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Produits biochimiques et réactifs

Produits biochimiques et réactifs

Les biochimiques et réactifs sont des substances fondamentales pour la recherche et le développement dans des domaines tels que la biotechnologie, la biologie moléculaire, la pharmacologie et la médecine. Ces produits sont essentiels pour une variété d'applications, y compris la synthèse de composés, l'analyse d'échantillons biologiques, la recherche sur les processus métaboliques et la production de médicaments. Chez CymitQuimica, nous proposons une large sélection de biochimiques et réactifs de haute qualité et pureté, adaptés à divers besoins scientifiques et industriels. Notre catalogue comprend des enzymes, des anticorps, des acides nucléiques, des acides aminés et de nombreux autres produits, tous conçus pour soutenir les chercheurs et les professionnels dans leurs projets de recherche et développement, garantissant des résultats fiables et reproductibles.

Sous-catégories appartenant à la catégorie "Produits biochimiques et réactifs"

130493 produits trouvés pour "Produits biochimiques et réactifs"

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  • [Rhodamine Green]-LifeAct (Abp140 1-17)


    [Rhodamine Green]-LifeAct (Abp140 1-17) contains the 17amino acid peptide Lifeact derived from amino acids 1-17 of the Saccharomyces cerevisiae actin binding protein, Abp140. These first 17 amino acids of Abp140 are crucial in allowing Lifeact to localise to actin filaments (F-actin) and therefore it can be used as a cytoskeletal marker. On application, lifeact can be used in the study of plant development and pathogen defence as filamentous actin within the plant actin cytoskeleton is important in key processes such as cell division, membrane trafficking and stomatal movements.The addition of the Rhodamine Green fluorophore, Rhodamine Green allows the location of the LifeAct (Abp140 1-17) to be detected.
    Masse moléculaire :2,279.1 g/mol

    Ref: 3D-CRB1100899

    1mg
    386,00€
    100µg
    206,00€
    500µg
    282,00€
  • CA125 antibody (HRP)


    Mouse Monoclonal CA125 antibody

    Ref: 3D-61-1065

    500µl
    415,00€
  • Morphine antibody


    The Morphine antibody is a highly specialized monoclonal antibody used in the field of Life Sciences. It is designed to target and bind to morphine, an opioid analgesic drug commonly used for pain management. The antibody is activated when it comes into contact with morphine, allowing for precise detection and measurement.

    Ref: 3D-10-1380

    1mg
    170,00€
  • Ac-VKSRDDSQLNGDPSALLNPC-NH2


    Ac-VKSRDDSQLNGDPSALLNPC-NH2 is a custom peptide that can be synthesized rapidly by our peptide experts in under 2 weeks. Ac-VKSRDDSQLNGDPSALLNPC-NH2 is provided at greater that >85% purity (HPLC) from Cymit Quimica for a variety of research applications. We also offer Ac-VKSRDDSQLNGDPSALLNPC-NH2 in bulk quantities in addition to our standard pack sizes.Please enquire for more information about Ac-VKSRDDSQLNGDPSALLNPC-NH2 at the technical inquiry form on this page

    Degré de pureté :Min. 95%

    Ref: 3D-VAB-07836

    1mg
    461,00€
  • Dengue Virus NS1 Mouse Monoclonal Antibody


    Dengue Virus NS1 Mouse Monoclonal Antibody is an antigen for use in IVD applications. Please enquire for more information about Dengue Virus NS1 Mouse Monoclonal Antibody including the price, delivery time and more detailed product information at the technical inquiry form on this page.

    Ref: 3D-AZ1492

    ne
    À demander
  • CD9 antibody


    CD9 antibody was raised in rabbit using residues 36-50 [RFDSQTKSIFEQETN] of the 25 kDa human protein as the immunogen.
    Degré de pureté :Min. 95%

    Ref: 3D-70R-CR037

    100µg
    555,00€
  • H-VDFTLSSER^-OH


    Peptide H-VDFTLSSER^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.

