Produits biochimiques et réactifs

<p>Research peptide, 95% TFA salt</p>

<p>GRAF-1</p>

<p>Janus kinase-2 (JAK2) is a non-receptor tyrosine kinase implicated in signalling via members of the type II cytokine receptor family (such as interferon receptors), the GM-CSF receptor family (IL-3R, IL-5R and GM-CSF-R), the gp130 receptor family (e.g., IL-6R), and the single chain receptors (e.g. Epo-R, Tpo-R, GH-R, PRL-R). The JAK/signal transducer and activator of transcription (STAT) pathway is a key cellular pathway which is involved in immunity, cell division, cell death and tumour formation. The JAK/STAT pathway is activated by leptin and the leptin receptor and results in phosphorylation of STAT3 and its translocation to the nucleus where it activates the transcription of various target genes.Mutations and gene fusions involving JAK2 have been implicated in polycythemia vera, essential thrombocythemia, and myelofibrosis as well as other myeloproliferative disorders and leukaemia.</p>

<p>The 6-Fluoro-3-indoxyl-beta-D-galactopyranoside is a powerful antituberculosis drug that falls under the class of rifamycins. It is highly effective in treating tuberculosis infections due to its bactericidal activity. This compound works by binding to DNA-dependent RNA polymerase, inhibiting transcription and replication, thereby preventing bacterial growth. Extensive research has shown its high efficacy using advanced techniques such as transcription-quantitative polymerase chain and patch-clamp technique. The active form of this drug undergoes various metabolic transformations, including hydrolysis by esterases or glucuronidases, oxidation by cytochrome P450 enzymes, reduction by glutathione reductase, or conjugation with glucuronic acid. Additionally, it specifically targets markers expressed at high levels in Mycobacterium tuberculosis strains and inhibits their growth in culture.</p>

<p>Mycoplasma pneumoniae antibody was raised in mouse using purified Mycoplasma pneumoniae as the immunogen.</p>

<p>Amino acids 40-54 derived from the Immunogenic Myelin Oligodendrocyte protein (MOG). Produced by oligodendrocytes, MOG is an integral part of the oligodendrocyte surface membrane, located in the central nervous system (CNS) and plays an important role in the maintenance and disintegration of the myelin sheath. Unique within their immunoglobulin superfamily, MOG is composed of a transmembrane hydrophobic domain, an extracellular immunoglobulin variable (IgV) domain, a short cytoplasmic loop and within the membrane bilayer there is a second hydrophobic region and after this, a cytoplasmic end. In addition to 218 amino acids of the mature MOG protein, it contains a 29 amino acids long signal peptide.<br>MOG has not only been found to be expressed in the CNS but also at low levels in the peripheral nervous system. Generally MOG is expressed during myelination and functions to maintain the myelin sheath’s structurally integrity through mediating interactions between the myelin and the immune system. This is possible due to its adhesion characteristics and its external location which makes it accessible to antibodies and T-cells. Furthermore is has been suggested that MOG is involved in regulating oligodendrocyte microtubule stability and it can be used as a differentiation marker for oligodendrocyte maturation.Myelin forms a lipid layer around neurons which insulates them. MOG has immunodmainant epitopes: 1-22; 35-55 and 92-106 and this is located at the dimer interface which is formed by MOG IgV domains forming a dimer. These MOG epitopes are recognized by encepalitogenic T cells as foreign antigens. As a result demyelination occurs and this happens in the disease state of Multiple Sclerosis (MS).<br>As MOG is associated with inflammatory demyelinating diseases within the CNS such as neuromyelitis optica spectrum disorders and acute disseminated encephalomyelitis, this MOG (40-54) product can be used to induce these disease states in animals models.<br>One-Letter Formula: YRSPFSRVVHLYRNG</p>

<p>Please enquire for more information about IgM Mu Chain Goat Polyclonal Antibody, Affinity Purified including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Custom research peptide; min purity 95%. For different specs please use the Peptide Quote Tool</p>

<p>Peptide H-FSISWAR^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.</p>

<p>17b-Testosterone 7 Conjugate for use in immunoassays</p>

<p>Peptide H-AQLANDVVL^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.</p>

