Toxicologie

<p>Applications Suvorexant-d6 is the labeled analog of Suvorexant (S870000), a dual (non-selective) orexin receptor antagonist in development by Merck &amp; Co. for the treatment of insomnia. It works by turning off wakefulness rather than by inducing sleep. Users of higher doses had an increased rate of suicidal ideation.<br>References Cox, C., et al.: J. Med. Chem., 53, 5320 (2010); Baxter, C., et al.: Org. Process Res. Dev., 15, 367 (2011); Winrow, C., et al.: J. Neurogenet., 25, 52 (2011); Mieda, M., et al.: CNS Drugs, 27, 83 (2013); Osborne, R.: Nat. Rev. Drug Discov., 12, 492 (2013)<br></p>

<p>Applications Labelled Bilirubin (B385300), a principal pigment of bile and constituent of many biliary calculi.<br>References Stenhagen, R., et al.: Biochem. J., 33, 1591 (1939), Gray, et al.: J. Chem. Soc., 2264, 2268 (1961),<br></p>

<p>Applications Indoleacetic Acid is the most common and naturally occuring plant hormone in the auxin class of hormones. It effects cell elongation, cell division as well as plant growth and development.<br></p>

<p>Applications O-Hydroxyethyl Metronidazole is the hydroxy ethyl analogue and impurity of the antiprotozoal agent Metronidazole (M338880). O-Hydroxyethyl Metronidazole as well as other 1-substituted-2-methyl-5-nitroimidazoles showed potential antitrichomonal activity.<br>References Kajfez, F. et al.: J. Med. Chem., 11, 167 (1968);<br></p>

<p>Applications Nucleoside analog; specific inhibitor of hepatitis B virus (HBV) replication. Antiviral.<br>References Standring, D.N., et al.: Antiviral. Chem. Chemother., 12, 119 (2001), Hernandez-Santiago, B., et al.: Antimicrob. Agents Chemother., 46, 1728 (2002), Lai, C.-L., et al.: Hepatology, 40, 719 (2004), Han, S.-H.B., et al.: Expert Opin. Invest. Drugs, 14, 511 (2005),<br></p>

<p>Applications T-705RTP-13C5 Sodium Salt is a labeled salt derivative of T-705 (F103350) which has activity against the lethal H5N1 influenza A viruses.<br>References Yousuke, F., et al.: Antimicrob Agent Chemother., 49, 981 (2005); Kiso, M., et al.: Proc. Natl. Acad. Sci. U.S.A., 107, 882 (2010)<br></p>

<p>Applications Isotope labelled ethyl alcohol, used in alcoholic beverages in suitable dilutions. Other uses are as solvent in laboratory and industry , in the manufacture of denatured alcohol, pharmaceuticals, in perfumery, in organic synthesis. Used as antiseptic.<br>References Wiberg, G.S., et al.: Toxicol. Appl. Pharmacol., 16, 718 (1970), Brown, N.A., et al.: Science, 206, 573 (1979),<br></p>

<p>Stability Hygroscopic<br>Applications Tenofovir (T018500) impurity.<br></p>

<p>Applications The main cis-monohydroxylated metabolite of Praziquantel (P702095).<br>References Buehring, K., et al.: Eur. J. Drug Metab. Pharm., 3, 179 (1978), Moldeus, P., et al.: Methods Enzymol., 52, 60 (1978), Cioli, D., et al.: Pharmacol. Ther., 68, 35 (1995),<br></p>

<p>Applications 3-(1-Ethylpropyl)phenyl Methylcarbamate is a component of the carbamate insecticide Bufencarb (B689385).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Kmellar, B., et al.: Food Addit. Contam., 27, 1415 (2010); Kaufmann, A., et al.: Anal. Bioanal. Chem., 403, 1233 (2012);<br></p>

<p>Applications A potent inhibitor of taurine transport.<br>References Guidotti, A., et al.: Pharmacol. Res. Commun., 2, 341 (1970),<br></p>

<p>Applications Ketotifen is used as an antiasthmatic. Ketotifen is an antiallergic agent.<br>References Tsuji, F., et al.: Biol. Pharm. Bull., 33, 1050 (2010), Al O., et al.: J., Mol., Liq., 155, 103 (2010), Uccello-Barretta, G., et al.: Int. J. Pharm., 395, 122 (2010),<br></p>

<p>Applications Ammeline is a metabolite of Melamine (1) (M208700), which acts as a non-protein nitrogen food additive (2). Also present in pet foods as well (3).Drinking water contaminant candidate list 3 (CCL 3) compound as per United States Environmental Protection Agency (EPA). Environmental contaminants; Food contaminants.<br>References 1. Mast RW. et al.: Food Chem Toxicol. 1983 Dec;21(6):807-10.2. Ehling S. et al.: Food Addit Contam. 2007 Dec;24(12):1319-25.3. Vail T. et al.: J Anal Toxicol. 2007 Jul-Aug;31(6):304-12.<br></p>

<p>Applications 3-Carboxy-N,N,N-trimethyl-2-[(1-oxo-2-hexen-1-yl)oxy]-1-propanaminium chloride salt is used to increase the gastrointestinal absorption of drugs. It is used also to diagnose specific metabolic diseases.<br>References Yang, S. et al.: J. Chrom., 857, 251 (2007);<br></p>

<p>Applications Prenalterol is a β1-adrenergic agonist and used as an cardiotonic (1,2,3).<br>References (1) Ma, C., et al.: J. Pharm. Biomed. Anal., 47, 677 (2008)(2) Scheiber, J., et al.: J. Med. Chem., 52, 3103 (2009(3) Broadley, K., et al.: Biochem. Pharmacol., 80, 1537 (2010)<br></p>

<p>Applications S-(-)-Warfarin-d5 is the labelled analog of S-(-)-Warfarin, an enantiomer of Warfarin (W498500). Coumarin anticoagulant.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Hagan, E.C., et al.: J. Am. Pharm. Assoc. Sci. Ed., 42, 379 (1953), Bell, R.G., et al.: Biochemistry, 11, 1959 (1972), Valente, J.E., et al.: J. Med. Chem., 20, 1489 (1977), Back, N., et al.: Pharmacol. Res. Commun., 10, 445, (1978), Babhair, S.A., et al.: Anal. Profiles Drug Subs., 14, 423 (1985), Takahashi, H., et al.: Echizen, Clin. Pharmacokinet., 40, 587 (2001),<br></p>