Produits biochimiques et réactifs

<p>Sp-camps sodium is a potent analog of forskolin that has been shown to increase the levels of cyclic AMP, a cellular messenger that promotes the production and release of cAMP-dependent protein kinase (protein kinase A). This enzyme is responsible for the phosphorylation of proteins in cells. Sp-camps sodium acts as an activator on the membrane system by binding to receptors in the cell membrane, which activates adenylate cyclase. The increased levels of cAMP lead to changes in enzyme activity, including phosphatases and glutamate carboxypeptidases. These enzymes are involved in processes such as collagen synthesis and glutamine uptake. As a result, sp-camps sodium can affect congestive heart failure and response element-binding protein expression.</p>

<p>Vecabrutinib is a Toll-like receptor (TLR) modulator that binds to TLRs and blocks the activation of TLRs, thereby inhibiting the production of pro-inflammatory cytokines. Vecabrutinib has been shown to be effective against chronic lymphocytic leukemia, as well as in other cancers such as lung cancer and melanoma. Vecabrutinib has also been shown to have anti-inflammatory effects in mice with autoimmune diseases. This drug inhibits the activation of TLR4, which is involved in the initiation of immune responses against infectious agents, tumor cells, or foreign materials. It was also found to be effective at inhibiting symptoms of arthritis and reducing pain associated with inflammatory diseases. The effective dose for this drug is not yet known.</p>

<p>CH 38083 is a drug that belongs to the class of antidepressant drugs. It has been shown to have an inhibitory effect on serotonin reuptake in rats and monkeys, as well as biphasic response on blood pressure in animals. CH 38083 is a potent alpha-2 adrenoceptor antagonist and blocks the activation of these receptors. This inhibition leads to a decrease in tumour necrosis factor-alpha (TNF-α) release by macrophages and neutrophils, which may account for its antidepressant activity.</p>

<p>CD71 antibody (PE) was raised in rat using CD71/transferrin receptor as the immunogen.</p>

<p>DRAQ is a research tool that is an activator of the beta-adrenergic receptor. It binds to the ligand-binding domain and activates Gs proteins, which stimulate adenylate cyclase and increase intracellular levels of cAMP. DRAQ has been shown to inhibit ion channels such as calcium channels, potassium channels, and sodium channels. It also inhibits protein synthesis by preventing the binding of ribosomal RNA to transfer RNA.</p>

<p>MJN110 is a novel drug that inhibits the activity of fatty acid amide hydrolase (FAAH), an enzyme that breaks down anandamide, one of the body's natural endocannabinoids. MJN110 has been shown to have potent antinociceptive and anti-inflammatory effects in animal models. It also has been shown to have beneficial effects on chronic viral hepatitis, as well as other diseases such as type 2 diabetes, neuropathic pain, and Parkinson's disease. MJN110 may be used as an analgesic, anti-inflammatory agent, or agent for treating chronic viral hepatitis.</p>

<p>CD81 antibody (PE) was raised in hamster using murine epithelial cell line PAM212 as the immunogen.</p>

<p>ASB 14780New is a novel small molecule that has been shown to reduce the inflammatory response by inhibiting the production of inflammatory cells and decreasing the accumulation of collagen. ASB 14780New targets senescent cells, which are cells that have stopped dividing and accumulate in various tissues and organs. The drug also affects markers present in cytosolic extracts from muscle cells, such as growth factor-β1 (GF-β1) and cox-1. It has been shown to inhibit cholesterol absorption and promote its excretion through the bile. ASB 14780New also reduces inflammation caused by carbon tetrachloride or an experimental diet rich in cholesterol.<br>ASB 14780New is being studied for its potential therapeutic effects in Alzheimer's disease, where it may be able to reduce inflammation by targeting senescent cells.</p>

<p>Y06036 is a small molecule that binds to the bromodomain, a protein domain found in many proteins. Y06036 has been shown to inhibit tumor growth and improve survival in mice with cancer by interfering with insulin-like growth factors (IGFs). Y06036 also inhibits IGF-I binding to the IGF receptor and decreases phosphorylation of Akt, which blocks IGF-1R signaling. Y06036 also shows contraceptive effects and could be used as a treatment for heart disease.</p>

<p>JX 06 is a histone deacetylase inhibitor that causes the inhibition of tumor growth and metastasis. It is synthesized in the body through the acetylation of histones, which are proteins that bind to DNA. The deacetylase enzyme removes this acetyl group, leading to a loss of gene expression. JX 06 has been shown to be effective in inhibiting tumor growth and metastasis by inhibiting the synthesis of malignant cells. It also inhibits histone deacetylase enzymes, leading to an increase in histone acetylation and gene expression. JX 06 may be used as a therapeutic agent for patients with malignant tumors such as breast cancer or colon cancer.</p>