    Ref: 3D-PP42099

    ne
    À demander
  • [Lys0]-Bradykinin (Kallidin) Heavy


    Bradykinins and their associated kinins are inflammatory mediators produced during inflammation. The two main kinins in mammals are the nonapeptide bradykinin, BK (1-9) and the decapeptide kallidin (KD), [Lys0]-BK(1-10). Their biological actions are mediated by two distinct receptors, termed B1 and B2.BK is involved in several pathophysiological processes, such as inflammation, pain, cell proliferation, and tumours. It plays a crucial role in corneal epithelial cells, corneal stromal cells, and fibroblasts.Inflammation has been reported as one significant hallmark of breast cancer in relation to tumour development, metastasis, and invasion. The bradykinin receptor 1 (B1R) associated with kallidin is highly expressed on inflammatory breast tumour cells thus providing a promising targeting site for tumour recognition and sufficient receptor mediated endocytosis.
    Degré de pureté :Min. 95%
    Masse moléculaire :1,197.7 g/mol

    Ref: 3D-CRB1300685

    25nMol
    206,00€
  • Dinitrophenyl ERAP1 peptide


    WRVYEKC(Dnp)ALK-acid
    Masse moléculaire :1,600.7 g/mol

    Ref: 3D-CRB1100903

    1mg
    470,00€
    100µg
    346,00€
    500µg
    386,00€
  • Biotin HER-2 substrate peptide


    Human epidermal growth factor receptor (HER-2)/epidermal growth factor receptor-2 (ErbB-2), is a key receptor linked to metastasis in tumours. The oncogenic ErbB-2 receptor has intrinsic receptor tyrosine kinase (RTK) activity, the receptor is activated by ligand binding which induces receptor dimerization. These RTK complexes can activate mitogen-activated protein kinase (MAPK) and phosphoinositol 3-kinase (PI3K)/Akt pathways. This peptide has been identified as a substrate for HER-2/ErbB-2 as it is phosphorylated upon receptor activation and therefore acts as a marker for receptor activation in kinases assays. Contains a covalently attached N-terminal biotin tag for convenient detection and purification.
    Masse moléculaire :2,062.44 g/mol

    Ref: 3D-CRB1000260

    1mg
    332,00€
    500µg
    254,00€
  • Boc-Val-Pro-Arg-AMC


    Boc-VPR-AMC is a fluorogenic peptide substrate composed of the short peptide chain, Valine-Proline-Arginine (VPR) and the fluorophore, 7-amino-4-methlycoumarin (AMC). Fluorogenic peptide substrates such as Boc-VPR-AMC have high sensitivity and specificity and therefore can be used to detect molecules of interest. For example within the field of scientific forensics, Boc-VPR-AMC can be used to investigate deposits of saliva in situ. When Fluorogenic peptide substrates are incubated with specific enzymes, fluorescence is emitted due to the release of the fluorophore from the peptide-fluorophore bond. When Boc-APR-AMC interacts with its target enzyme, the 7-amino-4-methylcoumarin fluorophore is released causing a fluorescent emission at 440nm.

    Masse moléculaire :627.3 g/mol

    Ref: 3D-CRB1101016

    50mg
    543,00€
    250mg
    1.616,00€
  • NPY1R antibody


    NPY1R antibody was raised in rabbit using a 15 amino acid peptide from mouse NPY1R as the immunogen.
    Degré de pureté :Min. 95%

    Ref: 3D-70R-NR001

    100µg
    1.176,00€
  • SARS-CoV-2 Nucleoprotein (271-285)


    The coronavirus (CoV) nucleoprotein is the major component of CoV structural proteins. The nucleoprotein has a critical role in virus assembly and RNA transcription. The nucleoprotein is essential in the formation of helical ribonucleoproteins and in regulating viral RNA synthesis. The nucleoprotein can also regulate infected host cellular mechanisms. It is highly expressed during infection and may induce protective immune responses against SARS-CoV and SARS-CoV-2.The nucleoprotein residues TQAFGRRGPEQTQGN (271-285) from SARS-CoV-2 have been identified as a T-cell epitope with a predicted HLA restriction. Immune targeting of confirmed epitopes may potentially offer protection against SARS-CoV-2 and help the development of vaccines for long-lasting immunity.

