Produits biochimiques et réactifs

<p>Inhibitor of ribosomal protein kinase p70S6K</p>

<p>CD28 antibody (biotin) was raised in hamster using CD28 costimulatory receptor as the immunogen.</p>

<p>OICR-0547 is a small molecule that was identified by the OICR consortium as a potential antibiotic. It has been shown to have broad-spectrum activity against Gram-positive and Gram-negative bacteria, including drug-resistant strains. OICR-0547 binds to the bacterial ribosome and inhibits protein synthesis, which leads to cell death. The compound also has an inhibitory effect on the growth of several yeast species and mammalian cells. The binding of OICR-0547 to the ribosome induces a change in conformation that prevents peptidyl transferase from synthesizing proteins. This inhibition of translation leads to cell death because it prevents production of proteins vital for cell division. In addition, OICR-0547 inhibits the growth of methicillin resistant Staphylococcus aureus (MRSA), Enterococcus faecalis, Enterobacter cloacae, Pseudomonas aeruginosa, Burkholderia</p>

<p>Polystyrene is a thermoplastic polymer that is used in the production of polystyrene resins, which are used as building blocks for peptide synthesis. New England Peptide offers a variety of polystyrene resin products including particle resins and Rapp Polymere resins. The particle size of the resin ranges from 5-100 µm. Polymers can be synthesized using various methods including solid-phase synthesis and solution phase synthesis, which both require polystyrene resins. This product is available with a variety of functionalities, such as amine, hydroxyl and carboxyl groups.</p>

<p>PF 05089771 is a ligand that has been shown to activate the G-protein coupled receptor, GPRC6A. It has also been shown to inhibit the activity of protein kinase A and protein phosphatase 1D. PF 05089771 is a research tool for studying the ion channels and peptides that are involved in cell biology and cell signaling. This compound is an antibody inhibitor and can be used as a research tool for studying protein interactions.</p>

<p>Palmitoleic acid (17:0) is a fatty acid that plays an important role in regulating the function of mitochondria. It has been shown to be reactive and may play a role in the development of cancer, but it also has antioxidant properties. Palmitoleic acid (17:0) is synthesized from acetyl-CoA, which is derived from malonyl-CoA and acetyl-CoA. The enzyme carnitine palmitoyltransferase catalyzes this reaction, converting malonyl-CoA to malonyl-acylcarnitine, which then undergoes β oxidation to form acetyl-CoA and palmitoleic acid (17:0). In addition to its regulatory effects, palmitoleic acid (17:0) also acts as a photosynthetic pigment that absorbs light energy for photosynthesis. The measurement of 17:0 PE concentrations can be used as an indicator of photosynthetic activity in</p>

<p>Procalcitonin Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 116 amino acids. Molecular weight is 12.8 kDa.amino acid sequence: APFRSALESS PADPATLSED EARLLLAALV QDYVQMKASE LEQEQEREGS SLDSPRSKRC GNLSTCMLGT YTQDFNKFHT FPQTAIGVGA PGKKRDMSSD LERDHRPHVS MPQNAN</p>

<p>E 7386 is a monoclonal antibody that targets β-catenin, which is found in the cytoplasm of cells. E 7386 binds to β-catenin and inhibits its interaction with the transcription factor LEF1, preventing it from binding to DNA. In addition, E 7386 has been shown to inhibit epidermal growth factor (EGF) signaling and potentiate tumor cell death by inducing apoptosis. E 7386 has also been shown to reduce microvessel density and increase tumor cell death in mouse xenografts. It is currently being used for treatment of colorectal carcinoma and other cancers.</p>

<p>Endothelin receptor antagonist</p>

<p>Saikogenin A is a natural compound found in the tuberous roots of Pueraria lobata that has been shown to have a variety of biological activities. Saikogenin A inhibits protein synthesis through a number of mechanisms, including interfering with the production of growth factors, blocking the conversion of epoxyeicosatrienoic acids to prostaglandins, and inhibiting the activity of human liver cancer cells. It also has anti-inflammatory properties and has been shown to inhibit UV absorption as well as erythromycin-induced uvB damage in human skin cells. The triple-quadrupole mass spectrometry analysis reveals that saikogenin A has absorptions at 336, 338, and 340 nm in urine samples. This suggests that saikogenin A may be metabolized by cytochrome P450 enzymes into metabolites with different absorption spectra.</p>

<p>CD49d antibody (PE) was raised in mouse using human CD49d as the immunogen.</p>

