Toxicologie

<p>Applications A thienopyrimidine derivative as herbicides.<br>References Kourounakis, A., et al.: Drug Dev. Res., 2000, 49(4), 227 (2000),<br></p>

<p>Applications 6-Keto-testosterone Cypionate, is a derivative of Testosterone Cypionate (T155100), which is an anabolic steroid with androgenic properties. Testosterone Cypionate is also used for testosterone therapy in males with hypogonadism. (Controoled Substance)<br>References Rabkin, J.G. et al.: J. Clin. Psychopharmacol., 19, 19 (1999); Hajjar, R. et al.: J. Clin. Endocrinol. Metab., 82, 3793 (1997); Rhoden, E. et al.: J. Sex Med., 7, 277 (2010);<br></p>

<p>Applications N-Acetyl-S-(4-hydroxy-2-methyl-2-trans-buten-1-yl)-L-cysteine is a metabolite of Isoprene.<br>References Pecivova, P. et al.: J. Sci. Food Agric., 90, 1681 (2010); Hui, N. et al.: Meat Sci. Appl., 74 (2001); Kiviharju, K. et al.: J. Biotechnol., 117, 299 (2005);<br></p>

<p>Applications Pitavastatin 1-Phenylethylamide is an impurity of Pitavastatin (P531000), which is a competitive inhibitor of HMG-CoA reductase. Antilipemic.<br>References Aoki, T., et al.: Arzneim.-Forsch., 47, 904 (1997), Yamada, I., et al.: Xenobiotica, 33, 789 (2003), Park, S., et al.: Clin. Ther., 27, 1074 (2005),<br></p>

<p>Applications Fluenetil is a fluenethyl acaricide.<br>References Johannsen, F. R., et al.: Comp. Gen. Pharmacol., 5, 101 (1974), Johannsen, F. R., et al.: J. Econ. Entomol., 67, 5 (1974)<br></p>

<p>Applications (6R,7S)-Cefoperazone Sodium Salt is the enantiomer of Cefoperazone (C242900) as an impurity.<br>References Fabre, H., et al.: J. Pharm. Sci., 73, 611 (1984), Strasters, J., et al.: Anal. Chem., 63, 2503 (1991), Chen, Z., et al.: World Notes Antibiot., 25, 249 (2004),<br></p>

<p>Applications (-)-Dimethyl 2,3-O-isopropylidene-L-tartrate is used as a reagent to synthesize (+)-Migrastatin, a natural macrolide compound produced by Streptomyces 1 &amp; 2 that acts as a tumour migration cell inhibitor. (-)-Dimethyl 2,3-O-isopropylidene-L-tartrate is also a derivative of Tartaric acid (L-isomer: T007630 &amp; D-isomer: T007625), a compound that is used as a chiral complexing agent in synthetic chemistry.<br>References Chen, L., et al.: Nature, 464, 1062 (2010); Gaul, C., et al.: J. Am. Chem. Soc., 125, 6042 (2003); Heldin, E., et al.: Chromatographia, 32, 407 (1991)<br></p>

<p>Applications Ledipasvir-d6 is labelled Ledipasvir (L320100) which is most commonly used in combination with sofosbuvir for treatment in chronic hepatitis C genotype 1 patients. It inhibits an important viral phosphoprotein, NS5A, which is involved in viral replication, assembly, and secretion.<br>References Lawitz, E., et al.: J. Hepatol., 57, 24 (2012); Afdhal, N., et al.: New England J. Med., 370, 1889 (2014)<br></p>

<p>Applications An impurity of the antiviral drug Oseltamivir (O700100). It is a COVID19-related research product.<br></p>

<p>Applications N-Docosanoyl Taurine is found to activate multiple members of the transient receptor potential (TRP) family of calcium channels, including TRPV1 and TRPV4 which are expressed in kidney.<br>References Saghatelian, A., et al.: Biochem., 45, 9007-9015 (2006)<br></p>

<p>Applications Terbufos-d10 (O,O-diethyl-d10) (CAS# 1276197-42-2) is a useful isotopically labeled research compound.<br></p>

<p>Applications Isotope labelled (2R)-3-Carboxy-2-[(9-carboxy-1-oxononyl)oxy]-N,N,N-trimethyl-1-propanaminium Inner Salt is a useful intermediate that is often used in the metabolic studies of insulin production in humans.<br>References Shah, S.H.; et al.: Diabetologia, 55, 321 (2012)<br></p>

<p>Applications Vidarabine, is an antiviral drug which is active against herpes simplex and varicella zoster viruses.<br>References Sneader, W., et al.: Drug Discovery, 258 (2005); Lee, W. W., et al.: J. Am. Chem. Soc., 82, 2648 (1960);<br></p>

