Toxicologie

<p>Applications Isotope labelled (L)-Suberyl Carnitine is a metabolite of L-Carnitine (C184110).<br>References Millington, D., et al.: J. Inherit. Metab. Dis., 13, 321 (1990), Chace, D., et al.: Clin. Chem., 49, 1797 (2003),<br></p>

<p>Applications 6-Chloropyridine-2-carboxylic Acid is an intermediate of Sorafenib b(S676850), a multiple kinase inhibitor targeting both RAF kinase and receptor tyrosine kinases that promote angiogensis. Antineoplastic.<br>References Richly, H., et al.: Int. J. Clin. Pharmacol. Ther., 41, 620 (2003); Khire, U.R., et al.: Bioorg. Med. Chem. Lett., 14, 783 (2004); Wilhelm, S.M., et al.: Cancer Res., 64, 7099 (2004); Rini, B.I., et al.: Expert Opin. Pharmacother., 7, 453 (2006)<br></p>

<p>Applications Fensulfothion Sulfide is a metabolite of the insecticide fensulfonthion (F265490), an inhibitor of cholinesterase activity.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Solly, S.R.B., et al.: New. Zea. J. Agri. Res., 14, 88 (1971); Hansch, C., et al.: Biochem. Toxicol. Insectic. Proc., 33 (1970);<br></p>

<p>Applications N,N-Dimethyl-2-aminosulfonyl-4-formamidobenzamide is a key intermediate in the preparation of the sulfonylurea herbicide Foramsulfuron (F685003).<br>References Liu, Q., et al.: Xiandai Nongyao, 11, 19 (2012); Ford, M. J., et al.: From PCT Int. Appl. (2001), WO 2001042226 A1 20010614<br></p>

<p>Stability Hygroscopic<br>Applications Cotarnine Chloride is an oxidative degradation product of the drug Noscapine.<br>References Johansson, M., et al.: J. Pharm. Biomed. Anal., 7, 1055 (1989), Ukhin, L., et al.: Chem. Nat. Compds., 40, 156 (2004),<br></p>

<p>Applications 3,3'-Iminobis(N,N-dimethylpropylamine) is used as a reagent in the synthesis of a novel class of anticancer agents called antracenylisoxazole lexitropsin conjugates. 3,3'-Iminobis(N,N-dimethylpropylamine) is also part of a group of stabilizers (Hindered Amino Stabilizers) that prevent the thermo-oxidative degradation of polypropylene.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Gijsman, P. &amp; Gitton-Chevalier, M.: Polym. Degrad. Stabil., 81, 483 (2003); Han, X., et al.: Bioorgan. Med. Chem., 17, 1671 (2009);<br></p>

<p>Applications Monosodium Acid Methane Arsonate Sesquihydrate is an environmental toxic compound. It also functions as a commonly used herbicide for weed control in grass.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Matteson, A. R., et al.: J. Environ. Qual., 43, 379 (2014); Lee, J. S., et al.: Hamilton &amp; Hardy's Industrial Toxicology (6th Edition), 45 (2015); Rosen, B. P., et al.: Proceedings of the International Congress on Arsenic in the Environment, 5th, Buenos Aires, Argentina, 309 (2014);<br></p>

<p>Applications Dimethachor CGA 369873 is a metabolite of Dimethachlor (D460273), which is a pesticide which has been detected in agricultural soil runoff.<br>References Zajicek, A., et al.: Water Sci. Tech., 77, 1879 (2018)<br></p>

<p>Stability Hygroscopic<br>Applications Angiotensin converting enzyme (ACE) inhibitor. Antihypertensive.<br>References Demolis, P., et al.: Fundam. Clin. Pharmacol., 8, 80 (1994), Vandenburg, M.J., et al.: Br. J. Clin. Pharmacol., 37, 265 (1994),<br></p>

<p>Applications Miproxifene is an active metabolite of TAT-59 against human breast cancer.<br>References Toko, T., et al.: Cancer Chemo. Pharm., 39, 390 (1997); Matsunaga, Y., et al.: Chem. Pharm. Bull., 42, 2582 (1994)<br></p>

<p>Applications This is a mixture of (R)-Apomorphine-11-sulfate and (R)-Apomorphine-10-sulfate (A727515), a derivative of (R)-Apomorphine (A727500).<br>References Neumeyer, J.L., et al.: J. Pharm. Sci., 59, 1850 (1970); Ginos, J.Z., et al.: J. Med. Chem., 18, 1194 (1975); Muhtadi, F.J., et al.: Anal. Profiles Drug Subs., 20, 121 (1991)<br></p>

<p>Applications Alclometasone-17,21-dipropionate is an synthetic glucocorticoid steroid used for inflammatory skin conditions. Alclometasone-17,21-dipropionate is topically used in dermatology as an anti-inflammatory, antipruritic, antiallergic, antiproliferative and vasoconstrictive agent.<br>References Teraki, Y., et al.: Dermatol., 224, 309 (2012); Yamamoto, Y., et al.: int. J. Pharma., 426. 54 (2012); Aggerwal, A., et al.: J. Int. Med. Res., 10, 414 (1982);<br></p>

