Toxicologie

<p>Applications (R,R)-Sertraline acts as a selective serotonin reuptake inhibitor that displays minor antifungal activity as well.<br>References Young, T. et al.: J. Antimicrob. Chemother., 51, 1045 (2003);<br></p>

<p>Applications 2,6-Dichlorobenzonitrile (DCBN or dichlobenil) is a herbicide and is slightly toxic for humans. It is metabolized in the liver by the enzyme CYP2A6.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Li, H., et al.: Soil Sci. Soc. Am. J., 67, 122 (2003); Shedletzky, E., et al.: Plant Physiol., 94, 980 (1990)<br></p>

<p>Applications Testosterone Laurate-d23 is the isotopic analog of Testosterone Laurate. Testosterone Laurate is a derivative of testosterone(T155000), which is used in analytical studies to determine testosterone and nandrolone esters in race horse plasma for doping control through UPLC-ESI-MS-MS.<br>References You, Y., et al.: J. Chromato., 1218, 3982 (2011); Guan, F., et al.: Mass Spectrom., 45, 1270 (2010)<br></p>

<p>Applications O,O,O-Trimethyl-O-(3,5,6-trichloro-2-pyridinyl)diphosphosrodithioate is an impurity of Chlorpyrifos (C425300), an insecticide; acaricide.<br>References Smith, G.N., et al.: J. Agric. Food Chem., 15, 132 (1967); Schafer, et al.: Toxicol. Appl. Pharmacol., 21, 315 (1972)<br></p>

<p>Applications Gabapentin Lactam-d6, is the labeled analogue of Gabapentin Lactam (G117275), that reduces protein aggregates and improves motor performance in a transgenic mouse model of Huntington’s disease. It opens mitochondrial ATP-dependent potassium channels.<br>References Zucker, B.,et al.: Naunyn Schmiedebergs Arch. Pharmacol., 370, 131 (2004)<br></p>

<p>Stability Hygroscopic<br>Applications (±)-Mevalonolactone-4,4,5,5-d4 (CAS# 349553-98-6) is a useful isotopically labeled research compound.<br></p>

<p>Applications Metopimazine (MPZ) is used to prevent emesis during chemotherapies. Antiemetic.<br>References Catz, P., et al.: Int. J. Pharm., 58, 93 (1990), Sato, K., et al.: J. Pharm. Sci., 80, 104 (1991), Herrstedt, J., et al.: Cancer Chemother. Pharmacol., 33, 53 (1996), Sigsgaard, T., et al.: J. Clin. Onc., 19, 2091 (2001),<br></p>

<p>Applications The R-enantiomer of Baclofen (B108000) metabolite.<br></p>

<p>Applications 17β-neriifolin could be considered a candidate for the treatment of hepatocellular carcinoma. It can also work as an inhibitor of hERG channel trafficking.<br>References Zhao, Q., et al.:Fitoterapia, 82, 735 (2011); Wang, L., et al.: J. Pharmacol. Exper. Ther., 320, 525 (2007)<br></p>

<p>Stability Hygroscopic<br>Applications Atorvastatin (A791750) impurity.<br>References Kearney, A.S., et al.: Pharm. Res., 10, 1461 (1993); Heinonen, T.M., et al.: Clin. Ther., 18, 853 (1996);<br></p>

<p>Stability Moisture Sensitive<br>Applications Oxyfedrine acts as a vasodilator affecting the coronary base flow.<br>References Baraka, Y. et al.: J. Drug Res., 12, 161 (1980);<br></p>

<p>Applications 4-Hydroxy Flecainide is an analogue of Flecainide (F390000).<br>References Blom, Y., et al.: J. Chromatogr., 653, 138 (1993),<br></p>

<p>Applications 1-Chloro-1-desmethylpiperazinyl-bosutinib is a useful intermediate in the green preparation of the anti-tumor agent Bosutinib (B676095). It is a COVID19-related research product.<br>References Mao, Y., et al.: Synthesis, 47, 3133 (2015); Chen, H., et al.: Zhongguo Yiyao Gongye Zazhi, 44, 1086 (2013); Yin, X. J., et al.: Molecules, 4261 (2010)<br></p>

<p>Stability Acid Sensitive<br>Applications 17β-(Trimethylsiloxy)testosterone is an anabolic steriod, and a derivative compound of Testosterone (T155000), Principal hormone of the testes, produced by the interstitial cells. Major circulating androgen; converted by 5α-reductase in androgen-dependent target tissues to 5α-dehydrotestosterone which is required for normal male sexual differentiation. Also converted by aromatization to Estradiol.Testerone is a controlled substance (anabolic steroid). Androgen.<br>References McFarland, K., et al.: Science, 245, 494 (1989), Heckert, L., et al.: Mol. Endocrinol., 12, 1499 (1998), Themmen, A., et al.: Endocr. Rev. 21, 551 (2000), Kumar, R., et al.: Biol. Reprod., 65, 710 (2001),<br></p>

<p>Applications Used in the preparation of Epostane (E588850).<br></p>

<p>Impurity Fulvestrant Impurity E;<br>Applications Fulvestrant (F862500) impurity E.<br></p>