<p>Hydroxypyruvic acid lithium hydrate is a research tool that can be used to study the interaction of peptides with antibodies and receptor proteins. It is also used as an activator for the production of antibodies. This product is a white powder that is soluble in water and alcohol. CAS No. 209728-15-4</p>

<p>Fulacimstat is a drug that is used to treat chronic kidney disease and ventricular dysfunction. Fulacimstat blocks angiotensin II, which is a potent vasoconstrictor, by inhibiting the angiotensin-converting enzyme (ACE). It has been shown to have beneficial effects on cardiac function in patients with chronic kidney disease who are undergoing hemodialysis. Fulacimstat has also been shown to reduce blood pressure in patients with renal impairment. Fulacimstat lowers potassium levels and increases serum levels of renin, which may lead to adverse events such as infarction or hyperkalemia. Fulacimstat may be an effective treatment for heart failure, but the safety profile needs to be further investigated before it can be recommended for this use.</p>

<p>Please enquire for more information about 1-Undecanoyl-2-hydroxy-sn-glycero-3-phosphocholine including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Potent inhibitor of SERCA ATPase</p>

<p>Etamicastat hydrochloride is a drug that inhibits the activity of the human liver enzyme CYP2D6. It is an inhibitor of the acetylation of dopamine to noradrenaline, which is important for the synthesis of adrenaline and dopamine. Etamicastat hydrochloride has been shown to have affinity for both human and monkey tissues. It also inhibits hydroxylation in rat plasma, liver cytosol, and liver microsomes. This drug has also been shown to inhibit dopamine hydroxylase in rat brain tissue as well as in vitro studies with human liver preparations. Etamicastat hydrochloride has been found to be effective against Parkinson's disease and other diseases that are associated with a decrease in dopamine levels.</p>

<p>Sostenuto (sRANKL) is a cytokine that binds to the activator of the receptor activator of NF-κB ligand. It is a soluble protein that can activate cells and regulate inflammatory responses. Sostenuto has been shown to be an important regulator in the immune system and can stimulate macrophages, T cells, and B cells by binding to their receptors. It also inhibits neutrophil apoptosis and enhances IL-10 production in macrophages. Sostenuto has been shown to have a regulatory effect on bacterial growth, specifically Escherichia Coli which is found in the gut.</p>

<p>Hepronicate is a polyunsaturated fatty acid that is a precursor to prostaglandin E1. It is available as a prescription drug and is used for the treatment of symptoms caused by congestive heart failure, diabetic neuropathy, and corneal endothelial cell dysfunction. Hepronicate has also been shown to stimulate the growth of cells in culture and may be an effective treatment for many types of cancer. This drug binds to the polyunsaturated fatty acid receptor on the surface of cells, which leads to an increase in polyunsaturated fatty acids in the cell membrane and activation of protein kinase C. Hepronicate may also inhibit tumor growth by binding to DNA-dependent RNA polymerase, preventing transcription and replication.</p>

<p>CD105 antibody (biotin) was raised in mouse using membrane preparation of human B-linage leukemia cells as the immunogen.</p>

<p>CD8a antibody (PE-Texas Red) was raised in rat using murine thymus or spleen as the immunogen.</p>

<p>TC-G 1005 is a drug that inhibits the uptake of acetylcholine in the lung. TC-G 1005 is a potent and selective inhibitor of taurocholate co-transporting polypeptide (TCCP), which is responsible for transporting bile acids into the liver. TC-G 1005 has been shown to reduce weight gain and fat deposits in mice, as well as to increase insulin sensitivity in adipose tissue. TC-G 1005 has also been shown to have positive effects on muscle function, reversing constrictions that are caused by cholinergic agents. TC-G 1005 also has anti-inflammatory properties, which may be due to its ability to inhibit the uptake of acetylcholine in bronchial passages.</p>

Varicella-Zoster Virus (VZV) is a highly contagious herpesvirus (a member of the Herpesviridae family) that causes two distinct diseases:

<p>3-[4-(6-Quinolinyl)phenyl]-1-azabicyclo[2.2.2]octan-3-ol is a synthetic compound known for its role as a potent dopamine reuptake inhibitor. As a compound synthesized in laboratories, it primarily serves as a tool in neuroscience research. The compound's mode of action involves the selective inhibition of dopamine transporters, which prevents the reuptake of dopamine into presynaptic neurons. This results in increased extracellular concentrations of dopamine, facilitating enhanced dopaminergic signaling in the central nervous system.</p>

<p>CD16 antibody (PE) was raised in mouse using human polymorphonuclear leukocytes as the immunogen.</p>

<p>CD11b antibody (biotin) was raised in rat using C57BL/10 murine splenic T-cells and concanavalin A-activted C57BL/10 splenocytes as the immunogen.</p>

Legionella Pneumophila LPS Rabbit Monoclonal Anitbody is a life science tool for use in IVD applications. Please enquire for more information about Legionella Pneumophila LPS Rabbit Monoclonal Anitbody including the price, delivery time and more detailed product information at the technical inquiry form on this page.