    Masse moléculaire :1,645.8 g/mol

    Ref: 3D-CRB1001806

    1mg
    282,00€
    500µg
    206,00€
  • Bacillus anthracis (Anthrax) antibody


    Bacillus anthracis (anthrax) antibody was raised in mouse using protective antigen of Bacillus anthracis as the immunogen.

    Ref: 3D-10-B02B

    1mg
    721,00€
  • Mouse anti Human IgG (Fc)


    Human IgG antibody (Fc) was raised in mouse using affinity pure hum#an IgG Fc as the immunogen.

    Ref: 3D-10-I17B

    500µg
    472,00€
  • Formyl-Δ-toxin (1-26)


    θ-toxin forms pores on the surface of host cells which can lead to cytolysis or activation of the inflammatory response. θ-toxin can induce mast cell degranulation. The toxin produced by S.aureus has been strongly linked to atopic dermatitis. As a natural antimicrobial it has been used as a template for novel and more potent antimicrobial peptides.
    Degré de pureté :Min. 95%
    Couleur et forme :Powder
    Masse moléculaire :3,006.56 g/mol

    Ref: 3D-CRB1001650

    1mg
    282,00€
    500µg
    206,00€
  • IGF2 antibody


    IGF2 antibody was raised in mouse using human anti-globulin conjugated to IGF-II as the immunogen.

    Ref: 3D-10R-I135A

    100µg
    819,00€
  • IYPTNGYTR

    CAS :
    Custom research peptide; min purity 95%. For different specs please use the Peptide Quote Tool
    Formule :C49H73N13O15
    Masse moléculaire :1,084.18 g/mol

    Ref: 3D-PP50735

    ne
    À demander
  • Icatibant [M+6] Heavy


    Icatibant [M+6] Heavy
    Degré de pureté :Min. 95%
    Masse moléculaire :1,309.7 g/mol

    Ref: 3D-CRB1301516

    25nMol
    470,00€
  • H-ILFFLFLLLPLSPFSLIF-OH


    H-ILFFLFLLLPLSPFSLIF-OH is a custom peptide that can be synthesized rapidly by our peptide experts in under 2 weeks. H-ILFFLFLLLPLSPFSLIF-OH is provided at greater that >95% purity (HPLC) from Cymit Quimica for a variety of research applications. We also offer H-ILFFLFLLLPLSPFSLIF-OH in bulk quantities in addition to our standard pack sizes.Please enquire for more information about H-ILFFLFLLLPLSPFSLIF-OH at the technical inquiry form on this page

    Degré de pureté :Min. 95%

    Ref: 3D-VAB-06868

    1mg
    461,00€
  • H-ADSNPRGVAAYLSRPSPGGC-OH


    H-ADSNPRGVAAYLSRPSPGGC-OH is a custom peptide that can be synthesized rapidly by our peptide experts in under 2 weeks. H-ADSNPRGVAAYLSRPSPGGC-OH is provided at greater that >95% purity (HPLC) from Cymit Quimica for a variety of research applications. We also offer H-ADSNPRGVAAYLSRPSPGGC-OH in bulk quantities in addition to our standard pack sizes.Please enquire for more information about H-ADSNPRGVAAYLSRPSPGGC-OH at the technical inquiry form on this page

    Degré de pureté :Min. 95%

    Ref: 3D-VAB-07326

    1mg
    461,00€
  • β-Amyloid (12-20)


