Produits biochimiques et réactifs

<p>SM1-71-R is a novel small molecule with a targeted, covalent mechanism of action. It is a multitargeted kinase inhibitor that has been shown to inhibit the activity of FGFR1, FGFR2, and FGFR3, which are members of the fibroblast growth factor receptor family. SM1-71-R has been shown to have high potency in inhibiting FGFR1, FGFR2 and FGFR3 in cellular assays. It also has high selectivity for cysteine residues in kinases.</p>

<p>MB 07811 is a lipid-lowering drug that belongs to the group of statins. It reduces cholesterol by inhibiting an enzyme (3-hydroxy-3-methylglutaryl coenzyme A reductase) in the liver that is involved in the production of cholesterol. MB 07811 has been shown to be safe and well tolerated and has been used for the treatment of primary hypercholesterolemia, non-alcoholic fatty liver disease, and non-alcoholic fatty liver.</p>

<p>Lycobetaine is a positively charged ion channel activator and inhibitor with high purity. It has been used extensively as a research tool in pharmacology, cell biology, and biochemistry. Lycobetaine has been shown to inhibit the binding of an antibody to its receptor by competing for the receptor site on the antibody. The peptide has also been shown to activate ion channels by interacting with their binding sites on the protein surface. Lycobetaine has a molecular weight of 6071 Da and is soluble at pH 2-6.</p>

<p>Kinesin spindle protein (KSP) inhibitor</p>

<p>Oxytocin antagonist</p>

<p>CC 0651 is a novel compound that inhibits the enzymes of the ubiquitin-proteasome system by binding to ubiquitin ligases. CC 0651 has been shown to inhibit the enzyme activities of ubiquitin ligases in vitro and in vivo, leading to cancer cell death. This anticancer activity may be due to its ability to inhibit the ubiquitin-proteasome system, which is required for protein degradation and DNA repair. In addition, CC 0651 is a potent inhibitor of lysine residues and is able to cross the cell membrane due to its amide group.</p>

<p>Triosephosphate isomerase 1 (TPI1) is a cytosolic enzyme that catalyzes the conversion of dihydroxyacetone phosphate and glyceraldehyde-3-phosphate to erythrose-4-phosphate and phosphoenolpyruvate. TPI1 has been shown to be an important regulator of glycolysis and gluconeogenesis, as well as in the maintenance of cellular redox state. This protein can act as both an inhibitor and activator depending on its interaction with other proteins. TPI1 has been implicated in the development of cancer, diabetes, Alzheimer's disease, Parkinson's disease, and atherosclerosis. TPI1 is also a research tool for studies into ion channels, receptor binding, and antibodies.</p>

<p>Paeonol-d3 is a useful research tool for studying protein interactions, ion channels, and cell biology. It is also used as a pharmacological agent for the treatment of inflammation and cancer. Paeonol-d3 has been shown to be an agonist at GABA receptors, which are known to play a role in pain regulation. This drug also can inhibit the production of prostaglandin E2 (PGE2) by inhibiting cyclooxygenase-1 (COX-1) and COX-2 enzymes.</p>

<p>NSC-70220 is a high purity, soluble synthetic peptide that is a potent activator of the human angiotensin II type 2 receptor (AT2R). It has been shown to activate AT2R in multiple cell types and tissues, including cultured cells and tissues from human, mouse, rat, and zebrafish. NSC-70220 has also been shown to be an inhibitor of protein interactions.</p>

<p>Inhibitor of ALK and TRK kinases</p>

<p>VE 821 is a chemical inhibitor that inhibits the activity of the protein ornithine decarboxylase (ODC). This enzyme is essential for the synthesis of polyamines, which are essential for cell growth. VE 821 has been shown to be effective in inhibiting the growth of solid tumours and leukemia cells. It also inhibits the production of DNA, RNA, and proteins by cells. VE 821 has minimal toxicity to healthy cells, and has been shown to work synergistically with other pharmacological agents such as radiation therapy.</p>

<p>NF279 is a low-potency, orally active, small molecule that was designed to act as a potent and selective antagonist of the P2Y receptor. It binds to the p2y receptor and blocks its activity. NF279 has demonstrated efficacy against autoimmune diseases in animal models, and it is being studied as a potential treatment for HIV infection. In addition, NF279 has been shown to reduce the release of glutamate in primary cells, which may contribute to its ability to treat anxiety disorders. NF279 also blocks detrusor muscle contractions and reduces intracellular Ca2+ levels in bladder cells isolated from rats with overactive bladders.</p>

<p>YM 976 is a fatty acid that has been shown to have pharmacological effects on the bowel. YM 976 inhibits inflammatory bowel disease by binding to the fatty acid receptor, thereby inhibiting the production of proinflammatory mediators. This drug also has inhibitory effects on cyclic nucleotide phosphodiesterase and signal transduction pathways. It is also used for treating infectious diseases and autoimmune diseases because it inhibits transcription-polymerase chain reactions and inflammation. YM 976 also has hydroxyl groups that are involved in the inhibition of human macrophages, which may be related to its anti-inflammatory properties.</p>

