Toxicologie

<p>Applications N-Ethyl-N-(2-hydroxyethyl)perfluorooctylsulphonamide is a perfluorinated alkyl sulfonamide (PFAS) used in a variety of consumer products for surface protection. It is a pollutant found in the air.<br>References Shoeib, M., et al.: Environ. Sci. Technol., 39, 6599 (2005); Martin, J., et al.: Anal. Chem., 74, 584 (2002)<br></p>

<p>Applications Xanthohumol is found in the hop plant Humulus Lupulus. Xanthohumol decreases inflammation, oxidative stress, and angiogenesis during the healing of skin wounds in type 1 diabetic rats.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Costa, R., et. al.: J. Nat. Prod., 76, 2047 (2013) Yuan, Y., et. al.: Eur. J. Pharmaceut. Sci., 53, 55 (2014)<br></p>

<p>Applications Pigment Violet 23 is an organic pigment found in various colourings such as tattoo inks, visual art and archeological objects. Pigment Violet 23 is also used in the preparation of nano silica-filled color resists.<br>References Persechino, S.; et al.: Spectrochim. Acta, Part A, 206, 547 (2019); Domenech-Carbo, M. T.; et al.: ChemTexts, 2, 1 (2016); Lee, C.; et al.: Adv. Polym. Tech., 31, 163 (2012).<br></p>

<p>Applications An orally active, antimycotic allylamine related to naftifine. A specfic inhibitor of squalene epoxidase, a key enzyme in fungal ergosterol biosynthesis.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Petranyi, G., et al.: Science, 224, 1239 (1984), Ryder, N.S., et al.: Antimicrob. Agents Chemother., 27, 252 (1985), Evans, E.G.V., et al.: Br. Med. J., 318, 1031 (1999),<br></p>

<p>Impurity Ofloxacin EP Impurity E<br>Applications Desmethyl Ofloxacin (Ofloxacin EP Impurity E) is a metabolite of Ofoxacin (O245750), a fluorinated quinolone antibacterial.<br>References Leysen, D., et al.: Antimicrob. Agents Chemother., 33, 1 (1989); Polk, R., et al.: J. Antimicrob. Chemother., 27, 17 (1991); Todo, Y., et al.: Chem. Pharm. Bull., 42, 2049 (1994); Furuhata, K., et al.: Biol. Pharm. Bull., 21, 456 (1998); Monk, J.P., et al.: Drugs, 33, 346 (1987); Drlica, K., Curr. Opin. Microbiol. 2, 504 (1990)<br></p>

<p>Stability Hygroscopic<br>Applications Clarithromycin 9-Oxime is an impurity of Clarithromycin (C559750), a macrolide antibiotic.<br>References Stephanic, V. et al.: J. Med. Chem., 54, 719 (2011); Chen, X. et al.: Zhong. Yao., 17, 32 (2008);<br></p>

<p>Applications Antitrypanosomal agent.<br>References Tettey, J., et al.: J. Pharm. Biomed. Anal., 21, 1 (1999), Newton, P., et al.: Lancet Infect. Dis., 6, 602 (2006),<br></p>

<p>Applications Spirodiclofen is a tetronic acid acaricide fungicide used in controlling red mites. Spirodiclofen is used in cannabis testing kits as a component of pesticide mixes (P698240).<br>References Kramer, T., et al.: Pest. Manage. Sci., 67, 1285 (2011); Ilias, A., et al.: Crop. Protect., 42, 305 (2012); Bretschneider, T., et al.: Modern. Crop. Protect. Compounds., 3, 1108 (2012)<br></p>

<p>Applications Felodipine-13C4, d3 is the labeled analogue of Felodipine (F232375), a dihydropyridine calcium channel blocker.<br>References Berntsson, P.B., et al.: Acta Pharm. Suec., 18, 221 (1981); Kratochwil, N., et al.: Biochem. Pharmacol., 64, 1355 (2002); O'Brien, S., et al.: J. Med. Chem., 48, 1287 (2005); Castilho, M., et al.: Bioorg. Med. Chem., 14, 516 (2006)<br></p>

<p>Stability Hygroscopic<br>Applications Fosfomycin Tromethamine is used as an antibiotic compound in the treatment of urinary tract infections.<br>References Keating, G. et al.: Drugs, 73, 1951 (2013); Demir, T. et al.: Int. J. Infect. Dis., 17, e966 (2013);<br></p>

<p>Stability Hygroscopic<br>Applications Cobicistat is a HIV protease inhibitor and has been coadministered with low-dose ritonavir (R535000) as a pharmacoenhancer, significantly increasing their plasma concentrations.<br>References Von, H., Exp. Rev. Clin. Pharmacol., 5, 557 (2012); Lepist, E.I., et al.: Antimicrob. Agent. Chemother., 56, 5409 (2012); Orr, S.T.M., et al.: J. Med. Chem., 55, 4896 (2012);<br></p>

<p>Stability Hygroscopic<br>Applications Oseltamivir-d5 Phosphate is the isotope labelled analog of Oseltamivir (O701000); an orally active inhibitor of influenza virus neuraminidase; converted in vivo to the active acid metabolite. Also an antiviral drug. It is a COVID19-related research product.<br>References Oliyai, R., et al.: Pharm. Res., 15, 1300 (1998); Kim, C.U., et al.: Med. Chem. Res., 8, 392 (1998); Hayden, F.G., et al.: N. Engl. J. Med., 341, 1336 (1999); Treanor, J.J., et al.: J. Am. Med. Assoc., 283, 1016 (2000)<br></p>

<p>Applications Topramezone is a herbicide that belongs to the class of pyrazolones or benzoylpyrazoles. It can be used to control broad leaved weeds and grass weeds in maize crop protection.<br>References Gitsopoulos, K.T., et al.: Crop Protection, 29, 1091-1093 (2010); Zhang, J., et al.: Crop Protection, 52, 26-32 (2013)<br></p>