Toxicologie

<p>Applications Forsythoside A is used as an antiinflammatory agent in traditional Chinese medicine.<br>References Li, H. et al.: Phytother. Res., 25, 338 (2011);<br></p>

<p>Applications (S)-8,14-Dihydroxy Efavirenz, is a metabolite of Efavirenz (E425000), a nonnucleoside HIV-1 reverse transcriptase inhibitor. Antiviral.<br>References Young, S.D., et al.: Antimicrob. Ag. Chemother., 39, 2602 (1995),<br></p>

<p>Applications Prostanozol (P838700) derivative.<br></p>

<p>Applications O-Ethyl Adefovir is an intermediate in the synthesis of Mono-POM Ethyl Adefovir (M567050), which is an analogue of the antiviral drug Adefovir (A247500) with a mono-POM ester protecting group.<br>References Starrett, J.E. et al.: J. Med. Chem., 37, 1857 (1994);<br></p>

<p>Applications A metabolite of Propranolol.<br>References Otton, S., et al.: Br. J. Clin. Pharmacol., 30, 751 (1990), Fujita, S., et al.: J. Pharmacol. Exp. Ther., 264, 226 (1993), Bichara, N., et al.: Drug Metab. Dispos., 24, 112 (1996), Tasaki, T., et al.: J. Biochem., 123, 162 (1998),<br></p>

<p>Applications (S)-3-Aminobutan-1-ol can be used as an intermediate in the preparation of compounds having HIV integrase inhibitory activity.<br>References Johns, B. et al.: J. Med. Chem., 56, 5901 (2013);<br></p>

<p>Applications N-Propiononitrile-6-chloro-naphthalene Hydroxychloroquine is a useful research intermediate and an impurity of Hydroxychloroquine (B419750 ) which is an antimalarial; antirheumatic; lupus erythematosus suppressant. It is a COVID19-related research product<br>References Yarden, Y., et al.: Nature, 323, 226 (1986), Seifert, R., et al.: J. Biol. Chem., 264, 8771 (1989), Gahl, W., et al.: Mol. Genet. Metab., 76, 234 (2002), Card, J., et al.: Toxicol. Sci., 75, 169 (2003),<br></p>

<p>Applications A new anti-inflammatory drug. Effect of SAS 650 (Furofenac) on malondialdehyde production by platelets.<br>References Bertoli, D., et al.: Int. J. Tissue Reactions, 2, 217 (1980),<br></p>

<p>Impurity Fulvestrant Impurity E;<br>Applications Fulvestrant (F862500) impurity E.<br></p>

<p>Applications Dealkyl Fluticasone Furoate is a Fluticasone Furoate(F599510) raw material impurity which is a synthetic corticosteroid derived from fluticasone for treatment of seasonal allergic rhinitis.<br>References DeWester, J., et al.: Allergy Asthma Proc., 24, 331 (2003), Hughes, S., et al.: Drug Metab. Dispos., 36, 2337 (2008), Meltzer, E., et al.: Clin. Drug Investig., 29, 79 (2009),<br></p>

<p>Applications N-(3-Aminopropyl)-N-methylcarbamic Acid tert-Butyl Ester Hydrochloride is used as a reactant in the synthesis of 8-((dimethylamino)methyl)-1-(3-(dimethylamino)propyl)-1,7,8,9-tetrahydrochromeno[5,6-d]imidazol-2-amine, an inhibitor of the hepatitis C virus.<br>References Dirov, S.M., et. al.: J. Chem. Crystallogr., 43, 235 (2013)<br></p>

<p>Impurity Anastrozole Diacid Impurity<br>Applications Anastroloze Diacid is a derivative of Anastrozole (A637425), an aromatase inhibitor. Used as an antineoplastic. Anastrozole Diacid Imp<br>References Plourde, P.V., et al.: Breast Cancer Res. Treat., 30, 103 (1994), Buzdar, A.U., et al.: Cancer, 79, 730 (1997)<br></p>

<p>Applications (Z)-1,1'-(2-(2,4-Difluorophenyl)prop-1-ene-1,3-diyl)bis(1H-1,2,4-triazole) is an impurity of Fluconazole (F421000), an antifungal.<br>References Richard, K. et al.: Antimicrob. Ag. Chemother., 27, 832 (1985),<br></p>

<p>Applications Hydrobromic acid is a strong acid that is used in conjunction with Phenol (P318005) to carry out rapid cleavage of sulfonamides. Hydrobromic acid is also used as a catalyst to reduce sulfoxides, such as Dimethyl sulfoxide (D479380).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Aida, T., et al.: Tetrahedron Lett., 14, 39 (1973); Snyder, H. &amp; Geller, H.: J. Am. Chem. Soc., 74, 4864 (1952)<br></p>

<p>Applications (3S)-10-(1-Aminocyclopropyl)-9-fluoro-2,3-dihydro-6-hydroxy-3-methyl-7H-pyrido[1,2,3-de]-1,4-benzoxazin-7-one is an impurity and degredation product of Pazufloxacin, a fluorinated quinolone antibiotic.<br>References Demachi, Kumiko, et al.: Yakugaku Zasshi, 115(9), 716-31 (1995);Fukuoka, Y., et al.: Antimicrob. Ag. Chemother., 37, 384 (1993);Todo, Y., et al.: Chem. Pharm. Bull., 42, 2569 (1994)<br></p>

<p>Applications ((2R,5S)-5-(4-Amino-5-fluoro-2-oxopyrimidin-1(2H)-yl)-1,3-oxathiolan-2-yl)methyl hydrogen ((((R)-1-(6-amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)phosphonate is an impurity of Emtricitabine (E525000), a reverse transcriptase inhibitor. It is an effective antiviral agent against HIV, HBV, and other viruses replicating in a similar manner. A nucleoside analog structurally related to Lamivudine (L172500).<br>References FASEB J., 13, 1511 (1999), Molina, J.-M., et al.: J. InfecSchinazi, R.F., et al.: Antimicrob. Ag. Chemother., 36, 2423 (1992), Shockeor, J.P., et al.: Xenobioica, 26, 189 (1996), Feng, J.Y., et al.: . Dis., 182, 599 (2000)<br></p>

<p>Applications (2E)-3-(2-Thiazolyl)-2-propenoic Acid is a useful synthetic intermediate. It is used as an intermediate for HIV-1 protease inhibitor.<br>References Baloglu, E., et al.: PCT Int. Appl. (2014), WO 2014085607 A1 20140605<br></p>