<p>WYC-209 is a synthetic compound that has the potential to be an effective cancer therapy. It inhibits the activity of signal pathways that are involved in tumor development, including the PI3K/Akt and ERK1/2 pathways. The molecule also inhibits the expression of IL-6 and IL-8, which are cytokines that stimulate tumor growth. This drug may also inhibit cancer stem cells, which are responsible for tumor recurrence. WYC-209 has not been tested on humans, but studies have shown it to be safe in mice with melanoma. It has been shown to inhibit the growth of tumors in these animals without any toxicity or side effects.</p>

<p>DSR-6434 is a Toll-like receptor modulator that is used in the treatment of human immunodeficiency virus. It has been shown to inhibit the production of cytokines and chemokines, which are necessary for viral replication. This molecule also has the potential to be used as a therapeutic agent in autoimmune diseases, hepatitis, and renal cell cancer. DSR-6434 is a small molecule drug that binds to Toll-like receptor 4 (TLR4). The compound blocks TLR4 signaling through a neutralizing mechanism by binding to TLR4 on the surface of cells, preventing it from activating downstream signaling pathways. DSR-6434 has been shown to have clinical activity against colorectal carcinoma in preclinical studies.</p>

<p>FTI-277 hydrochloride is a small molecule inhibitor of farnesyltransferase, which is critical in the post-translational modification of proteins such as the Ras oncoproteins. Derived through meticulous chemical synthesis, this compound targets the enzymatic pathway responsible for the farnesylation of proteins, a key step for their localization and function within cell membranes.</p>

<p>Vasoactive Intestinal Peptide (VIP) Antiserum is a research tool that can be used to investigate the function of VIP in different cell types. VIP Antiserum is also an inhibitor of Protein interactions and may have applications in pharmacology.</p>

<p>E3 Ligase ligand 14 is a linker that binds to the E3 ubiquitin ligase, which selectively targets proteins for degradation. It is a chimeric molecule that consists of two parts: ubiquitin and an indoleamine. This linker has been shown to be active in metabolic disorders such as obesity and diabetes, as well as psychiatric disorders such as schizophrenia and depression. The linker can be used as a targeted drug or as a diagnostic tool in the identification of psychiatric conditions. E3 Ligase ligand 14 is also an inhibitor of the E3 ubiquitin ligase, which selectively targets proteins for degradation. It binds to the E3 ubiquitin ligase, which selectively targets proteins for degradation. It is a chimeric molecule that consists of two parts: ubiquitin and an indoleamine. This linker has been shown to be active in metabolic disorders such as obesity and diabetes, as well as psychiatric disorders such as schizophrenia and depression</p>

<p>Umbralisib hydrochloride is a research tool for the study of ion channels, peptides and proteins. It is a selective inhibitor of the human receptor PDGFRA, which has been shown to be essential for tumor growth in vitro.</p>

<p>Salusin-beta is a peptide that is used as a research tool for the study of ion channels and protein interactions. Salusin-beta inhibits potassium currents in cells, which may be due to its ability to bind to receptor sites on the cell membrane. It also inhibits the activity of protein kinase C and calcium channels. Salusin-beta has been shown to be an inhibitor of protein interactions, such as those between α-synuclein and synaptotagmin, which are involved in Parkinson's disease.</p>

<p>SB 203580 hydrochloride is a p38 MAPK inhibitor that binds to the receptor site of the human serum albumin. It has been shown to have a significant effect on cell proliferation and cell migration in corneal endothelial cells and epidermal growth factor receptor-positive epithelial cells in culture. SB 203580 hydrochloride also inhibits protease activity, which may be related to its ability to inhibit tumor necrosis factor-α (TNF-α) production. SB 203580 hydrochloride is a nanoparticulate composition that can be used for treatment of inflammatory disorders such as asthma, COPD, and rheumatoid arthritis.</p>

<p>Sabeluzole is a drug that is used to treat symptoms caused by excessive glutamate in the brain. It has been shown to be effective in the treatment of neuropathic pain and bowel disease. Sabeluzole is an analog of zolpidem, which is a sedative hypnotic drug that belongs to the class of pharmacological agents called imidazopyridines. This drug also has anti-inflammatory properties and has been found to be effective against inflammatory bowel disease, diabetic neuropathy, and fatty acid oxidation disorders.</p>

<p>BMS-986020 is an inhibitor of the receptor tyrosine kinase, epidermal growth factor receptor (EGFR). The inhibition of EGFR has been shown to inhibit tumor cell proliferation and induce apoptosis. BMS-986020 is a high purity, water-soluble peptide that inhibits the growth of cancer cells in vitro by binding to the extracellular domain of EGFR. This drug may also be used as a research tool for studying protein interactions and antibody production.</p>

<p>Sedative; anti-convulsant</p>

<p>Pf-04217903 phenolsulfonate is a new chemical entity that has been shown to act as an inhibitor of the ion channels TRPC1, TRPC4, and TRPV6. It has also been shown to inhibit the binding of peptide ligands to their cognate protein receptors. Pf-04217903 phenolsulfonate is a high-purity reagent with a purity greater than 99%.</p>

<p>KAG-308 is a research tool that is used as an activator or ligand for receptor binding. It has been shown to have a high affinity for the nicotinic acetylcholine receptor, which is important in the transmission of signals from the nervous system to muscles and glands. KAG-308 also interacts with ion channels and is a potential inhibitor of protein synthesis.</p>

