Toxicologie

Applications Higenamine acts through inhibition of middle cerebral artery occlusion (MCAO)-mediated HMGB1 release in vivo. Useful towards ischemic injuries.
References Ha, Y. et al.: Apoptosis., 17, 463 (2012);

Impurity Clobetasol Propionate EP Impurity A / Betamethasone Dipropionate EP Impurity B
Applications Betamethasone 17-Propionate (Clobetasol Propionate EP Impurity A) is a degradation product of Betamethasone. Glucocorticoid.
References Andersson, P., et al.: J. Pharm. Pharmacol., 36, 763 (1984), Wurthwein, G., et al.: Biopharm. Drug Dispos., 11, 381 (1990), Samtani, M., et al.: J. Pharm. Sci., 93, 726 (2004), Samtani, M., et al.: Drug Metab. Dispos., 33, 1124 (2005),

Applications A β1 selective aryloxypropanolamine andrenergic antagonist. Used in the treatment of a variety of cardiovascular disorder.
References McGourty, J.C., et al.: Br. J. Clin. Pharmacol. 20, 555 (1985), Lennard, M.S., et al.: Biochem. Pharmacol., 35, 2757 (1986),

Impurity Pilocarpine Hydrochloride EP Impurity B
Stability Hygroscopic
Applications Pilocarpic Acid Sodium Salt is an imidazole derivative used in the preparation of novel sequentially labile pilocarpine prodrugs for improved ocular delivery.
References Bungaard, H. et al.: J. Med. Chem., 28, 978 (1985); Jarvinen, T.e t al.: Int. J. Pharmac., 79, 233 (1992);

Applications Tralomethrin-d5, is the labeled analogue of Tralomethrin (T712400), which is a pyrethroid insecticide. It is effective against most members of class Arachnida as well as insects.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Laskowski, D.A., et al.: Review Env. Conatmin. Toxic., 174, 49 (2002); Tanaka, Y., et al.: Shokuhin Eiseigaku Zasshi, 41, 335 (200);

Applications An impurity of Zolpidem (Z650000).

Stability Hygroscopic
Applications A new nitrification inhibitor to be used on solid and in liquid fertilizers and slurry.

Stability Hygroscopic
Applications Asenapine N-β-D-Glucuronide is a metabolite of Asenapine (A788000).
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package

Applications Bicyclomycin benzoate is a polar metabolite with activity against Gram negative bacteria.

Applications Anidulafungin, is a semisynthetic echinocandin that inhibits glucan synthase, an enzyme important in the formation of (1→3)-β-D-glucan, a major fungal cell wall component, and thus is used as antifungal drug.
References Denning, D. W., et al.: J. Antimicrob. Chemother, 40, 611 (1997); Vazquez, J. A., et al.: Clin. Ther., 27(6), 657 (2005);

Applications A metabolite of 17α-Methyltestosterone (M326400).
References Dumasia, M., et al.: Xenobiotica, 11, 323 (1981), Tang, P., et al.: Anal. Biochem., 182, 289 (1989),

Applications Bictegravir-15N, d2 is the labeled version of Bictegravir, which is a novel, potent inhibitor of HIV-1 integrase with an IC50 of 7.5 nM.
References Tsiang M. et al.: Antimicrob Agents Chemother. 2016 Nov 21;60(12):7086-7097;

Applications Ethylphenidate Hydrochloride is the transesterification metabolite of Methylphenidate (M325880) and ethanol.
References Patrick, K.S., et al.: J. Med. Chem., 48, 2876 (2005); Naito, T., et al.: Chem. Pharma. Bull., 12, 588 (1964);

Applications 2'-O-Methyl Uridine-d3 is an isotope labelled compound of 2'-O-Methyl Uridine (M338200), a uridine analog used for the preparation of antiviral nucleoside derivatives as inhibitors of subgenomic hepatitis C virus RNA replication.
References Gratzner, H., et al.: Science, 218, 474 (1982), Jarvis, T., et al.: J. Biol. Chem., 271, 29107 (1996), Pavco, P., et al.: Clin. Cancer Res., 6, 2094 (2000),

