Toxicologie

Applications Copper Acetoarsenite has been used as a rodenticide and insecticide, and also as a pigment, despite its toxicity. It is also used as a blue colorant for fireworks.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Gaines, T.: Toxicol. Appl. Pharm., 2, 88 (1960); Jameson, F.: Paint Manu., 13, 6 (1943)

Stability Hygroscopic
Applications A histamine H2-receptor antagonist which inhibits gastric acid secretion. Antiulcerative.
References Bradshaw, J., et al.: Brit. J. Pharmacol., 66, 464 (1979), Berstad, A., et al.: Scand. J. Gastroenterol, 15, 637 (1980), Hohnjec, M., et al.: Anal. Profiles Drug Subs., 15, 533 (1986),

Applications Gestagenic Testosterone (T155000) derivative. A steroid ligand for the cytosol androgen receptor (AR) of rat prostate.
References Ojasoo, T. et al.; J. Steroid Biochem. 27, 255 (1987); Dore, J. et al.; J. Med. Chem. 29, 54 (1986)

Applications Acephate acts as a contact and systemic insecticide in agriculture through pesticide formulations. Through perinatal exposure studies, it has been linked to hyperglycemia, changes in lipid metabolism and type 2 diabetes (1). Acephate exposed Drosophila melanogaster potentially display an L-ascorbic acid mediated defense (2). Drinking water contaminant candidate list 3 (CCL 3) compound as per United States Environmental Protection Agency (EPA), environmental, and food contaminants. Standard for Pesticide detection. Useful in cannabis testing kits as a component of pesticide mixes (P698240).
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References 1. Ribeiro, T. et al.: Toxicology. 2016 Nov 30;372:12-21. 2. Rajak, P. et al.: J. Hazard. Mater. 2017 Jan 5;321:690-702.

Stability Light Sensitive
Applications A labelled metabolite of Dapsone.
References Preuss, C.V., et al.: Biochem. Pharmacol., 51, 1661 (1996),

Applications Principle alkaloid of opium.This is a controlled substance (opiate). Analgesic (narcotic).
References Buchwald, M.E., et al.: J. Pharmacol. Exp. Ther., 71, 197 (1941), Muhtadi, F.J., et al.: Anal. Profiles Drug Subs., 17, 259 (1988),

Applications Adamantane-d16 is used in the fast catalytic hydroxylation of hydrocarbons with ruthenium porphyrins. Unlabeled adamantane derivatives have been used to treat influenza, as well as serve as NMDA receptor channel blockers for a wide range of pharmaceutical application.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Wang, C. et al.: Inorg. Chem. 45, 4769 (2012); Thomas. A. et al.: J. Neurosci., 25, 3312 (2005); Deyde, V. et al.: Exp. Rev. Mol. Diag., 9, 493 (2009);

Applications Isoprocarb is a non-systematic carbamate insecticide. Isoprocarb functions by reversibly inactivating the enzyme acetylcholinesterase in insects.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Voss, G.: Anzeig. Schaedling., 40, 73 (1967); Metcalf, R.L. et al.: J. Agric. Food Chem., 15, 1022 (1967); Nishioka, T. et al.: Pest. Biochem. Physiol., 6, 320 (1976);

Applications Mieshuan is a pesticide. It is effective against house and wild rodents, including rats and mice.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Teng, T., et al.: Zhonghua Yufang Yixue Zazhi, 13, 220 (1979); Deng, Z.: Chinese J. Preventive Medicine, 13, 220 (1979)

Applications Labelled Propofol β-D-Glucuronide methyl ester (P829810). Propofol β-D-Glucuronide methyl ester is a precursor to metabolite Propofol β-D-Glucuronide (P829780).