<p>(+)-Etomoxir sodium salt hydrate is a chemical compound classified as a carnitine palmitoyltransferase 1 (CPT1) inhibitor, which is a compound derived synthetically. Its mode of action involves the inhibition of the enzyme CPT1, which is pivotal in the transport of long-chain fatty acids into the mitochondria for β-oxidation. This inhibition effectively blocks fatty acid oxidation pathways, leading to alterations in metabolic states.Etomoxir is commonly utilized in scientific research to study metabolic processes, particularly those related to energy metabolism and metabolic disorders. It serves as a valuable tool in exploring mechanisms involved in diabetes, obesity, and cardiovascular diseases by allowing researchers to scrutinize the metabolic adaptations to impaired fatty acid oxidation. Furthermore, it is used in cellular and animal models to investigate metabolic inflexibility and mitochondrial function. Its application extends to cancer research, where metabolic reprogramming is a focus, aiding in the understanding of tumor progression and potential therapeutic interventions targeting metabolic pathways.</p>

<p>Fulvestrant S enantiomer is a peptide inhibitor that binds to the estrogen receptor alpha. It is an activator of the estrogen receptor and has been shown to be a potent ligand for the estrogen receptor. Fulvestrant S enantiomer can be used as a research tool for studying protein interactions, ligands, and receptors. This product is of high purity and is suitable for use in life science experiments involving ion channels or antibodies.</p>

<p>2-Amino-4-(isopropyl-d7-amino)-6-chloro-triazine is a synthetic ligand that binds to the N-methyl D-aspartate (NMDA) receptor. It is used as a research tool to study the NMDA receptor and its interactions with other proteins. 2-Amino-4-(isopropyl-d7-amino)-6-chloro-triazine binds to the glutamate site on the NMDA receptor and can be used as an activator or inhibitor of this protein. It has been shown that 2AMINO4 (CAS No. 1216649) can inhibit glutamate release in rat hippocampus slices, which may be due to its ability to block calcium channels. This agent also blocks postsynaptic currents in cultured neurons, thereby inhibiting neuronal excitation.</p>

<p>HLM006474 is a small molecule inhibitor of the E2F transcription factor. HLM006474 binds to the E2F protein and prevents it from binding to DNA, thereby inhibiting transcriptional regulation. This drug has been shown to be effective in animal models of cancer, hepatic steatosis, and diabetes. HLM006474 also inhibits CDK4/6-mediated phosphorylation of retinoblastoma protein (pRB), leading to inhibition of cell proliferation and tumor growth. These effects are accompanied by decreased levels of insulin resistance and increased insulin sensitivity in diabetic patients.</p>

<p>BW A868C is a peptide that is related to the beta-amyloid peptide. It has been shown to inhibit neuronal death by blocking the Ca2+ response and also has anti-inflammatory properties. This drug has been tested in experimental models of allergic airway inflammation, but does not have any therapeutic effect in mice with established airway inflammation. BW A868C appears to be a low potency agonist for EP receptors, which may be due to its inability to cross the blood brain barrier.</p>

<p>Rilmazafone hydrochloride is a potent inhibitor of the enzyme peptidyl-prolyl cis-trans isomerase A (PPIA). It binds to PPIA and prevents the formation of peptidyl-prolyl bonds in proteins. Rilmazafone hydrochloride is used as a research tool to study protein interactions, as an activator for peptides, and as a high purity reagent for life sciences. The active form of this drug binds to ligands on antibody molecules and blocks the activity of ion channels.</p>

<p>Phrixotoxin 3 is a neurotoxin that belongs to the class of bioconjugate chemistry. It has been shown to have inhibitory effects on voltage-dependent calcium channels in ganglion cells and on voltage-gated sodium channels in rat dorsal root ganglia. Phrixotoxin 3 has also been shown to bind to bacteria, including gram-negative bacteria, and to target complementarity regions. The amino acid composition of Phrixotoxin 3 is homologous with a region of the C3 protein, which is involved in the complement system. This neurotoxin can be used as a research tool for investigating the role of voltage-gated channels in pain pathways.</p>

<p>BioA-IN-13 is a peptide that interacts with the N-terminal region of the human A1 adenosine receptor. It has been shown to have an agonist effect on this receptor, which is activated by a ligand binding to its extracellular domain. BioA-IN-13 has also been shown to be an inhibitor of ion channels, such as sodium and potassium channels. This peptide can be used as a research tool in cell biology experiments and for studying protein interactions.</p>

<p>TC SL C5 is a monoclonal antibody that binds to the extracellular domain of human growth hormone receptor and inhibits its activity. The antibody is useful as a research tool in cell biology, pharmacology, and ligand-receptor interactions. TC SL C5 has been shown to inhibit the activation of human platelets by thrombin, which is mediated by the binding of thrombin to its receptor on platelets. TC SL C5 also inhibits the ionic current in rat brain cells, which may be due to its ability to bind to potassium channels.</p>