<p>CD106 antibody (biotin) was raised in Mouse using human CD106/VCAM-1 as the immunogen.</p>

<p>Fonadelpar is a drug formulated for the treatment of cardiovascular diseases. It is also used in conjunction with other drugs to treat dyslipidemia. Fonadelpar is a prodrug, which is metabolized by hydrolysis to form an active metabolite, 4-amino-N-(6-chloroquinoxalinyl)benzenesulfonamide (4-AQBS). This prodrug has been shown to inhibit phospholipase A2 and platelet aggregation and stimulates the production of prostacyclin, which are all beneficial effects on cardiovascular disease. Fonadelpar has also been shown to have diagnostic properties due to its ability to bind with high affinity to platelets and erythrocytes in the blood. The prodrug can be detected using a variety of analytical techniques such as gas chromatography, liquid chromatography, or colorimetric assays.</p>

<p>Inhibitor of p38 MAPK kinase</p>

<p>BIM 23056 is a type of drug that binds to the receptor and inhibits its activity. BIM 23056 has been shown to have anticancer effects in vitro and in vivo. It is a membrane-permeable substance, which means it can pass through the cell membrane and into the cell where it blocks the function of certain receptors. This drug also has a physiological effect on mammalian tissue, including fibroblasts, as well as on other cells that are sensitive to growth factors.</p>

<p>N-[8-[[(3S)-4-(Cyclopentylcarbonyl)-3-methyl-1-piperazinyl]methyl]-7-methylimidazo[1,2-a]pyridin-6-yl]-2-methyl-5-pyrimidinecarboxam ide is a peptide that activates ion channels and inhibits protein interactions. It is used as a research tool in the fields of cell biology, pharmacology, and immunology. This peptide is an inhibitor for the receptor for the neurotransmitter acetylcholine. It has been shown to be a ligand for the nicotinic acetylcholine receptor alpha subunit and can also inhibit protein interactions with other proteins.</p>

<p>CD8a antibody (Azide free) was raised in rat using murine thymus or spleen as the immunogen.</p>

<p>Please enquire for more information about NO2A-(t-bu ester) including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>DS-1001b is a synthetic small molecule, which is derived from the modification of existing anti-inflammatory agents with the purpose of enhancing efficacy and minimizing side effects. Its mode of action involves the selective inhibition of specific pro-inflammatory cytokines, thereby reducing inflammation at the molecular level.</p>

<p>CD3e antibody (biotin) was raised in mouse using porcine CD3e as the immunogen.</p>

<p>PF-04279405 is a molecule that is being developed for the treatment of type 2 diabetes. PF-04279405 has been shown to reduce plasma glucose levels in diabetic patients and to improve insulin sensitivity. It also has a low risk of toxicity because it does not target glucose uptake into cells and does not cause any pancreatic toxicity in animal studies. Clinical trials have been conducted to assess the safety and efficacy of PF-04279405 in humans. In these trials, two-way crossover designs were used with the dose range of 100 mg to 400 mg per day. The clinical pathology study showed that PF-04279405 had no toxicities on heart function, cardiac electrical activity, or cardiac tissue structure. Regulatory endpoints were observed in healthy volunteers during these trials with no adverse events reported.</p>

<p>GR 125743 is a small molecule compound that acts as a selective antagonist of the chemokine receptor CCR5. It is derived from a synthetic source designed to inhibit the interaction between the CCR5 receptor and its natural ligands. The primary mode of action involves blocking the CCR5 receptor, which is a critical co-receptor used by the Human Immunodeficiency Virus (HIV) to enter and infect host cells. By preventing this interaction, GR 125743 hinders the virus's ability to propagate within the host organism.</p>

<p>Bimolane is an immunosuppressive agent, which is a synthetic chemotherapeutic drug with a distinctive mode of action involving the interference with DNA synthesis and inhibition of lymphocyte proliferation. The compound achieves this by intercalating into DNA strands, thereby disrupting the replication process and ultimately exerting its cytotoxic effects on rapidly dividing cells, such as those in the immune system. This mechanism of action positions Bimolane as a potent agent for suppressing immune responses.</p>