Applications (S)-Ropivacaine acts as a local anaesthetic for use during medical procedures. Frequently used in epidural procedures as a labor analgesia
References Bataille, A. et al.: Brit. J. Anaesthesia., 112, 703 (2014); Zhai, Y. et al.: Int. j. Pharm., 47, 103 (2014); Yue, H. et al.: Chin Med. J., 126. 4301 (2013);

Applications An agricultural fungicide. Kresoxim-methyl is also useful in cannabis testing kits as a component of pesticide mixes (P698235).
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Gold, R.E. et al.: Pestic. Sci., 43, 250 (1995); Creemers, P. et al.: Meded. Fac. Landbouwwet. Univ. Gent, 61, 431 (1996); Gold, R.E. et al: Mod. Fungic. Antifungal Compd., 11, 79 (1996);

Applications Ethynyl Estradiol-13C2 is isotope labelled version of Ethynyl Estradiol (E685100) which can be used in biological and analytical studies of simultaneous determination of UV-​filters and estrogens in aquatic invertebrates by modified Quick, Easy, Cheap, Effective, Rugged, and Safe extraction and liquid chromatography tandem mass spectrometry.
References 1. Koetsawang, S. et al.: Contraception. 1982 March:25(3) p231-2412. Cuttler, L. et al.: J. Endocrinol. Metab. 1985 Jun;60(6):1087-92.

Stability Hygroscopic
Applications Meclocycline is a tetracycline antibiotic that is topically used for skin infections and irritations.
References Gohil, V.M., et al.: Nature. Biotechol., 28, 249 (2010); Paemen, L., et al.: Biochem. Pharmacol., 52, 105 (1996);

Applications Isocarbofos D7 (isopropyl D7) is the labelled analogue of Isocarbophos(I789303). Isocarbophos is an organophosphorus pesticide residue found in spicy foods and nuts.
References Gao, Y., et al.: Huaxue Shiji, 39, 1083 (2017); Dong, Y., et al.: Fenxi Huaxue, 45, 1397 (2017)

Applications Growth hormone-release inhibiting factor; treatment of severe, acute hemorrhage of gastroduodenal ulcers; experimental antidiabetic.
References Brazeau, P., et al.: Science, 179, 77 (1973), Siler, T.M., et al.: J. Clin. Endocrinol. Metab., 37, 632 (1973), Pradayrol, L., et al.: Biochem. Biophys. Res. Commun., 85, 701 (1978), Mandarino, L., et al.: Nature, 291, 76 (1981),

Applications Des-[(E)-Methyl-3-methyoxyacrylate] Picoxystrobin is an impurity of Picoxystrobin(P437600). Picoxystrobin is a methoxyacrylate strobilurin fungicide designed for the control of wide range of cereal diseases.
References Walorczyk, S., et al.: J. Chromatograph. A., 1251, 219 (2012); Roszko, M., et al.: J. Am. OIl. Chemist. Soc., 89, 389 (2012);

Applications A deuterated tyrosine kinase inhibitor. Highly specific for BCR-ABL, the enzyme associated with chronic myelogenous leukemia (CML) and certain forms of acute lymphoblastic leukemia (ALL). It is a COVID19-related research product.
References Schindler, T., et al.: Science, 289, 1938 (2000), Drucker, B.J., et al.: N. Engl. J. Med., 344, 1031 (2001),

Applications Triclabendazole Sulfoxide-D3 is a stable isotopically labelled metabolite of Triclabendazole (T774175), an anthelmintic.
References Wolff, K., et al.: Vet. Parasitol., 13, 145 (1983)

Impurity Azithromycin EP Impurity G
Applications 3’-N-Desmethyl-3’-N-tosyl Azithromycin (Azithromycin EP Impurity G) is an Azithromycin (A927000) impurity.
References Kirst, H., et al.: Antimicrob. Agents Chemother., 33, 1419 (1989), Gandhi, R., et al.: J. Pharm. Biomed. Anal., 23, 1073 (2000),

