Produits biochimiques et réactifs

<p>Avocadene acetate is a synthetic compound, which is a pharmacologically active ester synthesized in laboratories. It is derived from acetic acid and specialized organic compounds, tailored for specific biochemical interactions. Its mode of action involves the modulation of various enzymatic pathways, potentially impacting cellular functions and metabolic processes, although the exact mechanisms may vary depending on the application and target system.</p>

<p>Saridegib is a novel, potent and selective inhibitor of the protein kinase C-epsilon (PKC-epsilon). Saridegib has been shown to inhibit the activity of PKC-epsilon in vitro. PKC-epsilon is expressed in high levels in metastatic pancreatic cancer cells, which are resistant to conventional chemotherapy. Saridegib inhibits cancer cell growth and survival by blocking the production of inflammatory cytokines such as interleukin-1beta (IL-1β) and tumor necrosis factor alpha (TNFα). Saridegib also inhibits human skin cancer cells by inhibiting the production of IL-8 and TNFα. This drug has also been shown to be effective against inflammatory diseases such as rheumatoid arthritis and psoriasis.</p>

<p>Please enquire for more information about Boc-Gly-Arg-OH including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Please enquire for more information about Acetyl-(D-Arg2)-GRF (1-29) amide (human) trifluoroacetate salt including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Please enquire for more information about (Gln9)-Amyloid b-Protein (1-40) trifluoroacetate salt including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Please enquire for more information about PSY1 Precursor Peptide including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Chalcone compound that decreases HSP90 levels and inhibits prostate cancer cell growth and migration in vitro</p>

<p>Please enquire for more information about BMS-470539 including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>H-9 hydrochloride is a selective protein kinase inhibitor, which is synthetically derived. It primarily inhibits cyclic nucleotide-dependent protein kinases, including protein kinase A (PKA) and protein kinase G (PKG), along with myosin light chain kinase (MLCK). The mode of action involves competitive inhibition at the ATP binding site of these kinases, thereby impacting phosphorylation pathways crucial for multiple physiological functions. The selective inhibition by H-9 hydrochloride allows for detailed exploration of kinase-mediated signaling pathways in cellular biology. Moreover, it is extensively utilized in studies involving cell motility, smooth muscle contraction, and signal transduction. The relevance of H-9 hydrochloride in academic research lies in its ability to provide insights into kinase activity modulation and its ensuing effects on cellular dynamics. This compound serves as an invaluable tool for scientists aiming to elucidate the complex role of protein kinases in health and disease, enabling the development of innovative therapeutic strategies.</p>

<p>Copeptin (rat) trifluoroacetate salt is a peptide that belongs to the group of protein inhibitors. It can inhibit the activity of the acetylcholine receptor, which leads to an increase in muscle tone and rigidity. Copeptin is also used as a research tool for studying protein interactions, antibody-antigen reactions, cell biology, ligand-receptor binding, pharmacology and life sciences. Copeptin has been shown to inhibit ion channels such as nicotinic receptors and potassium channels. The CAS number for copeptin (rat) trifluoroacetate salt is 86280-64-0.</p>

<p>Please enquire for more information about Fmoc-D-Pro-D-Pro-D-Pro-D-Pro-OH including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Please enquire for more information about N-(3-Amino-2-hydroxy-3-oxopropyl)-L-valyl-N-phenyl-L-leucinamide including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Catalogue peptide; min. 95% purity</p>

<p>A Good's buffer substance, pKa = 6.15 at 20 degree C.MES, also known as 4-Morpholineethanesulfonic acid, is a morpholinic buffer with an optimal pH range of 5.5-6.7 and a pKa of 6.1. This buffering agent can be used in culture media and capillary electrochromatography. It does not coordinate metal ions</p>