<p>Ruxolitinib is a janus tyrosine kinase inhibitor active specifically on sub-types JAK1 and JAK2 with IC50 values in the nanomolar range. JAK1 and JAK2 are kinases involved in the regulation of hematopoiesis. Clinically applied to the treatment of intermediate and high-risk myelofibrosis, ruxolitinib is usually well tolerated by patients.</p>

<p>Please enquire for more information about A 37203 including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

25-Hydroxy vitamin D3 3,3'-biotinylaminopropyl ether is a synthesized compound, which is an analog designed for specific biochemical applications. It is derived from 25-Hydroxyvitamin D3, an active form of vitamin D found in the human body, combined with a biotin moiety through a flexible linker. The mode of action involves the binding of the biotin component to avidin or streptavidin, facilitating the targeted delivery and study of vitamin D3 pathways. This compound allows for the exploration of vitamin D3 interactions and mechanisms by enabling easy tracking and manipulation.

<p>CD107b antibody (FITC) was raised in rat using glycoproteins purified from BALB/c mouse embryo 3T3 cell line as the immunogen.</p>

<p>Glp-1 receptor agonist 2 is a research tool that is used as an inhibitor. It can be used for cell biology, pharmacology, and ion channels. Glp-1 receptor agonist 2 has been shown to inhibit ligand binding to the glucagon receptor and has been shown to activate the G protein-coupled receptor. This drug has also been found to inhibit the activity of protein phosphatase 1 in cells. Glp-1 receptor agonist 2 is a high purity product that can be used for many applications in life science research.</p>

<p>3-Methylguanine is an inhibitor of glycosylases, which are enzymes that remove methyl groups from the bases of DNA and RNA. 3-Methylguanine has been shown to inhibit the growth of cancer cells in a number of studies. It is also involved in the carcinogenesis of colon cancer cells by inducing DNA methylation. 3-Methylguanine inhibits the synthesis of proteins by human cells and can be used to detect proteins with high levels of methylation. The optimum pH for 3-methylguanine is neutral (pH 7). It can be found in urine samples.</p>

<p>Symadex is a caproic acid-based probiotic product that contains live bacteria. The bacteria are selected for their ability to produce pyrimidine compounds, which are necessary for the synthesis of DNA, and have potent antitumor activity. Symadex has been shown to inhibit the growth of various carcinoma cell lines and prostate cancer cells in vitro, with hydroxyl groups on the molecule binding to DNA duplexes. Symadex also possesses Toll-like receptor activation and immunomodulatory properties. This product may be used as a diagnostic or therapeutic agent in infectious diseases, as well as autoimmune diseases such as rheumatoid arthritis.<br>&gt;&gt;END&gt;&gt;</p>

<p>CD40 antibody (PE) was raised in rat using CD40 as the immunogen</p>

<p>Tannin albuminate is a protein complex, which is formed by the interaction of tannins and albumin. It primarily originates from plant sources that produce tannins, such as oak bark or various other tannin-rich materials, and egg albumin or other albumin sources. The mode of action of tannin albuminate involves its ability to form protective films over inflamed mucosal surfaces, thus exerting an astringent effect. This effect reduces secretions and protects against irritants, which is particularly beneficial in treating gastrointestinal disturbances.</p>

<p>CD8a antibody (CY5) was raised in Mouse using the alpha chainc of chicken CD8 as the immunogen.</p>

<p>CD106 antibody (biotin) was raised in rat using murine CD106/VCAM-1 as the immunogen.</p>

<p>C-82 is a synthetic chemical inhibitor, which is commonly sourced from laboratory-derived compounds and characterized through organic chemistry techniques. Its mode of action involves selective inhibition of specific enzymes or proteins within particular biochemical pathways, rendering it useful for dissecting complex biological systems. This specificity allows researchers to elucidate the roles of individual components within larger networks by observing downstream effects of inhibition.</p>

<p>Rose bengal is a fluorescent dye that is used in biochemical research as a cell-labeling agent. It can be used to label cells for microscopy, flow cytometry, and other techniques. Rose bengal binds to DNA and RNA and can activate ion channels in the plasma membrane, which leads to depolarization of the membrane potential. This chemical has been shown to inhibit ligand-dependent activation of G protein-coupled receptors by binding to the receptor's extracellular domain. Rose bengal has also been shown to be an effective inhibitor of phospholipase A2 activity.</p>

<p>KLRG1 antibody (PE) was raised in hamster using activated NK (A-LAK) cells from B6 mice as the immunogen.</p>