<p>Applications Itraconazole Desethylene-seco-piperazine Di-N-formyl Impurity is a by-product in the synthesis of Itraconazole Desethylene-seco-piperazine Mono-N-formyl Impurity (I937520), which is an impurity of Itraconazole (I937500). Itraconazole is an orally active antimycotic structurally related to Ketoconazole. Antifungal. It is a COVID19-related research product.<br>References Espinel-Ingroff, A., et al.: Antimicrob. Agents Chemother., 26, 5 (1984), Heykants, J., et al.: Mycoses, 32, Suppl 1, 67 (1989), Sugar, A.M.,et al.: Curr. Clin. Top. Infect. Dis., 13, 74 (1993),<br></p>

<p>Applications An derivative of Codeine<br>References Okuda, S., et al.: Chem. Pharm. Bull., 12, 104 (1964),<br></p>

<p>Applications Asenapine Maleate, is a 5-HT receptor antagonist developed for the treatment of acute schizophrenia and bipolar mania. Antagonist of serotonin, norepinephrine, dopamine and histamine receptors.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Tarazi. F.I., et al.: Drugs. Today., 45, 865 (2009); Boboaca, S.D., et al.: Int. J. Molec. Sci., 12, 4348 (2011); Audinot, V., et al.: Neuropsycopharmacol., 25, 410 (2001);<br></p>

<p>Applications 3-Aminobenzotrifluoride is a known human toxin that can cause bacterial mutation and hepatocyte unscheduled DNA synthesis.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Reinhold, D., et al.: T. ASAE, 49, 2077 (2006); Thompson, C., et al.: Environ. Mutagen., 5, 803 (1983)<br></p>

<p>Applications Fenoxaprop-ethyl is a pesticide.<br>References Chen, L., et al.: Anal. Bioanal. Chem., 406, 1481 (2014); Yoshida, M., et al.: J. Toxicol. Sci., 38, 205 (2013); EPA: Federal Register, 78, 78746 (2013); EPA: Federal Register, 79, 26158 (2014)<br></p>

<p>Applications A labelled NS3 serine protease inhibitor of hepatitis C virus. It is a COVID19-related research product.<br>References Malcolm, B., et al.: Antimicrob. Agents Chemother., 50, 1013 (2006); Cubero, M., et al.: Virology, 370, 237 (2008); Venkatraman, S., et al.: J. Med. Chem., 49, 6074 (2006);<br></p>

<p>Applications Labelled Lubiprostone is a bicyclic fatty acid metabolite analog of Prostaglandin E1. It activates specific chloride channels in the gastrointestinal tract to stimulate intestinal fluid secretion, increase gastrointestinal transit, and improve symptoms of constipation.<br>References Farthing, M., et al.: Drugs, 56, 11 (1998), Pare, P., et al.: Am. J. Gastroenterol., 96, 3130 (2001), Sloots, C., et al.: Aliment. Pharmacol. Ther., 16, 759 (2002), Coremans, G., et al.: Digestion, 67, 82 (2003),<br></p>

<p>Applications The minor glucuronide metabolite of Chloramphenicol (C325030).<br>References Simons, P., et al.: Xenobiotica, 22, 1267 (1992), Kaji, H., et al.: Drug Metab. Dispos., 33, 60 (2005),<br></p>

<p>Applications Prometon-d3 (methoxy-d3) (CAS# 1219803-43-6) is a useful isotopically labeled research compound.<br></p>

<p>Applications Butyric Anhydride-3,3,3',3',4,4,4,4',4',4'-d10 (CAS# 1398065-70-7) is a useful isotopically labeled research compound.<br></p>

<p>Applications Dilactic Acid is derived from 2,2'-Oxybis-propanoic Acid Diethyl Ester (O870540), which is an intermediate used in the preparation of the organochlorine pesticide Bis(2-chloroisopropyl) Ether. Bis(2-chloroisopropyl) Ether is used as a nematicide to control parasitic nematodes in agriculture.<br>References Chiyonishio, T., et al.: Tott.-ken Nog. Shik. Ken. Hok., 13, 29 (1973); Moreno Horn, M., et al.: 179, 234 (2003);<br></p>

<p>Applications Hydroxy[[2-[[[2-(2-methoxyethoxy)propyl]amino]carbonyl]phenoxy]acetato(2-)]mercurate(1-) Coordination Compound, cna be used as a a mercurial diuretic.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References best, M.M., et. al.: Am. J. Med. Sci., 225, 132 (1953)<br></p>