<p>PF 05175157 is a potent small molecule, orally active inhibitor of fatty acid synthase (FAS) that causes hepatocyte steatosis in vitro and in vivo. PF 05175157 is also an inhibitor of the enzyme stearoyl-CoA desaturase 1 (SCD1), which converts saturated to monounsaturated fatty acids. The compound has been shown to reduce liver and body weight gain in mice fed a high-fat diet, as well as to improve dyslipidemia and hepatic steatosis. PF 05175157 has been evaluated clinically for the treatment of obesity, type 2 diabetes mellitus, and nonalcoholic fatty liver disease. PF 05175157 was granted orphan drug designation for the treatment of pediatric chronic kidney disease by the FDA on June 6, 2015.</p>

<p>Please enquire for more information about 5-TAMRA-Amyloid beta-Protein (1-40) trifluoroacetate salt including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>GLP-1 (1-37) (human, bovine, guinea pig, mouse, rat) trifluoroacetate salt is a posttranslational modification of the endogenous human hormone GLP-1. It is a synthetic form of this hormone that has been modified to allow for improved stability and solubility. This peptide is found in the pancreatic alpha cells and intestinal L cells and stimulates the release of insulin from pancreatic beta cells. GLP-1 (1-37) (human, bovine, guinea pig, mouse, rat) trifluoroacetate salt has also been shown to increase glucose uptake by muscle tissue as well as stimulate the release of incretin hormones such as glucagon-like peptide 1 and gastric inhibitory polypeptide. GLP-1 (1-37) (human, bovine, guinea pig, mouse, rat) trifluoroacetate salt</p>

<p>Please enquire for more information about Amyloid beta-Protein (29-40) including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Please enquire for more information about Tyr-Amyloid P Component (27-38) amide trifluoroacetate salt including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Catalogue peptide; min. 95% purity</p>

<p>Please enquire for more information about Arg-Glu(EDANS)-(Asn670,Leu671)-Amyloid beta/A4 Protein Precursor770 (668-675)-Lys(DABCYL)-Arg trifluoroacetate salt including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Inhibitor of MDM2 E3 ubiquitin-protein ligase and MRP1 transporter</p>

<p>PV-10 is a peptide that activates ion channels. It is an agonist for the nicotinic acetylcholine receptor (nAChR) and a low-affinity antagonist for the N-methyl-D-aspartate receptor (NMDAR). PV-10 binds to specific sites on the nAChR, which causes the channel to open and allow ions to flow into the cell. This leads to depolarization of the membrane, which triggers an action potential in neurons. PV-10 is also able to bind to other proteins such as NR1 subunits of NMDARs and alpha 7 subunits of nAChRs. These interactions inhibit the function of these receptors and prevent them from opening their channels. This prevents calcium influx into cells, blocking neurotransmitter release and preventing the activation of downstream pathways that lead to neuronal death. PV-10 has been shown to be selective for certain types of ion channels over others</p>

<p>Please enquire for more information about Mca-Amyloid beta/A4 Protein Precursor770 (667-676)-Lys(Dnp)-Arg-Arg amide trifluoroacetate salt including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>C18:1 Ceramide (d17:1/18:1(9Z)) is a sphingolipid, which is originally sourced from plant or synthetic lipid precursors. Ceramides are integral components of the cellular lipid bilayer and are crucial for maintaining the integrity and function of the skin barrier. Their mode of action involves participating in cell signaling pathways that regulate cellular differentiation, proliferation, and apoptosis.</p>

<p>Catalogue peptide; min. 95% purity</p>

<p>AZD 5991 is a cell-specific compound that inhibits the apoptosis pathway. It has been shown to have potent antitumor activity against T-cell lymphomas and other cancers in vitro and in vivo. AZD 5991 targets cyclin D2 and PCSK9, which are proteins involved in the regulation of the cell cycle, thereby inhibiting tumor growth. This drug also exhibits potent inhibition of ribosome synthesis, which may be due to its ability to inhibit protein synthesis by targeting the enzyme activities required for ribosome production. AZD 5991 also exhibits anti-inflammatory properties that may be due to its ability to inhibit colony-stimulating factor (CSF) production.</p>

<p>Catalogue peptide; min. 95% purity</p>

<p>Please enquire for more information about Boc-beta-cyclopropyl-Ala-OH·DCHA including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Sarafotoxin A is a low potency β-amino acid analog that inhibits the inflammatory activity of endothelin-A. It has been shown to inhibit the production of reactive oxygen species, which may be due to its inhibition of fatty acid synthesis. Sarafotoxin A also has diagnostic properties and can be used in the diagnosis of inflammatory diseases.</p>

