Produits biochimiques et réactifs

<p>The Insulysin FRET substrate [Mca]/[Dnp] is a synthetic insulysin peptide substrate that contains an N-terminal fluorescent 7-methoxycoumarin (Mca) group and a C-terminal 2, 4-dinitrophenyl (Dnp) quencher. This FRET peptide exhibits internal fluorescence quenching when intact, however hydrolysis of the peptide between the donor/acceptor pair generates fluorescence, enabling the quantitative measure of enzymatic activity.Insulysin, also known as insulin-degrading enzyme (IDE), is a highly conserved zinc metallopeptidase that contains an inverted zincin motif (HXXEH), characteristic of the inverzincin family of proteases. Insulysin functions as a dimer and exhibits allosteric kinetics, whereby small substrate peptides and polyphosphates such as ATP can act as enzyme activators. The endopeptidase cleaves a wide variety of substrates that are diverse in length, structure and sequence and exhibits a preference for basic or bulky hydrophobic residues.Insulysin is ubiquitously expressed and is responsible for insulin catabolism and the degradation of many bioactive peptide substrates including glucagon, TGF-alpha, β-endorphin, dynorphins and atrial natriuretic peptide. Insulysin also selectively degrades amylin and β-amyloid amyloidogenic peptides at multiple sites.Fluorescence Resonance Energy Transfer (FRET) peptides are convenient tools for the study of peptidase specificity and enzymatic activity.</p>

<p>Peptide H-RPPGFSPF^R-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.</p>

<p>Custom research peptide; min purity 95%. For different specs please use the Peptide Quote Tool</p>

<p>Kemptide is a synthetic substrate of the PKA catalytically active subunit (PKAc), and can bind along with ATP to PKAc. It contains 5-Carboxyfluorescein (5-FAM), a widely used green fluorescent tag.</p>

<p>Complement C3 protein is a colloidal glycoprotein that plays a crucial role in the immune system as part of the Complement Proteins. It can be neutralizing, meaning it helps to eliminate pathogens and foreign substances from the body. This protein is commonly used in research and diagnostic applications.</p>

<p>Please enquire for more information about IgM Mu Chain Goat Polyclonal Antibody, Affinity Purified including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Research peptide, 95% TFA salt</p>

<p>Alpha-melanocyte stimulating hormone (alpha-MSH) is a melanocortin family neuropeptide which plays important roles in metabolic and immune homeostasis. It is formed from the cleavage of adrenocorticotropic hormone, the cleavage product of proopiomelanocortin hormone. alpha-MSH is expressed ubiquitously to varying degrees in a wide variety of cells including the hypothalamus, monocytes and retinal pigment epithelial cells. alpha-MSH is a non-selective agonist of melanocortin receptors.alpha-MSH is a suppresser of inflammation from both innate and adaptive immune pathways, it is involved in hair and skin pigmentation (through MC1 receptor activation), has reproductive functions, cardio protective functions and regulates food intake and energy metabolism. The N-terminal of the peptide is protected by an acetyl group.</p>

<p>Peptide H-VSFEDSVISLSGDHSIIGR^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.</p>

<p>For preparation of acids, alcohols, thiols, or amines</p>

<p>Peptide H-GPSVFPLAPSSR^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.</p>

<p>Anti-microbial peptide (AMP) designed using only residues G, L, and K (GLK-19). Active against-Escherichia coli-with higher activity relative to human AMP LL-37 and also weakly active against methicillin-resistant Staphylococcus aureus (MRSA), but not-active against HIV-1. Activity against E. coli with a minimal inhibitory concentration (MIC) at 10 mM.</p>

<p>H-GLIGLRIVFTVLSIV-OH is a custom peptide that can be synthesized rapidly by our peptide experts in under 2 weeks. H-GLIGLRIVFTVLSIV-OH is provided at greater that &gt;80% purity (HPLC) from Cymit Quimica for a variety of research applications. We also offer H-GLIGLRIVFTVLSIV-OH in bulk quantities in addition to our standard pack sizes.Please enquire for more information about H-GLIGLRIVFTVLSIV-OH at the technical inquiry form on this page</p>

<p>Peptide H-GLQAQGYGVR^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.</p>

<p>ASC 09, also known as TMC-310911, is a protease inhibitor developed to treat HIV infections. Recently, ASC 09 has been evaluated for the treatment of SARS-CoV-2 as it shows potential inhibition in silico of SARS-CoV-2 main protease and SARS-CoV main proteases.</p>