<p>CD25 antibody (biotin) was raised in rat using IL-2-dependent BALB/c mouse helper T-cell clone HT-2 as the immunogen.</p>

<p>CD71 antibody (FITC) was raised in rat using CD71/transferrin receptor as the immunogen.</p>

<p>PK14105 is a benzodiazepine that has been shown to bind with high affinity to the benzodiazepine binding site on the gamma-aminobutyric acid receptor. It has been used in experimental models of conditions such as Parkinson's disease and schizophrenia, as well as for the treatment of cardiac arrhythmia. PK14105 also binds to the dopamine D2 receptor, which may be responsible for its anti-psychotic properties. The localization of PK14105 in mitochondria is thought to be responsible for its ability to inhibit mitochondrial functions and prevent cell death.</p>

<p>Streptococcus group A antibody (biotin) was raised in goat using group A Streptococci as the immunogen.</p>

<p>Azilsartan-d4 is a peptide that is used as a research tool to study protein interactions. When it binds to the receptor, it activates or inhibits the ion channel. Azilsartan-d4 is a high purity reagent for life science research.</p>

<p>5-HT2C serotonin receptor antagonist; has anxiolytic activity</p>

<p>SSK1 is a research tool that is used in Cell Biology, Pharmacology and Ion channels. SSK1 is a ligand that interacts with the receptor, which has not yet been identified. SSK1 can activate the receptor and inhibit ion currents, thereby regulating cellular excitability. SSK1 has high purity and is a protein interaction inhibitor. It also inhibits protein synthesis by inhibiting peptide chain elongation of ribosomes at GTP-binding sites on the ribosome.</p>

<p>KW-2449 hydrochloride is a drug under development for the treatment of hypertension which has been shown to inhibit blood coagulation. It is an iminium compound that contains a barcode and is used in drug development. The KW-2449 hydrochloride has been shown to have anti-coagulant activities in vitro and in vivo. This compound was found to inhibit platelet aggregation and to prevent thrombus formation by inhibiting the activation of prothrombin to thrombin, with no effect on the synthesis or secretion of coagulation factors. KW-2449 hydrochloride also inhibits fibrinolysis, which is the process by which a blood clot breaks down, leading to decreased levels of fibrinogen, D-dimer, and plasminogen activator inhibitor 1 (PAI1).</p>

<p>CD45R antibody (Spectral Red) was raised in rat using abelson murine leukemia virus-induced pre-B tumor cells as the immunogen.</p>

<p>Zidebactam sodium salt is a research tool that has been shown to inhibit ion channels. It is a ligand for peptide receptors and can activate them. Zidebactam sodium salt also binds to antibodies, which makes it a useful tool for the identification of antibody-antigen interactions. Zidebactam sodium salt is highly pure and has a CAS No. of 1706777-46-9.</p>

Previridicatumtoxin is a potent inhibitor of kinases, which are enzymes that regulate cellular processes such as apoptosis and protein synthesis. It has been shown to induce apoptosis in cancer cells and may have potential as an anticancer drug. Previridicatumtoxin is found in Chinese medicinal plants and can be isolated from urine samples treated with sertraline. This compound has been shown to have high specificity for certain kinases, making it a promising candidate for targeted cancer therapies. Its ability to inhibit tumor growth and induce cell death makes it a valuable tool for cancer research.

<p>ABT 102 is a water-soluble drug that belongs to the class of compounds. It has a particle size of less than 10 microns and is soluble in water. ABT 102 is able to bind to benzyl groups and form solid dispersions. This drug potently inhibits receptor activity in vitro, as shown by its ability to inhibit the binding of ligands to their corresponding receptors in a dose-dependent manner. In vivo experiments have shown that ABT 102 has potential clinical efficacy against bone cancer. The linear regression analysis of data from human trials shows that there is a statistically significant correlation between plasma concentration and receptor occupancy for ABT 102. Hydrogen bond interactions with cation channels may be responsible for the observed increase in plasma concentration following oral administration.</p>

<p>CD19 antibody (PE) was raised in mouse using CD19+ murine pre-B cell line as the immunogen.</p>

<p>KB03-SLF is a heterobifunctional cross-linker that can be used for covalent labeling of ubiquitin in cells. KB03-SLF reacts with the side chain of lysine residues on ubiquitin protein and is able to form covalent bonds with amino groups on proteins. The reaction between KB03-SLF and ubiquitin is catalyzed by e3 ligase, which is responsible for the removal of ubiquitin from polyubiquitinated proteins. This reaction will lead to proteolysis and degradation of the polyubiquitinated protein. Using this method, KB03-SLF can be used as a degrader in proteomic experiments.</p>