<p>VU 0424465 is an antibody that binds to the extracellular domain of the N-methyl-D-aspartate receptor (NMDAR). It inhibits glutamate binding to the NMDAR and blocks NMDA receptor channels. This inhibition prevents the opening of ion channels, which has been shown in a variety of cell types. VU 0424465 is being used as a research tool to study protein interactions and receptor signaling pathways.</p>

<p>CPA 926 is a potent inhibitor that has shown to be effective in treating cancer. It is an analog of the kinase inhibitor, which has been found in urine samples from Chinese medicinal herbs. CPA 926 works by inhibiting kinases, which are enzymes that play a crucial role in the regulation of cell growth and division. By inhibiting these kinases, CPA 926 promotes apoptosis (programmed cell death) in cancer cells, thereby reducing tumor growth. This anticancer drug has been tested on human cancer cells and has shown promising results in pre-clinical studies. CPA 926 is a potential candidate for the development of new therapies for various types of cancer.</p>

<p>Sparteine acts as an inhibitor of voltage-gated sodium channels. In organic chemisty, it is used for chiral synthesis.</p>

<p>HLI 373 dihydrochloride is a research tool that can be used as an activator or ligand. It has been shown to bind to the receptor and cell biology, which can be used for ion channels, high purity, protein interactions, pharmacology, peptides, and life science. HLI 373 dihydrochloride is a potent inhibitor of the voltage-gated potassium channel Kv1.5 in neuronal cells.</p>

<p>Inhibitor of PI3K kinases</p>

<p>4-Amino-5-[4-[[[[2-fluoro-5-(trifluoromethyl)phenyl]amino]carbonyl]amino]phenyl]-6-(4-methoxyphenyl)furo[2,3-d]pyrimidine hydrochlor ide is an antibody that can be used for the detection of protein interactions. It is a high purity product with a CAS number of 501693-25-0. This product is a research tool that can be used to study ion channels, cell biology, and pharmacology.</p>

<p>Glesatinib hydrochloride is a small-molecule kinase inhibitor, specifically targeting the MET, RON, and AXL receptor tyrosine kinases. This compound is synthesized chemically, showcasing specificity towards pathways implicated in various malignancies. The mode of action involves competitively inhibiting ATP binding, which is critical for the phosphorylation and activation of downstream signaling pathways that promote cell proliferation, survival, and metastasis. By impeding these pathways, Glesatinib hydrochloride effectively hampers the growth and spread of cancer cells.</p>

<p>4-(((4-chlorophenyl)amino)methyl)-N,N-diethylaniline is a research tool that belongs to the class of organic compounds. It is used as a pharmacological tool for studying protein interactions and ion channels. This compound has been shown to be an inhibitor of acetylcholine esterase (AChE), which can be used in the treatment of neurodegenerative diseases such as Alzheimer's disease. 4-(((4-Chlorophenyl)amino)methyl)-N,N-diethylaniline also has been shown to activate potassium channels and inhibit calcium channels, making it useful for the study of cardiac arrhythmias.</p>

<p>EPZ020411 is a synthetic, small-molecule compound that inhibits the methylation of histones and their associated proteins. EPZ020411 has been shown to inhibit tumor growth in xenograft models. The most effective dose of EPZ020411 was found to be 10 μM for inhibiting protein methylation and decreasing mitochondrial membrane potential. EPZ020411 is a reactive molecule that may be used as a probe for studying the biological sample or cellular system in which it is incubated.</p>

<p>CD45.1 antibody (PE-CY7) was raised in mouse using CD45.1 as the immunogen.</p>

<p>CD20 antibody (Allophycocyanin) was raised in mouse using human CD20 as the immunogen.</p>

<p>Platelet-derived growth factor β-receptor fragment 742-758 is a synthetic peptide, which is a derivative of the PDGF β-receptor sourced through chemical synthesis. This peptide interacts with the PDGF signaling pathway by mimicking a part of the PDGF β-receptor, which plays a critical role in cellular communication and proliferation. This fragment specifically affects the interaction of the receptor with its natural ligands, PDGF-BB, thereby inhibiting its downstream signaling cascade.</p>

<p>TNF-α-IN-1 is a recombinant human TNF-α that is produced in E. coli and purified by affinity chromatography. It interacts with TNF receptors and blocks the activation of these receptors by binding to them. TNF-α-IN-1 also inhibits ion channels, such as voltage gated potassium channels, which are involved in the propagation of an action potential in neurons. TNF-α-IN-1 has been shown to be a potent inhibitor of cell proliferation in vitro. In addition, it has been used as a research tool for studying the molecular mechanisms of signal transduction pathways mediated by receptor proteins and peptides.END&gt;</p>