<p>EBE-A 22 is a tyrosine kinase inhibitor that binds to the ATP-binding site of the enzyme and prevents it from transferring phosphate groups. It is orally active and has been shown to inhibit tumor growth in mice with Ewing sarcoma, myeloma cell lines, and squamous carcinomas. EBE-A 22 has also been shown to inhibit tyrosine kinase activity, leading to decreased proliferation of various cells and inhibition of ribosome synthesis. This drug also inhibits receptor activity by binding to the ATP-binding site on the receptor, preventing it from eliciting a cellular response.</p>

<p>Ropivacaine-d7 hydrochloride is a high purity, research tool for the study of protein interactions. This product is an antagonist of the N-methyl-D-aspartate (NMDA) receptor, and is a ligand for the nicotinic acetylcholine receptors (AChR). Ropivacaine-d7 hydrochloride has been shown to inhibit ion channels such as voltage gated sodium channels and calcium channels. It also blocks ligand binding to AChRs, which may be useful in developing new drugs for the treatment of pain.</p>

<p>Bufotalidin is a caffeic acid derivative that has been shown to have inhibitory properties on the heart and locomotor activity. Bufotalidin was shown to decrease the cardiac contractility of isolated rat hearts by inhibiting calcium influx. It also inhibits basic protein kinase C (PKC) in HL-60 cells, which may be due to its ability to inhibit PKC translocation from the cytosol to the membrane. Bufotalidin also has an inhibitory effect on autophagy, which is a process that breaks down cellular components. The molecular mechanisms underlying these effects are not yet understood.</p>

<p>BI 9564 is a small molecule that binds to the bromodomain and interacts with the histone acetyltransferase activity, which is involved in inflammatory diseases. BI 9564 also has anti-cancer effects, and can be used for the treatment of various types of cancer, including pancreatic cancer. It inhibits the growth of stem cells, which are important for kidney function. BI 9564 has been shown to induce cell death in glomerular filtration rate cells, cardiac muscle cells and growth factor-dependent cells.</p>

<p>6-Ethyl-4-[4-(1,3,4-thiadiazol-2-yl)piperazin-1-yl]thieno[2,3-d]pyrimidine, dihydrochloride is a ligand that binds to and activates the receptor. It has been used as a research tool in cell biology to study ion channels and protein interactions. 6Et4TTP has also been used as an inhibitor of peptides and antibodies. The chemical name for this compound is 6-ethyl-4-[4-(1,3,4-thiadiazol-2-yl)piperazin-1-yl]thieno[2,3d]pyrimidine, dihydrochloride. The CAS number for this compound is 1934302 - 23 - 4.</p>

<p>YUKA1 is a protein that in humans is encoded by the YUK1 gene. It regulates cellular growth, differentiation and migration. YUKA1 has been shown to be overexpressed in breast cancer tissues, and has been shown to promote angiogenesis and tumor growth. This protein also interacts with the epidermal growth factor receptor (EGFR), which is a cell surface receptor tyrosine kinase involved in regulating cell proliferation, survival and motility. Yuka1 has been shown to bind histone H3 lysine 36 (H3K36) at specific regions of DNA called CpG islands. These regions are found near genes that are turned on or off by methylation, which can lead to changes in gene expression levels.</p>

<p>ANQ 11125 is a linker that is used to connect therapeutic molecules to blood-based transport vectors. This linker has been shown to be efficient in conjugating the therapeutic molecules to cells of all types, including those from humans and animals.</p>

<p>SPI 009 is an antibiotic that has shown a high degree of activity against Enterobacter aerogenes. SPI 009 was developed to treat infections caused by Gram-negative bacteria, such as Pseudomonas aeruginosa. It binds to the bacterial membrane and lyses cells by disrupting the integrity of the membrane. SPI 009 also inhibits the production of efflux pumps in Gram-negative bacteria, which are used to expel antibiotics from the cell. This leads to a decrease in resistance to antibiotics and may allow for more effective treatment of drug-resistant strains.</p>

<p>The Kisspeptin 10 is a peptide that has been used as an inhibitor to research the function of G-protein coupled receptors and their ligands. The Kisspeptin 10 is a high purity antibody that can be used in immunohistochemistry, Western blotting, or ELISA experiments. The CAS number for the Kisspeptin 10 is 478507-53-8.</p>

<p>Galanin is a peptide that is used as a research tool to study ion channels, cell biology, and pharmacology. It binds to the galanin receptor and activates it. The gene encoding for this protein has been cloned and expressed in E. coli.</p>

<p>4-Chloro-3-(5-methyl-3-((4-(2-(pyrrolidin-1-yl)ethoxy)phenyl)amino)benzo[E][1,2,4]triazin-7-yl)phenyl benzoate hydrochloride is a potent inhibitor of the fibroblast growth factor receptor 1 (FGFR1). FGFR1 signaling promotes the growth of blood vessels and tissues, including pancreatic β cells. The inhibition of this receptor blocks the proliferation of both endothelial cells and pluripotent stem cells. This drug is biocompatible and can be used for implanting tissues in vivo. 4-Chloro-3-(5-methyl-3-((4-(2-(pyrrolidin-1-yl)ethoxy)phenyl)amino)benzo[E][1,2,4]triazin-7-yl)phenyl ben</p>

