Toxicologie

<p>Stability Hygroscopic<br>Applications Deuterated, Memantine (M218000) which is used as an antiparkinsonian and antispasmodic.<br>References Rohde, H., et al.: Fortschr. Med., 100, 2023 (1982), Kornhuber, J., et al.: Eur. J. Pharmacol., 166, 589 (1989), Gortelmeyer, R. and Erbler, H.: Arzneimittel-Forsch., 42, 904 (1992)<br></p>

<p>Applications Ethionamide-d3 is the isotope labelled analogue of Ethionamide (E890420), a antibacterial (tuberculostatic) agent.<br>References Banerjee, A., et al.: Science, 263, 227 (1994), Newton, G., et al.: J. Bacteriol., 178, 1990 (1996), Baulard, A., et al.: J. Biol. Chem., 275, 28326 (2000), Koledin, T., et al.: Arch. Microbiol., 178, 331 (2002), Cardoso, R., et al.: Antimicrob. Agents Chemother., 48, 3373 (2004),<br></p>

<p>Stability Very Hygroscopic<br>Applications Clindamycin-13C,D3 Hydrochloride is the labeled analog of Clindamycin (C580000, HCl salt), a semi-synthetic antibiotic prepared from Lincomycin. Antibacterial.<br>References Birkenmeyer, R.D., et al.: J. Med. Chem., 13, 616 (1970); Oesterling, et al.: J. Pharm. Sci., 59, 63 (1970); Gray, J.E., et al.: Toxicol. Appl. Pharmacol., 21, 516 (1972); Brown, L.W., et al.: Anal. Profiles Drug Subs., 10, 75 (1981)<br></p>

<p>Applications Niclosamide is used as an anthelmintic drug (Cestodes).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Loftsson, T., et al.: J. Pharm. Sci., 85, 1017 (1996), Malik, N., et al.: Anti. Cancer Drugs, 10, 767 (1999), El-Sayed, M., et al.: Pharm. Res., 18, 23 (2001),<br></p>

<p>Impurity Mometasone Furoate EP Impurity F<br>Applications 6-Oxo Mometasone Furoate (Mometasone EP Impurity F) is an impurity of Mometasone Furoate (M490000), a topical corticosteroid used as an anti-inflammatory.<br>References Shapiro, E.L., et al.: J. Med. Chem., 30, 1581 (1987); Graft, D., et al.: J. Allergy Clin. Immunol., 98, 724 (1996)<br></p>

<p>Applications A phosphocholine ester metabolite of the immunosuppressant macrolide SDZ RAD (also known as Everolimus E945400) which is an analog of the parent drug Rapamycin (R124000).<br>References Zollinger, M. et al.: Drug. Metab. Disp., 36, 1457 (2008); Kovarik, J. M., et al.: Clin. Pharmacol. Ther., 69, 48 (2001);<br></p>

<p>Stability Hygroscopic<br>Applications Octenidine is an antiseptic (topical). Octenidine is a cationic surfactant and bis-(dihydropyridinyl)-decane derivative.<br>References Slee, A.M., et al.: Antimicrob. Agents Chemother., 23, 531 (1983), Ghannoum, M.A., et al.: J. Antimicrob. Chemother., 25, 237 (1990), Allen, M., et al.: Microbiology, 152, 989 (2006), Ojha, A., et al.: Mol. Microbiol., 66, 468 (2007),<br></p>

<p>Applications Daptomycin is a Cyclic lipopeptide antibiotic derived from a fermentation product of Streptomyces roseosporus; disrupts plasma membrane function in gram-positive bacteria. Antibacterial.<br>References Allen, N.E., et al.: Antimicrob. Agents Chemother., 31, 1093 (1987), Tully, F.P., et al.: Expert Opin. Invest. Drugs, 8, 1223 (1999),<br></p>

<p>Applications An endogenous estrogen metabolite, risk-factor for development of breast cancer.<br>References Beral, V., et al.: Lancet, 362, 419 (2003), Nelson, R., et al.: Clin. Chem., 50, 373 (2004), Malekinejad, H., et al.: J. Agric. Food Chem., 54, 9785 (2006),<br></p>

<p>Stability Hygroscopic<br>Applications A labelled metabolite of Bisphenol A.<br>References Zalko, D., et al.: Drug Metab. Dispos., 26, 28 (1998), Matthews, J., et al.: Chem. Res. Toxico., 14, 149 (2001), Kinjo, J., et al.: Biol. Pharm. Bull., 27, 185 (2004), Murata, M., et al.: Biochemistry, 43, 2569 (2004),<br></p>

<p>Applications The major metabolite of Mosapride (M731000).<br>References Somogyi, A., et al.: Clin. Pharmacokinet., 8, 463 (1983), Cashman, J., et al.: Drug Metab. Dispos., 21, 587 (1993), Berkman, C., et al.: Biochem. Pharmacol., 50, 565(1995), Blake, B., et al.: Xenobiotica, 25, 377 (1995),<br></p>

<p>Stability Hygroscopic<br>Applications Iso Cyclosporin H is an impurity of Cyclosporin H (C988920).<br>References Borel, J., et al.: Pharmacol. Rev., 41, 259 (1990); Brooks, C., et al.: Clin. Chem., 39, 457 (1993); Lee, Y., et al.: J. Pharm. Biomed. Anal., 22, 183 (2000);<br></p>

<p>Stability Hygroscopic<br>Applications Myristoyl-L-carnitine-d3 Hydrochloride is labelled Myristoyl-L-carnitine Hydrochloride (M884745), a long-chain fatty ester of carnitine which is accumulated and released into the circulation, in fatty-acid oxidation defects. Pattern of Lauroyl-L-carnitine can be diagnostic for a number of ß-oxidation defects.<br>References Ventura, F., et al.: Clinica Chimica Acta, 281, 1 (1999); Pourfarzam, M., et al.: Clinical Chem,, 40, 2267 (1994); Schaefer, J., et al.: Pediatric Res., 37, 354 (1995)<br></p>

<p>Applications Psychotropic agent with anxiolytic and anticonvulsant activity.<br>References Boissier, J.R., et al.: Therapie, 27, 325 (1972), Bente, D., et al.: Arzneim. Forsch., 25, 944 (1975),<br></p>

<p>Applications A metabolite of Phenanthrene (P294800(P)), which is a polycyclic aromatic hydrocarbon; an environmental pollutant.<br>References Boyland, E., et al.: Biochem. J., 84, 564 (1962); Hamada, S., et al.: Mutat. Res., 495, 127 (2001); Shimada, T., et al.: Drug Metab. Dispos., 29, 1176 (2001); Moennikes, O., et al.: Cancer Res., 64, 4707 (2004); Albig, A., et al.: Mol. Biol. Cell., 16, 609 (2005); Di Toro, D. et al.: Environ. Toxicol. Chem., 19, 1971 (2000); Vines, C. et al.: Aquat. Toxicol., 51, 225 (2000); Incardona, J. et al.: Toxicol. Appl. Pharmacol., 196, 191 (2004); Junghans, M., et al.: Aquat. Toxicol., 76, 93 (2006);<br></p>

<p>Applications Gestagenic Testosterone (T155000) derivative. A steroid ligand for the cytosol androgen receptor (AR) of rat prostate.<br>References Ojasoo, T. et al.; J. Steroid Biochem. 27, 255 (1987); Dore, J. et al.; J. Med. Chem. 29, 54 (1986)<br></p>