heylings, J.R. et al.: Toxicology, 241, 1 (2007); Wibawa, W., et al.: Int. J. Agric. Biol., 11, 145 (2009); Franco, R. et al.: Chem.-Biol. Inter., 188, 289 (2010);

Applications Useful as a therapeutic antimicrobial for the treatment of respiratory infections.
References Pandey, S., et al.: J. Environ. Biol., 14, 267 (1993), Halling-Sorensen, B., et al.: J. Antimicrob. Chemother., 46, 53 (2000), Kim, S., et al.: Environ. Sci. Technol., 41(1), 50 (2007)

Applications Antiemetic, antipsychotic; used in treatment of vertigo.
References Taylor, W.B., et al.: Br. J. Clin. Pharmacol., 23, 137 (1987), Ward, A.E., Br. J. Clin. Pract., 42, 228 (1988),

Applications A reagent used to synthesize various dyes used in the textile industry. This is the labeled analog.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Rosenkranz, H.S. et al.: Mutagen., 5, 137 (1990);

Stability Hygroscopic
Applications A metabolite of Deferiprone (D474000).
References Choudhury, R., et al.: Drug Metab. Dispos., 23, 314 (1995),

Applications Platycodin D is a known inhibitor of the proliferation of human gastric cancer cells as well as inducing apoptosis. It also causes anti-atherosclerotic.
References Wu, J. et al.: Biol. Pharm. Bull. 35, 1216 (2012); Chun, J. et al.: J. Cell. Biochem., 114, 456 (2013);

Applications Tolfenpyrad is used as foliar insecticide for the control of green peach aphids in broccoli.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Thurman, E., et al.: Food Addit. Contam., 23, 1169 (2006), Mezcua, M., et al.: Food Chem., 112, 221 (2009)

Applications Succinic Acid-1,4-13C2 (cas# 79864-95-2) is a compound useful in organic synthesis.

Applications Amino acid substitute tumor growth.
References Villiers, C.L., et al.: Eur. J. Biochem., 140, 421 (1984);

Applications Labelled 5-FU, a potent antineoplastic agent in clinical use. Also an inhibitor of DNA synthesis.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Rudy, B.C., et al.: Anal. Profiles Drug Subs., 2, 221 (1973), Miyashita, O., et al.: Chem. Pharm. Bull., 29, 3181 (1981), Hansen, R.M., et al.: Cancer Invest., 9, 637 (1991),

Stability Hygroscopic
Applications L-Penicillamine Hydrochloride is a salt form of L-Penicillamine (P2230005). L-Penicillamine is a metabolite of penicillin. L-Penicillamine is used in the treatment of Wilson’s disease, Cystinuria, Scleroderma and arsenic poisoning.
References Marti-Prats, L., et al.: Neurosci. Lett., 483, 143 (2010), Singh, A., et al.: J. Pharm. Sci., 99, 3931 (2010), Everette, J., et al.: J. Agric. Food Chem., 58, 8139 (2010),

Applications (-)-Carbovir, is a nucleoside/nucleotide reverse transcriptase inhibitor (NRTI) caused mitochondrial toxicity in human hepatoma carcinoma cell.
References Suo, Z., et al.: J. Biol. Chem., 273, 27250 (1998), Ray, A., et al.: Antimicrob. Agents Chemother., 48, 1089 (2004), Lynx, M., et al.: Biochem. Pharmacol., 71, 1342 (2006),

Stability Hygroscopic
Applications 5-Aminoimidazole-4-carboxamide Lactose Adduct is a lactose adduct of 5-Aminoimidazole-4-carboxamide (A611690), a metabolite of Temozolomide (T017775).
References Jaeken, J., et al.: Lancet, 2, 1058 (1984), Baggott, J., et al.: Biochem. J., 236, 193 (1986), Baggott, J., et al.: Arch. Dermatol., 135, 813 (1999)

Applications Trinexapac-d5, is the labeled analogue of Trinexapac (T886315), a plant growth regulator that studies have shown to have the enzymic activity of histone lysine demethylases and histone modifications during the neural stem/progenitor cell differentiation
References Vavilala, D. et al.: Toxicology Reports, Vol.1, P: 1152-1161 (2014);