<p>Irreversible inhibitor of EGFR receptor</p>

<p>WAY-169916 is a novel, orally active, nonsteroidal anti-inflammatory drug (NSAID) that inhibits the activity of inflammatory genes by binding to and blocking the response element. WAY-169916 has shown efficacy in vivo in animal models of cardiac and renal diseases. It has also been shown to lower diastolic blood pressure in rats with chronic heart failure. WAY-169916's mechanism of action is not fully understood but may involve inhibition of the activity of 17β-estradiol and/or its receptor. This drug also has an antiinflammatory effect on bowel disease models in mice by inhibiting inflammation through mechanisms that are yet to be elucidated.</p>

<p>ZJ 43 is an advanced biochemical compound that serves as a precision-targeted reagent, specifically designed for cellular and molecular biology applications. Derived from synthetic organic chemistry techniques, it features a high degree of purity and specificity, allowing it to interact with cellular proteins without significant off-target effects.</p>

<p>Tisocromide is a peptide that binds to the GABA receptor and activates it. It has been shown to inhibit the activity of ion channels, which may be due to its ability to bind to ligands such as benzodiazepines or barbiturates. Tisocromide also binds to antibodies, which can be used for research purposes. This drug is an inhibitor of cell biology and has been shown to be effective against cancer cells in vitro.</p>

<p>Please enquire for more information about Difloxacin-d3 including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Acid-dPEG®13-NHS Ester is a PEG compound with two different functional groups (also known as heterobifunctional). Unlike homobifunctional PEG compounds (same functional group on both ends), this type of compounds are more versatile as have two different anchor points. Acid-dPEG®13-NHS Ester is used as a linker and spacer to add a PEG moiety, via pegylation (a bioconjugation technique) to proteins, peptides, oligonucleotides, small molecules and nanoparticles.</p>

<p>Padmatin is a flavonoid that has been reported to have radical scavenging activity. It is found in the leaves of the plant, and has been shown to have antioxidant effects in assays. Padmatin also exhibits a sweet taste and may be used as a natural sweetener. The chemical structure of padmatin includes two phenylpropanoid units, eriodictyol and putatively taxifolin, which are both responsible for its antioxidant properties. Padmatin has been shown to have hydroxyl radical scavenging activity in the presence of p-coumaric acid, hexane and an electrospray ionization mass spectrometer (ESI-MS).</p>

<p>3-Hydroxy-2-phenyl-N-[(1R)-1-phenylpropyl]quinoline-4-carboxamide hydrochloride is a medicine that is used to treat symptoms of Parkinson's disease. It is an antagonist of the tachykinin receptor, which is a type of neurotransmitter that has been implicated in the development of Parkinson's disease. 3-Hydroxy-2-phenyl-N-[(1R)-1-phenylpropyl]quinoline-4-carboxamide hydrochloride can be administered as an amorphous drug or in solid dispersions. The drug is stable and does not show any signs of crystallization or dissolution at 37°C. It also has a low solubility in water, which makes it suitable for use as an electrospun nanofiber that can be used to treat Parkinson's disease symptoms.</p>

<p>Antrazafen is an antibacterial drug that belongs to the class of fatty acids. It is used as a diagnostic agent to identify damaged cardiac tissue, and has been shown to have biological properties that can be used in autoimmune diseases. Antrazafen inhibits the production of inflammatory bowel disease by preventing activation of effector proteins, which are proteins that are involved in the immune response. This drug also prevents chronic arthritis by inhibiting glycosidic bonds. The biocompatible polymer coating on antrazafen makes it suitable for use in humans with damaged tissue or joints.</p>

<p>ML 339 is a novel immunosuppressant drug that has been shown to be effective in the treatment of autoimmune diseases. It is a selective, reversible inhibitor of phosphodiesterase 4 (PDE4) and prevents the breakdown of cyclic adenosine monophosphate (cAMP), a signaling molecule that is important for immune responses. In animal models, ML 339 has been shown to suppress immune responses and prevent the development of autoimmune disease. It has also been shown to preserve transplanted organs from rejection.</p>

<p>Inhibitor of protein kinase B</p>

<p>N-Methylcinnamylamine is an analog of indirubin, which is known to have potent anticancer properties. This compound has been shown to inhibit the growth of tumor cells by inducing apoptosis, or programmed cell death. N-Methylcinnamylamine also inhibits the activity of β-glucan and kinases in cancer cells, leading to decreased proliferation and increased cell death. Chinese researchers have found that this compound can be excreted in urine after administration, making it a promising candidate for cancer therapy. N-Methylcinnamylamine has shown significant potential as an inhibitor of tumor growth and may prove to be a valuable addition to cancer treatment regimens.</p>

<p>Esomeprazole magnesium salt is an enantiomerically pure proton pump inhibitor, which is derived from the class of compounds known as benzimidazoles. It is a synthetic compound, sourced through chemical synthesis that provides chirally-selective therapeutic effects. Through its mode of action, this compound specifically targets and irreversibly inhibits the H+/K+ ATPase enzyme situated on the gastric parietal cells, effectively blocking the final step of acid production in the stomach.</p>

<p>Inhibitor of Aurora B kinase</p>

<p>UR 1102 is a chemical compound used primarily in biomedical research, sourced from synthetic chemical processes. It operates as a selective modulator with the ability to interact with targeted biological pathways or receptors, depending on its specific design and formulation. The mode of action includes binding to particular sites, thereby influencing signaling cascades or biochemical processes within the system.</p>