    Aβ has been identified as the key subunit of the extracellular plaques found in the brains of patients with Alzheimer's disease (AD) and Down's syndrome (DS). Aβ has therefore been extensively studied as a potential target for treatment of AD.Aβ is formed from the cleavage of the large, transmembrane protein- APP (amyloid precursor protein). Cleavage of APP by β- and then γ-secretases results in the formation of Aβ. Aβ can aggregate to produce amyloid-β oligomers, which are thought to be highly neurotoxic. Over time Aβ can further aggregate to produce the characteristic senile plaques present in AD and DS. Aβ can be degraded by enzymes such as neprilysin, insulin degrading enzyme or endothelin converting enzyme. At physiological levels Aβ may be involved in controlling synaptic activity and neuronal survival.
    Couleur et forme :Powder
    Masse moléculaire :1,153.6 g/mol

    Ref: 3D-CRB1001403

    1mg
    282,00€
    500µg
    206,00€
  • Hemoglobin A1c antibody


    Hemoglobin A1c antibody was raised in mouse using fructusyl derived peptide corresponding to the N-terminal of the beta-chain of human hemoglobin as the immunogen.

    Ref: 3D-10-H12B

    100µg
    356,00€
  • CMX-8933


    The CMX-8933 peptide is a fragment of the goldfish brain neurotrophic factor ependymin which can increases the enzymatic activity of c-Jun N-terminal kinase (JNK), increase the phosphorylation of JNK and c-Jun proteins, and increase cellular levels of c-Jun and c-Fos mRNAs.
    Masse moléculaire :1,192.6 g/mol

    Ref: 3D-CRB1001208

    1mg
    282,00€
    500µg
    206,00€
  • Beta Endorphin (1-27) Light


    β-endorphin is a opioid neuropeptide that is produced in certain neurons within the central nervous system and peripheral nervous system. β-endorphin has been known to be associated with hunger, thrill, pain, maternal care, sexual behaviour, and reward cognition. β-endorphin is an agonist of the opioid receptors it preferentially binds to the μ-opioid receptor.β-endorphin has been primarily studied for its influence on nociception (i.e., pain perception). β-endorphin modulates pain perception both in the central nervous system and the peripheral nervous system. The hypothalamus responds to the pain signal by releasing β-endorphin through the periaqueductal grey network, which mainly acts to inhibit the release of GABA, a neurotransmitter which prevents the release of dopamine.
    Degré de pureté :Min. 95%
    Masse moléculaire :3,020.6 g/mol

    Ref: 3D-CRB1001032

    25nMol
    206,00€
  • Ac-GPLD-[Rh110]-[D-Pro]


    Fluorogenic substrate peptide to assay the caspase-like peptidic activity of the 20S proteasome. In its intact state this peptide is non-fluorescent, however when the Rhodamine fluorophore is released upon hydrolysation, fluorescence can be detected. This peptide is therefore a useful tool for analysing enzyme activity.The presence of the D-proline residue on the C terminal of the rhodamine molecule ensures one directional rhodamine cleavage which simplifies fluorescence studies. Rhodamine 110 is a laser grade fluorescent dye with excitation maxima at 496 nm and emission maxima at 522 nm.
    Masse moléculaire :851.3 g/mol

    Ref: 3D-CRB1101107

    1mg
    1.028,00€
    5mg
    3.774,00€
  • KRAS antibody


    KRAS antibody was raised in Rabbit using Human KRAS as the immunogen

    Ref: 3D-70R-18176

    50µl
    540,00€
  • Sildenafil citrate - Bio-X ™

    CAS :
    A potent selective inhibitor of cGMP-specific phosphodiesterase type 5 (PDE-5), thereby reducing the degradation rate of cGMP. Sildenafil is used to treat erectile dysfunction and pulmonary arterial hypertension. Sildenafil citrate is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready to use products for assay development, screening or other R&D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.
    Formule :C28H38N6O11S
    Degré de pureté :Min. 95%
    Masse moléculaire :666.7 g/mol