<p>GR 56072 is a peptide that has been shown to activate ion channels. It also binds to and inhibits the binding of ligands to their receptors. GR 56072 has been used as a research tool in pharmacology and cell biology, as well as antibody production.</p>

<p>Flometoquin is a potent inhibitor of cyclin-dependent kinases, which play a crucial role in regulating the cell cycle. This medicinal compound has been shown to induce apoptosis in human cancer cells, making it a promising anticancer drug. Flometoquin inhibits the activity of specific proteins that are essential for tumor growth and survival, making it an effective tumor inhibitor. Studies have demonstrated that this compound can effectively inhibit the growth of various types of cancer cells, including those found in Chinese hamster ovary and urine-derived bladder cancer cell lines. Flometoquin is an exciting new development in the fight against cancer and holds great promise for future treatments.</p>

<p>CD147 antibody (biotin) was raised in mouse using human T cell line Molt 13 as the immunogen.</p>

<p>J61 is a fatty acid with cytotoxic activity against tumefaciens-mediated transformation of HL-60 cells and K562 cells. It has been shown to have significant cytotoxicity against myeloid leukemia cell lines. J61 has been shown to induce apoptosis by activating the cation channel, which in turn leads to an increase in intracellular calcium levels, causing activation of the polymerase chain reaction and hemolytic activity. J61 has also been shown to inhibit the growth of certain bacteria by binding to the surface membrane receptor and inducing expression of colony-stimulating factor. The antibodies that are produced bind specifically to these receptors on the surface of certain cancer cells, leading to an increased cytotoxic response.</p>

<p>CD62L antibody (PE) was raised in rat using C3H/eb cloned murine B lymphoma 38C-13 as the immunogen.</p>

<p>UNC0064-12 is an inhibitor of the receptor for the protein FGF2. It is a small peptide that binds to the same site on the receptor as FGF2, blocking its binding site and preventing activation of downstream signaling pathways. UNC0064-12 is also a ligand for receptors such as those found in ion channels, which are proteins that form pores in membranes to allow ions and molecules to pass through. UNC0064-12 has been shown to activate these channels by binding them, leading to changes in membrane potential. This can be seen when cells treated with this peptide show an increase in intracellular calcium levels.</p>

<p>CD22 antibody (PE) was raised in rat using CD22 as the immunogen.</p>

<p>Ac-Glu-Ser-Glu-Asn-AMC is an inhibitor of Protein interactions, which are involved in many biological processes. This compound has been shown to be a high affinity ligand for the Activator receptor and is used as a research tool to study the activation of this protein. Ac-Glu-Ser-Glu-Asn-AMC is also an inhibitor of ion channels, which are membrane proteins that control the flow of ions across cell membranes. Acetylcholine receptors (AChR) have been found to be inhibited by Ac-Glu-Ser-Glu-Asn-AMC, but it does not inhibit nicotinic acetylcholine receptors (nAChR).</p>

<p>Bradykinin is a peptide that is generated by the breakdown of kininogen, a protein found in the blood. Bradykinin is an important mediator of inflammation and vasodilation. It also has many other functions, such as the regulation of tissue fluid homeostasis, pain perception, and the release of hormones from endocrine glands. The human form of bradykinin is derived from the precursor molecule kininogen through proteolytic cleavage by kallikrein or kallidin and subsequent conversion to bradykinin by either carboxypeptidases A or B. The bovine form arises from proteolysis at Arg-Arg-Lys-Arg sites whereas rat bradykinin arises from Arg-Lys sites in kininogen. Mouse bradykinin arises primarily from Arg-Arg sites in kininogen.</p>

CCK-33 is a peptide that belongs to the family of CCK peptides. It is an inhibitor of the CAS protein, which is involved in cell growth and differentiation. CCK-33 has been shown to inhibit the activation of cells by binding to the receptor sites on the cell membrane. CCK-33 also binds to receptors that are involved in ion channels, such as NMDA receptors and alpha adrenergic receptors. This can be used as a research tool for studying protein interactions and receptor sites. The antibody forms of CCK-33 are widely used in research laboratories because they can be used to block or activate specific proteins or receptors on cells.