<p>Endogenous peptide GPR83 agonist derived from processing of precursor protein, proSAAS. It is widely expressed in a number of species where it is involved in feeding, stress modulation and addiction and reward circuits.</p>

<p>Serum levels of thyroglobulin (Tg) is considered a valuable measurement for quantitively evaluating thyroid cancer treatment efficacy. Immunoassays are commonly used for Tg level evaluation but return many false negatives. This is due to a large proportion of patients expressing anti-Tg antibodies (TgAb), which outcompete the reagent antibodies for Tg.Liquid chromatography-tandem mass spectrometry (LC-MS/MS) is potentially better at quantification of Tg as TgAb should less influence it. Tg digestion with trypsin yields the specific peptide Tg-FSP peptide (FSPDDSAGASALL) that is a reliable target for LC-MS/MS and unique to Tg.The Tg-FSP heavy arginine residue at position 14 is isotopically labelled with carbon-13 (9) and nitrogen-15 (1), giving this peptide a mass increase of 10 compared to the unlabelled peptide. This will allow absolute quantification applications such as quantitative proteomics, the quantification of complex protein mixtures at very low concentrations, or NMR studies.</p>

<p>Peptide H-VQHNTKYSVVIR-NH2 is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.</p>

<p>H-IAIDLFK-OH is a custom peptide that can be synthesized rapidly by our peptide experts in under 2 weeks. H-IAIDLFK-OH is provided at greater that &gt;98% purity (HPLC) from Cymit Quimica for a variety of research applications. We also offer H-IAIDLFK-OH in bulk quantities in addition to our standard pack sizes.Please enquire for more information about H-IAIDLFK-OH at the technical inquiry form on this page</p>

<p>Influenza virus budding from infected cells requires membrane remodelling, is a multistep process with many proteins involved. Therefore there are numerous stages and proteins that could be antiviral targets if the mechanism can be better understood.The matrix 2 (M2) protein has recently been shown to be essential for completion of membrane scission at the end of buddinng. Initially, proteins aid membrane curvature, including matrix 2 (M2) protein, a bud forms, and finally membrane scission occurs to release the bud at the neck from the membrane occurs- M2 amphipathic helix domain in the cytoplasmic tail is essential for completion of scission to release the virus bud. The residues 44-62, provided here, have been identified as the motif responsible for allowing the scission mechanism to occur. Work is ongoing to understand the exact molecular mechanism by comparison to other scission proteins such as Arf1, Epsin1. Use of this M2 peptide motif may provide functional knowledge of virus budding and lead to novel antiviral drugs.</p>

<p>H-LVVVGADGVGK-OH is a custom peptide that can be synthesized rapidly by our peptide experts in under 2 weeks. H-LVVVGADGVGK-OH is provided at greater that &gt;95% purity (HPLC) from Cymit Quimica for a variety of research applications. We also offer H-LVVVGADGVGK-OH in bulk quantities in addition to our standard pack sizes.Please enquire for more information about H-LVVVGADGVGK-OH at the technical inquiry form on this page</p>

<p>Peptide Cy5-TFSDLWKLL-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.</p>

<p>Tet-20, is a synthetic cathelicidin-derived peptide. It was tested as infection-resistant coating for medical devices. When tethered on an implant surface Tet-20 exhibited broad antimicrobial activities both in vivo and in vitro. It can stop biofilm formation and appears to be non-toxic to eukaryotic cell. Tet-20 antimicrobial peptide is often sued as a control peptide and has antifouling.</p>

<p>Cytomegalovirus (CMV) is a prevalent human pathogen of concern in the immunocompromised such as during organ transplant or in AIDs patients- it can potentially be fatal. Due to the commonness of CMV, one strategy being developed is prevention of viral reactivation in immunosuppressed groups. Current antivirals have significant toxicity thus pushing the search for a specific CMV therapy.Murine CMV has been well established as a model for human CMV, including its susceptibility to T cell mediated clearance. The immediate-early protein 1 (IE1) was fragmented and used to find the best IE1 epitope as a vaccine. YPHFMPTNL, provided here, recognized by H-2 Ld-restricted CD8+ T cells was the best epitope of IE1 for T cell recognition. The fragment has been used to successfully generate CD8+ T cell clones specific for the IE1 epitope of murine CMV. This peptide has the potential to further the development of antiviral immunotherapy for CMV and better understand its ability to evade the host immunity.</p>

