Produits biochimiques et réactifs

<p>Applications (8Z,11Z,14Z)-8,11,14-Heptadecatrienoic Acid, is a naturally occurring hydroxylated fatty acid that is found in Acinetobacter species. It acts as a partial agonist of free fatty acid receptor 1 (FFAR1/GPR40) and GPR84 receptors in vitro. It also inhibits bovine hepatic ligase (Ki = 4.4 μM) and mouse kidney mitochondrial medium-chain acyl-CoA synthetase by 48% at a concentration of 40 μM.<br>References Moss, C.W., et al.: J. Clin. Microbiol. 26(3), 484-492 (1988).; Kaspersen, M.H., et al.: Med. Chem. Commun. 8(6), 1360-1365 (2017).<br></p>

<p>Applications Tetrahydro 11-Deoxycorticosterone is a metabolite of 11-Deoxycorticosterone (DOC) (D232590).<br>References Fedele, E., et al.: J. Neurochem., 75, 782 (2000), Adkins, C., et al.: J. Biol. Chem., 276, 38934 (2001), Erceg, S., et al.: Brain Res., 1036, 115 (2005),<br></p>

<p>Applications Indole-3-acetyl-L-glutamic Acid is an indole-3-acetyl-amino acid conjugate involved in regulatory mechanisms for the control of auxin activity during physiological and pathophysiological responses.<br>References Ostrowski, M., et al.: J Plant Physiol, 191, 63-72 (2016)<br></p>

<p>Applications M1G is a secondary DNA damage product arising from primary reactive oxygen species (ROS) damage to membrane lipids or deoxyribose. It is a guanine adduct formed by reaction of malondialdehyde with DNA.<br>References Ham, A., et al.: Chem. Res. Toxicol., 13, 1243 (2000), Sharma, R., et al.: Clin. Cancer Res., 7, 1452 (2001), Jeong, Y., et al.: Chem. Res. Toxicol., 18, 51 (2005),<br></p>

<p>Stability Moisture Sensitive<br>Applications A useful synthetic intermediate for making potent and selective coronary vasodilators.<br>References Niiya, K., et al.: J. Med. Chem., 35, 4557 (1992)<br></p>

<p>Stability Light Sensitive<br>Applications A labelled vitamin precursor.<br></p>

<p>Applications A proteinogenic amino acids involved in the biosynthesis of purines and pyrimidines. Inhibitor of serine palmitoyltransferase. A neuromodulator.<br>References Junjaud, G. et al.: J. Neurochem., 98, 1159 (2006); Hanada, K. et al.: FEBS Lett., 474, 63 (2000); Pollegionni, L. et al.: Cell. Mol. Life Sci., 67, 2387 (2010);<br></p>

<p>Applications Protected L-Tyrosine (T899975), an amino acid, used by cells to synthesize proteins. L-Tyrosine is biologically converted from L-phenylalanine and is in turn is converted to L-DOPA and further converted into the neurotransmitters: dopamine, norepinephrine, and epinephrine.<br>References Rasmussen D.D. et al.: J. Clin. Endocrinol. Metab., 57, 760 (1983); Bagchi, S.P. et al.: Biochem. Pharmacol., 26, 900 (1977)<br></p>

<p>Applications Isotope labelled 2-Bromoethanol is an widely used intermediate in organic synthesis.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Tian, Z., et al.: Int. J. Quant. Chem., 111, 631 (2011); Thayer, F.K., et al.: Org. Syntheses., 6, (1926);<br></p>

<p>Applications Phosphoglycolic Acid is used in studies pertaining to biological and metabolic processes. It can be used in the study of human apurinic/apyrimidinic endonuclease (Ape) and its role in double strand break repair. It also has been seen to complex with cPEPCK (cytosolic phosphoenolpyruvate carboxykinase) during the study of its inhibition by various substrate analogues.<br>References Suh, D. et al.: Nucl. Acids Res., 25, 2495 (1997); Stiffin, R. et al.: Biochem., 47, 2099 (2008);<br></p>

<p>Applications Adipic Acid Dihydrazide is used to functionalize magnetic nanoparticles for gylcopeptitde enrichment and identification. Adipic Acid Dihydrazide can also be used as a chain extension for liquid rubber.<br>References Cao, Q., et. al.: Analyst, 139, 603 (2014); Cutts, E.: Chem. Industry, 7, 280 (1974)<br></p>

<p>Applications A glycidol fatty acid esters in edible oils. An acyl acceptor for the unspecific bifunctional wax ester synthase/acyl-CoA:Diacylglycerol acyltransferase.<br>References Masukawa, Y. et al.: J. Am. Oil. Chem. Soc., 88, 15 (2011); Kalscheuer, R. et al.: Eur. J. Lipid. Sci. Tech., 105, 578 (2003)<br></p>

<p>Applications Boric Acid, Pinacol Ester was a useful reagent in the study of hydrogen peroxide inducible DNA croslsinking agents as anticancer prodrugs.<br>References Kuang, Y., et al.: J. Am. Chem. Soc., 133, 19278 (2011);<br></p>

<p>Stability Hygroscopic<br>Applications Poly(ethylene Glycol) molecules of an average molecular mass of 20000. Poly(ethylene Glycol) is used in various applications from industrial chemistry to biological chemistry. Recent research has shown PEG maintains the ability to aid the spinal cord injury recovery process, helping the nerve impulse conduction process in animals. In rats, it has been shown to aid in the repair of severed sciatic axons, helping with nerve damage recovery. It is industrially produced as a lubricating substance for various surfaces to reduce friction. PEG is also used in the preparation of vesicle transport systems in with application towards diagnostic procedures or drug delivery methods.<br>References Borgens, R. et al.: J. Neurosci. Res., 66, 1179 (2001); Stavisky, R. et al.: Neurosci. Lett., 376, 98 (2005); Nalam, P. et al.: Tribiol. Lett., 37, 541 (2010); Steinmetz, N. et al.: J. Am. Chem. Soc., 131, 17093 (2009); Li, X. et al.: J. Am. Chem. Soc., 133, 11147 (2011); Li, L. et al.: Int. J. Pharm., 447, 192 (2013);<br></p>

<p>Applications m-Toluidine is a reagent that is used in the synthesis of torsemide and its derivatives which are used as a diuretic.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Lesne, M., et al.: In. J. Clin. Pharmacol. Ther. Toxicol., 20, 382 (1982), Brater, D.C., et al.: Clin. Pharmacol. Ther., 42, 187 (1987),<br></p>

<p>Applications Meleagrin is a is an antibiotic derived from the deep ocean and is identified as an inhibitor of the bacterial enoyl-acyl carrier protein reductase. (Fabl). Inhibits the growth of S. aureus, E.coli, and S.pneumoniae<br>References Shang, Z. et al.: Chin. J. Ocean. Limn., 30, 305 (2012);<br></p>