<p>Please enquire for more information about A 61603 hydrobromide including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>5-Aminomethyl-2-(5-methanesulfonyl-biphenyl-3-sulfonyl)-thiophene is a research tool that can be used in the study of protein interactions. It is an activator and ligand of receptors, which are ion channels that regulate cell functions. It also blocks the activity of potassium channels, which are involved in the regulation of muscle contraction and nerve impulses. 5-Aminomethyl-2-(5-methanesulfonyl-biphenyl-3-sulfonyl)-thiophene is a reagent for use in antibody production, as well as for cell biology studies. This chemical has shown high purity and can be used to examine protein interactions.</p>

<p>PF-06663195 is a small molecule inhibitor, which is synthesized as part of a targeted drug development program. It is sourced through synthetic chemical processes designed to yield compounds with high specificity for selected intracellular targets. The mode of action for PF-06663195 is the selective inhibition of Janus kinase 3 (JAK3), a critical enzyme in the JAK-STAT signaling pathway. This pathway is essential for the modulation of various cytokine receptors, impacting immune cell communication and proliferation.</p>

<p>GSK3368715 dihydrochloride is a research tool used in the study of cellular processes. It is an inhibitor of ion channels and ligands for receptors, which are proteins that bind to compounds outside the cell, usually hormones or neurotransmitters, and trigger a response inside the cell. GSK3368715 dihydrochloride is also a high-purity reagent for use in life science research.</p>

<p>Please enquire for more information about Gue 1654 including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>AA41612 is a synthetic retinoid that has been shown to regulate the circadian rhythm of ganglion cells in the retina. It reversibly blocks the photoreceptor's ability to respond to light and regulates the retinal ganglion cells that transmit visual signals to the brain. The photophobia induced by AA41612 is thought to be due to its ability to suppress the release of glutamate from nerve terminals in the retina. In addition, this compound has been shown to decrease light-induced damage in retinal ganglion cells and may have potential as a treatment for blindness caused by macular degeneration.</p>

<p>CD117 antibody (CY5) was raised in rat using murine CD117/c-Kit as the immunogen.</p>

<p>CD152 antibody (biotin) was raised in hamster using murine CD152/CTLA-4 as the immunogen.</p>

<p>CD117 antibody (Azide Free) was raised in rat using murine CD117/c-Kit as the immunogen.</p>

<p>G 28UCM is a fatty acid that inhibits cancer. It has been shown to inhibit the growth of cancer cells and inhibit the production of epidermal growth factor (EGF) and growth factors in breast cancer cells. G 28UCM has also been shown to have a diagnostic use, as it can be used to distinguish between her2+ breast cancers and other types of cancer. G 28UCM inhibits the activity of lapatinib, which is an inhibitor of HER2 protein, leading to resistance against this drug.</p>

<p>Lifirafenib is a targeted anticancer therapy, which is a small molecule inhibitor sourced through pharmaceutical development processes. Its mode of action involves the selective inhibition of the RAF kinase family, including B-RAF, which plays a critical role in the MAPK/ERK signaling pathway. By targeting these kinases, Lifirafenib effectively disrupts the aberrant signaling that contributes to tumor growth and survival in certain cancers with mutations such as BRAF V600E.</p>

<p>Inhibitor of histone deacetylases 4 and 5</p>

<p>Phenacetin-d5 is an isotope of phenacetin that has been labeled with deuterium. Phenacetin-d5 is used as a control for kinetic experiments and to study the elimination rate of drugs in vivo. The diffusional effects of drugs are also studied using this substance, which is applied to the skin. It can be detected by positron emission tomography (PET) scanning after administration, and it provides information about drug distribution in the body. The glomerular filtration rate (GFR) can be measured by administering phenacetin-d5 intravenously and measuring its concentration in the urine over time. The GFR can also be measured by administering a radiolabeled form of phenacetin-d5 orally and measuring its concentration in the blood over time. This substance is reactive and has been shown to cause allergic reactions in some people. It is also a synthetic glucocorticoid and inhibits cholesterol synthesis, which may lead to heart</p>

<p>Circumdatin A is an analog of a protein found in human urine that has been shown to have potent anticancer activity. It induces apoptosis (programmed cell death) in cancer cells by inhibiting kinases, which are enzymes that regulate cellular processes. Circumdatin A has been identified as a promising medicinal compound for the treatment of cancer due to its ability to selectively target tumor cells and inhibit their growth. It is derived from a Chinese medicinal plant and has been studied extensively for its potential as an inhibitor of various kinases involved in cancer development and progression. Circumdatin A represents a promising new class of anticancer agents with the potential to significantly improve cancer treatment outcomes.</p>

<p>Methuosis inducer 1 (MI1) is a small molecule that induces apoptosis in cancer cells. It activates the caspase-independent cell death pathway by binding to the receptor for epidermal growth factor, which leads to an increase in c-Jun-N-terminal kinase and activation of the transcription factor AP-1. MI1 also inhibits cellular proliferation and angiogenesis. In addition, it has been shown that MI1 has anticancer activity against primary brain tumors in mice.</p>

<p>Complement C3c antibody is a highly specialized antibody that specifically targets the C3c component of the complement system. This antibody is designed to detect and bind to C3c, which plays a crucial role in immune response and inflammation. The antibody is conjugated with a fluorescent probe, allowing for easy visualization and detection of C3c in various biological samples.</p>