<p>MK 0893 is a synthetic compound that acts as a liver X receptor (LXR) antagonist, which is derived from targeted drug discovery efforts focusing on nuclear receptor modulation. Its mode of action involves competitively inhibiting ATP binding at the LXR, effectively reducing the receptor's transcriptional activity. LXRs are nuclear receptors that regulate cholesterol, fatty acid, and glucose homeostasis by modulating gene expression.</p>

<p>8-Chloro-3-pentyl-1H-purine-2,6(3H,7H)-dione is a small molecule that interacts with protein receptors. It has been shown to be an activator of the ion channel TRPM8. This compound also binds to and inhibits the receptor for peptides that are related to pain pathways. 8-Chloro-3-pentyl-1H-purine-2,6(3H,7H)-dione is a fluorescent ligand that can be used as a research tool in cell biology. 8C8PD is not yet approved for clinical use but has potential for use in the treatment of conditions such as chronic pain and inflammatory disorders.</p>

<p>HA155 is a new drug candidate for the treatment of skin cancer. It has been shown to inhibit pro-inflammatory factors, such as tumor necrosis factor (TNF) and interleukin-1β (IL-1β), that are associated with cancer growth. HA155 also inhibits the production of reactive oxygen species and the activation of nuclear factor κB in human carcinoma cells. HA155 has been shown to be effective against inflammatory diseases in mice, such as psoriasis and rheumatoid arthritis. The molecule acts by binding to adenosine receptors on immune cells, thereby inhibiting their response to inflammation.</p>

<p>ML324 is a selective small-molecule modulator, which is a synthetically derived compound with the capacity to regulate molecular pathways. Specifically, it acts as an inhibitor of autophagy, a cellular degradation process critical for maintaining homeostasis.</p>

<p>PNU 74654 is a novel agent that has been shown to be active in cancer and other proliferative disorders. It inhibits the activity of cell signaling pathways by binding to and blocking the epidermal growth factor receptor, leading to reduced levels of cellular proliferation. In addition, PNU 74654 induces apoptosis in cancer cells by inhibiting transcriptional regulation and receptor activity. PNU 74654 also has antitumor effects on experimental models of breast cancer by inducing tumor cell lysis. The drug has been shown to be effective against a range of resistant breast cancer cells as well as various cancers tissues in rats.</p>

<p>NCC007 is a drug that inhibits casein kinase. Casein kinase is involved in cell proliferation and differentiation. NCC007 is being studied for its potential use as an anticancer therapeutic. Inhibition of casein kinase leads to the phosphorylation of casein, which may inhibit tumor growth by disrupting the circadian rhythm. NCC007 has been shown to be effective against cancer cells grown in vitro and in vivo. This drug also has the ability to modulate cellular pathways, such as endogenous protein synthesis, cellular signaling, and cell cycle progression. Optimization of cancer drugs has been shown using x-ray crystal structures of the human protein Csk-1 (casein kinase).</p>

<p>ARI-3099 hydrochloride is a peptide that is used as a research tool for studying ion channels and protein interactions. This peptide has been shown to activate the receptor and ligand, which leads to pharmacological effects. ARI-3099 hydrochloride is an inhibitor of protein interactions. It binds to the receptor and ligand, preventing the formation of protein complexes. ARI-3099 hydrochloride is also an inhibitor of ion channels and can be used as a research tool for studying these channels in cell biology.</p>

<p>Sphinganine-d7 is a stable isotope-labeled analog of sphinganine, which is a bioactive lipid used extensively in biochemistry and molecular biology. This compound is derived from the natural sphingolipid backbone, with six deuterium atoms incorporated to facilitate tracking and measurement in scientific studies. The mode of action involves its role as a precursor in the biosynthesis of more complex sphingolipids, which are crucial components of cell membranes and play a role in signaling pathways.</p>

<p>Wy-135 is a potential drug that has shown inhibition of cyclin-dependent kinases. It has been shown to inhibit G1 phase cell cycle progression and induce apoptosis in a dose-dependent manner. Wy-135 has also been shown to inhibit the growth of cancer cells in culture. This compound may be useful as an anti-cancer agent and chemotherapeutic drug. Wy-135 inhibits cellular proliferation and induces apoptosis by inhibiting protein synthesis, DNA replication, and enzyme activity. The cocrystal structure of Wy-135 with cyclin was determined and its inhibitory activities were analyzed by cycle analysis. Wy-135's effects on cancer cells are due to its ability to inhibit the enzymatic activities involved in cell division, including protein synthesis and DNA replication.</p>

<p>Verazide is an oxide that acts as an enzyme inhibitor. It is a white, crystalline solid with a molecular weight of 199.22 g/mol and an empirical formula of C6H14O4N2O3. The hydroxyl group on the molecule forms hydrogen bonding interactions with amino acid residues in the active site of enzymes, inhibiting their function. Verazide inhibits bacterial growth by binding to the ribosomal RNA at the 50S subunit, preventing protein synthesis and thus cell division. It also has antiviral properties and can be used to treat hepatitis B and C as well as cardiovascular diseases such as cirrhosis or renovascular disease. Verazide is not active against viruses that replicate through DNA intermediates, such as herpesviruses or adenoviruses.</p>