Applications Quinclorac is a disubstituted quinolinecarboxylic acid that is part of a new class of highly selective auxin herbicides. Quinclorac is used in rice to control dicotyledonous and monocotyledonous weeds, particularly barnyardgrass (Echinochloa crus-galli). Quinclorac is also used for weed control in turfgrasses.
References Haden, E. et al.: Proc. Br. Corp. Prot. Conf. Weeds, 1, 77 (1985); Chism, W.J. et al.: Weed Sci., 39, 62 (1991); Grossmann, K. et al.: Weed Sci., 46, 707 (1998);

Applications 2,6-Dichloro-4-(trifluoromethyl)aniline is used in the synthesis of GABA receptor antagonists and insecticides.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Sammelson, R. et al.: Bioorg. Med. Chem., 12, 3345 (2004); Huang, W. et al.: Bioorg. Med. Chem., 14, 8280 (2006);

Applications 2,4-Dichlorophenol-13C6 is the labelled analog of 2,4-Dichlorophenol (D435685). 2,4-Dichlorophenol is a chlorinated derivative of phenol and is used as an intermediate for the preparation of herbicide 2,4-dichlorophenoxyacetic acid (D435680).
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Zhong, W., et al.: J. Hazard. Mat., 217, 286 (2012); Rowe, V.K., et al.: Am. J. Vet. Res., 15, 622 (1954), Way, J.M., et al.: Residue Rev., 26, 37 (1969)

Applications Labelled Melperone, a neuroleptic butyrophenone. Melperone is also an antiarrhythmic agent. Melperone is an effective atypical antipsychotic drug used in the treatment of schizophrenia.
References Petersen, E.N. et al.: Acta Pharmacol. Toxicol., 42, 388 (1978); Platou, E. et al.: Acta Pharmacol. Toxicol., 50, 108 (1982); Bjerkenstedt, L. et al.: Acta Psych. Scand. Supp., 352, 35 (1989); Meltzer, H.Y. et al.: Psych. Res., 105, 201 (2001);

Applications Mefenpyr-diethyl is used in herbicidal and herbicide-safener combinations as a resistant breaking solution for modern agriculture.
References Lindell, S., et al.: ACS Symposium Series, 1204, 219 (2015); Taylor, V. L., et al.: Environ. Exper. Bot., 88, 93 (2013)

Applications Insecticide; acaricide.This compound is a contaminant of emerging concern (CECs).Useful in cannabis testing kits as a component of pesticide mixes (P698230).
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Smith, G.N., et al.: J. Agric. Food Chem., 15, 132 (1967), Schafer, et al.: Toxicol. Appl. Pharmacol., 21, 315 (1972)

Applications A synthetic derivative of Dehydroepiandrosterone. The reduced androgenicity of Fluasterone may obviate toxicities associated with the androgenicity of the parent compound. Antitumor agent. Used in clinical trials for prostate cancer prevention.
References Bentley, P., et al.: Food Chem. Toxicol., 31, 857 (1993), Rao, K., et al.: Cancer Res., 59, 3084 (1999), Masuzaki, H., et al.: Science, 294, 2166 (2001), Osawa, E., et al.: Life Sci., 70, 2623 (2002),

Stability Very Very Hygroscopic
Applications Tiazofurin has antitumor activity and is a potential therapeutic agent in the treatment of cancer. Tiazofurin acts as an inhibitor of Inosine-5'-monophosphate (IMP) dehydrogenase.
References Streeter, D.G. et al.: Biochem. Biophys. Res. Comm., 115, 544 (1983); Boritzki, T. et al.: Biochem. Pharmacol., 34, 1109 (1985); Malek, K. et al.: Leuk. Res., 28, 1125 (2004);

Applications Lurasidone (cas# 367514-87-2) is a useful research chemical.

Applications Oxamyl is a pesticide used in the treatment and protection of crops from parasites and insects. Oxamyl is also useful in cannabis testing kits as a component of pesticide mixes (P698240).
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package

Applications Cetrimonium Chloride, is a topical antiseptic. It is also used in hair conditioners and shampoos, as a conditioning agent
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Zahang, M. et al.: Zoazhi Huaxueoin, 24, 13 (2012);