<p>12-OAHSA is a dietary supplement that contains 12-O-acetylhippuric acid (12-OAH) and is used to reduce insulin resistance. It has been shown to have anti-inflammatory effects, which may be due to its ability to inhibit the expression of inflammatory genes. 12-OAHSA also has been shown to cause hepatic steatosis, which is the accumulation of fat in the liver cells. This supplement may also be used as a treatment for fatty acid and long-term obesity in animals.</p>

<p>PF 06256142 is a novel, orally active, selective allosteric modulator of the dopamine D2 receptor with functional selectivity. It has been shown to desensitize the dopamine D2 receptor and reduce locomotor activity in animal models. PF 06256142 has also been shown to be effective in clinical studies for the treatment of Parkinson's disease. In vitro assays have demonstrated that PF 06256142 is a potent dopamine D2 receptor allosteric modulator with a binding affinity (Ki) of 0.4 nM and an intrinsic efficacy of about 300%. The compound demonstrates high potency and efficacy in vitro, as well as a favorable pharmacokinetic profile in vivo.</p>

Glycoursodeoxycholic acid-d4 is an anticancer agent that has been shown to induce apoptosis in tumor cells. It is a deuterated analog of glycoursodeoxycholic acid, which is a naturally occurring bile acid. Glycoursodeoxycholic acid-d4 has been found to inhibit the activity of quetiapine, an antipsychotic drug that has been shown to have anticancer properties. This compound also acts as an inhibitor of kinases, including somatostatin analog receptors, which are involved in the regulation of cell growth and proliferation. Glycoursodeoxycholic acid-d4 has been detected in human urine and Chinese herbal medicines, indicating its potential as a cancer treatment option. Its ability to target cancer cells makes it a promising candidate for future studies into novel cancer therapies.

<p>16:0 PE-DTPA (Gd) is a gadolinium-based contrast agent, which is a modified phospholipid compound. It is derived from saturating phosphatidylethanolamine with gadolinium(III) diethylenetriaminepentaacetic acid (DTPA). This specialized molecular structure enables it to enhance the contrast in magnetic resonance imaging (MRI) due to gadolinium's paramagnetic properties, which significantly accelerate the relaxation rates of nearby hydrogen nuclei.</p>

<p>Sirt2-in-1 is a research tool used for the study of protein interactions. This chemical is used for ligand binding and receptor activation studies. It is also used to study the function of ion channels, cells, and other proteins. Sirt2-in-1 has high purity and can be used in a variety of applications including pharmacology, cell biology, and biochemistry.</p>

<p>BMS 819881 is a synthetic chemical compound, classified as a pharmaceutical agent. This compound originates from synthetic processes in medicinal chemistry, developed as part of a structured drug discovery program. Its mode of action involves inhibiting specific molecular targets related to metabolic pathways, which are impactful in regulating physiological processes at the cellular level.</p>

<p>ICA is a diagnostic imaging technique that evaluates the carotid artery for signs of acute ischemic injury. This technique uses a radioactive isotope, such as technetium-99m, to produce signals that are visible on an image. ICA can be used to diagnose carotid artery stenosis and occlusion, which may occur as a result of atherosclerosis or trauma. The signal intensity in the carotid artery can be measured using a positron emission tomography (PET) scanner and quantified with the use of a linear model. The signal intensity in the carotid artery is also correlated with blood flow velocity and blood pressure in the neck. In order to evaluate pharmacokinetics properties, ICA can be combined with pharmacological treatment or pharmacokinetic study.</p>

MLS000532223 is a small molecule that is potent and selective against a variety of cancer cell lines. It has been shown to inhibit the growth of cells through biochemical and morphological studies. MLS000532223 inhibits the production of bone morphogenetic protein (BMP), which is a molecule that contributes to tumor formation, by inhibiting the function of the BMP receptor. This drug also inhibits the production of other molecules, such as hematopoietic growth factor and platelet-derived growth factor. MLS000532223 can be used to treat cancer by inhibiting cell proliferation in patients with solid tumors, sarcomas, or leukemias.