<p>Research peptide, 95% TFA salt</p>

<p>For preparation of acids, alcohols, thiols, or amines</p>

<p>Peptide H-SGTL^GHPGSLDDTTYER^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.</p>

<p>Peptide H-VGTQFTR^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.</p>

<p>Ubenimex is a protease inhibitor drug that is being studied for the treatment of acute myelocytic leukemia. This drug is an aminopeptidase N, B and leukotriene A4 hydrolase inhibitor. It is also used in the treatment of hypercholesterolaemia.</p>

<p>Purified recombinant EBNA1 protein (His tag)</p>

<p>Famotidine is a selective histamine H2-receptor antagonist used in the treatment of gastric hypersecretory disorders. Famotidine is effective in the treatment of duodenal and gastric ulcers, particularly when they are caused by the prolonged use of nonsteroidal antiinflammatory drugs (NSAIDs). To improve retention in the stomach, famotidine has experimentally been formulated as buoyant tablets that remained floating for up to 10 hours in vitro (Jaimini, 2007).</p>

<p>Peptide H-VYI^HPF-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.</p>

<p>Peptide H-DFTFVCPTEI-NH2 is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.</p>

<p>Anti-FADD antibody corresponding to a region within the human FADD protein sequence</p>

<p>DNA antibody was raised in mouse using calf thymus DNA as the immunogen.</p>

<p>Candesartan is an anti-hypertensive drug used in the treatment of hypertension. This drug is an antagonist of the GPCR angiotensin II receptor I and works to relax smooth muscles and lower blood pressure.<br>Candesartan cilexetil is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready-to-use products for assay development, screening or other R&amp;D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.</p>

<p>Rabbit polyclonal GPRIN3 antibody</p>

<p>H-GLSQTVTSAVETSATASSK-OH is a custom peptide that can be synthesized rapidly by our peptide experts in under 2 weeks. H-GLSQTVTSAVETSATASSK-OH is provided at greater that &gt;75% purity (HPLC) from Cymit Quimica for a variety of research applications. We also offer H-GLSQTVTSAVETSATASSK-OH in bulk quantities in addition to our standard pack sizes.Please enquire for more information about H-GLSQTVTSAVETSATASSK-OH at the technical inquiry form on this page</p>

<p>Peptide H-MPSKSASLRHTEAC-NH2 is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.</p>

<p>Peptide H-ITCAEEGWSPTPK^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.</p>

<p>Cyclo[CO-(CH2)2-CO-D-Nal(2')-Arg-Trp-Lys]-NH2 is a peptide that blocks the melanocortin receptor and inhibits the synthesis of MSH. Cyclo[CO-(CH2)2-CO-D-Nal(2')-Arg-Trp-Lys]-NH2 has been shown to inhibit the growth of cancer cells in culture. It also has antiinflammatory properties and is used for the treatment of skin conditions such as psoriasis and vitiligo.</p>

<p>NMDA glutamate receptor antagonist</p>

<p>Serlopitant is a potent and selective antagonist of the adenosine A3 receptor. It has been shown to have analgesic effects in animals, and has been used to treat chronic cough in humans. Serlopitant also binds to the neurokinin-1 receptor, which is involved in inflammatory skin diseases such as psoriasis and atopic dermatitis. Clinical studies have shown that serlopitant may be effective in treating cancer, kidney disease, and heart disease. Serlopitant is an analog of nalmefene (a drug that was previously approved for use in Europe), but it is 100 times more potent than nalmefene and does not show any affinity for opioid receptors.</p>

<p>CD19 antibody was raised in mouse using human CD19 as the immunogen.</p>

<p>FCGR3B</p>

<p>H-YPWT-OH is a custom peptide that can be synthesized rapidly by our peptide experts in under 2 weeks. H-YPWT-OH is provided at greater that &gt;95% purity (HPLC) from Cymit Quimica for a variety of research applications. We also offer H-YPWT-OH in bulk quantities in addition to our standard pack sizes.Please enquire for more information about H-YPWT-OH at the technical inquiry form on this page</p>