Impurity Oxifloxacin EP Impurity F
Applications Levofloxacin N-oxide is an impurity of Ofloxacin (O245750), which is a fluorinated quinolone antibacterial.
References Horstkotter, C., et al.: J. Chromatography Biomed. Sci. Appli., 754, 169 (2001); Monk, J.P., et al.: Drugs, 33, 346 (1987), Drlica, K., Curr. Opin. Microbiol. 2, 504 (1990)

Impurity Clindamycin Phosphate EP Impurity F
Applications Lincomycin 2-Phosphate (Clindamycin Phosphate EP Impurity F) is the derivative of Lincomycin (L466200), a lincosamide antibiotic that forms cross-links within the peptidyl transferase loop region of the 23S rRNA. Inhibits bacterial protein synthesis. Antibacterial.
References Mason, D.J., et al.: Antimicrob. Agents Chemother., 555 (1962), Gray, et al.: Toxicol. Appl. Pharmacol., 6, 476 (1964), Muti, H.Y., et al.: Anal. Profiles Drug Subs. Excip., 23, 269 (1994),

Applications Sarafloxacin is a quinolone antibiotic drug that was discontinued in 2001. Useful for biological studies and can be detected with colloidal gold test strips.
References Jia, F., et al.: Agric. Biotechnol., 8, 172 (2019)

Applications Defluoro Dolutegravir is an impurity of Dolutegravir (D528800), a second generation HIV-1 integrase strand transfer inhibitor. Dolutegravir is currently in Phase III clinical trials for the treatment of HIV infection. Dolutegravir has been shown to potently inhibit HIV replication in cells such as peripheral blood mononuclear cells (PBMCs), MT-4 cells and CIP4 cells infected with a self-inactivating PHIV lentiviral vector.
References Kobayashi, M. et al. Antimicrob Agents Chemother., 55, 813 (2011); Garrido, C. et al.: Antiviral, Res., 90, 164 (2011); Lenz, J.C.C. et al.: Exp. Opin. Invest. Drugs, 20, 537 (2011);

Applications Irgarol is a highly specific and effective inhibitor of photosynthesis. This makes it ideal, combined with its very low water solubility, for use in long-life antifouling coatings for marine applications to prevent the growth of algae.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Okamura, H., et al.: J. Environ. Sci. Health, B34, 225 (1999); Comber, S., et al.: Sci. Total Environ., 286, 61 (2002); Gatidou, G, et al.: Environ. Int., 33, 70 (2007);

Applications 4-Hydroxy Coumarin is a plant derived antioxidant, protecting against lipid peroxidation, as well as a potential inhibitor of HIV-1 Integrase.
References Foti, M. et al.: J. Agric. F., 44, 497 (1996); J. Med. Chem., 40, 242 (1997);

Stability Light Sensitive
Applications A novel pharmaceutical compound based on PDE IV inhibitors; used in the treatment of respiratory complaints.
References Gomez, et al.: Br. J. Anaesth., 74, 549 (1995),

Applications Labelled Tinidazole. Antiprotozoal (Trichomonas, Giardia); antiamebic; antibacterial.
References Miller, M.W., et al.: J. Med. Chem., 13, 849 (1970), Oderdea, G., et al.: Gut, 33, 1328 (1992),

Applications Bisphenol AP-d5 is the isotope labelled analog of Bisphenol AP. Bisphenol AP is used to prepare triphenylmethane derivatives as inhibitors of hepatitis C virus helicase. It is a derivative of Bisphenol A (B519495) which is a monomer used for policarbonate and epoxy resins.
References Chen, C., et al.: J. Med. Chem., 52, 2716 (2009); Krishnan, A.V., et al.: Endocrinology, 132, 2279 (1993); Steinmetz, R., et al.: Trends Endocrinol. Metab., 9, 124 (1998); Petersen, H., et al.: Eur. Food Res. Technol., 216, 355 (2003)