<p>(2S)-1-[2-[(3-Hydroxy-1-adamantyl)amino]acetyl]pyrrolidine-2-carboxylic acid 2,2,2-trifluoroacetic acid is an inhibitor that binds to the active site of protein kinase A (PKA). It is a noncompetitive inhibitor with a Ki of 0.03 μM for PKA. The inhibition of PKA by this drug has been shown to enhance the activation of glycogen synthase kinase 3β (GSK3β) and increase the phosphorylation of β-catenin at Ser33. This drug has also been shown to inhibit ion channels such as voltage gated sodium channels and calcium channels.</p>

<p>cGMP-dependent kinase inhibitor peptide is a protein that inhibits the activity of cGMP-dependent kinases. This inhibitor binds to the active site of these enzymes and prevents them from phosphorylating proteins on serine and threonine residues. The inhibition of these two enzymes can lead to cell death by oxidative injury, neuronal death, or cancer cell death. cGMP-dependent kinase inhibitor peptide has been shown to inhibit tumor growth in mice by inhibiting cyclase activity in cancer tissues. It also blocks the proliferation of cells that have undergone cardiac injury, such as papillary muscle cells.</p>

<p>Please enquire for more information about Zopiclone-d8 N-oxide including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

Legionella Pneumophila Mouse Monoclonal Anitbody is a life science tool for use in IVD applications. Please enquire for more information about Legionella Pneumophila Mouse Monoclonal Anitbody including the price, delivery time and more detailed product information at the technical inquiry form on this page.

<p>Piragliatin is a potent inducer of glucose-dependent insulinotropic peptide (GIP) receptor. It has been shown to have a hypoglycemic effect in tissue culture and to reduce hepatic steatosis in mice. Piragliatin also potentiates the effect of glp-1r agonists, which are used for the treatment of type 2 diabetes mellitus, by increasing glucose uptake into fat cells and enhancing insulin secretion.</p>

<p>GSK598809 is a non-selective, high-affinity, amide-type dopamine D2 receptor antagonist that is currently in phase II clinical trials for the treatment of dystonia. This drug binds to the D2 receptor with high affinity and specificity and has shown efficacy in animal models of Parkinson's disease. GSK598809 has been shown to have low expression in humans, as well as no adverse effects on human red blood cells. It also has a low potential for abuse or dependence due to its lack of activity at other neurotransmitter receptors.</p>

<p>BSF-466895 is a Research Tool that can be used in Cell Biology, Pharmacology, and Ion channels research. It is an inhibitor of ion channels. BSF-466895 has a CAS Number of 262442-90-0 and belongs to the group of Ligands. This compound has a purity level of &gt;98% and its molecular weight is 584.14 g/mol. The molecular formula for BSF-466895 is C22H30N2O3S2. BSF-466895 has been shown to activate receptors and it can also be used as an antibody for protein interactions studies.</p>

<p>Alobresib is a lysine-specific inhibitor of the bromodomain and extra-terminal domain (BET) family. Alobresib has been shown to selectively inhibit H3K27me3 binding to the BET family of proteins, which may be an important event in cancer development. Alobresib also has the potential to be repositioned as an antineoplastic drug that can be used for the treatment of cancer, such as leukemia, lymphoma, and myeloid leukemia.</p>

<p>(2S)-1-(7-Ethylfuro[2,3-G]indazol-1-yl)propan-2-amine is a pharmacologically active compound that acts as a synthetic amine derivative. This compound is derived from the indazole class of heterocyclic aromatic organic compounds, which are renowned for their significant biological activities. The mechanism of action primarily involves its interaction with molecular targets within cancerous cells, potentially leading to the modulation of signal transduction pathways or inhibition of specific enzymes crucial for tumor growth and survival.</p>

<p>Mc-Val-Cit-PAB-mmaf is a monomethyl auristatin conjugate that has been designed to selectively target tumor cells. It is an agent for the treatment of cancer. Mc-Val-Cit-PAB-mmaf is a high affinity drug that binds to albumin, a protein found in the blood and are used as molecular markers for targeting tumor cells. The covalent binding of Mc-Val-Cit-PAB-mmaf with albumin results in the accumulation of this drug in tumors, highlighting its therapeutic potential. This drug also has antitubulin activity and can be used to target and kill tumor cells.</p>

<p>Inhibitor of histone methyltransferase G9a</p>

<p>CD90 antibody (Spectral Red) was raised in rat using murine T-Cell hybridoma c6/G8, produced by fusion of porl insulin-specific BALB/c T cells with the AKR thymoma line BW 5147 as the immunogen.</p>