Stability Moisture Sensitive
Applications Melphalan Hydrochloride is used in combined intravitreal chemotherapy with topotecan hydrochloride for viable vitreous seeding from retinoblastoma. Also, it is an anti-cancer chemotherapy drug.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Ghassemi, F., et al.: JAMA Ophthalmol., 132, 936-941 (2014); Gao, L. P., et al.: Adv. Mater. Res., 781-784, 993-998 (2013);

Applications Testosterone (T155000) derivative. It is a potent androgen with anabolic properties. Since the begining of the year 2005, the use of steroid precursors (prohormones) is illegal in the United States. Controlled substance.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Liao, S., et al.: J. Biol. Chem., 248, 6154 (1973), Saartok, T., et al.: Endocrinology, 114, 2100 (1984), Sugawara, T., et al.: J. Biol. Chem., 278, 42487 (2003),

Applications Testosterone Cypionate is an anabolic steroid with androgenic properties. Testosterone Cypionate is used for testosterone therapy in males with hypogonadism.Controlled Substance.
References Rabkin, J. G., et al.: J. Clin. Psychopharmacol., 19, 19 (1999); Hajjar, R., et al.: J. Clin. Endocrinol. Metab., 82, 3793 (1997); Rhoden, E., et al.: J. Sex Med., 7, 277 (2010);

Applications Desacetyllanatoside C is a derivative of Lanatoside C (L173800), glycosides isolated from various species of Digitalis. Cardiotonic.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Novotny, J., et al.: J. Biol. Chem., 258, 14433 (1983), Farr, C., et al.: J. Med. Chem., 45, 3257 (2002), Van Dongen, M., et al.: Drug Discov. Today, 7, 471 (2002),

Applications A major metabolite of Methylphenidate.
References Redalieu, E., et al.: Drug Metab. Dispos., 10, 708 (1982), Brewer, E., et al.: J. Pharm. Sci., 87, 395 (1998), Shah, V., et al.: Pharm. Res., 17, 1551 (2000), Tanaka, N., et al.: Anal. Chem., 73, 420 (2001),

Applications SR 9009 is a synthetic REV-ERB agonist that regulates circadian behavior and metabolism; has potential use in the treatment of sleep disorders and metabolic diseases. It is a lead compound for a new class of cancer drugs associated with the body’s circadian clock.
References Solt, L.A., et. al.: Nature, 485, 62 (2012); Chem. and Eng. News. p.8, Jan. 15, 2018

Applications Cymoxanil-d3 (methoxy-d3) (CAS# 2140803-92-3) is a useful isotopically labeled research compound of Cymoxanil(C988995). Cymoxanil is a fungicide applied as a seed treatment or as a foliar application to the plants to control late blight.
References Dhingani, J. C., et al.: J. Pure. App. Microbiol., 6, 1683 (2012); Bakirici, G.T., et al.: Food. Chem., 135, 1901 (2012);

Applications JNJ 42041935 is a selective hypoxia-inducible factor (HIF) prolyl hydroxylase (PHD) enzyme inhibitor. It can potentially be used for the treatment of inflammation-induced anemia.
References Barrett, T., et al.: Mol. Pharmacol., 79, 910 (2011); Thirstrup, K., et al.: Pharmacol. Res., 64, 268 (2011);

Applications O-Ethyl O-Phenyl S-Propyl Phosphorothioate is an organophosphates pesticide/insecticide. A pesticide in herbal medicines.
References Nie, C., et al.: Jingxi Huagong Zhongjianti, 38, 59 (2008); Bi, F., et al.: Huaxue Gongye Yu Gongcheng, 18, 156 (2001); Ivashina, S. A.: Gigiena i Sanitariya, 11, 76 (1984)