Applications Selexipag is an orally available, highly selective, long-acting prostacyclin (IP) receptor agonist prodrug. It is a potential drug for the treatment of various vascular disorders such as pulmonary arterial hypertension and arteriosclerosis obliterans.
References Kuwano, K., et al.: J. Pharm. Exp. Ther., 322, 1181 (2007);

Applications A potentially related compound in cephalosporin antibacterial compounds. An isomer of Cefuroxime (C248050).
References Chavette, R., et al.: J. Med. Chem., 9, 741 (1966), Miyouchi, M., et al.: J. Chem. Pharm. Bull., 38, 1906 (1990), Sugioka, T., et al.: Chem. Pharm. Bull., 38, 1998 (1990),

Applications Labelled insecticidal, acaricidal, and fungicidal combinations of carboxamides and other pesticides.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Dugo, G., et al.: Food Chem., 16, 435 (2005), Caldas, E., et al.: Toxicology, 222, 132 (2006), Cabras, P., et al.: J. Agric. Food Chem., 45, 2244 (1997), Wilkinson, C., et al.: Regul. Toxicol. Pharmacol., 31, 30 (2000),

Stability Light Sensitive, Temperature Sensitive
Applications An antineoplastic.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Mathe, G., et al.: Cancer Letters, 27, 285 (1985), Levegue, D., et al.: Clin. Pharmacokinet., 31, 184 (1996), Curran, M.P., et al.: Drugs Aging., 19, 695 (2002),

Applications A labelled antibacterial used in the treatment of dermatitis herpetiformis.
References Francis, J., et al.: Br. J. Pharmacol., 5, 565 (1950), Uetrecht, J., et al.: Clin. Dermatol., 7, 111 (1989); Reszka, K., et al.: Chem. Res. Toxicol., 22, 1137 (2009), Santos, J., et al.: Bioorg. Med. Chem., 17, 3795 (2009), Varma, M., et al.: J. Med. Chem., 52, 4844 (2009),

Applications 4,4-Dibromo-2,4-dihydro-5-methyl-3H-pyrazol-3-one is used in the preparation of antimoebic compounds such as thiosemicarbazide derivatives. Also used in the preparation of triazine molecules displaying antifungal activity.
References Singh, S. et al.: Eur. J. Pharm. Sci., 25, 255 (2005); Tewari, A. et al.: Indian. J. Chem. B., 41B, 664 (2002);

Stability Hygroscopic
Applications N-Ethyl-N-(3-sulfobenzyl)sulfanilic Acid Disodium Salt can be obtained from 3-Sulfobenzaldehyde Sodium Salt (S689165) which can be used for the preparation of a series of novel sulfonamide derivatives, as inhibitors of the enzyme histone deacetylase (HDAC) as a novel approach to the treatment of cancer.
References Finn, P., et al.: Helvetica Chimica Acta, 88 (7), 1630 (2005);

Applications Quaternary ammonium composition to treat herpes, pseudomonas, staph, hepatitis and other infectious diseases.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Berr, S., et al.: J. Phys. Chem., 91, 4760 (1987), Jones, M., et al.: Eur. J. Pharm. Biopharm., 48, 101 (1999), Okano, L., et al.: Langmuir, 16, 3119 (2000),

Impurity Cefixime EP Impurity D
Applications (E)-Cefixime is an isomeric impurity of the third generation cephalosporin antibiotic, Cefixime (C242800).
References Bian, L. et al.: Yao. Fen. Zaz., 30, 872 (2010); Rajadurai, R. et al.: Anal. Chem. Ind. J., 9, 265 (2010);

Applications Semi-synthetic antibiotic related to Penicillin. Antimicrobial.
References Robinson, B., et al.: Biochem. Med. Metab. Biol., 48, 122 (1992), Lesnefsky, E., et al.: J. Biol. Chem., 279, 47961 (2004), Marroquin, L., et al.: Toxicol. Sci., 97, 539 (2007),

Applications Pefloxacin Mesylate Dihydrate is an analog of norfloxacin that inhibits topoisomerase.