Toxicologie

<p>Applications Carboxyformamido Metazachlor Benzoic Acid is a metabolite of Metazachlor (M225855) which is a chloroacetanilide herbicide used on vegetable crops.<br>References Hollender, J., et al.: Environ. Sci. Technol., 43, 7862 (2009); Dresen, S., et al.: Anal. Bioanal. Chem., 396, 2425 (2010); Liu, B., et al.: J. Agric. Food Chem., 58, 2673 (2010);<br></p>

<p>Applications Ibudilast-d7 is the labeled analogue of Ibudilast (I125000), a leukotriene D4 antagonist. Used as an antiallergic, antiasthmatic, and vasodilator (cerebral).<br>References Nishino, K., et al.: Japan J. Pharmacol., 33, 267 (1983); Ohashi, M., et al.: Arch. Int. Pharmacodyn., 280, 216 (1986); Armstead, W.M., et al.: J. Pharmacol., Exp. Ther., 244, 138 (1988)<br></p>

<p>Applications Lindane-d6 is very toxic. It was an effective insecticide on mosquitoes, house flies, and on German and American cockroaches.<br>References Tanaka, K., et al.: Pestic. Biochem. Physiol., 6, 386-391 (1976)<br></p>

<p>Applications Phosphfolan-methyl is an insecticide used in the treatment of crops and protection from pests.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Chen, H. et al.: Sepu, 29, 409 (2011);<br></p>

<p>Applications 10,11-Dihydro-10-hydroxy Carbamazepine O-β-D-Glucuronide is a metabolite of Carbamazepine (C175840).<br>References Burkhart, C., et al.: Clin. Exp. Allergy, 32, 1635 (2002), Pearce, R., et al.: Drug Metab. Dispos., 30, 1170 (2002), Naisbitt, D., et al.: Mol. Pharmacol., 63, 732 (2003), Farrell, J., et al.: Br. J. Clin. Pharmacol., 57, 690(2004),<br></p>

<p>Applications Labelled selective COX-2 inhibitor<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Kulmacz, R.J., et al.: J. Biol. Chem., 264, 14136 (1989), Kalgutkar, A.S., et al.: J. Med. Chem., 43, 2860 (2000), Hata, A.N., et al.: Mol. Pharmacol., 67, 640 (2005), Tuccinardi, T., et al.: J. Med. Chem., 49, 984 (2006),<br></p>

<p>Applications Analgesic; sedative; anesthetic.Controlled substance (opiate).<br>References DeRossi, R., et al.: Vet. J., 178, 294 (2008), Hoecker, J., et al.: Anesthesiol., 109, 95 (2008), Fliri, A., et al.: J. Med. Chem., 52, 8038 (2009),<br></p>

<p>Applications Antineoplastic; non-selective steroidal aromatase inhibitor that prevents the conversion from androgen to estrogen. Used in in the treatment of familial male precocious puberty. An effective anti-tumor agent.<br>References Dunkel, L.: Mol. Cell. Endocrinol., 254, 207 (2006); Eugster, E. A.: Treat. Endocrinol., 3, 141 (2004); Holbeck, S.L. et al.: Mol. Cancer Therap., 9, 1451 (2010);<br></p>

<p>Stability Hygroscopic<br>Applications Bialaphos Sodium Salt is a herbicide.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Mase, S.: Japan Pesticide Info., 45, 27 (1984)<br></p>

<p>Applications Phorate Oxon is a toxic metabolite of Phorate (P353500), an inhibitor of acetylcholinesterase and pseudocholinesterase.<br>References Bowman, M.C. et al.: J. Agric. Food Chem., 17, 138 (1969); Hong, J.U. et al.: Han’guk Nong. Hakh., 26, 104 (1983); Szeto, S. et al.: J. Agric. Food Chem., 30, 1082 (1982);<br></p>

<p>Applications Palmitoyl-L-carnitine Hydrochloride is a long-chain fatty ester of carnitine which is accumulated and released into the circulation, in fatty-acid oxidation defects. Pattern of Lauroyl-L-carnitine can be diagnostic for a number of ß-oxidation defects.<br>References Ventura, F., et al.: Clinica Chimica Acta, 281, 1 (1999); Pourfarzam, M., et al.: Clinical Chem,, 40, 2267 (1994); Schaefer, J., et al.: Pediatric Res., 37, 354 (1995)<br></p>

<p>Applications Acetoguanide is a degradation product of the sulfonylurea herbicide Iodosulfuron.<br>References Pramauro, E., et al.: Environ. Sci. Technol., 27, 1790 (1993); Rouchard, J., et al.: Toxicol. Environ. Chem., 85, 103 (2003); Brigante, M., et al.: J. Agric. Food Chem., 53, 5347 (2005);<br></p>

<p>Applications 2-Hydroxy-α,α,4-trimethylcyclohexanemethanol is used in protection measures in the prevention of tick-born diseases. Acaricide.<br>References Cisak, E. et al.: Annals Agri. Env. Med., 19, 625 (2012); Gbenou, J. et al.: Mol. Biol. Rep., 40, 1127 (2013);<br></p>

<p>Applications Used as an antithrombotic.<br>References Mills, D.C.B., et al.: Arterioscler. Thromb., 12, 430 (1992), Feuerstein, G., et al.: Exp. Opin. Invest. Drugs, 4, 425 (1995)<br></p>

<p>Applications Spirotetramat Metabolite BYI08330-mono-hydroxy can be used in analytical study of chemometric-​assisted QuEChERS extraction method for the residual analysis of thiacloprid, spirotetramat and spirotetramat's four metabolites in pepper.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Li, S., et al.: Food Chem, 192, 893 (2016)<br></p>