Applications A labelled form of Hexythiazox (H298500), which is a mite growth regulator and a thiazolidine based acaricide that has long-lasting effects against many kinds of mites and is applied at any stage of the plant growth from budding to fruiting. Useful in cannabis testing kits as a component of pesticide mixes (P698240).
References Martini,X., et al.: Pest. Manage. Sci., 68, 1471 (2012); Gilbert-Lopez, B., et al.: Food. Control., 26, 341 (2012);

Applications 3-Hydroxy Tibolone-d5, is the labeled analogue of 3-Hydroxy Tibolone, a synthetic steroid with weak estrogenic, androgenic and progestogenic activity. A pharamceutical used in the treatment of menopausal syndrome.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Belman, S., et al.: Cancer Res., 32, 450 (1972), Shirahashi, H., et al.: Chem. Pharm. Bull., 41, 1664 (1993), Hoyte, R., et al.: Steroids, 58, 13 (1993), Sandker, G., et al.: Xenobiotica, 24, 143 (1994), Colombo, D., et al.: Eur. J. Med. Chem., 40, 69 (2005),

Applications Isovaleryl L-Carnitine-d3 Chloride is labelled Isovaleryl L-Carnitine Chloride (I917580) which is used to prepare carnitine benzyl esters as neuroprotectant prodrugs.
References Gong, X., et al.: J. Chem. Res., 6, 327 (2008)

Applications Labelled Isoprothiolane, a dithiolane pesticide. Isoprothiolane is commonly used in agriculture as a fungicide to control planthoppers and blast disease in rice plants.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Chin, K.M.: Malay. Agric. J., 50, 221 (1975); Ikeda, Y. et al.: Biosci. Biotech. Biochem., 57, 288 (1993); Nakamura, H.: Rev. Plant Prot. Res., 10, 1 (1977); Reddy, A.P.K. et al.: Pesticide, 22, 21 (1988);

Applications Main Quinfamide (Q670600) metabolite.
References Bailey, D., et al.: J. Med. Chem., 22, 599 (1979),

Applications Metyrapone acts as a glucocorticoid synthesis inhibitor, maintaining stress-hormone levels.
References Keller, C. et al.: Drug. Alc. Dep., 133, 405 (2013); Vilela, F. et al.: Neuroendocrinol., 97, 322 (2013);

Applications A labelled dihydropyridine calcium channel blocker. It is used as a vasodilator (cerebral).
References Allen, G.S., et al.: N. Engl. J. Med., 308, 619 (1983), Schluter, H.: Arzneim.-Forsch., 36, 1733 (1986), Deyo, R.A., et al.: Science, 243, 809 (1989),

Applications Spirodiclofen is a tetronic acid acaricide fungicide used in controlling red mites. Spirodiclofen is used in cannabis testing kits as a component of pesticide mixes (P698240).
References Kramer, T., et al.: Pest. Manage. Sci., 67, 1285 (2011); Ilias, A., et al.: Crop. Protect., 42, 305 (2012); Bretschneider, T., et al.: Modern. Crop. Protect. Compounds., 3, 1108 (2012)

Applications β-Cypermethrin is a pyrethroid compound that is used as an insecticide to eliminate unwanted pests from crop fields. β-Cypermethrin has been advertised to be safe for humans despite the fact that considered a possible human carcinogen.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Chen, S., et al.: Appl. Micro. 94, 505 (2012); Li, Z., et al.: Bull. Env. Cont. Toxicol., 80, 335 (2008)

Impurity Valproic Acid USP Related Compound B
Applications A constitutional isomer of Valproic acid; a potent anticonvulsant. Sodium valproate impurity C. Valproic Acid USP Related Compound B.
References Levy, R., et al.: Pharm. Res., 8, 551 (1991), Barton, M., et al.: Epilepsy Res., 47, 217 (2001), Fox, A., et al.: Pain, 105, 355 (2003), Archer, D., et al.: Anesth. Analg., 104, 180 (2007),