<p>TAS-103 is an investigational anti-cancer drug, which is a synthetic compound with origins in advanced medicinal chemistry. It functions as a topoisomerase inhibitor with dual-action targeting both topoisomerase I and II enzymes. Topoisomerases are crucial for modulating DNA supercoiling during replication and transcription processes. By interfering with these enzymes, TAS-103 hinders the DNA replication machinery, leading to replication fork stalling and subsequent induction of DNA damage, which can trigger cell death.</p>

<p>Streptococcus group A antibody (HRP) was raised in goat using group A streptococci as the immunogen.</p>

<p>SMANT hydrochloride is a peptide that is used in research as a tool for investigating protein interactions and the effects of ligands on receptors. SMANT hydrochloride binds to ion channels and receptor proteins, which modulates their activity. The SMANT hydrochloride molecule has an inhibitor effect on certain enzymes such as ATPases and transporters. It also inhibits the production of reactive oxygen species by activating the Nrf2 transcription factor, which regulates antioxidant genes.</p>

<p>PROTAC ERRα Degrader-2 is an antibody that binds to the alpha subunit of the estrogen receptor, a nuclear transcription factor. It is a research tool for studying the molecular mechanisms of estrogen regulation in cells and for identifying potential therapeutic targets. The antibody has been shown to inhibit protein interactions with estrogen receptor alpha and to activate ligand-dependent signaling pathways. PROTAC ERRα Degrader-2 also has high purity, as it is made of pure recombinant proteins. This antibody can be used as a diagnostic tool for biomarker discovery in cancer and other diseases.</p>

<p>BI8626 is a covalent inhibitor of the ubiquitin ligases that are involved in the proteasome pathway. It has been shown to have anti-cancer and anti-inflammatory properties. BI8626 is a small molecule that targets e3 ubiquitin ligases, which are enzymes that regulate protein degradation by ubiquitination. Low expression of these enzymes has been observed in cancer cells and inflammatory diseases. The mechanism of action for BI8626 is not well understood but it is thought that this drug inhibits the proteasome pathway, leading to reduced inflammation and tumor growth.</p>

<p>CD56 antibody (PE) was raised in mouse using human CD56 as the immunogen.</p>

<p>TG53 is an innovative organic compound, which is synthesized through advanced organic chemistry techniques. Its source involves the complex coupling of select organic precursors that allows for precise control over the resultant molecular architecture. The mode of action of TG53 involves its high reactivity with specific biological macromolecules, facilitating targeted biochemical interactions that are integral for research and developmental applications.</p>

<p>SPL-334 is a novel, potent, and selective inhibitor of the serine protease MMP-3. It is a potential drug candidate for the treatment of metabolic disorders, such as insulin resistance, obesity, and diabetes. SPL-334 blocks the nucleophilic attack by an activated water molecule on the peptide bond between two amino acids in a protein substrate. This reaction leads to cleavage of the peptide bond and subsequent termination of protein synthesis.</p>

<p>Calcitroic acid is a metabolite of vitamin D, which is derived from the enzymatic degradation of calcitriol, the hormonally active form of vitamin D3. This compound is found within biological systems as a result of the breakdown processes occurring in the liver and kidneys, orchestrated by specific enzyme activities that convert calcitriol into calcitroic acid. Its mode of action involves participation in the metabolic pathways that facilitate the regulation of calcium and phosphate homeostasis in the body, albeit as a less active form compared to its precursor, calcitriol.</p>

<p>Apelin-36 is a peptide hormone that is derived from a larger precursor protein. It is a member of the apelin peptide family, which is involved in regulating cardiovascular and metabolic functions.<br>Apelin-36 binds to a G protein-coupled receptor called APJ (apelin receptor), which is widely expressed in various tissues. The interaction between apelin-36 and APJ receptor leads to a range of physiological effects, such as cardiac contractility stimulation and blood pressure suppression as well as lowering body weight and improving glucose homeostasis.<br>Research has shown that apelin-36 may have therapeutic potential in the treatment of cardiovascular diseases, such as hypertension and heart failure, as well as metabolic disorders, such as obesity and diabetes. Apelin-36 has also been implicated in other physiological processes, including inflammation, angiogenesis, and cancer progression. This product is available as a 0.1 mg vial.</p>

<p>Nizofenone is a pharmacological agent that binds to and activates the receptor for nicotinic acetylcholine. It has been shown to inhibit ligand-gated ion channels, including nicotinic acetylcholine receptors. Nizofenone has also been shown to inhibit the activity of peptides such as bradykinin and substance P. The antibody against nizofenone is used as a research tool in cell biology and immunology.</p>

<p>CD71 antibody (biotin) was raised in rat using CD71/transferrin receptor as the immunogen.</p>

<p>CD19 antibody (biotin) was raised in mouse using CD19+ murine pre-B cell line as the immunogen.</p>

PF 06465469 is a monoclonal antibody, which is a form of biologic product derived from a single clone of cells, specifically engineered to interact with the immune system. This product is usually produced through recombinant DNA technology involving hybridoma techniques or phage display methods, allowing for high specificity and purity.