    Ref: 3D-BS164405

    10mg
    135,00€
  • Fas Receptor protein


    Region of Fas Receptor protein corresponding to amino acids MRLSSKSVNA QVTDINSKGL ELRKTVTTVE TQNLEGLHHD GQFCHKPCPP GERKARDCTV NGDEPDCVPC QEGKEYTDKA HFSSKCRRCR LCDEGHGLEV EINCTRTQNT KCRCKPNFFC NSTVCEHCDP CTKCEHGIIK ECTLTSNTKC KEEGSRS.
    Degré de pureté :Min. 95%

    Ref: 3D-30R-AF031

    20µg
    501,00€
  • chitinase-3-like protein 1 (CH3L1) Heavy


    Chitinase-3-like protein (CHI3L1) is an 18-glycosylhydrolase family member and a neutrophil auto-antigenic target, however CHI3L1 lacks chitinase activity due to an amino acid change in the catalytic region.Up-regulated expression of CHI3L1 is found in several autoimmune diseases and cancers including inflammatory bowel disease (Crohn's disease and ulcerative colitis), rheumatoid arthritis and gastric and breast cancers as well as other tumours. CHI3L1 promotes cancer metastasis by triggering the mitogen-activated protein kinase (MAPK) signalling pathway. CHI3L1 may encourage the adhesion of pathogenic intestinal bacteria in the gut and antibodies recognising CHI3L1 are found in patients with Crohn's disease and rheumatoid arthritis.CHI3L1 is expressed in synovial cells, chondrocytes, smooth muscle cells, macrophages, neutrophils and colonic epithelial cells. CHI3L1 may also play a role in tissue remodelling, cell migration and cell adhesion in different cell types. The leucine residue at position 8 of this peptide is isotopically labelled with carbon-13 (6) and nitrogen-15 (1), giving this peptide a mass increase of 7 compared to the unlabelled peptide.
    Degré de pureté :Min. 95%
    Masse moléculaire :1,177.7 g/mol

    Ref: 3D-CRB1301446

    25nMol
    470,00€
  • α-Casozepine

    CAS :
    Alpha-Casozepine (alpha-CZP) is a tryptic hydrolysate of bovine milk alphas1-casein. The presence of bile salts facilitates alpha-CZP absorption through a Caco2 monolayer. alpha-CZP shows similarities to benzodiazepines with its anxiolytic-like activity but lack the common side effects of habituation or sedation. alpha-CZP binds to the GABAA receptor at the benzodiazepine site.  alpha-CZP binds with a significantly lower affinity than benzodiazepines.Intraperitoneal administration of Alpha-Casozepine (alpha-CZP) to rodents results in anticonvulsant and sleep-protecting effects. Human administration reduces physiological stress symptoms in stressed and control patients. alpha-CZP modulated neuronal activity in brain regions linked to anxiety regulation in mice.
    Formule :C60H94N14O16
    Masse moléculaire :1,267.47 g/mol

    Ref: 3D-CRB1001691

    1mg
    282,00€
    500µg
    206,00€
  • Teduglutide (GLP2 2G)

    CAS :
    Teduglutide is a GLP-2 analogue, in which the alanine at position 2 has been substituted with glycine making the peptide resistant to degradation by dipeptidyl peptidase-4 (DPP-4)- Teduglutide therefore has a longer half-life than GLP-2 (2-3 hours for teduglutide vs 7 min for GLP-2). Teduglutide has high bioavailability after subcutaneous administration, suggesting that teduglutide has enhanced biological activity, relative to native GLP-2.GLP-2 is a gut hormone produced in the enteroendocrine L cells of gastrointestinal tract by the cleavage of the 160-amino-acid proglucagon molecule. GLP-2 is secreted following the ingestion of food and carries out its activities via the GLP-2 G-protein coupled receptors (GLP-2Rs). GLP-2 has a range of roles within the cell, including: anti-inflammatory effects- promoting the expansion of the intestinal mucosa- stimulating intestinal blood flow- inhibiting gastric acid secretion and gastric emptying- increasing intestinal barrier function and enhancing nutrient and fluid absorption.
    Formule :C164H252N44O55S
    Couleur et forme :Powder
    Masse moléculaire :3,749.8 g/mol

    Ref: 3D-CRB1000390

    1mg
    470,00€
    500µg
    386,00€
  • H-NTLYLQMNSLR^-OH


    Peptide H-NTLYLQMNSLR^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.