<p>Impurity Clobazam EP impurity E<br>Applications Impurity of Clobazam (C582500), a benzodiazepine psychotherapeutic agent. Clobazam (CLB) has proven efficacy against multiple seizure types. An anxiolytic; anticonvulsant and a controlled substance (depressant).<br>References Gastaut, H., et al.: Epilepsia, 20, 437 (1979), Guberman, A., et al.: Can J. Neurol. Sci., 17, 311 (1990), Munn, R., et al.: Pediatr. Neurol. 9, 465 (1993),<br></p>

<p>Applications Minodronic acid is developed for osteoporosis treatment.<br>References Tanishima, S., et al.: Clin. Interv. Aging, 8, 185 (2013)<br></p>

<p>Applications Cyclobutanecarboxylic Acid, can be used as an organic building block in the chemical synthesis. It is also an Antiinflammatory agent.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Grassy, G. et al.: Euro. J. Med. Chem., 14, 493, (1979);<br></p>

<p>Applications: An impurity contained in samples of all trans-retinoic acid.<br>References Newton, D., et al.: Cancer Res., 40, 3413 (1980), Curley, R., et al.: Bioorg. Med. Chem. Lett., 2, 1133 (1992), Tanaka, H., et al.: Chem. Pharm. Bull., 43, 356 (1995), Patel, J., et al.: J. Med. Chem., 47, 6716 (2004),<br></p>

<p>Impurity Fluticasone USP Related Compound B<br>Applications An impurity of Fluticasone Propionate (F599500), a derivative of Flumethasone (F455000). An antiallergic; anti-asthmatic; anti-inflammatory. Fluticasone USP Related Compound B.<br>References Matuszewski, B, et al.: Anal. Chem., 75, 3019 (2003), Fekete, S., et al.: J. Pharm. Biomed. Anal., 49, 64 (2009), Meltzer, E.O., et al.: J. Allergy Clin. Immunol., 86, 221 (1990), Mitchison, H.C., et al.: Gut, 32, 260 (1991), Phillipps, G.H., et al.: J. Med. Chem., 37, 3717 (1994)<br></p>

<p>Applications Fipexide Hydrochloride is one of five potential drug candidates to overcome the melphalan-induced vascular toxicity.<br>References Yang, Y., et al.: Tumour Biol., 37, 6709-6718 (2016);<br></p>

<p>Applications Epoxy Metradiene is an impurity from synthesis of Fluorometholone (F593145),a glucocorticoid; anti-inflammatory.<br>References Kupferman, A., et al.: Arch. Ophthlmol., 640, 100 (1982); Tokunaga H., et al.: Chem. Pharm. Bull., 32, 4012 (1984);<br></p>

<p>Applications Used as an antihypertensive and antianginal.<br>References Gross, G.J., et al.: Gen. Pharmacol., 14, 677 (1983), Molyvdas, P.A. and Sperelakis, N.: J. Cardiovasc. Pharmacol., 8, 449 (1986), Mizuno, K., et al.: Res. Comm. Chem. Pathol. Pharmacol., 52, 3 (1986)<br></p>

<p>Impurity Fluocinolone Acetonide EP Impurity I<br>Applications 14,15-Dehydro Fluocinolone Acetonide is an impurity of Fluocinolone Acetonide (F455800); a glucocorticoid and anti-inflammatory agent.<br>References Sammul, et al.: J. Assoc. Off. Agric. Chem., 47, 952 (1964); Emerson, M.V., et al.: BioDrugs, 21, 245 (2007)<br></p>

<p>Stability Light Sensitive<br>Applications Prifinium Bromide is a synthetic antispasmodic drug; parasympatholytic. Prifinium Bromide is used as a quartenary anticholinergic agent.<br>References Kumada, S. et al.: Arzneim.-Forsch., 20, 237 (1970); Nakai, T. et al.: Arzneim.-Forsch., 20, 1112 (1970); Bettini, V. et al.: Farm. Ed. Prat., 33, 392 (1978);<br></p>

<p>Impurity Rosuvastatin Formyl Impurity<br>Applications Rosuvastatin intermediate.<br>References Watanabe, M., et al.: Bioorg. Med. Chem., 5, 437 (1997),<br></p>

<p>Stability Hygroscopic<br>Applications A degradation product of Betamethasone (B327000).<br>References Andersson, P., et al.: J. Pharm. Pharmacol., 36, 763 (1984), Wurthwein, G., et al.: Biopharm. Drug Dispos., 11, 381 (1990), Samtani, M., et al.: J. Pharm. Sci., 93, 726 (2004), Samtani, M., et al.: Drug Metab. Dispos., 33, 1124 (2005),<br></p>

<p>Applications CPI 613 is a class of non-redox-active lipoate derivative that disrupts cancer cell mitochondrial metabolism and are potent anticancer agents in vivo.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Zachar, Z. et al.: J. Mol. Med., 89, 1137 (2011); Lee, K. et al.: Drug Met. Lett., 5, 163 (2011)<br></p>