<p>Catalogue peptide; min. 95% purity</p>

<p>Catalogue peptide; min. 95% purity</p>

<p>Please enquire for more information about (Val34)-Amyloid b-Protein (1-40) trifluoroacetate salt including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Please enquire for more information about Ac-Val-Arg-Pro-Arg-AMC trifluoroacetate salt including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Catalogue peptide; min. 95% purity</p>

<p>Diabzi sting agonist-1 is a biological molecule that is the tautomer of diabzol. It has been shown to have antifungal properties in vitro, and is shown to be effective against bowel disease when administered orally. Diabzi sting agonist-1 binds to fungal cell walls by hydrogen bonding interactions with nitrogen atoms on the pyrazole ring. This binding leads to protonation and conformational changes that lead to the release of bound form of the drug, which inhibits cellular growth. The redox potentials of this molecule are high enough for it to be used as an electron donor or acceptor.</p>

<p>Catalogue peptide; min. 95% purity</p>

<p>Antifreeze Polypeptide 6 (AFP6) is a protein that belongs to the family of antifreeze proteins. AFP6 binds to ion channels and prevents the flow of ions, which prevents the formation of ice crystals. It also has been shown to interact with other proteins, such as receptors and peptides. This protein has been shown to be a research tool for studying cell biology and pharmacology. The CAS number for AFP6 is 122604-16-4.</p>

<p>Catalogue peptide; min. 95% purity</p>

<p>Catalogue peptide; min. 95% purity</p>

<p>Octreotide acetate-d8 is an analog of somatostatin, a hormone that inhibits the secretion of growth hormone and other hormones. It is used in the treatment of cancer, particularly tumors that have high levels of testosterone or somatostatin receptors. Octreotide acetate-d8 acts as an inhibitor of kinases, which are enzymes involved in cell signaling pathways that regulate cell growth and division. This drug has been shown to induce apoptosis (programmed cell death) in cancer cells by inhibiting kinase activity. Octreotide acetate-d8 has demonstrated anticancer effects in Chinese hamster ovary cells and has been used as a research tool for studying the mechanisms of action of kinase inhibitors. This drug can be detected in urine samples using mass spectrometry techniques due to its deuterium labeling at the acetate group.</p>

<p>Catalogue peptide; min. 95% purity</p>

<p>Please enquire for more information about α-Azacitidine including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Catalogue peptide; min. 95% purity</p>

<p>Catalogue peptide; min. 95% purity</p>

<p>Sartorypyrone is active against the Gram-positive bacteria B. subtilis, K. rhizophila, and M. smegmatis</p>

<p>Catalogue peptide; min. 95% purity</p>

<p>Catalogue peptide; min. 95% purity</p>

<p>Catalogue peptide; min. 95% purity</p>

<p>Catalogue peptide; min. 95% purity</p>

<p>Catalogue peptide; min. 95% purity</p>

<p>Catalogue peptide; min. 95% purity</p>

<p>Catalogue peptide; min. 95% purity</p>

<p>Catalogue peptide; min. 95% purity</p>

<p>Catalogue peptide; min. 95% purity</p>

<p>Catalogue peptide; min. 95% purity</p>

<p>Catalogue peptide; min. 95% purity</p>

<p>Please enquire for more information about Myelin Oligodendrocyte Glycoprotein (35-55) (human) trifluoroacetate salt including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Catalogue peptide; min. 95% purity</p>

<p>Catalogue peptide; min. 95% purity</p>

<p>Catalogue peptide; min. 95% purity</p>

<p>Catalogue peptide; min. 95% purity</p>

<p>Catalogue peptide; min. 95% purity</p>

<p>Catalogue peptide; min. 95% purity</p>

<p>Catalogue peptide; min. 95% purity</p>

<p>Catalogue peptide; min. 95% purity</p>

<p>Isosulfan blue is a dye that has been used for decades to detect skin cancer in vivo. It is a synthetic compound that binds to the lymphatic system and can be used as an analytical method for detecting cancer. Isosulfan blue is excreted through the urine and can be detected by plasma mass spectrometry, making it a useful tool for assessing toxicity levels in humans. The chemical structure of Isosulfan blue is similar to many other dyes, which makes it difficult to study its toxicity in vivo.</p>