    Ref: 3D-PP40225

    ne
    À demander
  • H-RDQSFQHLSSFPPVSALVES-OH


    H-RDQSFQHLSSFPPVSALVES-OH is a custom peptide that can be synthesized rapidly by our peptide experts in under 2 weeks. H-RDQSFQHLSSFPPVSALVES-OH is provided at greater that >95% purity (HPLC) from Cymit Quimica for a variety of research applications. We also offer H-RDQSFQHLSSFPPVSALVES-OH in bulk quantities in addition to our standard pack sizes.Please enquire for more information about H-RDQSFQHLSSFPPVSALVES-OH at the technical inquiry form on this page

    Degré de pureté :Min. 95%

    Ref: 3D-VAB-07654

    1mg
    461,00€
  • CBP antibody


    CBP antibody was raised in mouse using recombinant Creb-Binding Protein (Cbp)

    Ref: 3D-10R-1204

    50µg
    466,00€
  • PARP1 (487-496) peptide


    Amino acids 487-496 of Poly(ADP-ribose) polymerase 1 (PARP1). PARP1 is a nuclear DNA repair enzyme that binds to DNA when damage is detected. PARP1 coordinates double and single strand break repair by first cleaving NAD+ into nicotinamide and ADP-ribose, and then synthesising poly-(ADP-ribose) (PAR) chains from ADP-ribose on target proteins (PARylation). PARylation of histone proteins mediates relaxation of the chromatin and recruitment of DNA-break repair enzymes.PARP1 can also act as a transcriptional co-activator, modulating the expression of itself and many other genes by direct binding to or PARylation of enhancers and promoters. PARP1 is also involved in maintaining mtDNA.PARP1 belongs to the PARP family which has 7 known and 10 putative members. PARP1 accounts for >85% of the PARP activity in cellular systems.
    Degré de pureté :Min. 95%
    Couleur et forme :Powder
    Masse moléculaire :1,106.6 g/mol

    Ref: 3D-CRB1000661

    1mg
    282,00€
    500µg
    206,00€
  • Streptococcus Group A antibody


    Streptococcus group A antibody was raised in rabbit using group A streptococci as the immunogen. Streptococcus Group A (Strep A) is a type of bacteria known as Streptococcus pyogenes. It is a Gram-positive, beta-hemolytic bacterium that commonly causes infections in humans. Strep A can cause mild infections such as strep throat, scarlet fever, and impetigo, or severe infections namely cellulitis, necrotizing fasciitis, and sepsis.
    Degré de pureté :Min. 95%

    Ref: 3D-70-XR73_R

    1mg
    283,00€
  • IDR 1002


    Synthetic host defence peptide derivative with strong anti-inflammatory properties.

    Masse moléculaire :1,651 g/mol

    Ref: 3D-CRB1001189

    1mg
    282,00€
    500µg
    206,00€
  • GPS1573


    GPS1573 is a potent and dose-dependent peptide antagonist of adrenocorticotrophic (ACTH) -stimulated melanocortin type 2 receptor (MC2R). Along with GPS1574, GPS1773 is an ACTH analogue and as such antagonises MC2R in the nanomolar range.The clinical relevance of GPS1573 is related to Cushing's disease and syndrome, which are both associated with a hypercortisolemic state. Selective antagonism of MC2R using GPS1573 may be a novel treatment modality for Cushing's disease and syndrome.
    Degré de pureté :Min. 95%
    Couleur et forme :Powder