<p>CD106 antibody (PE) was raised in Mouse using human CD106/VCAM-1 as the immunogen.</p>

<p>GS 39783-d8 is a baclofen analogue that has been shown to bind to the GABA receptor and is an agonist at this receptor. GS 39783-d8 has been shown to have a synergistic effect with other drugs, such as amitriptyline, in experimental models of inflammatory skin diseases. It has also been shown to inhibit cancer cell growth in prostate cancer cells. The pharmacokinetic properties of GS 39783-d8 are similar to those of baclofen, with a half-life of 2 hours and no active metabolites. This agent has also been shown to be effective against symptoms associated with Parkinson's disease and may have therapeutic potential for other neurological disorders.</p>

<p>N-[[4-(1-Methylpyrazol-4-yl)phenyl]methyl]-6-[7-(3-pyrrolidin-1-ylpropoxy)imidazo[1,2-a]pyridin-3-yl]pyrimidin-4-amine is a research tool that activates the Ligand and Receptor. It has been developed as a ligand for GPCR receptors, such as the cannabinoid receptor 1 (CB1). This drug also functions as an inhibitor of ion channels, including sodium channels and potassium channels. NMPPIPA also inhibits protein synthesis by binding to ribosomes.</p>

<p>Agomelatine (L(+)-tartaric acid) is a synthetic antidepressant, which is derived from chemical synthesis. It acts primarily by serving as an agonist at melatonin MT1 and MT2 receptors and as an antagonist at 5-HT2C serotonin receptors. This dual mechanism of action is particularly significant as it helps regulate sleep-wake cycles and mood by re-establishing normal circadian rhythms.</p>

<p>CD23 antibody (PE-CY7) was raised in rat using CD23 low affinity IgE Fc receptor as the immunogen.</p>

<p>CD38 antibody (Allophycocyanin) was raised in rat using CD38 as the immunogen.</p>

<p>PS-1145 dihydrochloride is a synthetic chemical compound that acts as a selective inhibitor of the enzyme IκB kinase β (IKK-β). This compound is typically derived through complex chemical synthesis techniques in laboratory environments. PS-1145 targets the NF-κB signaling pathway by directly binding to IKK-β, thereby inhibiting its activity. This inhibition prevents the phosphorylation and subsequent degradation of IκB proteins, which in turn retains NF-κB in the cytoplasm and prevents its transcriptional activity in the nucleus.</p>

<p>EG 00229 Trifluoroacetate (EG) is a natural compound that has been shown to have axonal growth-promoting properties and the potential to be used as a specific treatment for cancer. EG is a heterocyclic molecule with a molecular weight of 208.2 daltons. It binds to the receptor site on the surface of cells, which leads to cell proliferation and survival. In vitro assays have shown that EG has anti-inflammatory effects in microglia cells, which are associated with pain models in vivo. This drug is also able to promote nerve growth in vitro, suggesting it may be useful for treating neurological disorders such as Alzheimer’s disease or Parkinson”s disease.</p>

<p>Folcysteine is an enzyme inhibitor that inhibits the synthesis of protein and DNA. It has been shown to have a high affinity for folate receptors, which are involved in the growth of cells. Folcysteine is used as a diagnostic tool for diseases such as rheumatoid arthritis, osteoarthritis, and psoriasis. It can be used in vivo or in vitro to detect the presence of specific antibodies in blood serum or tissue extracts. This drug has also been shown to inhibit transcription-polymerase chain reactions (PCR) and polymerase chain reactions (PCR). The use of folcysteine as a therapeutic agent is limited due to its toxicity, but it may be useful for research purposes.</p>

<p>Inhibitor of Janus kinase JAK3; anti-cancer agent</p>

<p>Hemopressin is a synthetic, orally active, insulin-sensitizing agent. Hemopressin modulates the activity of the insulin receptor by binding to the carboxy terminal domain. This leads to increased insulin sensitivity and glucose uptake in peripheral tissues. Hemopressin has been shown to be effective against experimental models of autoimmune diseases, such as diabetes mellitus type 1 and multiple sclerosis. The drug significantly decreased blood pressure in healthy rats and had no effect on cancer cells or bacterial surface.</p>

<p>AG 1406 is a small molecule that modulates the expression of genes that are involved in nerve function. The protein-protein interactions of AG 1406 were examined using a microarray and cytoscape. This agent was found to interact with nuclear factor-kappa B, which is an inflammatory pathway that is activated by cytokines and stress. AG 1406 also interacts with metal surfaces, such as those present on glyphosate, to produce an inhibitory effect on the growth of plants.</p>

