Toxicologie

<p>Applications t-Butyldimethylsilyl Tylosin is an intermediate used in the synthesis of Tylosin-d3 (T947652), which is labelled Tylosin (T947650). Tylosin is a macrolide antibiotic isolated from a strain of Streptomycetes fradiae found in soil from Thailand. Antibacterial.<br>References Hamill, et al.: Antibiot. Chemother., 11, 328 (1961), Corcoran, J.W., et al.: J. Antibiot., 30, 1012 (1977), Seno, E.T., et al.: Antimicrob. Agents. Chemother., 11, 455 (1977),<br></p>

<p>Applications Isolopinavir is a metabolite of Lopinavir (L469480); a selective HIV protease inhibitor and antiviral.<br>References Sham, H.L., et al.: Antimicrob. Ag. Chemother., 42, 3218 (1998); Kumar, G.N., et al.: Drug Metab. Dispos., 27, 86 (1999); Murphy, R.L., et al.: Antiviral Ther., 4, Suppl. 3, 85 (1999)<br></p>

<p>Applications (1H-Indol-3-yl)methanamine is an indolic Tryptophan-derived metabolite with antifungal defense properties against Arabidopsis mlo2 mutant.<br>References Consonni, C., et al.: Plant Physiol., 152, 1544 (2010), Mahboobi, S., et al.: Archiv der Pharmazie , 327, 105 (1994)<br></p>

<p>Applications 6-Chloro-2-cyclohexyl-2,3-dihydro-1,3-dioxo-1H-isoindole-5-sulfonamide is an intermediate in the synthesis of Chlorexolone (C327080), a sulfonamide based antibiotic.<br></p>

<p>Applications Emtricitabine Isopropyl Carbamate is a derivative of Emtricitabine (E525000). Emtricitabine is a reverse transcriptase inhibitor. It is an effective antiviral agent against HIV, HBV, and other viruses replicating in a similar manner.<br>References FASEB J., 13, 1511 (1999), Molina, J.-M., et al.: J. InfecSchinazi, R.F., et al.: Antimicrob. Ag. Chemother., 36, 2423 (1992), Shockeor, J.P., et al.: Xenobioica, 26, 189 (1996), Feng, J.Y., et al.: . Dis., 182, 599 (2000)<br></p>

<p>Stability Hygroscopic<br>Applications 2-Chloroethyl benzoate (cas# 939-55-9) is a useful research chemical.<br></p>

<p>Applications 9-​(2-​Chloropropyl) Tenefovir is an impurity of Tenofovir (T018500). Tenofovir is an acyclic phosphonate nucleotide analogue and reverse transcriptase inhibitor. It is used as an anti-HIV agent. Antiviral.<br>References Shaw, J.-P., et al.: Pharm. Res., 14, 1824 (1997); Wyles, D., et al.: Clin Infect. Dis., 40, 174 (2005), Peng, J., et al.: J. Clin. Pharmacol., 46, 265 (2006), Seminari, E., et al.: J. Antimicrob. Chemother., 60, 831 (2007);<br></p>

<p>Applications 4-Hydroxybenzoyl Chloride is used in preparation of lysine sulfonamides as HIV-protease inhibitors.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Stranix, B., et al.: Bioorg. Med. Chem. Lett., 16, 3459 (2006);<br></p>

<p>Applications N-(6-Bromo-4-hydroxyquinazolin-2-yl)guanidine (CAS# 74189-10-9) is a useful research chemical compound.<br></p>

<p>Applications o-Carbomethoxybenzyl Sulfonamide is a useful reactant in organic synthesis.<br>References Jiang, Lin, et al.: Youji Huaxue, 26(2), 203-206 (2006)<br></p>

<p>Applications U 75875, is a peptidomimetic inhibitor, that inhibits HIV-1 gag-pol protein. In human peripheral blood mononuclear cells and in a continuous cell line, U-75875 completely blocked HIV replication, so it can be used as therapeutic potential of protease inhibitors for treatment of HIV infection.<br>References Ashorn, P., et al.: Proceedings of the National Academy of Sciences of the United States of America, 87, 7472 (1990);<br></p>