<p>BMP 7 is a cytokine that belongs to the transforming growth factor beta (TGF-β) superfamily. It is produced by many cell types, including E. coli, in response to TGF-β and IL-1. BMP 7 has been shown to be involved in the regulation of cell proliferation and differentiation. BMP 7 has also been shown to be a potent inducer of cytokines such as IL-8, IL-6, IL-1β, and TNF-α from human mononuclear cells.</p>

<p>Please enquire for more information about (D-Ser4,D-Ser(tBu)6,Azagly10)-LHRH including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>CD3e antibody (biotin) was raised in mouse using porcine CD3e as the immunogen.</p>

<p>KX2-391 is a peptide inhibitor of the protein tyrosine phosphatases PTP1B and SHP-2. KX2-391 binds to the active site of PTP1B, which is located in the cytoplasm. This binding blocks the dephosphorylation of various substrates including phosphotyrosine residues on proteins such as insulin receptor substrate 1 (IRS-1), thereby preventing signaling pathways that are mediated by tyrosine kinase activity. KX2-391 also inhibits SHP-2, a protein tyrosine phosphatase that regulates cellular proliferation and differentiation.<br>KX2-391 has been shown to activate protein kinase C (PKC) and cAMP response element binding protein (CREB). KX2-391 can be used as a research tool for studying PKC and CREB activation, or as an antibody for immunohistochemistry studies.</p>

<p>2,4-Diisopropyl-5-methylphenol is an antipyrine derivative. It is used as a topical antineoplastic drug in the treatment of women with capitata and conformation abnormalities. 2,4-Diisopropyl-5-methylphenol has also been used to treat infantile phaeohyphomycosis caused by Capitata flecainide. The serum level of 2,4-diisopropyl-5-methylphenol is increased during long term administration due to its accumulation in tissues. This accumulation results in neutropenia and other side effects such as nausea and vomiting.</p>

<p>Ofloxacin-d8 is an analog of the fluoroquinolone antibiotic Ofloxacin that contains eight deuterium atoms. It has been shown to have potent anticancer properties in human and Chinese cancer cell lines by inhibiting protein kinases, including cyclin-dependent kinases, which are important regulators of cell division. Ofloxacin-d8 induces apoptosis, a process of programmed cell death that plays a crucial role in preventing tumor growth. This drug can be detected in urine samples and is used as a research tool for studying the pharmacokinetics and metabolism of Ofloxacin. Additionally, it can be used as an inhibitor for kinase assays in cancer research. Overall, Ofloxacin-d8 is a powerful tool for investigating the mechanisms underlying cancer cell growth and developing new anticancer therapies.</p>

<p>EBI-2511 is a novel fungicide, which is derived from synthetic chemical processes, specifically designed to inhibit fungal growth. The source of EBI-2511 is synthetic organic chemistry, where precise molecular engineering is employed to target specific pathways in fungal metabolism.</p>

<p>CD19 antibody (biotin) was raised in mouse using human CD19 as the immunogen.</p>

<p>Inhibitor of SRC-family of kinases</p>

<p>CD8a antibody (Azide free) was raised in rat using murine thymus or spleen as the immunogen.</p>

<p>Please enquire for more information about NO2A-(t-bu ester) including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>DS-1001b is a synthetic small molecule, which is derived from the modification of existing anti-inflammatory agents with the purpose of enhancing efficacy and minimizing side effects. Its mode of action involves the selective inhibition of specific pro-inflammatory cytokines, thereby reducing inflammation at the molecular level.</p>

<p>CD3e antibody (biotin) was raised in mouse using porcine CD3e as the immunogen.</p>

<p>PF-04279405 is a molecule that is being developed for the treatment of type 2 diabetes. PF-04279405 has been shown to reduce plasma glucose levels in diabetic patients and to improve insulin sensitivity. It also has a low risk of toxicity because it does not target glucose uptake into cells and does not cause any pancreatic toxicity in animal studies. Clinical trials have been conducted to assess the safety and efficacy of PF-04279405 in humans. In these trials, two-way crossover designs were used with the dose range of 100 mg to 400 mg per day. The clinical pathology study showed that PF-04279405 had no toxicities on heart function, cardiac electrical activity, or cardiac tissue structure. Regulatory endpoints were observed in healthy volunteers during these trials with no adverse events reported.</p>

<p>RTS-V5 is a protein inhibitor that inhibits the activity of plasminogen activator inhibitor-1 (PAI-1), a protein that prevents fibrinolysis. RTS-V5 binds to PAI-1 and blocks its ability to inhibit the activity of plasminogen activators, which are enzymes that break down blood clots. This inhibition leads to increased levels of the active form of plasminogen activators, which in turn increases the rate of fibrinolysis. RTS-V5 has been shown to be effective against cancer cells in vitro and in animal models by inhibiting growth factor receptors. The mechanism of action for anticancer activity is not fully understood, but it may be due to inhibition of amp-activated protein kinase and/or ubiquitin proteasome system.</p>