<p>Gly-L-Asp-L-Asp-L-Asp-L-Asp-L-Lys (GLAD) is a peptide that has been shown to inhibit the activity of protein kinases. GLAD binds to the ATP binding site and prevents ATP from binding to the kinase, which inhibits the phosphorylation of other proteins. GLAD may also activate certain protein kinases by binding to their ATP binding site. GLAD is a valuable research tool for studying protein interactions, as well as for identifying new receptor ligands and ion channels.</p>

<p>Imidafenacin hydrochloride is an officinal drug that possesses both respiratory and pulmonary activity. It is used for the treatment of bronchitis, cough, and other symptoms of the common cold. Imidafenacin hydrochloride has been shown to have anesthetic properties with a rapid onset of action. The mechanism of action is not well understood but may be due to its interaction with other drugs that have anaesthetic properties such as tetrahydropalmatine and salivary alkali.</p>

<p>Chloroacetaldehyde (2,4-dinitrophenyl)hydrazone is an anticancer compound that has been shown to exhibit inhibitory effects on tumor growth in Chinese hamsters. This compound is a potent inhibitor of kinases, which are enzymes involved in the regulation of protein activity and cell signaling pathways. Chloroacetaldehyde (2,4-dinitrophenyl)hydrazone analogs have also been shown to induce apoptosis in cancer cells by disrupting mitochondrial function and increasing oxidative stress. In addition to its antitumor properties, this compound has been used as a biomarker for testosterone metabolism in human urine samples. Chloroacetaldehyde (2,4-dinitrophenyl)hydrazone holds promise as a potential therapeutic agent for the treatment of cancer and other diseases associated with abnormal kinase activity.</p>

<p>4-Epi-ritonavir is a peptide inhibitor that binds to the HIV protease, which is an enzyme that cleaves viral polyproteins into their constituent proteins. The inhibition of this enzyme prevents the maturation of new viruses by blocking the formation of mature virus particles. 4-Epi-ritonavir has been shown to bind to the HIV protease with high affinity and specificity. It also activates other enzymes involved in protein synthesis and can be used as a research tool to study protein interactions.</p>

<p>1-[[2-Fluoro-4-(1-methylpyrazol-4-yl)phenyl]methyl]indole-2,3-dione is a fluorescent ligand that has been shown to bind to the serotonin receptor and other ion channels. It also has been used as a research tool in pharmacology, protein interactions, and cell biology. This product is used as an antibody activator or inhibitor.</p>

<p>Rosiglitazone is an anti-diabetic drug that belongs to the thiazolidinedione class of drugs. It is used as an adjunct to diet and exercise to maintain glycaemic control in type 2 diabetes. This drug acts as a selective agonist at peroxisome proliferator activated receptors (PPAR) in target tissues for insulin action such as adipose tissue, skeletal muscle, and liver. Activation of these receptors regulates the transcription of insulin-responsive genes involved in the control of glucose production, transport, and utilization.</p>

<p>Cloethocarb is a kinase inhibitor that has shown promising results in the treatment of cancer. It works by inhibiting kinases, which are enzymes that play a crucial role in cancer cell growth and survival. In Chinese hamster ovary cells, cloethocarb has been shown to inhibit hyaluronan synthesis and induce apoptosis. Additionally, it has been found to be effective in inhibiting the growth of human tumor cells and preventing the spread of cancer. Cloethocarb also acts as an analog inhibitor of somatostatin, a hormone that regulates various physiological functions such as insulin secretion and gastric acid secretion. It can be detected in urine samples and may have potential therapeutic applications in the treatment of various cancers, including those resistant to traditional chemotherapy agents.</p>

<p>GSK1059865 is a clinical candidate for the treatment of Parkinson's disease. It is a selective and potent D2 receptor agonist that has been shown to be safe and well-tolerated in humans. GSK1059865 binds to the D2 dopamine receptor, which is located on neurons in the striatum, where it inhibits glutamate release. GSK1059865 also binds to other dopamine receptors, but with much lower affinity. This drug has been shown to increase locomotor activity in wild-type mice, as well as prevent locomotor deficits induced by the administration of 6-hydroxydopamine (6-OHDA).</p>

<p>ZCZ 011 is a synthetic compound, which is derived from an engineered biochemical process designed for high specificity in binding interactions. It operates primarily through a targeted mechanism that involves interaction with specific molecular targets, thereby modulating cellular pathways with precision. This specificity is achieved through the compound’s unique structural attributes that allow for selective affinity towards its intended molecular targets.</p>

<p>ELA-32 is a drug that binds to the fatty acid receptor and inhibits tumor growth. It has been shown to inhibit the expression of target genes in cancer cells and to promote their death. ELA-32 is also effective in treating nerve diseases, such as Alzheimer's disease and Parkinson's disease. This drug binds to a specific receptor found on cellular membranes, which leads to reduced levels of cholesterol and fatty acids. ELA-32 is used for the diagnosis of preeclampsia during pregnancy and for the diagnosis of various cancers.</p>