<p>Catalogue peptide; min. 95% purity</p>

<p>Please enquire for more information about Leptin (138-167) (human) including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Catalogue peptide; min. 95% purity</p>

<p>Catalogue peptide; min. 95% purity</p>

<p>Catalogue peptide; min. 95% purity</p>

<p>Growth hormone-releasing factor (GRF) is a peptide fragment of amino acids 1–2 from GHRH (growth hormone-releasing hormone). This 1-29 region is the shortest fully functional fragment of GHRH. GRF is also known as sermorelin. Sermorelin binds to the growth hormone-releasing hormone receptor (GHRH-R), and acts as a surrogate for GHRH, causing growth hormone secretion.human: H-YADAIFTNSYRKVLGQLSARKLLQDIMSR-NH2rat:        H-HADAIFTSSYRR I LGQLYARKLLHEIMNR-NH2</p>

<p>Catalogue peptide; min. 95% purity</p>

<p>Catalogue peptide; min. 95% purity</p>

<p>Catalogue peptide; min. 95% purity</p>

<p>Catalogue peptide; min. 95% purity</p>

<p>Please enquire for more information about Vesicular Stomatitis Virus Nucleoprotein (52-59) trifluoroacetate salt including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Catalogue peptide; min. 95% purity</p>

<p>Nocistatin is a research tool that can be used in the study of protein interactions. It is a synthetic peptide that binds to receptor sites on cell membranes, which has been shown to inhibit ion channels and receptor-mediated signal transduction. Nocistatin (Bovine) has been shown to inhibit calcium ion channel activity and membrane depolarization by binding to the alpha1 subunit of GABA A receptors.</p>

<p>L-Lysyl-L-lysyl-L-lysyl-L-lysyl-L-lysine (LLLLLL) is an antibacterial agent that belongs to the class of pharmacological agents. LLLLLL has been shown to have antibacterial efficacy against oral pathogens, such as Streptococcus mutans and Porphyromonas gingivalis. LLLLLL binds to the bacterial cell wall by forming a covalent disulfide bond with cysteine residues on the peptidoglycan layer. This prevents cell wall synthesis, leading to cell death by inhibiting protein synthesis. LLLLLL has also been shown to have low toxicity in animal models for long periods of time, with high values in human serum.</p>

<p>Catalogue peptide; min. 95% purity</p>

<p>Catalogue peptide; min. 95% purity</p>

<p>Catalogue peptide; min. 95% purity</p>

<p>Catalogue peptide; min. 95% purity</p>

<p>Catalogue peptide; min. 95% purity</p>

<p>Catalogue peptide; min. 95% purity</p>

<p>Please enquire for more information about Amyloid beta/A4 Protein Precursor770 (586-595) (human, mouse, rat) trifluoroacetate salt including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Catalogue peptide; min. 95% purity</p>

<p>Catalogue peptide; min. 95% purity</p>

<p>TFA salt. Tripeptide containing hydroxyproline.</p>

<p>IGF-I (1-3) H-Gly-Pro-Glu-OH is a synthetic peptide that has been shown to be effective in treating neuronal death caused by glutamate. It binds to calcium ions and inhibits the activity of gamma-aminobutyric acid, which is an inhibitory neurotransmitter. IGF-I (1-3) H-Gly-Pro-Glu-OH also blocks fatty acid synthesis, leading to necrotic cell death. In vitro assays have shown that this drug can protect against blood group O erythrocytes from pyridoxal phosphate oxidation and protocatechuic acid binding. This drug has also been shown to increase locomotor activity in mice, as well as improve motor function in rats with experimental stroke.<br>IGF-I (1-3) H-Gly-Pro-Glu-OH is synthesized using a polymerase chain reaction technique and consists of amino acids 1 through 3 of</p>