<p>Lodoxamide is a type of ophthalmic medication known as a mast cell stabilizer, which is chemically synthesized from non-steroidal structures. It works by inhibiting the degranulation of sensitized mast cells and subsequent release of inflammatory mediators such as histamine. This action is achieved through the stabilization of the cell membrane of mast cells, thus preventing cellular activation.</p>

<p>H-AKFVAAWTLKAAA-OH is a custom peptide that can be synthesized rapidly by our peptide experts in under 2 weeks. H-AKFVAAWTLKAAA-OH is provided at greater that &gt;95% purity (HPLC) from Cymit Quimica for a variety of research applications. We also offer H-AKFVAAWTLKAAA-OH in bulk quantities in addition to our standard pack sizes.Please enquire for more information about H-AKFVAAWTLKAAA-OH at the technical inquiry form on this page</p>

<p>HBeAg antibody is a powerful tool used in Life Sciences research. It is an antibody that specifically targets and binds to the HBeAg protein, which is an important marker for hepatitis B virus infection. This antibody can be used in various applications, such as immunohistochemistry, western blotting, and enzyme-linked immunosorbent assays (ELISA). The HBeAg antibody has been shown to effectively neutralize the activity of HBeAg, preventing its interaction with host cells and inhibiting viral replication. Additionally, this antibody has demonstrated cytotoxic effects on infected cells, making it a potential therapeutic option for treating hepatitis B virus infections. Its high specificity and affinity make it a valuable tool for researchers studying the mechanisms of viral infections and developing new treatments.</p>

<p>H-GLLLTRDGGNNNNGS-OH is a custom peptide that can be synthesized rapidly by our peptide experts in under 2 weeks. H-GLLLTRDGGNNNNGS-OH is provided at greater that &gt;80% purity (HPLC) from Cymit Quimica for a variety of research applications. We also offer H-GLLLTRDGGNNNNGS-OH in bulk quantities in addition to our standard pack sizes.Please enquire for more information about H-GLLLTRDGGNNNNGS-OH at the technical inquiry form on this page</p>

<p>VMP1</p>

<p>Actin antibody was raised in mouse using synthetic N- terminus decapeptide of alpha-smooth-muscle isoform of actin as the immunogen.</p>

<p>Peptide H-TEEISEVK^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.</p>

<p>POLDIP3 is preferentially associated with CBC-bound spliced mRNA-protein complexes during the initial round of mRNA translation. POLDIP3 is deposited at the exon junction during pre-mRNA splicing. It becomes part of the exon junction complex (EJC), which then facilitates the recruitment of S6K1 to the spliced RNA to boost the translation efficiency of the spliced mRNA. In addition, POLDIP3 is involved in nuclear mRNA export mediated by association with the TREX complex.</p>

<p>Peptide H-DILLTQSPAILSVSPGER^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.</p>

<p>The EV71 antibody is a highly specialized monoclonal antibody that targets annexin A2, elastase, and pancreatic elastase. It is used in the field of Life Sciences to study autoantibodies and their role in various diseases. This antibody has been extensively studied for its ability to bind to insulin and fibronectin, two key proteins involved in cell signaling and tissue development. Additionally, the EV71 antibody has shown cytotoxic effects against cancer cells and has been used in research related to TGF-beta signaling pathways. Its high specificity and affinity make it an invaluable tool for researchers studying lectins, collagen, and other biomolecules.</p>

<p>hCG Beta antibody was raised in mouse using hCG as the immunogen.</p>

<p>Peptide H-GGYTLVSGYPK^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.</p>

<p>Insulin antibody is a specialized product used in the field of Life Sciences. It is an acidic monoclonal antibody that specifically targets insulin, a hormone involved in regulating blood sugar levels. This antibody can be used for various applications, such as studying insulin signaling pathways, investigating insulin resistance in adipose tissue, and examining the role of insulin in diseases like diabetes.</p>

<p>GAPDH antibody was raised in mouse using recombinant human GAPDH (1-335aa) purified from E.coli as the immunogen.</p>

<p>Peptide H-SGYLLPDTK^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.</p>

<p>Goat anti Human IgM secondary antibody (mu chain specific)</p>

<p>Peptide H-VDLLNQEIEFLK^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.</p>