<p>Inhibitor of Wnt signalling; inhibitor of acyltransferase purcupine</p>

<p>L-692429 is a peptide that activates the G protein coupled receptor. It has been shown to be an inhibitor of ion channels, which are important in the electrical signaling process of cells. L-692429 binds to the ligand binding site on the receptor and can activate it by stimulating G proteins. This drug is a high purity research tool for use in pharmacology, cell biology, or any other life science experiments.</p>

<p>4-Hydroxy trimethoprim-d9 is a peptide that is used as a research tool to study protein interactions. It can be used as an inhibitor of ion channels and ligands for receptors. 4-Hydroxy trimethoprim-d9 has been shown to inhibit the interaction between the bacterial cobalamin receptor and the ligand cobalamin, which prevents bacteria from producing coenzyme B12. This inhibition leads to bacterial cell death due to lack of coenzyme B12 in the cells.</p>

<p>CD3e antibody (Allophycocyanin) was raised in hamster using T cell receptor complexes derived from C6VL-BS thymoma cells as the immunogen.</p>

<p>β-Hydroxyisovalerylshikonin is a natural compound that is found in the roots of the plant Sophora flavescens. It has been shown to have anti-tumor properties, as well as anti-inflammatory and anti-oxidant effects. β-Hydroxyisovalerylshikonin has been shown to induce apoptosis in various cancer cells including HL60 cells, K562 cells, and 3T3-L1 preadipocytes. It also reduces human serum triglyceride levels, which may be due to its ability to activate transcriptional regulation. In addition, β-Hydroxyisovalerylshikonin has been shown to possess physiological function and basic structure similar to those of mammalian heme proteins.</p>

<p>E6446 (dihydrochloride) is a small molecule compound that acts as a selective inhibitor of the mitotic kinesin Eg5, also known as KIF11. This compound is synthetically derived and is typically utilized in laboratory research. Its mode of action involves binding to the motor domain of Eg5, thereby inhibiting its ATPase activity, which is crucial for the Eg5-driven separation of spindle poles during cell mitosis. By selectively targeting Eg5, E6446 effectively disrupts mitotic spindle formation, leading to cell cycle arrest and apoptosis in rapidly dividing cells.<br><br>These characteristics make E6446 an important tool in scientific research, particularly in the study of cancer cells and the development of anticancer therapies. Its ability to halt cell division without affecting other kinesins provides researchers with a precise method to investigate the role of mitotic kinesins in cell cycle progression and to screen for potential therapeutic compounds.</p>

<p>BSH-IN-1 is a peptide inhibitor of HCN channels. It blocks the flow of ions through the channel by binding to the extracellular domain of the HCN channel, blocking access to the pore region. This inhibition prevents action potentials from passing through and thus preventing the transmission of nerve impulses. BSH-IN-1 has been shown to be highly pure, with a purity level above 98%.</p>

<p>Briciclib is a quinoline derivative that is used for the treatment of cancer. It inhibits the translation of RNA into protein by binding to eukaryotic initiation factor 4A (eIF4A), which blocks cap-dependent translation. Briciclib has been shown to have anticancer activity in both cell and animal models. This drug also has diagnostic applications, including diagnostic agents for cancer cells.</p>

<p>CD62L antibody (biotin) was raised in rat using C3H/eb cloned murine B lymphoma 38C-13 as the immunogen.</p>

<p>Perlapine is a drug that binds to the central benzodiazepine receptor and inhibits the binding of ligands to this receptor. Perlapine is used in the treatment of neurological disorders, such as Parkinson's disease and chronic lymphocytic leukemia. It has also been shown to have strong inhibitory effects on serum prolactin levels in rats. The exact mechanism of action for perlapine is unknown, but it has been shown to bind to nitrogen atoms and may be an acetylcholine antagonist or nicotinic acetylcholine receptor antagonist.</p>

Dendrodolide L is a potent inhibitor of kinases and has been shown to exhibit significant anticancer activity against various tumor types. It is an analog of a natural product found in the Chinese medicinal plant Dendrobium nobile. Dendrodolide L has been tested on human cancer cell lines and has demonstrated strong inhibitory effects on cancer cell growth. This compound also induces apoptosis, or programmed cell death, in cancer cells. Additionally, dendrodolide L inhibits polysaccharides and adenosine production, which are known to promote tumor growth. This protein kinase inhibitor may hold promise as a potential therapeutic agent for the treatment of cancer.