    Ref: 3D-CRB1000575

    1mg
    282,00€
    500µg
    206,00€
  • CMVpp65 - 121 (VFTWPPWQAGILARN)


    Custom research peptide; min purity 95%. For different specs please use the Peptide Quote Tool

    Masse moléculaire :1,756.1 g/mol

    Ref: 3D-PP51019

    ne
    À demander
  • H-CEPVVPNAPPAYEKL-OH


    H-CEPVVPNAPPAYEKL-OH is a custom peptide that can be synthesized rapidly by our peptide experts in under 2 weeks. H-CEPVVPNAPPAYEKL-OH is provided at greater that >90% purity (HPLC) from Cymit Quimica for a variety of research applications. We also offer H-CEPVVPNAPPAYEKL-OH in bulk quantities in addition to our standard pack sizes.Please enquire for more information about H-CEPVVPNAPPAYEKL-OH at the technical inquiry form on this page

    Degré de pureté :Min. 95%

    Ref: 3D-VAB-03714

    1mg
    346,00€
  • Bovine IgG


    Bovine IgG is an immunoglobulin that plays a crucial role in the immune response. It acts as an inhibitory factor for oncostatin, a cytokine involved in cell growth and differentiation. Bovine IgG is commonly used in research laboratories for various applications, including the production of monoclonal antibodies and polyclonal antibodies. It can be used as a control or standard in immunoassays to measure the concentration of specific proteins or analytes. Bovine IgG is also used in the field of life sciences for studying various biological processes, such as signal transduction, gene expression, and protein interactions. With its high purity and stability, bovine IgG is an essential component in many experimental protocols.
    Degré de pureté :Min. 95%

    Ref: 3D-31-AB20

    50mg
    355,00€
  • AF10847


    Activation of the inflammatory response is critical to various infectious agents. Pro-inflammatory cytokines like-IL-1α and IL-1β are upregulated upon the initial detection of infection and bind to IL-1R1 to activate the signalling cascade. However, a hyperinflammatory response can lead to oxidative stress, apoptosis, and conditions such as diabetes, rheumatoid arthritis, cancer, and ischemia.To maintain homeostasis there are moderators of the inflammatory response. Binding of interleukin IL-1 to IL-1R1 stimulates the inflammatory cascade. Alternately, AF10847 binds to IL-1R1 resulting in significant conformational change of IL-1R1 but its lack of any cytokine activity locks IL-1R1 in an inactive state inhibiting a signalling event. AF10847 has an exceedingly high affinity for IL-1R1 compared to 1α and IL-1β.Extensive searches for lower molecular mass IL-1R antagonists-for oral delivery as a therapeutic for rheumatoid arthritis are being carried out. AF10847 is a 21-mer that has high affinity for the conserved IL-1R1 binding site that is also recognised by IL-1β. The remarkable high affinity of AF10847 for IL-1R1 makes it a perfect candidate for further investigations into novel IL-1R1 inhibitor development.
    Couleur et forme :Powder
    Masse moléculaire :2,604.2 g/mol