<p>Famotidine is a selective histamine H2-receptor antagonist used in the treatment of gastric hypersecretory disorders. Famotidine is effective in the treatment of duodenal and gastric ulcers, particularly when they are caused by the prolonged use of nonsteroidal antiinflammatory drugs (NSAIDs). To improve retention in the stomach, famotidine has experimentally been formulated as buoyant tablets that remained floating for up to 10 hours in vitro (Jaimini, 2007).</p>

<p>Hemoglobin antibody was raised in mouse using human hemoglobin as the immunogen.</p>

<p>CA 15-3 antibody was raised in mouse using human CA 15-3 antigen from a human cell line as the immunogen.</p>

<p>COVID-19 Spike recombinant antigen</p>

<p>Custom research peptide; min purity 95%. For different specs please use the Peptide Quote Tool</p>

<p>FITC antibody was raised in mouse using FITC-BSA as the immunogen.</p>

<p>Peptide Ac-IEELQSNHGVDDEDSDNDG-NH2 is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.</p>

<p>This sequence corresponds to the peptide bond between mammalian Lys63- (K63) linked Ub proteins- where (GG) corresponds to the C-terminus of the side chain appended Ub.K63-linked chains are the second most abundant linkage types found in cells and are modified with Met1-linked chains in mixed or branched architectures. K63-linked chains have a variety of non-degradative roles including- roles in intracellular trafficking, kinase signalling, DNA damage response, inflammatory signalling and NF-KB activation, however they may also be involved in some proteosome dependent pathwaysThe N-terminal arginine residue of this peptide is isotopically labelled with carbon-13 (6) and nitrogen-15 (4), giving this peptide a mass increase of 10 compared to the unlabelled peptide.</p>

<p>PLP(178-191) corresponds to amino acids 178 to 191 of the mouse ProteoLipid Protein (PLP).</p>

<p>Carbonic anhydrase II antibody was raised in rabbit using carbonic anhydrase II from human Erythrocytes as the immunogen.</p>

<p>Ac-SYSMEHARWGKPV-NH2 is a custom peptide that can be synthesized rapidly by our peptide experts in under 2 weeks. Ac-SYSMEHARWGKPV-NH2 is provided at greater that &gt;95% purity (HPLC) from Cymit Quimica for a variety of research applications. We also offer Ac-SYSMEHARWGKPV-NH2 in bulk quantities in addition to our standard pack sizes.Please enquire for more information about Ac-SYSMEHARWGKPV-NH2 at the technical inquiry form on this page</p>

<p>Avi tag is a short 15 amino acid peptide that is capable of biotin modification to the lysine residue without effecting the protein function. The avi tag with biotin is highly specific and stable which makes it an ideal choice for protein interaction studies via purification or detection. Avi tag is more effective than a His tag at protein purification, with these advantages the stabilised version with an N-terminal acetylation is a vital tool in many research fields including drug delivery and DNA-protein interactions.</p>

<p>Omeprazole is a proton pump inhibitor (PPI) that inhibits the production of gastric acid in the stomach. This is due to Omeprazole binding through a stable disulphide bond to the H+/K+ ATPase enzyme found on parietal cells, and preventing hydrogen ion transport. Consequently, gastric acid secretion is supressed. As a PPI, Omerprazole can be used to treat disorders where gastric acid is over-secreted. Examples of these disorders are gastroesophageal reflux disease (GERD) and peptic ulcer disease.</p>

<p>SGS-acid is a tripeptide consisting of a serine residue followed by a glycine and another serine residue. SGS-acid was synthesised from the dipeptide glycyl-L-serine (GS-acid)- the dipeptide GS-acid is also available in our catalogue. SGS-acid has a net charge of 0, it can act as a Bronsted base by accepting a hydron from a donor thus giving it diverse biological and chemical uses.</p>

<p>H-APETEPFLR-OH is a custom peptide that can be synthesized rapidly by our peptide experts in under 2 weeks. H-APETEPFLR-OH is provided at greater that &gt;95% purity (HPLC) from Cymit Quimica for a variety of research applications. We also offer H-APETEPFLR-OH in bulk quantities in addition to our standard pack sizes.Please enquire for more information about H-APETEPFLR-OH at the technical inquiry form on this page</p>