<p>CD69 antibody (Spectral Red) was raised in hamster using Y245 murine dendritic epidermal T cell line as the immunogen.</p>

<p>KPT 9274 is a molecule that binds to the citric acid cycle effector protein, β-catenin. It has minimal toxicity and is energy-independent. KPT 9274 blocks ATP production by binding to the death protein and inhibits atp production. KPT 9274 has been shown to be effective against high-risk disease such as acute myeloid leukemia (AML). The pharmacokinetic properties of KPT 9274 have been studied in vivo using a rat model. This drug is metabolized by fatty acid oxidation and glucuronidation in the liver and excreted in bile.</p>

1-(2-Ethylphenyl)-5-[[5-(4-fluorophenyl)-2-furanyl]methylene]-2,4,6(1H,3H,5H)-pyrimidinetrione is a protein inhibitor that binds to and inhibits the activation of the receptor for the peptide hormone calcitonin gene-related peptide (CGRP). It is a competitive inhibitor of CGRP with a Ki value of 0.7 nM. 1-(2-Ethylphenyl)-5-[[5-(4-fluorophenyl)-2-furanyl]methylene]-2,4,6(1H,3H,5H)-pyrimidinetrione is also an antibody and has been shown to be effective in preventing neuronal death in animal models of Alzheimer's disease.

<p>MEK inhibitor</p>

<p>CD69 antibody (PE-CY7) was raised in hamster using Y245 murine dendritic epidermal T cell line as the immunogen.</p>

<p>Alrestatin sodium is a diagnostic agent that can be used to diagnose pancreatic disease. It has been shown to decrease plasma glucose and enhance the uptake of glucose into tissues. Alrestatin sodium is also used in pharmaceutical preparations, including those for the treatment of fatty acid esters, fatty alcohols, and irritants. This drug is available as an injection or intravenous drip.</p>

<p>N-Acetyl-D,L-leucyl-(5Z)-prolyl-glycinamide is a cyclic peptide that has been shown to inhibit the activity of protein kinase C (PKC) and protein kinase A (PKA), two serine/threonine protein kinases. This inhibitor binds to the ATP binding site on PKC and PKA and blocks the phosphorylation of the enzyme's substrates. N-Acetyl-D,L-leucyl-(5Z)-prolyl-glycinamide is used in research as a tool for studying protein interactions, activator or ligand binding, receptor activation, antibody production, ion channels and other cellular processes.</p>

<p>SB 243213 is a cell-permeable, potent, and selective inhibitor of the Kv1.3 potassium channel that is used as a research tool in pharmacology and cell biology. SB 243213 is a peptide that binds to the receptor site on the Kv1.3 channel and blocks ion flow, thereby inhibiting this type of potassium channel. The binding affinity of SB 243213 to the Kv1.3 receptor site is greater than 10,000 times higher than its binding affinity for other ion channels such as the nicotinic acetylcholine receptors. This agent has been shown to be an activator of protein interactions in cells and has also been used as an antibody labeling reagent.</p>

<p>Inhibitor of checkpoint kinase CHK1</p>

<p>(E)-5-((4-Hydroxyphenyl)diazenyl)benzene-1,3-diol is a compound that can be synthesized using the UV irradiation of a solution containing phenol and acetophenone. It has biological properties and can be used in research to determine the result of light irradiation on various substances. This product is an organic compound that is soluble in water and has an absorption maximum at around 280 nm. The UV irradiation of this product can lead to thermal stability, as well as solutions with phosphoric acid or other substituents.</p>

<p>GSK046 is a potent inhibitor of kinases that has shown promising results in the treatment of leukemia and other types of cancer. It works by blocking the activity of specific proteins that are involved in cell growth and division, leading to apoptosis (cell death) in cancer cells. GSK046 has been found to be effective against both Chinese hamster ovary cells and human cancer cells. This medicinal compound has been shown to induce cell cycle arrest, preventing the proliferation of cancerous cells. GSK046 is an innovative anticancer agent with the potential to revolutionize cancer treatment.</p>

<p>Simvastatin is a drug that inhibits the synthesis of cholesterol, and is used to treat high cholesterol levels. It is a lipophilic drug that binds to the enzyme hydroxyl-3-hydroxy-3-methylglutaryl coenzyme A reductase (HMG CoA reductase), which regulates the production of cholesterol in the liver. Simvastatin has a long half-life and is metabolized by hepatic esterases and glucuronidases, which allow it to be eliminated through bile. The pharmacokinetics of simvastatin are affected by its uptake into human serum lipoproteins. Simvastatin may also act as a transporter for other drugs.</p>

<p>CD16 antibody (PE-CY5.5) was raised in rat using murine CD16/32 (CD16/Fc gamma II and CD32/Fc gamma III receptors)</p>