    Ref: 3D-CRB1001504

    1mg
    282,00€
    500µg
    206,00€
  • Galanin (13-20) Mouse


    Galanin is widely distributed in the central nervous, peripheral, and endocrine systems. Galanin's overarching function is as an inhibitory, hyper-polarizing neuromodulator for classical neurotransmitters like acetylcholine and serotonin. Galanin interacts with 3 receptor subtypes, GalR1-3 G protein-coupled receptors inserted into the plasma membrane. GalR1 is believed to activate a Gβγ pathway to regulate MAPK activation. GalR2 can also activate the MAPK pathway, but unlike GalR1, there is detectable inositol phosphate production. GalR3 is associated with the Galphai/o pathway. Activation of the receptor leads to a cellular influx of K+. Each receptor has been associated with neurological diseases such as GalR3 and epilepsy.Galanin is a key regulator of growth hormone and insulin release and adrenal secretion however the role galanin plays is not clear. Administration of galanin to animal models leads to inhibition of insulin secretion but this is not replicated in humans.N-terminal galanin fragments naturally occur in vivo, but their relevance is unclear. Some N-terminal fragments reduce metabolic and functional disorders in experimental heart damage. Their relative abundance varies, with fragment (13-20) being one of the lowest quantities detected. The physiological relevance of the galanin fragment (13-20) and its affinity to the various Gal receptors has yet to be made clear. Binding assays and displacement assays in rat brain tissue have been performed with similar N-terminal galanin fragments to try and elucidate their function. Using N-terminal fragments such as galanin (13-20) can help clarify the role of full-length galanin in various roles, such as during myocardial ischemia and reperfusion injury. This may highlight new agonists/antagonists for the galanin GalR receptors that can be therapeutic targets.
    Masse moléculaire :957.5 g/mol

    Ref: 3D-CRB1000402

    1mg
    282,00€
    500µg
    206,00€
  • Ac-CLDSPLPLRQRLKLRFQST-OH


    Peptide Ac-CLDSPLPLRQRLKLRFQST-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.

    Ref: 3D-PP45769

    ne
    À demander
  • Myoglobin antibody


    Myoglobin antibody was raised in mouse using human Myoglobin as the immunogen.
    Degré de pureté :Min. 95%

    Ref: 3D-10C-CR8010M1

    ne
    À demander
  • H-WLISQNK-OH


    H-WLISQNK-OH is a custom peptide that can be synthesized rapidly by our peptide experts in under 2 weeks. H-WLISQNK-OH is provided at greater that >95% purity (HPLC) from Cymit Quimica for a variety of research applications. We also offer H-WLISQNK-OH in bulk quantities in addition to our standard pack sizes.Please enquire for more information about H-WLISQNK-OH at the technical inquiry form on this page

    Degré de pureté :Min. 95%

    Ref: 3D-VAB-00426

    1mg
    246,00€
  • Polybia-MPII


    The crude venom of the wasp Polybia paulista consists of 30% polybia-MPII. Polybia-MPII is a mastoparan, it is rapidly distributed around the organism point of inoculation via the circulation. As a secretagogue, polybia-MPII has myotoxic action and minor neurotoxic effects. Polybia-MPII has been injected sub-cutaneously and intra-muscularly into mice for pathology and immunohistochemistry assays.As an antimicrobial agent, polybia-MPII is highly effective, with a lower haemolysis rate compared to other mastoparans. Polybia-MPII also shows considerable anti-fungal activity.
    Masse moléculaire :1,612 g/mol

    Ref: 3D-CRB1001712

    1mg
    282,00€
    500µg
    206,00€
  • H-DDLYVSDAFHK^-OH


    Peptide H-DDLYVSDAFHK^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.

    Ref: 3D-PP42661

    ne
    À demander
  • Influenza A NP (44-52) (HLA-A1)


    Influenza A NP (44-52) (HLA-A1) is a CEF control peptide that is derived from Influenza A. Influenza A is an enveloped negative-strand RNA virus that is capable of interfering with host transcription, which can ultimately cause cell death. The action of the virus particles decreases the downstream gene occupancy of RNA polymerase II, as well as instigating cellular stress, resulting in the failure of polymerase II termination at poly(A) sites. Influenza A NP (44-52) (HLA-A1) is defined as a CEF control peptide due to its antigenic properties. Clinically, this peptide is a suitable epitope for CD8+ T cells and can be used to stimulate the release of IFNg. HLA-A1 refers to the cell HLA type that this peptide acts on.The nucleoprotein (NP) is a structural protein that encapsulates the negative strand of viral RNA. NP plays a critical role in the transition of influenza virus RNA synthesis from transcription mode to replication mode.
    Masse moléculaire :1,070.5 g/mol

    Ref: 3D-CRB1001470

    1mg
    282,00€
    500µg
    206,00€