<p>[Cy3B]-LifeAct (Abp140 1-17) contains the 17amino acid peptide Lifeact derived from amino acids 1-17 of the Saccharomyces cerevisiae actin binding protein, Abp140. These first 17 amino acids of Abp140 are crucial in allowing Lifeact to localise to actin filaments (F-actin) and therefore it can be used as a cytoskeletal marker. On application, lifeact can be used in the study of plant development and pathogen defence as filamentous actin within the plant actin cytoskeleton is important in key processes such as cell division, membrane trafficking and stomatal movements.The addition of the Cy-Dye fluorophore, Cy3B allows the location of the LifeAct (Abp140 1-17) to be detected. Cy3B is described as being conformationally locked meaning it is less likely to undergo photo-isomerization and one of its main applications is within DNA related studies.</p>

<p>Peptide H-Stearyl-WEAALAEALAEALAEHLAEALAEALEALAA-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.</p>

<p>H-QELVLENVTENFNMW-OH is a custom peptide that can be synthesized rapidly by our peptide experts in under 2 weeks. H-QELVLENVTENFNMW-OH is provided at greater that &gt;80% purity (HPLC) from Cymit Quimica for a variety of research applications. We also offer H-QELVLENVTENFNMW-OH in bulk quantities in addition to our standard pack sizes.Please enquire for more information about H-QELVLENVTENFNMW-OH at the technical inquiry form on this page</p>

<p>Purified recombinant Hepatitis C Virus Nucleocapsid p22 protein</p>

<p>CMV pp65 (415-429) (HLA-B7) is a CEF (cytomegalovirus, Epstein-Barr virus, and influenza virus) control peptide that is derived from the Cytomegalovirus (CMV). CMV is capable of infecting a wide range of human cell types, where the body's primary immune response to CMV is innate, and relies on inflammatory cytokines and costimulatory molecules in order to control the spread of the virus. CMV pp65 (415-429) (HLA-B7) is defined as a CEF control peptide due to its antigenic properties. Clinically, these peptides are suitable epitopes for CD8+ T cells and can be used to stimulate the release of IFNg. HLA-B7 refers to the cell HLA type that this peptide acts on.</p>

<p>Amrinone is a phosphodiesterase type 3 inhibitor that is used in the treatment of congestive heart failure. It is considered a vasodilator that increases stroke volume and cardiac output by stimulating myocardial contractility. Amrinone results in increased cAMP and cGMP which leads to an increase in calcium influx thus creating a positive inotropic effect.</p>

<p>N-terminal biotin adrenocorticotropic hormone (ACTH). ACTH, also known as corticotropin, is a cleavage product from a larger precursor proopiomelanocortin (POMC). This 39 amino acid-peptide hormone is produced in the anterior pituitary gland upon stimulation by the corticotropin releasing hormone from the hypothalamus in response to stress. It stimulates the secretion of steroid hormone, specifically glucocorticoids in the adrenal cortex by acting through a cell membrane receptor (ACTH-R). In mammals, the action of ACTH is limited to those areas of the adrenal cortex in which the glucocorticoid hormones cortisol (hydrocortisone) and corticosterone are formed. ACTH has little control over the secretion of aldosterone, the other major steroid hormone from the adrenal cortex.</p>

<p>Gastric inhibitory polypeptide (GIP) is an inhibiting hormone of the secretin family of hormones. While GIP is a weak inhibitor of gastric acid secretion, its main role is to stimulate insulin secretion - in a glucose-dependent mechanism. Therefore, GIP is referred to as a glucose-dependent insulinotropic peptide.GIP is derived from a 153-amino acid pro-protein encoded by the GIP gene and circulates as a biologically active 42-amino acid peptide. It is synthesised by K cells, which are found in the mucosa of the duodenum and the jejunum of the gastrointestinal tract. GIP receptors are seven-transmembrane proteins found on β-cells in the pancreas. These β-cells are those that are able to simultaneously detect glucose and release insulin as a result to GIP binding.The clinical relevance of GIP is related to type 2 diabetes mellitus (T2DM)- studies have found that T2DM diabetics are unresponsive to GIP and have lower levels of GIP secretion after a meal when compared to non-diabetics. In research involving knockout mice, it was found that absence of the GIP receptors correlates with resistance to obesity.</p>

<p>Peptide H-DISEMFLQIYK^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.</p>

<p>Purified native Heartworm Heartworm protein</p>

<p>Please enquire for more information about H-LGGNETQVR^-OH including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>