<p>Applications Tetrahydrophthalic Acid is a plasticizer; used in preparation method of concrete coating. Also, used in preparation method of polyester resin for two-piece can ink.<br>References Mao, X., et al.: Faming Zhuanli Shenqing, (2020); Zhang, L., et al.: Faming Zhuanli Shenqing, (2020);<br></p>

<p>Applications is the labeled analogue of Cyprodinil (C989060), which is a a broad-spectrum fungicide of the class of pyrimidinamines. It is commonly used for protection of cereal crops and fruits against fungal infections.<br>References Heye, U.J. et al.: Bright. Crop Prot. Conf., Pests Dis., 2, 501 (1994); Boric, B. et al.: Pesticidi, 12, 277 (1997); Knauf-Beiter, G. et al.: Plant Dis., 79, 1098 (1995);<br></p>

<p>Applications Isotope Labelled Asenapine N-β-D-Glucuronide (A788005). Asenapine N-β-D-Glucuronide is a metabolite of Asenapine (A788000).<br></p>

<p>Applications 4-Phenylphenol is a reagent used in the synthesis of pyrrolo[1,2-c]imidazole dione derivatives as selective serotonin 5-HT1A receptor agonists with antinociceptive activity.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Valhondo, M., et al.: J. Med. Chem., 56, 7851 (2013); Nichols, D., et al.: Chem. Rev., 108, 1614 (2008)<br></p>

<p>Applications 2,5-Bis(Trifluoromethyl)Nitrobenzene (cas# 320-88-7) is a useful research chemical.<br></p>

<p>Stability Unstable in Solution<br>Applications Cefathiamidine is an antibacterial agent that exhibits a broad spectrum of bactericidal activity against gram-positive bacteria.<br>References Chen, H.Y., et al.: J. Antimicrob. Chemother., 12, 19 (1983); Philpott-Howard, J., et al.: Scand. J. Infect. Dis. Suppl., 39, 109 (1983); Chen, H.Y., et al.: J. Med. Microbiol., 23, 141 (1987);<br></p>

<p>Applications 1-Chloro-3-fluoro-2-propanol is a component of Gliftor (G410000) which is a rodenticide.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Menon, K., et al.: J. Biochem. Mol. Toxicol., 15, 47 (2001); Xie, W., et al.: J. Hygiene Res. 31, 316 (2002)<br></p>

<p>Applications Protected, labelled Ambrisentan.<br></p>

<p>Stability Hygroscopic<br>Applications A metabolite of Venlafaxine.<br></p>

<p>Applications N-[[2'-(1H-Tetrazol-5-Yl)[1,1'-Biphenyl]-4-Yl]Methyl]Amine (cas# 147225-68-1) is a useful research chemical.<br></p>

<p>Applications 1-[4-[[(2R,4S)-2-(2,4-Dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-4-(4-nitrophenyl)piperazine is an intermediate in the synthesis of derivatives of Itraconazole (I937500), an orally active antimycotic and antifungal compound.<br>References Heeres, J., et al.: J. Med. Chem., 27, 894 (1984);<br></p>

<p>Applications Hexanoyl-d11 Glycine is labelled Hexanoyl Glycine (H281200) which is an acylaminoacid derivative as antipsychotic drug.<br>References Willard, H., et al.: J. Clin. Invest., 65, 690 (1980), Huang, S., et al.: J. Pharm. Exp. Therap., 298, 264 (2001), Reihl, P., et al.: J. Biol. Chem., 280, 39809 (2005),<br></p>

<p>Applications A Quinidine labelled metabolite.<br>References Small, D.L., J. Chem. Med., 22,1014 (1979), Guentert, T.W., et al.: Eur. J. Drug Metab. Pharmacokinet., 7, 31 (1982), Chang, Y.F., et al.: Neurochem. Res., 13, 455 (1988),<br></p>

<p>Applications Labelled analogue of cis-Entacapone, the (Z)-Isomer of Entacapone (E558500) polymorphic form B. Antiparkinsonian.<br>References Karlsson, M., et al.: J. Pharm. Biomed. Anal., 10, 593 (1992), Nissinen, E., et al.: Arch. Pharmacol., 346, 262 (1992), Wikberg, T., et al.: Eur. J. Drug Metab. Pharmacokinet., 18, 359 (1993),<br></p>

<p>Applications A metabolite of Ranolazine (R122500).<br></p>

<p>Stability Unstable in Solution<br>Applications (S)-(-)-Carbidopa is a peripheral decarboxylase inhibitor that is commonly used in combination with L-DOPA (D533751) for treatment of Parkinsonism. S(-)-Carbidopa ( has also been shown to prolong the elimination half-life of L-DOPA from blood plasma and skeletal muscle.<br>References Henry, G.M. et al.: Psychosom. Med., 38, 95 (1976); Leguire, L.E. et al.: Invest. Ophthalmol. Vis. Sci. 34, 3090 (1993); Deleu, D. et al.: Naun. Schmied. Arch. Pharmacol. 348: 576 (1993);<br></p>