<p>Dihydrodiol ibrutinib is a tyrosine kinase inhibitor drug that has been shown to inhibit the growth of cancer cells by targeting the epidermal growth factor receptor. It can be used to treat non-Hodgkin's lymphoma and chronic lymphocytic leukemia. Dihydrodiol ibrutinib inhibits wild-type mouse cyp3a4 and human cyp3a4, which are responsible for metabolizing this drug. This inhibition leads to an increase in the blood concentration of dihydrodiol ibrutinib, which is currently being studied as a potential treatment for autoimmune diseases. The IR spectroscopy studies show that dihydrodiol ibrutinib binds to tubule cells in the kidney, which may lead to renal toxicity. The FTIR spectroscopy also showed that this drug binds with trifluoroacetic acid (TFA) during sample preparation, which may affect its stability.</p>

<p>N-Desmethyl imatinib mesylate is an active metabolite of Imatinib Mesylate, a drug used to treat metastatic colorectal cancer. The compound is an inhibitor of the tyrosine kinase activity of the epidermal growth factor receptor (EGFR) and is taken orally. N-Desmethyl imatinib mesylate has been shown to be effective in women with metastatic colorectal cancer, producing a hematologic response in 67% of patients. This compound has also been found to have a longer half-life than Imatinib Mesylate and may be used as a substitute for this drug in women with metastatic colorectal cancer who are unable to take oral medications.</p>

<p>1-(2-Benzyl-5-methylpyrazol-3-yl)-3-(3,4-difluorophenyl)urea is a synthetic chemical compound, which is typically synthesized through a series of organic reactions involving substituted pyrazoles and urea derivatives. This compound is primarily sourced from laboratory synthesis using controlled conditions to ensure purity and stability. Its mode of action involves the inhibition of specific protein kinases, which are essential in various signaling pathways within cells. By targeting these enzymes, this compound can disrupt cell proliferation and induce apoptosis, making it a valuable tool in cancer research.</p>

<p>PF-04701475 is a drug that inhibits the mitochondrial pathway of glutamate metabolism, which leads to the production of reactive oxygen species and neurodegeneration. PF-04701475 has been shown to be effective in treating symptoms of Alzheimer's disease in preclinical studies. It also has anti-inflammatory properties and may be useful for treating nervous system diseases, such as Parkinson's disease. PF-04701475 is currently under clinical development for the treatment of Parkinson's disease.</p>

<p>Pancoprida is a bioactive peptide, which is a synthetic compound derived from rational peptide design and combinatorial chemistry techniques. It functions through the modulation of specific receptor pathways, primarily targeting neuronal and inflammatory processes. Pancoprida exhibits high affinity for serotonin receptors, influencing neurotransmitter release and uptake, and also modulates certain cytokine pathways, thereby reducing inflammation.</p>

<p>2-Carbamoyl-4-(4-fluorophenyl)-5-(2-(4-(3-fluorobenzylidene)piperidine-1-yl)ethyl)thiazole is a Research Tool. 2-Carbamoyl-4-(4-fluorophenyl)-5-(2-(4-(3-fluorobenzylidene)piperidine-1-yl)ethyl)thiazole is a ligand that inhibits ion channels and may be used to study protein interactions. 2-Carbamoyl-4-(4-fluorophenyl)-5-(2-(4-(3-fluorobenzylidene)piperidine-1-yl)ethyl)thiazole is a Receptor Ligand with high purity for life science research use. CAS No. 204718-47-8</p>

<p>N-trityl candesartan trityl ester is a peptide that is an activator of the angiotensin receptor, which is a class of G protein-coupled receptors. This compound has been shown to inhibit ion channels and ligand-gated receptors. It also binds to anti-angiotensin II antibody and can be used as a research tool for cell biology.</p>

<p>SCH79797 is a thrombin inhibitor that blocks the conversion of pro-thrombin to thrombin. SCH79797 prevents neuronal death by inhibiting the activation of the neuronal apoptosis signal pathways and blocking signals from cytosolic calcium. This drug also inhibits the production of pro-inflammatory cytokines, including tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β), by blocking toll-like receptor signaling pathways. SCH79797 has been shown to be effective in models of Parkinson's disease and other neurological disorders and is an antagonist at basic protein sites.</p>

<p>CLK1-IN-1 is a small molecule compound, specifically a selective inhibitor, which is synthesized in laboratory settings. This product targets CDC-like kinases (CLKs), particularly CLK1, which are a group of serine/threonine-protein kinases involved in the regulation of alternative splicing. CLK1-IN-1 functions by binding to the active site of CLK1, thereby inhibiting its kinase activity. This inhibition can modulate the splicing of pre-mRNA, which is crucial for understanding regulatory mechanisms in gene expression.</p>

<p>Influenza A antibody was raised in mouse using Influenza A from A/Texas strain as the immunogen.</p>

<p>Bromoclenbuterol is a beta-2 receptor agonist used in the treatment of bronchospasm. Bromoclenbuterol binds to the beta-2 receptor, which causes the opening of potassium channels and an increase in the flow of potassium ions. This results in hyperpolarization of smooth muscle cells, relaxation of bronchial muscles, and increased airway caliber. Bromoclenbuterol is also used as a research tool for studying protein interactions and as an antibody for cell biology.</p>